Tnnt2 (troponin T2, cardiac type) - Rat Genome Database

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Gene: Tnnt2 (troponin T2, cardiac type) Rattus norvegicus
Analyze
Symbol: Tnnt2
Name: troponin T2, cardiac type
RGD ID: 3882
Description: Enables protein-macromolecule adaptor activity and troponin I binding activity. Involved in several processes, including actin crosslink formation; cardiac muscle contraction; and regulation of muscle filament sliding speed. Located in myofibril. Part of troponin complex. Human ortholog(s) of this gene implicated in intrinsic cardiomyopathy (multiple). Orthologous to human TNNT2 (troponin T2, cardiac type); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; INTERACTS WITH (E)-thiamethoxam; 1-naphthyl isothiocyanate; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: cardiac muscle troponin T; cardiac troponin T2; cTnT; Ctt; CTTG; RATCTTG; Tnnt3; tnTc; Troponin T cardiac; troponin T type 2 (cardiac); Troponin T, cardiac; troponin T, cardiac muscle; troponin T2; troponin T2 cardiac; troponin T2, cardiac
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81349,819,123 - 49,837,125 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1349,822,304 - 49,837,125 (+)EnsemblGRCr8
mRatBN7.21347,267,325 - 47,285,390 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1347,267,204 - 47,285,388 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1349,880,350 - 49,893,175 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01351,168,415 - 51,181,238 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01348,432,330 - 48,444,960 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01352,662,974 - 52,680,992 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1352,662,996 - 52,680,990 (+)Ensemblrn6Rnor6.0
Rnor_5.01357,711,369 - 57,729,182 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41348,872,972 - 48,885,815 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1347,589,409 - 47,602,135 (+)NCBICelera
RGSC_v3.11348,887,014 - 48,899,858 (+)NCBI
Cytogenetic Map13q13NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-dexrazoxane  (ISO)
(E)-thiamethoxam  (EXP)
1,2-dimethylhydrazine  (ISO)
1,3-benzothiazole-2-thiol  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-diaminotoluene  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
3-methyladenine  (EXP)
3-phenylprop-2-enal  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-azacytidine  (EXP)
5-methoxypsoralen  (EXP)
6-propyl-2-thiouracil  (EXP)
7beta-aminocephalosporanic acid  (ISO)
7H-xanthine  (EXP)
8-Br-cAMP  (ISO)
9H-xanthine  (EXP)
acrolein  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
ammonium hexachloroplatinate  (ISO)
amphetamine  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
cantharidin  (ISO)
carbofuran  (EXP)
carbon nanotube  (ISO)
celastrol  (EXP)
chelerythrine  (ISO)
chloropicrin  (ISO)
choline  (ISO)
Citreoviridin  (EXP,ISO)
cobalt atom  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
crocin-1  (EXP)
cytarabine  (ISO)
D-glucose  (ISO)
daunorubicin  (EXP)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibutyl phthalate  (EXP)
diethylstilbestrol  (ISO)
dioxygen  (ISO)
disodium selenite  (EXP,ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
Echimidine  (EXP)
ellagic acid  (EXP)
endosulfan  (EXP)
epalrestat  (ISO)
epichlorohydrin  (ISO)
fenvalerate  (EXP)
ferruginol  (EXP)
folic acid  (ISO)
fonofos  (ISO)
FR900359  (ISO)
fructose  (EXP)
gallic acid  (EXP)
gentamycin  (EXP)
glucose  (ISO)
graphite  (EXP)
Heliotrine  (EXP)
hexamethylene diisocyanate  (ISO)
hydrogen peroxide  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
isoprenaline  (EXP)
L-methionine  (ISO)
lipopolysaccharide  (ISO)
lutein  (EXP)
maraviroc  (ISO)
Mesaconitine  (EXP)
metaproterenol  (EXP)
methimazole  (EXP)
methoxychlor  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
naringin  (EXP)
nebivolol  (EXP)
nickel subsulfide  (EXP)
nitrofen  (EXP)
okadaic acid  (ISO)
