Slc6a3 (solute carrier family 6 member 3) - Rat Genome Database

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Gene: Slc6a3 (solute carrier family 6 member 3) Rattus norvegicus
Analyze
Symbol: Slc6a3
Name: solute carrier family 6 member 3
RGD ID: 3715
Description: Enables several functions, including amine binding activity; enzyme binding activity; and sodium:chloride symporter activity. Involved in several processes, including dopamine transport; response to cAMP; and response to ethanol. Located in neuron projection and plasma membrane. Is active in dopaminergic synapse; postsynaptic membrane; and presynaptic membrane. Biomarker of Parkinsonism; heroin dependence; high grade glioma; hyperprolactinemia; and hypertension. Human ortholog(s) of this gene implicated in attention deficit hyperactivity disorder; classic dopamine transporter deficiency syndrome; mild cognitive impairment; nicotine dependence; and obesity. Orthologous to human SLC6A3 (solute carrier family 6 member 3); PARTICIPATES IN alfentanil pharmacodynamics pathway; bupivacaine pharmacodynamics pathway; buprenorphine pharmacodynamics pathway; INTERACTS WITH (S)-amphetamine; (S)-naringenin; (S)-nicotine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: DA transporter; DAT; Dat1; sodium-dependent dopamine transporter; Solute carrier family 6 (neurotransmitter transporter dopamine) member 3; solute carrier family 6 (neurotransmitter transporter), member 3; Solute carrier family 6 (neurotransmitter transporter, dopamine), member 3; solute carrier family 6, member 3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Slc6a3m1Span
Genetic Models: F344-Slc6a3m1Span
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8131,537,990 - 31,578,962 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl131,537,990 - 31,578,962 (-)EnsemblGRCr8
mRatBN7.2129,709,443 - 29,750,413 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl129,709,443 - 29,750,413 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx129,510,573 - 29,551,545 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0135,510,418 - 35,551,390 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0129,711,198 - 29,752,170 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0132,323,011 - 32,363,983 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl132,321,580 - 32,363,983 (-)Ensemblrn6Rnor6.0
Rnor_5.0133,745,060 - 33,788,878 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4130,516,568 - 30,557,540 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera128,357,426 - 28,397,883 (-)NCBICelera
RGSC_v3.1130,518,078 - 30,558,861 (-)NCBI
Cytogenetic Map1p11NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(20S)-ginsenoside Rg3  (ISO)
(R)-noradrenaline  (ISO)
(R)-octopamine  (ISO)
(S)-amphetamine  (EXP,ISO)
(S)-naringenin  (EXP)
(S)-nicotine  (EXP,ISO)
1,2-dimethylhydrazine  (ISO)
1-(2-(diphenylmethoxy)ethyl)-4-(2-(4-azido-3-iodophenyl)ethyl)piperazine  (EXP)
1-[2-(benzhydryloxy)ethyl]-4-(3-phenylpropyl)piperazine  (EXP,ISO)
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,5-dimethoxy-4-bromophenethylamine  (ISO)
2-aminopropiophenone  (ISO)
2-phenylethylamine  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-[2-(diphenylmethoxy)ethyl]-1-[(4-azidophenyl)-methyl]-piperidine  (EXP)
4-nitrotoluene  (EXP)
7-nitroindazole  (ISO)
acrylamide  (EXP)
albiflorin  (EXP)
alcohol  (ISO)
all-trans-retinoic acid  (ISO)
alpha,alpha-trehalose  (ISO)
