Sts (steroid sulfatase) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Sts (steroid sulfatase) Rattus norvegicus
Analyze
Symbol: Sts
Name: steroid sulfatase
RGD ID: 3783
Description: Enables steryl-sulfatase activity. Involved in several processes, including response to estrogen; response to pH; and response to peptide hormone. Located in endoplasmic reticulum membrane and nuclear envelope. Biomarker of cryptorchidism and hypertension. Human ortholog(s) of this gene implicated in X-linked ichthyosis. Orthologous to human STS (steroid sulfatase); PARTICIPATES IN estradiol biosynthetic pathway; testosterone biosynthetic pathway; steroid hormone biosynthetic pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: arylsulfatase C; ASC; steroid sulfatase (microsomal), isozyme S; steryl-sulfatase; steryl-sulfate sulfohydrolase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X46,102,524 - 46,110,868 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX46,102,548 - 46,111,104 (+)EnsemblGRCr8
mRatBN7.2X42,225,131 - 42,233,403 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX42,225,372 - 42,233,402 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_UtxX43,541,128 - 43,549,235 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X47,008,476 - 47,016,583 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X44,673,210 - 44,681,317 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X45,420,418 - 45,428,748 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX45,420,596 - 45,428,750 (+)Ensemblrn6Rnor6.0
Rnor_5.0X45,646,021 - 45,654,127 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4X63,915,803 - 63,923,834 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
CeleraX42,864,036 - 42,872,067 (+)NCBICelera
RGSC_v3.1X63,969,271 - 63,977,302 (+)NCBI
Cytogenetic MapXq21NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,3-bisphospho-D-glyceric acid  (ISO)
2,3-bisphosphoglyceric acid  (ISO)
2,6-dinitrotoluene  (EXP)
2-hydroxy-5-nitrophenyl hydrogen sulfate  (ISO)
2-hydroxypropanoic acid  (ISO)
2-palmitoylglycerol  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4-\{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino\}benzoic acid  (ISO)
4-Hydroxytestosterone  (ISO)
4-nitrophenyl hydrogen sulfate  (ISO)
6-propyl-2-thiouracil  (EXP)
6alpha-methylprednisolone  (ISO)
9-cis-retinoic acid  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (EXP)
aflatoxin M1  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
androgen antagonist  (EXP)
androst-5-ene-3beta,17beta-diol  (ISO)
aristolochic acid A  (ISO)
arotinoid acid  (ISO)
arsenite(3-)  (ISO)
atrazine  (EXP)
azathioprine  (ISO)
benzimidazoles  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP)
bortezomib  (ISO)
butan-1-ol  (ISO)
Butylparaben  (EXP)
cadmium atom  (EXP)
cadmium dichloride  (EXP,ISO)
carmustine  (ISO)
celecoxib  (ISO)
chlorpromazine  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
copper(II) sulfate  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
danazol  (ISO)
DDE  (EXP)
deguelin  (ISO)
dehydroepiandrosterone  (ISO)
dehydroepiandrosterone sulfate  (ISO)
dibutyl phthalate  (EXP)
diclofenac  (ISO)
dicyclanil  (ISO)
diethylstilbestrol  (ISO)
disodium tetraborate  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
enzacamene  (EXP)
epoxiconazole  (EXP)
equilenin  (ISO)
estrone  (ISO)
estrone 3-sulfate  (ISO)
ethyl methanesulfonate  (ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
furan  (EXP,ISO)
genistein  (ISO)
gentamycin  (EXP)
Goe 6976  (ISO)
graphite  (EXP)
GSK-J4  (ISO)
hydrogen peroxide  (ISO)
leflunomide  (EXP)
linuron  (EXP)
lipopolysaccharide  (ISO)
LY294002  (ISO)
mercury dibromide  (ISO)
methimazole  (EXP)
methotrexate  (ISO)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
N-acetylsphingosine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-tosyl-L-phenylalanyl chloromethyl ketone  (ISO)
naphthalenes  (EXP)
nickel sulfate  (ISO)
nimesulide  (EXP)
okadaic acid  (ISO)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (EXP,ISO)
parthenolide  (ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosphatidic acid  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
prednisolone  (ISO)
Pregn-5-ene-3beta,20alpha-diol  (ISO)
prochloraz  (EXP)
procymidone  (EXP)
propiconazole  (EXP)
propranolol  (ISO)
rac-lactic acid  (ISO)
rotenone  (EXP,ISO)
rottlerin  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sirolimus  (ISO)
sodium aurothiomalate  (ISO)
sodium dichromate  (EXP)
stilbenoid  (ISO)
sulfadimethoxine  (EXP)
sulfamic acid  (ISO)
tazarotene  (ISO)
tazarotenic acid  (ISO)
thioacetamide  (EXP)
torcetrapib  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
Triptolide  (EXP)
troglitazone  (ISO)
trovafloxacin  (EXP)
undecane  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
wortmannin  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Secretory pattern of growth hormone regulates steroid sulfatase activity in rat liver. Eriksson L, etal., J Steroid Biochem. 1989 Sep;33(3):413-6.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Epidermal steroid sulfatase and cholesterol sulfotransferase are regulated during late gestation in the fetal rat. Hanley K, etal., J Invest Dermatol. 1997 Jun;108(6):871-5.