orciprenaline  (EXP)
ozone  (ISO)
paracetamol  (EXP)
paraquat  (EXP)
parathion  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirarubicin  (EXP)
pravastatin  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
pyridaben  (ISO)
quercetin  (EXP)
resveratrol  (ISO)
ribavirin  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
serpentine asbestos  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
sunitinib  (ISO)
tacrolimus hydrate  (ISO)
terbufos  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (ISO)
thiamethoxam  (EXP)
thiamine(1+) chloride  (EXP,ISO)
thiram  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP,ISO)
triclosan  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vincristine  (EXP)
zaragozic acid A  (EXP,ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cardiac myofibril  (IEA,ISO)
cardiac Troponin complex  (IEA,ISO)
cytoplasm  (ISO)
myofibril  (IDA,ISO)
sarcomere  (IEA,ISO)
striated muscle thin filament  (IEA,ISO,ISS)
troponin complex  (IBA,IDA,IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway   (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
atenolol pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bisoprolol pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
dilated cardiomyopathy pathway  (IEA)
diltiazem pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
hypertrophic cardiomyopathy pathway  (IEA)
ibutilide pharmacodynamics pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Exposure to diesel exhaust particulates induces cardiac dysfunction and remodeling. Bradley JM, etal., J Appl Physiol (1985). 2013 Oct 1;115(7):1099-106. doi: 10.1152/japplphysiol.00343.2013. Epub 2013 Jul 25.
2. Troponin T modulates sarcomere length-dependent recruitment of cross-bridges in cardiac muscle. Chandra M, etal., Biophys J. 2006 Apr 15;90(8):2867-76. Epub 2006 Jan 27.
3. Transgenic rat hearts expressing a human cardiac troponin T deletion reveal diastolic dysfunction and ventricular arrhythmias. Frey N, etal., Cardiovasc Res. 2000 Aug;47(2):254-64.
4. Hypertrophic cardiomyopathy: low frequency of mutations in the beta-myosin heavy chain (MYH7) and cardiac troponin T (TNNT2) genes among Spanish patients. Garcia-Castro M, etal., Clin Chem. 2003 Aug;49(8):1279-85.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. The solution structure of a cardiac troponin C-troponin I-troponin T complex shows a somewhat compact troponin C interacting with an extended troponin I-troponin T component. Heller WT, etal., Biochemistry. 2002 Dec 31;41(52):15654-63.
7. Cardiac troponin T (cTnT) in hemodialysis patients with asymptomatic and symptomatic atherosclerosis. Hojs R, etal., Arch Med Res. 2005 Jul-Aug;36(4):367-71.
8. Regulation of force and unloaded sliding speed in single thin filaments: effects of regulatory proteins and calcium. Homsher E, etal., J Physiol. 2000 Apr 1;524 Pt 1:233-43.
9. Isolation and characterization of cDNA clones encoding embryonic and adult isoforms of rat cardiac troponin T. Jin JP and Lin JJ, J Biol Chem 1989 Aug 25;264(24):14471-7.
10. Complete nucleotide sequence and structural organization of rat cardiac troponin T gene. A single gene generates embryonic and adult isoforms via developmentally regulated alternative splicing. Jin JP, etal., J Mol Biol 1992 Oct 20;227(4):1269-76.
11. Novel cardiac troponin T mutation as a cause of familial dilated cardiomyopathy. Li D, etal., Circulation. 2001 Oct 30;104(18):2188-93.
12. Correlation Between Relative Nasopharyngeal Virus RNA Load and Lymphocyte Count Disease Severity in Patients with COVID-19. Liu Y, etal., Viral Immunol. 2020 Apr 10. doi: 10.1089/vim.2020.0062.
13. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
14. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
15. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
16. Infantile restrictive cardiomyopathy resulting from a mutation in the cardiac troponin T gene. Peddy SB, etal., Pediatrics. 2006 May;117(5):1830-3.
17. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
18. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
19. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
20. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
21. Gene-based anchoring of the rat genetic linkage and cytogenetic maps: new regional localizations, orientation of the linkage groups, and insights into mammalian chromosome evolution. Szpirer C, etal., Mamm Genome 1998 Sep;9(9):721-34
22. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
23. Functional consequence of mutation in rat cardiac troponin T is affected differently by myosin heavy chain isoforms. Tschirgi ML, etal., J Physiol. 2006 Jul 1;574(Pt 1):263-73. Epub 2006 Apr 27.
24. Mutations in the genes for cardiac troponin T and alpha-tropomyosin in hypertrophic cardiomyopathy. Watkins H, etal., N Engl J Med 1995 Apr 20;332(16):1058-64.
25. Altered phosphorylation and calcium sensitivity of cardiac myofibrillar proteins during sepsis. Wu LL, etal., Am J Physiol Regul Integr Comp Physiol. 2001 Aug;281(2):R408-16.
26. Usefulness of rapid quantitative measurement of myoglobin and troponin T in early diagnosis of acute myocardial infarction. Yamamoto M, etal., Circ J. 2004 Jul;68(7):639-44.
Additional References at PubMed
PMID:2530435   PMID:8205619   PMID:9637714   PMID:10449439   PMID:10850966   PMID:11158969   PMID:12093807   PMID:12186860   PMID:12477932   PMID:12738802   PMID:12832403   PMID:15542288  
PMID:15830381   PMID:15923195   PMID:16326803   PMID:16754800   PMID:16981728   PMID:18397962   PMID:18721805   PMID:18781631   PMID:19189074   PMID:19801490   PMID:20014345   PMID:20537565  
PMID:20711602   PMID:21056973   PMID:22364878   PMID:22865385   PMID:23012479   PMID:23357173   PMID:24364879   PMID:25771144   PMID:32322013   PMID:32429250   PMID:35352799  


Genomics

Comparative Map Data
Tnnt2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81349,819,123 - 49,837,125 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1349,822,304 - 49,837,125 (+)EnsemblGRCr8
mRatBN7.21347,267,325 - 47,285,390 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1347,267,204 - 47,285,388 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1349,880,350 - 49,893,175 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01351,168,415 - 51,181,238 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01348,432,330 - 48,444,960 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01352,662,974 - 52,680,992 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1352,662,996 - 52,680,990 (+)Ensemblrn6Rnor6.0
Rnor_5.01357,711,369 - 57,729,182 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41348,872,972 - 48,885,815 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1347,589,409 - 47,602,135 (+)NCBICelera
RGSC_v3.11348,887,014 - 48,899,858 (+)NCBI
Cytogenetic Map13q13NCBI
TNNT2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381201,359,014 - 201,377,680 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1201,359,002 - 201,379,773 (-)Ensemblhg38GRCh38
GRCh371201,328,142 - 201,346,808 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361199,594,765 - 199,613,428 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341198,059,798 - 198,078,462NCBI
Celera1174,451,992 - 174,470,656 (-)NCBICelera
Cytogenetic Map1q32.1NCBI
HuRef1172,494,387 - 172,513,074 (-)NCBIHuRef
CHM1_11202,750,309 - 202,768,995 (-)NCBICHM1_1
T2T-CHM13v2.01200,616,823 - 200,635,489 (-)NCBIT2T-CHM13v2.0
Tnnt2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391135,763,933 - 135,780,006 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1135,764,092 - 135,779,998 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381135,836,315 - 135,852,268 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1135,836,354 - 135,852,260 (+)Ensemblmm10GRCm38
MGSCv371137,732,963 - 137,748,838 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361137,652,816 - 137,668,671 (+)NCBIMGSCv36mm8
Celera1138,471,192 - 138,487,068 (+)NCBICelera
Cytogenetic Map1E4NCBI
cM Map159.32NCBI
Tnnt2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540637,487,154 - 37,507,639 (-)Ensembl
ChiLan1.0NW_00495540637,491,462 - 37,507,360 (-)NCBIChiLan1.0ChiLan1.0
TNNT2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2148,009,649 - 48,022,660 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1147,974,336 - 47,987,350 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01176,957,298 - 176,976,033 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11181,258,314 - 181,277,048 (-)NCBIPanPan1.1PanPan1.1panPan2