aluminium hydroxide  (ISO)
AM-251  (EXP)
aminorex  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP,ISO)
Aroclor 1254  (EXP,ISO)
arsenite(3-)  (EXP,ISO)
atrazine  (EXP)
Azoxymethane  (ISO)
benzatropine  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bupropion  (ISO)
butyric acid  (EXP)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (EXP,ISO)
citalopram  (ISO)
clozapine  (ISO)
cocaine  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cyhalothrin  (EXP)
DADLE  (ISO)
DDD  (ISO)
DDE  (EXP,ISO)
DDT  (ISO)
deguelin  (ISO)
dextran sulfate  (ISO)
diazinon  (EXP)
dieldrin  (EXP,ISO)
diethyldithiocarbamic acid  (EXP)
diethylstilbestrol  (EXP)
dihydro-beta-erythroidine  (EXP)
dimethylarsinic acid  (EXP)
dithionite(2-)  (ISO)
dopamine  (EXP,ISO)
doxorubicin  (ISO)
elemental selenium  (EXP)
endosulfan  (EXP)
epoxiconazole  (ISO)
estrone  (ISO)
ethanol  (ISO)
fluoxetine  (EXP,ISO)
fulvestrant  (ISO)
ganglioside GM1  (EXP)
geraniol  (ISO)
glyburide  (ISO)
glyphosate  (ISO)
haloperidol  (EXP,ISO)
Harpagoside  (ISO)
heptachlor  (EXP,ISO)
herbicide  (EXP)
ibogaine  (ISO)
ibuprofen  (ISO)
iron atom  (EXP)
iron(0)  (EXP)
isoliquiritigenin  (ISO)
ketamine  (ISO)
linalool  (EXP)
lipopolysaccharide  (ISO)
LY294002  (ISO)
maneb  (ISO)
manganese atom  (EXP,ISO)
manganese(0)  (EXP,ISO)
manganese(II) chloride  (EXP,ISO)
Mazindol  (EXP,ISO)
Mecamylamine  (EXP)
melatonin  (EXP,ISO)
melittin  (ISO)
mephedrone  (EXP,ISO)
mepyramine  (ISO)
methamphetamine  (EXP,ISO)
methapyrilene  (ISO)
methcathinone  (ISO)
methoxychlor  (ISO)
methylmercury chloride  (ISO)
methylphenidate  (ISO)
minocycline  (ISO)
modafinil  (EXP,ISO)
monensin A  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
n-[4-(3-iodo-4-azidophenyl)butyl]-2beta-carbomethoxy-3beta-(4-chlorophenyl)tropane  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-ethyl-N-nitrosourea  (EXP)
N-methyl-4-phenylpyridinium  (EXP,ISO)
naltrexone  (ISO)
nicotine  (EXP,ISO)
nomifensine  (EXP,ISO)
Nonylphenol  (EXP)
octopamine  (ISO)
oleic acid  (ISO)
oxidopamine  (EXP,ISO)
paraquat  (EXP,ISO)
permethrin  (ISO)
phentermine  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
picoxystrobin  (ISO)
piperazines  (ISO)
piperidines  (ISO)
pirinixic acid  (EXP,ISO)
probenecid  (ISO)
propofol  (ISO)
quinoline yellow  (ISO)
quinolinic acid  (EXP)
quinpirole  (EXP,ISO)
raloxifene  (EXP)
reboxetine  (ISO)
reserpine  (ISO)
resveratrol  (EXP)
rotenone  (EXP,ISO)
rottlerin  (ISO)
RTI-121  (EXP)
SCH 23390  (ISO)
selenium atom  (EXP)
serotonin  (ISO)
simazine  (EXP,ISO)
sodium benzoate  (ISO)
staurosporine  (ISO)
sulpiride  (ISO)
Sunset Yellow FCF  (ISO)
tamoxifen  (EXP)
tartrazine  (ISO)
telmisartan  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP)
Theaflavin 3,3'-digallate  (ISO)
thifluzamide  (ISO)
thimerosal  (ISO)
titanium dioxide  (ISO)
toluene  (EXP)
trichostatin A  (EXP)
triphenyl phosphate  (EXP)
tryptamine  (ISO)
tyramine  (ISO)
valproic acid  (EXP,ISO)
vanoxerine dihydrochloride  (EXP,ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
WIN 55212-2  (EXP)
wortmannin  (ISO)
zinc atom  (EXP,ISO)
zinc sulfate  (EXP)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
axon  (IEA,ISO)
axon terminus  (IEA,ISO)
cell surface  (IEA,ISO)
dopaminergic synapse  (IDA)
flotillin complex  (IEA,ISO)
membrane  (IEA)
membrane raft  (IEA,ISO)
neuron projection  (IDA,IEA,ISO)
neuronal cell body  (IEA,ISO)
plasma membrane  (IBA,IDA,IEA,ISO)
postsynaptic membrane  (IDA)
