Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3882
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tnnt2
Name: troponin T2, cardiac type
Acc ID: CHEBI:64317
Term: isoprenaline
Definition: A secondary amino compound that is noradrenaline in which one of the hydrogens attached to the nitrogen is replaced by an isopropyl group. A sympathomimetic acting almost exclusively on beta-adrenergic receptors, it is used (mainly as the hydrochloride salt) as a bronghodilator and heart stimulant for the management of a variety of cardiac disorders.
Chemical ID: MESH:D007545
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tnnt2affects expressionEXP 6480464CTDIsoproterenol affects the expression of TNNT2 proteinPMID:17848144
Tnnt2decreases expressionEXP 6480464CTDIsoproterenol results in decreased expression of TNNT2 proteinPMID:34435724
Tnnt2increases expressionEXP 6480464CTDIsoproterenol results in increased expression of TNNT2 proteinPMID:17188415 PMID:17654401 PMID:19812120 PMID:19854236 PMID:21762681 PMID:22878004 PMID:24286936 PMID:32946155 PMID:35815753
Tnnt2increases secretionEXP 6480464CTDIsoproterenol results in increased secretion of TNNT2 proteinPMID:19146839 PMID:25537132
Tnnt2multiple interactionsEXP 6480464CTD5-Methoxypsoralen inhibits the reaction [Isoproterenol results in increased expression of TNNT2 protein]; Ellagic Acid inhibits the reaction [Isoproterenol results in increased expression of TNNT2 protein]; ferruginol inhibits the reaction [Isoproterenol results in increased expression of TNNT2 protein]; Gallic Acid inhibits the reaction [Isoproterenol results in increased secretion of TNNT2 protein]; Lutein inhibits the reaction [Isoproterenol results in decreased expression of TNNT2 protein]; naringin inhibits the reaction [Isoproterenol results in increased expression of TNNT2 protein]; Quercetin inhibits the reaction [Isoproterenol results in increased secretion of TNNT2 protein]; Vincristine inhibits the reaction [Isoproterenol results in increased secretion of TNNT2 protein]PMID:17188415 PMID:19146839 PMID:21762681 PMID:25537132 PMID:32946155 PMID:34435724 PMID:35815753
Go Back to source page   Continue to Ontology report