TNNT2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.171,598,306 - 1,620,531 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl71,598,306 - 1,613,741 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha71,565,151 - 1,580,081 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.071,523,217 - 1,537,269 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl71,506,647 - 1,543,842 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.171,510,291 - 1,525,219 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.071,618,096 - 1,633,001 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.071,642,705 - 1,657,644 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Tnnt2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934473,817,529 - 73,834,405 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365673,056,845 - 3,068,887 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365673,052,167 - 3,069,077 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TNNT2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1023,749,335 - 23,763,396 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11023,749,528 - 23,759,696 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21028,159,010 - 28,173,145 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TNNT2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12528,035,563 - 28,054,322 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2528,040,087 - 28,054,120 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605528,830,239 - 28,851,566 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tnnt2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248079,336,904 - 9,348,396 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248079,332,202 - 9,348,610 (+)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Tnnt2
138 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:212
Count of miRNA genes:87
Interacting mature miRNAs:91
Transcripts:ENSRNOT00000047682, ENSRNOT00000050284
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134863963493639634Rat
10755495Bp387Blood pressure QTL 3873.78arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133721624190057603Rat
9589141Insul28Insulin level QTL 2810.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)131186625456866254Rat
6893344Cm79Cardiac mass QTL 791.50.04heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)134627292251216694Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1338975045103588154Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133992469384924693Rat
71119Thym2Thymus enlargement QTL 23.8thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)134874981487285480Rat
61391Bp5Blood pressure QTL 55.6arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)132485392569853925Rat
4889861Pur29Proteinuria QTL 2913.80.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)133996821183286298Rat
2317040Aia21Adjuvant induced arthritis QTL 212.75joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)131238432057384320Rat
631645Bp121Blood pressure QTL 1213.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131746828262468282Rat
2317046Aia8Adjuvant induced arthritis QTL 83.9700000286102295joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)131238432057384320Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)13742179187286911Rat
1331784Bp222Blood pressure QTL 2222.944arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)132433543255601132Rat
61340Bp25Blood pressure QTL 254.20.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133708798382087983Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)134098358585983585Rat
724564Uae11Urinary albumin excretion QTL 115.7urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)134735425894285672Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1321120177109350286Rat
4145117Mcs27Mammary carcinoma susceptibility QTL 270.0001mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)134599007750392939Rat
1558644Cm45Cardiac mass QTL 453.60.002heart mass (VT:0007028)heart wet weight (CMO:0000069)132624480871244808Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133379409678794096Rat
61349Bp31Blood pressure QTL 315.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133992469384924693Rat
2303563Bw89Body weight QTL 896body mass (VT:0001259)body weight (CMO:0000012)133483494779834947Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1311081740103588154Rat