presynaptic membrane  (IDA)

Molecular Pathway Annotations     Click to see Annotation Detail View
alfentanil pharmacodynamics pathway  (ISO)
bupivacaine pharmacodynamics pathway  (ISO)
buprenorphine pharmacodynamics pathway  (ISO)
chloroprocaine pharmacodynamics pathway  (ISO)
citalopram pharmacodynamics pathway  (ISO)
cocaine pharmacodynamics pathway  (ISO)
codeine and morphine pharmacodynamics pathway  (ISO)
desipramine pharmacodynamics pathway  (ISO)
diphenoxylate pharmacodynamics pathway  (ISO)
escitalopram pharmacodynamics pathway  (ISO)
ethylmorphine pharmacodynamics pathway  (ISO)
fentanyl pharmacodynamics pathway  (ISO)
fluoxetine pharmacodynamics pathway  (ISO)
heroin pharmacodynamics pathway  (ISO)
hydrocodone pharmacodynamics pathway  (ISO)
hydromorphone pharmacodynamics pathway  (ISO)
imipramine pharmacodynamics pathway  (ISO)
levacetylmethadol pharmacodynamics pathway  (ISO)
levobupivacaine phgarmacodynamics pathway  (ISO)
levorphanol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
mepivacaine pharmacodynamics pathway  (ISO)
methadone pharmacodynamics pathway  (ISO)
nalbuphine pharmacodynamics pathway  (ISO)
naloxone pharmacodynamics pathway  (ISO)
naltrexone pharmacodynamics pathway  (ISO)
nicotine pharmacodynamics pathway  (ISO)
oxybuprocaine pharmacodynamics pathway  (ISO)
oxycodone pharmacodynamics pathway  (ISO)
oxymorphone pharmacodynamics pathway   (ISO)
Parkinson's disease pathway  (IEA)
pentazocine pharmacodynamics pathway  (ISO)
prilocaine pharmacodynamics pathway  (ISO)
procaine pharmacodynamics pathway  (ISO)
remifentanil pharmacodynamics pathway  (ISO)
ropivacaine pharmacodynamics pathway  (ISO)
tramadol pharmacodynamics pathway  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Methamphetamine increases dopamine transporter higher molecular weight complex formation via a dopamine- and hyperthermia-associated mechanism. Baucum AJ 2nd, etal., J Neurosci. 2004 Mar 31;24(13):3436-43.
2. Neonatal iron deficiency results in irreversible changes in dopamine function in rats. Beard J, etal., J Nutr. 2003 Apr;133(4):1174-9.
3. Flotillin-1 is essential for PKC-triggered endocytosis and membrane microdomain localization of DAT. Cremona ML, etal., Nat Neurosci. 2011 Apr;14(4):469-77. doi: 10.1038/nn.2781. Epub 2011 Mar 13.
4. Altered dopamine receptor and dopamine transporter binding and tyrosine hydroxylase mRNA expression following perinatal NMDA receptor blockade. du Bois TM, etal., Neurochem Res. 2008 Jul;33(7):1224-31. Epub 2008 Feb 8.
5. Dopamine transporter genotype as a risk factor for obesity in African-American smokers. Epstein LH, etal., Obes Res. 2002 Dec;10(12):1232-40.
6. Dopamine DRD2/ANKK1 Taq1A and DAT1 VNTR polymorphisms are associated with a cognitive flexibility profile in pathological gamblers. Fagundo AB, etal., J Psychopharmacol. 2014 Dec;28(12):1170-7. doi: 10.1177/0269881114551079. Epub 2014 Sep 18.
7. Dopamine transporters are dephosphorylated in striatal homogenates and in vitro by protein phosphatase 1. Foster JD, etal., Brain Res Mol Brain Res 2003 Jan 31;110(1):100-8.
8. Role of serotonin in the paradoxical calming effect of psychostimulants on hyperactivity. Gainetdinov RR, etal., Science 1999 Jan 15;283(5400):397-401.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Cloning and functional characterization of a cocaine-sensitive dopamine transporter. Giros B, etal., FEBS Lett 1991 Dec 16;295(1-3):149-54.
11. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
12. Stable expression of biogenic amine transporters reveals differences in inhibitor sensitivity, kinetics, and ion dependence. Gu H, etal., J Biol Chem. 1994 Mar 11;269(10):7124-30.
13. Role of dopamine transporter genotype and maternal prenatal smoking in childhood hyperactive-impulsive, inattentive, and oppositional behaviors. Kahn RS, etal., J Pediatr 2003 Jul;143(1):104-10.
14. Cloning and expression of a cocaine-sensitive rat dopamine transporter. Kilty JE, etal., Science 1991 Oct 25;254(5031):578-9.
15. Dopamine transporter site-directed mutations differentially alter substrate transport and cocaine binding. Kitayama S, etal., Proc Natl Acad Sci U S A. 1992 Aug 15;89(16):7782-5. doi: 10.1073/pnas.89.16.7782.
16. PLRP2 selectively localizes synaptic membrane proteins via acyl-chain remodeling of phospholipids. Kuge H, etal., J Lipid Res. 2020 Dec;61(12):1747-1763. doi: 10.1194/jlr.RA120001087. Epub 2020 Sep 22.
17. The association of dopamine pathway gene score, nicotine dependence and smoking cessation in a rural male population of Shandong, China. Li S, etal., Am J Addict. 2016 Sep;25(6):493-8. doi: 10.1111/ajad.12421. Epub 2016 Aug 4.
18. Chronic nicotine and smoking treatment increases dopamine transporter mRNA expression in the rat midbrain. Li S, etal., Neurosci Lett. 2004 Jun 3;363(1):29-32.
19. Changes in Expression of Dopamine, Its Receptor, and Transporter in Nucleus Accumbens of Heroin-Addicted Rats with Brain-Derived Neurotrophic Factor (BDNF) Overexpression. Li Y, etal., Med Sci Monit. 2017 Jun 9;23:2805-2815.
20. The dopamine transporter constitutively internalizes and recycles in a protein kinase C-regulated manner in stably transfected PC12 cell lines. Loder MK and Melikian HE, J Biol Chem 2003 Jun 13;278(24):22168-74. Epub 2003 Apr 7.
21. Alteration of striatal dopaminergic function induced by glioma development: a microdialysis and immunohistological study in the rat striatum. Lonjon M, etal., Neurosci Lett. 2004 Jan 9;354(2):131-4.
22. Regional and subcellular compartmentation of the dopamine transporter and tyrosine hydroxylase in the rat ventral pallidum. Mengual E and Pickel VM, J Comp Neurol. 2004 Jan 12;468(3):395-409.
23. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
24. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
25. Obesity is associated with genetic variants that alter dopamine availability. Need AC, etal., Ann Hum Genet. 2006 May;70(Pt 3):293-303.
26. The dopamine transporter is localized to dendritic and axonal plasma membranes of nigrostriatal dopaminergic neurons. Nirenberg MJ, etal., J Neurosci. 1996 Jan 15;16(2):436-47.
27. Genetic influence of dopamine receptor, dopamine transporter, and nicotine metabolism on smoking cessation and nicotine dependence in a Japanese population. Ohmoto M, etal., BMC Genet. 2014 Dec 20;15:151. doi: 10.1186/s12863-014-0151-2.
28. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
29. Deficits in dopamine clearance and locomotion in hypoinsulinemic rats unmask novel modulation of dopamine transporters by amphetamine. Owens WA, etal., J Neurochem. 2005 Sep;94(5):1402-10. Epub 2005 Jun 30.
30. The up-regulation of the striatal dopamine transporter's activity by cAMP is PKA-, CaMK II- and phosphatase-dependent. Page G, etal., Neurochem Int. 2004 Oct;45(5):627-32.
31. Leptin promotes dopamine transporter and tyrosine hydroxylase activity in the nucleus accumbens of Sprague-Dawley rats. Perry ML, etal., J Neurochem. 2010 Aug;114(3):666-74. Epub 2010 Apr 20.
32. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
33. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
34. Altered dopamine transporter function and phosphorylation following chronic cocaine self-administration and extinction in rats. Ramamoorthy S, etal., Biochem Biophys Res Commun. 2010 Jan 15;391(3):1517-21. doi: 10.1016/j.bbrc.2009.12.110. Epub 2009 Dec 24.
35. GOA pipeline RGD automated data pipeline
36. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
37. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
38. Grafts of adult subependymal zone neuronal progenitor cells rescue hemiparkinsonian behavioral decline. Richardson RM, etal., Brain Res. 2005 Jan 25;1032(1-2):11-22.
39. Acute ethanol decreases dopamine transporter velocity in rat striatum: in vivo and in vitro electrochemical measurements. Robinson DL, etal., Alcohol Clin Exp Res. 2005 May;29(5):746-55.
40. Intracerebroventricular administration of betacytotoxics alters expression of brain monoamine transporter genes. Salkovic-Petrisic M and Lackovic Z, J Neural Transm. 2003 Jan;110(1):15-29.
41. Decreased plasma membrane expression of striatal dopamine transporter in aging. Salvatore MF, etal., Neurobiol Aging. 2003 Dec;24(8):1147-54.
42. Cloning and expression of a cocaine-sensitive dopamine transporter complementary DNA. Shimada S, etal., Science 1991 Oct 25;254(5031):576-8.
43. Synthesis and pharmacology of 6-substituted benztropines: discovery of novel dopamine uptake inhibitors possessing low binding affinity to the dopamine transporter. Simoni D, etal., J Med Chem. 2005 May 5;48(9):3337-43.
44. A Pilot Study of Demographic and Dopaminergic Genetic Contributions to Weight Change in Kidney Transplant Recipients. Stanfill A, etal., PLoS One. 2015 Sep 25;10(9):e0138885. doi: 10.1371/journal.pone.0138885. eCollection 2015.
45. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
46. Affinity labeling the dopamine transporter ligand binding site. Vaughan RA, etal., J Neurosci Methods. 2005 Apr 15;143(1):33-40. Epub 2004 Dec 2.
47. Studies on the regulatory effect of Peony-Glycyrrhiza Decoction on prolactin hyperactivity and underlying mechanism in hyperprolactinemia rat model. Wang D, etal., Neurosci Lett. 2015 Oct 8;606:60-5. doi: 10.1016/j.neulet.2015.08.024. Epub 2015 Aug 18.
48. Brain dopamine transporter in spontaneously hypertensive rats. Watanabe Y, etal., J Nucl Med. 1997 Mar;38(3):470-4.
49. Regulation of dopamine transporter activity by carboxypeptidase E. Zhang H, etal., Mol Brain. 2009 May 6;2:10.
Additional References at PubMed
PMID:8628395   PMID:9247269   PMID:9520487   PMID:11150348   PMID:11343649   PMID:12480180   PMID:12521926   PMID:12958153   PMID:14499307   PMID:15128747   PMID:15505207   PMID:15935059  
PMID:16024787   PMID:16708013   PMID:16765459   PMID:16885233   PMID:17255098   PMID:17363452   PMID:17439486   PMID:17561841   PMID:17651428   PMID:17761882   PMID:17873367   PMID:17978168  
PMID:18198344   PMID:18216182   PMID:18588534   PMID:18671743   PMID:18845198   PMID:19046383   PMID:19135135   PMID:19357284   PMID:19766189   PMID:20170186   PMID:20688912   PMID:20816972  
PMID:21118819   PMID:21396352   PMID:21698001   PMID:21957239   PMID:22133315   PMID:22570010   PMID:22722938   PMID:22778840   PMID:23161550   PMID:23300642   PMID:23567316   PMID:23612789  
PMID:25179220   PMID:25943760   PMID:26048990   PMID:26056032   PMID:26658810   PMID:26707058   PMID:26911894   PMID:27789384   PMID:28116523   PMID:28167616   PMID:28495886   PMID:28894302  
PMID:30472113   PMID:30745563   PMID:31599465   PMID:31728018   PMID:33211914   PMID:34329711   PMID:35772468   PMID:37186440   PMID:37298724   PMID:37321389   PMID:37509143   PMID:38650303  


Genomics

Comparative Map Data
Slc6a3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8131,537,990 - 31,578,962 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl131,537,990 - 31,578,962 (-)EnsemblGRCr8