5. A novel steroidal selective steroid sulfatase inhibitor KW-2581 inhibits sulfated-estrogen dependent growth of breast cancer cells in vitro and in animal models. Ishida H, etal., Breast Cancer Res Treat. 2007 Feb 1;.
6. The effect of steroid sulfatase inhibition on learning and spatial memory. Johnson DA, etal., Brain Res. 2000 May 26;865(2):286-90.
7. Steroid sulfatase and the Y chromosome hypertensive locus of the spontaneously hypertensive rat. Johnson ML, etal., Steroids. 1995 Oct;60(10):681-5.
8. Microsomal steroid sulfatase: interactions with cytosolic steroid sulfotransferases. Kauffman FC, etal., Chem Biol Interact. 1998 Feb 20;109(1-3):169-82.
9. A monoclonal antibody to rat liver arylsulfatase C and its application in immunohistochemistry. Kawano J, etal., J Histochem Cytochem. 1989 May;37(5):683-90.
10. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
11. Cloning of the rat steroid sulfatase gene (Sts), a non-pseudoautosomal X-linked gene that undergoes X inactivation. Li XM, etal., Mamm Genome 1996 Jun;7(6):420-4.
12. Inhibition of steroid sulphatase activity by tricyclic coumarin sulphamates. Malini B, etal., J Steroid Biochem Mol Biol. 2000 Dec 31;75(4-5):253-8.
13. Dependence on surface pH and surface substrate concentration of activity of microsome-bound arylsulfatase C and the surface charge density in the vicinity of the enzyme. Masamoto K J Biochem (Tokyo). 1984 Mar;95(3):715-9.
14. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
15. Transmembranous disposition of arylsulfatase C in microsomal membranes of rat liver. Moriyasu M and Ito A, J Biochem (Tokyo). 1982 Oct;92(4):1197-204.
16. Testicular steroid sulfatase in a cryptorchid rat strain. Mouhadjer N, etal., J Steroid Biochem. 1989;34(1-6):555-8.
17. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
18. Effects of estrogen and growth hormone on steroid sulfatase activity and estrogen binding in rat liver. Nilsson B, etal., J Steroid Biochem. 1988 Mar;29(3):293-5.
19. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
20. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
21. Steroid sulfatase: a pivotal player in estrogen synthesis and metabolism. Purohit A, etal., Mol Cell Endocrinol. 2011 Jul 4;340(2):154-60. Epub 2011 Jun 30.