2301962Cm72Cardiac mass QTL 724.12heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)133379409660914504Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
12879477Bp401Blood pressure QTL 401arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133981472684814726Rat
1331750Bp220Blood pressure QTL 2202.98arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133996821184968211Rat
6893338Cm76Cardiac mass QTL 7600.99heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)132624480871244808Rat
12879472Bp399Blood pressure QTL 399arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134778041850392939Rat
11530006Niddm72Non-insulin dependent diabetes mellitus QTL 720.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)133828629883286298Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131103588154Rat
9589164Gluco66Glucose level QTL 666.670.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)131771133662711336Rat
7411662Foco29Food consumption QTL 2920.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)131186625456866254Rat

Markers in Region
D13Wox9  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.01357,714,346 - 57,714,528NCBIRnor5.0
RGSC_v3.41348,870,982 - 48,871,163RGDRGSC3.4
RGSC_v3.11348,885,025 - 48,885,206RGD
RH 3.4 Map13148.3UniSTS
RH 3.4 Map13148.3RGD
RH 2.0 Map13389.6RGD
Cytogenetic Map13q13UniSTS
D13Arb9  
Rat AssemblyChrPosition (strand)SourceJBrowse
SHRSP x BN Map1316.2498RGD
D13Mgh15  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81349,834,434 - 49,834,959 (+)Marker Load Pipeline
mRatBN7.21347,282,698 - 47,283,224 (+)MAPPERmRatBN7.2
Rnor_6.01352,678,302 - 52,678,826NCBIRnor6.0
Rnor_5.01357,726,492 - 57,727,016UniSTSRnor5.0
RGSC_v3.41348,883,127 - 48,883,651UniSTSRGSC3.4
Celera1347,599,447 - 47,599,971UniSTS
RGSC_v3.11348,897,169 - 48,897,694RGD
Cytogenetic Map13q13UniSTS
RH131106  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81349,836,229 - 49,836,960 (+)Marker Load Pipeline
mRatBN7.21347,284,494 - 47,285,225 (+)MAPPERmRatBN7.2
Rnor_6.01352,680,097 - 52,680,827NCBIRnor6.0
Rnor_5.01357,728,287 - 57,729,017UniSTSRnor5.0
RGSC_v3.41348,884,922 - 48,885,652UniSTSRGSC3.4
Celera1347,601,242 - 47,601,972UniSTS
RH 3.4 Map13149.6UniSTS
Cytogenetic Map13q13UniSTS
RH143263  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21347,275,549 - 47,275,782 (+)MAPPERmRatBN7.2
Rnor_6.01352,671,196 - 52,671,428NCBIRnor6.0
Rnor_5.01357,719,564 - 57,719,796UniSTSRnor5.0
RGSC_v3.41348,876,199 - 48,876,431UniSTSRGSC3.4
Celera1347,592,636 - 47,592,868UniSTS
RH 3.4 Map13149.8UniSTS
Cytogenetic Map13q13UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 145 91 90 59 55 59 6 319 155 11 124 81 92 31 11 11

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001415762 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001415763 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_012676 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006249822 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006249825 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006249828 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008769535 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008769536 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008769537 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008769538 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598672 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090363 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC096932 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC161855 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473958 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU295527 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M26051 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M26052 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M80829 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000047682   ⟹   ENSRNOP00000049297
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1349,824,049 - 49,837,122 (+)Ensembl
mRatBN7.2 Ensembl1347,267,204 - 47,285,388 (+)Ensembl
Rnor_6.0 Ensembl1352,662,996 - 52,680,990 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000050284   ⟹   ENSRNOP00000041541
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1349,824,049 - 49,837,122 (+)Ensembl
mRatBN7.2 Ensembl1347,267,204 - 47,285,388 (+)Ensembl
Rnor_6.0 Ensembl1352,667,969 - 52,680,794 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000084986   ⟹   ENSRNOP00000069434
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1349,822,471 - 49,837,125 (+)Ensembl