mRatBN7.2129,709,443 - 29,750,413 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl129,709,443 - 29,750,413 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx129,510,573 - 29,551,545 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0135,510,418 - 35,551,390 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0129,711,198 - 29,752,170 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0132,323,011 - 32,363,983 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl132,321,580 - 32,363,983 (-)Ensemblrn6Rnor6.0
Rnor_5.0133,745,060 - 33,788,878 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4130,516,568 - 30,557,540 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera128,357,426 - 28,397,883 (-)NCBICelera
RGSC_v3.1130,518,078 - 30,558,861 (-)NCBI
Cytogenetic Map1p11NCBI
SLC6A3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3851,392,794 - 1,445,440 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl51,392,794 - 1,445,514 (-)Ensemblhg38GRCh38
GRCh3751,392,909 - 1,445,555 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3651,445,909 - 1,498,538 (-)NCBIBuild 36Build 36hg18NCBI36
Build 3451,445,908 - 1,498,543NCBI
Celera51,429,610 - 1,484,220 (-)NCBICelera
Cytogenetic Map5p15.33NCBI
HuRef51,373,680 - 1,426,892 (-)NCBIHuRef
CHM1_151,392,820 - 1,445,528 (-)NCBICHM1_1
T2T-CHM13v2.051,303,172 - 1,357,405 (-)NCBIT2T-CHM13v2.0
Slc6a3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391373,684,270 - 73,726,791 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1373,684,866 - 73,726,791 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381373,536,128 - 73,578,672 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1373,536,747 - 73,578,672 (+)Ensemblmm10GRCm38
MGSCv371373,674,195 - 73,716,120 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361374,002,749 - 74,044,674 (+)NCBIMGSCv36mm8
Celera1375,865,546 - 75,907,463 (+)NCBICelera
Cytogenetic Map13C1NCBI
cM Map1340.1NCBI
Slc6a3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955504721,429 - 747,630 (-)Ensembl
ChiLan1.0NW_004955504721,470 - 747,553 (-)NCBIChiLan1.0ChiLan1.0
SLC6A3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v241,659,752 - 1,712,599 (-)NCBINHGRI_mPanPan1-v2
PanPan1.1 Ensembl51,437,567 - 1,488,829 (-)EnsemblpanPan2panpan1.1
SLC6A3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13411,209,118 - 11,245,456 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3411,210,939 - 11,246,742 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3415,719,083 - 15,755,282 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03411,109,747 - 11,147,167 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3411,109,762 - 11,147,159 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13411,160,852 - 11,196,981 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03411,139,913 - 11,176,047 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03411,350,821 - 11,387,021 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Slc6a3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213244,198,128 - 244,239,922 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936815359,775 - 400,690 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936815359,775 - 400,690 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC6A3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1679,186,108 - 79,220,297 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11679,186,114 - 79,220,302 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21685,853,611 - 85,887,787 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SLC6A3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.141,209,013 - 1,258,797 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl41,209,019 - 1,258,866 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605435,775,947 - 35,824,591 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc6a3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624751694,099 - 719,465 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624751694,165 - 720,287 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Slc6a3