22. GOA pipeline RGD automated data pipeline
23. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
24. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
25. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:2765556   PMID:12477932   PMID:15962010  


Genomics

Comparative Map Data
Sts
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X46,102,524 - 46,110,868 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX46,102,548 - 46,111,104 (+)EnsemblGRCr8
mRatBN7.2X42,225,131 - 42,233,403 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX42,225,372 - 42,233,402 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_UtxX43,541,128 - 43,549,235 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X47,008,476 - 47,016,583 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X44,673,210 - 44,681,317 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X45,420,418 - 45,428,748 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX45,420,596 - 45,428,750 (+)Ensemblrn6Rnor6.0
Rnor_5.0X45,646,021 - 45,654,127 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4X63,915,803 - 63,923,834 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
CeleraX42,864,036 - 42,872,067 (+)NCBICelera
RGSC_v3.1X63,969,271 - 63,977,302 (+)NCBI
Cytogenetic MapXq21NCBI
STS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X7,147,290 - 7,354,641 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX7,147,237 - 7,804,358 (+)Ensemblhg38GRCh38
GRCh37X7,065,331 - 7,272,682 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X7,147,472 - 7,282,682 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34X6,997,232 - 7,132,416NCBI
CeleraX11,363,616 - 11,498,571 (+)NCBICelera
Cytogenetic MapXp22.31NCBI
HuRefX4,994,733 - 5,130,162 (+)NCBIHuRef
CHM1_1X7,168,567 - 7,303,666 (+)NCBICHM1_1
T2T-CHM13v2.0X6,701,075 - 6,908,316 (+)NCBIT2T-CHM13v2.0
Sts
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X168,856,332 - 169,015,037 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX168,909,030 - 169,014,924 (-)EnsemblGRCm39 EnsemblGRCm39
Cytogenetic MapXF5NCBI
cM MapXY75.0NCBI
Sts
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554995,180,214 - 5,345,221 (+)Ensembl
ChiLan1.0NW_0049554995,180,451 - 5,347,862 (+)NCBIChiLan1.0ChiLan1.0
STS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X8,680,013 - 8,896,305 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X8,692,276 - 8,899,974 (+)NCBINHGRI_mPanPan1
PanPan1.1X7,015,812 - 7,211,919 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX7,047,017 - 7,207,540 (+)EnsemblpanPan2panpan1.1
STS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X4,396,867 - 4,470,093 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX4,325,665 - 4,467,284 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_TashaX4,298,275 - 4,448,414 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0X4,277,781 - 4,430,757 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX4,263,432 - 4,406,526 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X4,275,666 - 4,403,942 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X4,310,666 - 4,460,990 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X4,306,633 - 4,435,218 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Sts
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049532,971,765 - 3,048,416 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366441,325,713 - 1,395,923 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366441,328,327 - 1,395,856 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
STS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1X3,926,027 - 4,076,900 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1Y2,747,102 - 2,828,322 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X4,052,271 - 4,255,004 (+)NCBISscrofa10.2Sscrofa10.2susScr3
STS
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X5,601,746 - 5,813,916 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX5,709,410 - 5,812,224 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660567,198,855 - 7,399,995 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sts
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248344,853,045 - 4,978,111 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248344,805,556 - 4,975,264 (+)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Sts
42 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:42
Count of miRNA genes:41
Interacting mature miRNAs:41
Transcripts:ENSRNOT00000051897
Prediction methods:Miranda, Pita, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
731181Uae27Urinary albumin excretion QTL 272.70.0059urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)X197044046970440Rat
738035Stresp1Stress response QTL 14.960.000011stress-related behavior trait (VT:0010451)defensive burying - copingX45182909117740458Rat
631666Iddm5Insulin dependent diabetes mellitus QTL 5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X811148653111486Rat
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between duration of physical contact or close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X4493088389930883Rat