mRatBN7.2 Ensembl1347,267,204 - 47,285,388 (+)Ensembl
Rnor_6.0 Ensembl1352,667,969 - 52,680,794 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000108522   ⟹   ENSRNOP00000077671
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1349,822,304 - 49,837,122 (+)Ensembl
mRatBN7.2 Ensembl1347,270,616 - 47,285,388 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000152332   ⟹   ENSRNOP00000102457
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1349,828,646 - 49,837,125 (+)Ensembl
RefSeq Acc Id: NM_001415762   ⟹   NP_001402691
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81349,819,123 - 49,837,125 (+)NCBI
mRatBN7.21347,267,381 - 47,285,390 (+)NCBI
RefSeq Acc Id: NM_001415763   ⟹   NP_001402692
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81349,819,123 - 49,837,125 (+)NCBI
mRatBN7.21347,267,381 - 47,285,390 (+)NCBI
RefSeq Acc Id: NM_012676   ⟹   NP_036808
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81349,824,059 - 49,837,125 (+)NCBI
mRatBN7.21347,272,323 - 47,285,390 (+)NCBI
Rnor_6.01352,667,969 - 52,680,990 (+)NCBI
Rnor_5.01357,711,369 - 57,729,182 (+)NCBI
RGSC_v3.41348,872,972 - 48,885,815 (+)RGD
Celera1347,589,409 - 47,602,135 (+)RGD
Sequence:
RefSeq Acc Id: XM_039090363   ⟹   XP_038946291
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81349,829,691 - 49,837,125 (+)NCBI
mRatBN7.21347,267,349 - 47,285,390 (+)NCBI
RefSeq Acc Id: NP_036808   ⟸   NM_012676
- Peptide Label: isoform 1
- UniProtKB: P50753 (UniProtKB/Swiss-Prot),   F1LQ95 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000049297   ⟸   ENSRNOT00000047682
Ensembl Acc Id: ENSRNOP00000069434   ⟸   ENSRNOT00000084986
Ensembl Acc Id: ENSRNOP00000041541   ⟸   ENSRNOT00000050284
RefSeq Acc Id: XP_038946291   ⟸   XM_039090363
- Peptide Label: isoform X1
- UniProtKB: A6ICH0 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000077671   ⟸   ENSRNOT00000108522
RefSeq Acc Id: NP_001402691   ⟸   NM_001415762
- Peptide Label: isoform 2
- UniProtKB: B1WBR4 (UniProtKB/TrEMBL),   F1LQ95 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001402692   ⟸   NM_001415763
- Peptide Label: isoform 3
- UniProtKB: F1LMI8 (UniProtKB/TrEMBL),   A9YUA5 (UniProtKB/TrEMBL),   A0A8I5Y1F9 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000102457   ⟸   ENSRNOT00000152332

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P50753-F1-model_v2 AlphaFold P50753 1-299 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698855
Promoter ID:EPDNEW_R9374
Type:single initiation site
Name:Tnnt2_1
Description:troponin T2, cardiac type
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01352,663,033 - 52,663,093EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3882 AgrOrtholog
BioCyc Gene G2FUF-18189 BioCyc
Ensembl Genes ENSRNOG00000033734 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000047682 ENTREZGENE
  ENSRNOT00000050284 ENTREZGENE
  ENSRNOT00000084986 ENTREZGENE
Gene3D-CATH 1.20.5.350 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:9035753 IMAGE-MGC_LOAD
InterPro TNNT UniProtKB/Swiss-Prot
  Troponin UniProtKB/Swiss-Prot
  Troponin_sf UniProtKB/Swiss-Prot
KEGG Report rno:24837 UniProtKB/Swiss-Prot
MGC_CLONE MGC:187381 IMAGE-MGC_LOAD
NCBI Gene 24837 ENTREZGENE
PANTHER PTHR11521 UniProtKB/Swiss-Prot
  TROPONIN T, CARDIAC MUSCLE UniProtKB/Swiss-Prot
Pfam Troponin UniProtKB/Swiss-Prot
PhenoGen Tnnt2 PhenoGen
RatGTEx ENSRNOG00000033734 RatGTEx
Superfamily-SCOP SSF90250 UniProtKB/Swiss-Prot
TIGR TC216950
UniProt A0A8I5Y1F9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2QKB8_RAT UniProtKB/TrEMBL
  A0A8L2UPK2_RAT UniProtKB/TrEMBL
  A0ABK0LBG8_RAT UniProtKB/TrEMBL
  A6ICH0 ENTREZGENE, UniProtKB/TrEMBL
  A6ICH2_RAT UniProtKB/TrEMBL
  A9YUA5 ENTREZGENE, UniProtKB/TrEMBL
  B1WBR4 ENTREZGENE, UniProtKB/TrEMBL
  F1LMI8 ENTREZGENE
  F1LQ95 ENTREZGENE, UniProtKB/TrEMBL
  P50753 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-24 Tnnt2  troponin T2, cardiac type  Tnnt2  troponin T type 2 (cardiac)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-23 Tnnt2  troponin T type 2 (cardiac)  Tnnt2  troponin T2, cardiac  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Tnnt2  troponin T2, cardiac    troponin T2  Name updated 1299863 APPROVED
2002-06-10 Tnnt2  troponin T2      Name updated 70585 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression specific to heart tissues; expressed in cardiac muscle, slow skeletal muscle, and fast skeletal muscle 61489
gene_homology aa sequence shares 87% identity with bovine, 85% with rabbit, and 72% with chicken Tnnt2 730096