253 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:65
Count of miRNA genes:59
Interacting mature miRNAs:60
Transcripts:ENSRNOT00000040291
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313090Bmd69Bone mineral density QTL 694.40.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)1529322934184556Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1774611852746118Rat
4889451Eae29Experimental allergic encephalomyelitis QTL 295.51nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1774612152746121Rat
1357397Bw41Body weight QTL 414.190.0001body mass (VT:0001259)body weight (CMO:0000012)12940927974409279Rat
70179Xhs2X-ray hypersensitivity QTL 23.2intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)1143965634Rat
1558642Prcr2Prostate cancer resistance QTL 24.3prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)11037949255379492Rat
7421626Bp360Blood pressure QTL 3600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1694102251941022Rat
2313070Bss52Bone structure and strength QTL 524.40.0001body length (VT:0001256)body length (CMO:0000013)1529322934184556Rat
1357401Bw43Body weight QTL 433.75body mass (VT:0001259)body weight (CMO:0000012)1690935351909353Rat
631494Bp95Blood pressure QTL 95400.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)11731537851816258Rat
5684998Bss101Bone structure and strength QTL 1013.6tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)1690935351909353Rat
5684999Bss102Bone structure and strength QTL 1025.57e-07tibia strength trait (VT:1000284)tibia stiffness (CMO:0001735)1690935351909353Rat
2302038Pia31Pristane induced arthritis QTL 315.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)11282049457820494Rat
2317755Glom22Glomerulus QTL 223.8urine protein amount (VT:0005160)urine protein level (CMO:0000591)1134184556Rat
634353Rends2Renal damage susceptibility QTL 20.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)12065642065656420Rat
1578756Iddm22Insulin dependent diabetes mellitus QTL 222.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)12050832665508326Rat
631508Sald1Serum aldosterone level QTL 13.7blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)11168446456684464Rat
1331785Rf27Renal function QTL 274.643urine sodium amount (VT:0006274)urine sodium level (CMO:0000129)13070837587558729Rat
2313053Bss51Bone structure and strength QTL 513.80.0001tibia length (VT:0004357)tibia length (CMO:0000450)1529322934184556Rat

Markers in Region
D1Rat377  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2129,743,235 - 29,743,400 (+)MAPPERmRatBN7.2
Rnor_6.0132,356,806 - 32,356,970NCBIRnor6.0
Rnor_5.0133,780,289 - 33,780,453UniSTSRnor5.0
RGSC_v3.4130,550,363 - 30,550,527UniSTSRGSC3.4
RGSC_v3.4130,550,362 - 30,550,527RGDRGSC3.4
RGSC_v3.1130,553,307 - 30,553,472RGD
FHH x ACI Map121.7699UniSTS
FHH x ACI Map121.7699RGD
Cytogenetic Map1p11UniSTS
D1Wox51  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2129,708,849 - 29,708,992 (+)MAPPERmRatBN7.2
Rnor_6.0132,322,418 - 32,322,560NCBIRnor6.0
Rnor_5.0133,745,901 - 33,746,043UniSTSRnor5.0
RGSC_v3.4130,515,975 - 30,516,117UniSTSRGSC3.4
Celera128,356,833 - 28,356,975UniSTS
Cytogenetic Map1p11UniSTS
RH94715  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2129,708,645 - 29,708,778 (+)MAPPERmRatBN7.2
Rnor_6.0132,322,214 - 32,322,346NCBIRnor6.0
Rnor_5.0133,745,697 - 33,745,829UniSTSRnor5.0
RGSC_v3.4130,515,771 - 30,515,903UniSTSRGSC3.4
Celera128,356,629 - 28,356,761UniSTS
Cytogenetic Map1p11UniSTS
RH94400  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2129,708,037 - 29,708,210 (+)MAPPERmRatBN7.2
Rnor_6.0132,321,606 - 32,321,778NCBIRnor6.0
Rnor_5.0133,745,089 - 33,745,261UniSTSRnor5.0
RGSC_v3.4130,515,163 - 30,515,335UniSTSRGSC3.4
Celera128,356,021 - 28,356,193UniSTS
Cytogenetic Map1p11UniSTS
PMC304098P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2129,724,402 - 29,724,503 (+)MAPPERmRatBN7.2
Rnor_6.0132,337,973 - 32,338,073NCBIRnor6.0
Rnor_5.0133,761,456 - 33,761,556UniSTSRnor5.0
RGSC_v3.4130,531,530 - 30,531,630UniSTSRGSC3.4