Markers in Region
RH130579  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X42,233,114 - 42,233,299 (+)MAPPERmRatBN7.2
Rnor_6.0X45,428,460 - 45,428,644NCBIRnor6.0
Rnor_5.0X45,653,839 - 45,654,023UniSTSRnor5.0
RGSC_v3.4X63,923,546 - 63,923,730UniSTSRGSC3.4
CeleraX42,871,779 - 42,871,963UniSTS
RH 3.4 MapX589.3UniSTS
Cytogenetic MapXq12-q14UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 162 91 90 59 92 59 6 356 192 11 141 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000051897   ⟹   ENSRNOP00000043915
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX46,102,548 - 46,111,104 (+)Ensembl
mRatBN7.2 EnsemblX42,225,372 - 42,233,402 (+)Ensembl
Rnor_6.0 EnsemblX45,420,596 - 45,428,750 (+)Ensembl
RefSeq Acc Id: NM_012661   ⟹   NP_036793
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X46,102,760 - 46,110,868 (+)NCBI
mRatBN7.2X42,225,295 - 42,233,403 (+)NCBI
Rnor_6.0X45,420,717 - 45,428,748 (+)NCBI
Rnor_5.0X45,646,021 - 45,654,127 (+)NCBI
RGSC_v3.4X63,915,803 - 63,923,834 (+)RGD
CeleraX42,864,036 - 42,872,067 (+)RGD
Sequence:
RefSeq Acc Id: XM_006256961   ⟹   XP_006257023
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X46,102,524 - 46,110,868 (+)NCBI
mRatBN7.2X42,225,131 - 42,233,403 (+)NCBI
Rnor_6.0X45,420,418 - 45,428,748 (+)NCBI
Rnor_5.0X45,646,021 - 45,654,127 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006256962   ⟹   XP_006257024
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X46,102,665 - 46,110,868 (+)NCBI
mRatBN7.2X42,225,135 - 42,233,403 (+)NCBI
Rnor_6.0X45,420,428 - 45,428,748 (+)NCBI
Rnor_5.0X45,646,021 - 45,654,127 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063279793   ⟹   XP_063135863
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X46,102,688 - 46,110,868 (+)NCBI
Protein Sequences
Protein RefSeqs NP_036793 (Get FASTA)   NCBI Sequence Viewer  
  XP_006257023 (Get FASTA)   NCBI Sequence Viewer  
  XP_006257024 (Get FASTA)   NCBI Sequence Viewer  
  XP_063135863 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC53097 (Get FASTA)   NCBI Sequence Viewer  
  EDL96075 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000043915
GenBank Protein P15589 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_036793   ⟸   NM_012661
- Peptide Label: precursor
- UniProtKB: P15589 (UniProtKB/Swiss-Prot),   G3V9E5 (UniProtKB/TrEMBL),   A6IPT8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006257024   ⟸   XM_006256962
- Peptide Label: isoform X2
- UniProtKB: P15589 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006257023   ⟸   XM_006256961
- Peptide Label: isoform X1
- UniProtKB: P15589 (UniProtKB/Swiss-Prot),   G3V9E5 (UniProtKB/TrEMBL),   A6IPT8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000043915   ⟸   ENSRNOT00000051897
RefSeq Acc Id: XP_063135863   ⟸   XM_063279793
- Peptide Label: isoform X2
- UniProtKB: P15589 (UniProtKB/Swiss-Prot)
Protein Domains
Sulfatase N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P15589-F1-model_v2 AlphaFold P15589 1-577 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701824
Promoter ID:EPDNEW_R12348
Type:multiple initiation site
Name:Sts_1
Description:steroid sulfatase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X45,420,684 - 45,420,744EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3783 AgrOrtholog
BioCyc Gene G2FUF-2402 BioCyc
Ensembl Genes ENSRNOG00000032487 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000051897 ENTREZGENE
Gene3D-CATH 3.30.1120.10 UniProtKB/Swiss-Prot
  3.40.720.10 UniProtKB/Swiss-Prot
  Helix hairpin bin UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7193240 IMAGE-MGC_LOAD
InterPro Alkaline_phosphatase_core_sf UniProtKB/Swiss-Prot
  Sulfatase UniProtKB/Swiss-Prot
  Sulfatase_CS UniProtKB/Swiss-Prot
  Sulfatase_N UniProtKB/Swiss-Prot
KEGG Report rno:24800 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93550 IMAGE-MGC_LOAD
NCBI Gene 24800 ENTREZGENE
PANTHER ARYLSULFATASE FAMILY MEMBER UniProtKB/Swiss-Prot
  STERYL-SULFATASE UniProtKB/Swiss-Prot
Pfam Sulfatase UniProtKB/Swiss-Prot
  Sulfatase_C UniProtKB/Swiss-Prot
PhenoGen Sts PhenoGen
PROSITE SULFATASE_1 UniProtKB/Swiss-Prot
  SULFATASE_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000032487 RatGTEx
Superfamily-SCOP SSF53649 UniProtKB/Swiss-Prot
TIGR TC221301
UniProt A6IPT8 ENTREZGENE, UniProtKB/TrEMBL
  G3V9E5 ENTREZGENE, UniProtKB/TrEMBL
  P15589 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-02-01 Sts  steroid sulfatase  Sts  steroid sulfatase (microsomal), isozyme S  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-02-02 Sts  steroid sulfatase (microsomal), isozyme S  Sts  steroid sulfatase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Sts  steroid sulfatase      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression ubiquitously expressed in brain, lung, liver, kidney, adrenal, and testis 61497
gene_transcript contains 9 introns 61497
gene_transcript gene is not pseudoautosomal and is 8.2 kb long 61497