Celera128,372,004 - 28,372,104UniSTS
Cytogenetic Map1p11UniSTS


Genetic Models
This gene Slc6a3 is modified in the following models/strains:
F344-Slc6a3m1Span    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
9 6 20 105 74 73 42 29 42 6 165 69 85 39 55 31 8 8

Sequence


Ensembl Acc Id: ENSRNOT00000040291   ⟹   ENSRNOP00000047272
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl131,537,990 - 31,578,962 (-)Ensembl
mRatBN7.2 Ensembl129,709,443 - 29,750,413 (-)Ensembl
Rnor_6.0 Ensembl132,323,011 - 32,363,983 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000079987   ⟹   ENSRNOP00000070728
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl132,321,580 - 32,362,359 (-)Ensembl
RefSeq Acc Id: NM_012694   ⟹   NP_036826
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8131,537,990 - 31,578,962 (-)NCBI
mRatBN7.2129,709,443 - 29,750,413 (-)NCBI
Rnor_6.0132,323,011 - 32,363,983 (-)NCBI
Rnor_5.0133,745,060 - 33,788,878 (-)NCBI
RGSC_v3.4130,516,568 - 30,557,540 (-)RGD
Celera128,357,426 - 28,397,883 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_036826 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41100 (Get FASTA)   NCBI Sequence Viewer  
  AAA73143 (Get FASTA)   NCBI Sequence Viewer  
  AAB21099 (Get FASTA)   NCBI Sequence Viewer  
  EDL87653 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000047272
  ENSRNOP00000047272.1
GenBank Protein P23977 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_036826   ⟸   NM_012694
- UniProtKB: P23977 (UniProtKB/Swiss-Prot),   A6JUX6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000070728   ⟸   ENSRNOT00000079987
Ensembl Acc Id: ENSRNOP00000047272   ⟸   ENSRNOT00000040291

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P23977-F1-model_v2 AlphaFold P23977 1-619 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3715 AgrOrtholog
BioCyc Gene G2FUF-61924 BioCyc
Ensembl Genes ENSRNOG00000017302 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000040291 ENTREZGENE
  ENSRNOT00000040291.2 UniProtKB/Swiss-Prot
InterPro Na/ntran_symport UniProtKB/Swiss-Prot
  Na/ntran_symport_dopamine UniProtKB/Swiss-Prot
  SNS_sf UniProtKB/Swiss-Prot
KEGG Report rno:24898 UniProtKB/Swiss-Prot
NCBI Gene 24898 ENTREZGENE
PANTHER PTHR11616 UniProtKB/Swiss-Prot
  SODIUM-DEPENDENT DOPAMINE TRANSPORTER UniProtKB/Swiss-Prot
Pfam SNF UniProtKB/Swiss-Prot
PharmGKB SLC6A3 RGD
PhenoGen Slc6a3 PhenoGen
PRINTS DOPTRANSPORT UniProtKB/Swiss-Prot
  NANEUSMPORT UniProtKB/Swiss-Prot
PROSITE NA_NEUROTRAN_SYMP_1 UniProtKB/Swiss-Prot
  NA_NEUROTRAN_SYMP_2 UniProtKB/Swiss-Prot
  NA_NEUROTRAN_SYMP_3 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000017302 RatGTEx
Superfamily-SCOP SSF161070 UniProtKB/Swiss-Prot
TIGR TC234653
UniProt A6JUX6 ENTREZGENE, UniProtKB/TrEMBL
  P23977 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-09 Slc6a3  solute carrier family 6 member 3  Slc6a3  solute carrier family 6 (neurotransmitter transporter), member 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Slc6a3  solute carrier family 6 (neurotransmitter transporter, dopamine), member 3    solute carrier family 6, member 3  Name updated 1299863 APPROVED
2003-04-09 Slc6a3  solute carrier family 6, member 3    Solute carrier family 6 (neurotransmitter transporter, dopamine), member 3  Name updated 629478 APPROVED
2002-06-10 Slc6a3  Solute carrier family 6 (neurotransmitter transporter, dopamine), member 3      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization putative integral plasma membrane protein 730166
gene_expression expressed in substantia nigra and ventral tegmental area 730166
gene_function sodium-dependent dopamine transporter 730166
gene_function sodium-dependent dopamine transporter 730214
gene_function sodium-dependent dopamine transporter 730247
gene_protein 620 amino acid protein 730166
gene_regulation constitutively internalized and recycled to plasma membrane; protein kinase C activation accelerates endocytosis of protein and attenuates recycling to cell surface 1299034