RGD Reference Report - Leptin promotes dopamine transporter and tyrosine hydroxylase activity in the nucleus accumbens of Sprague-Dawley rats. - Rat Genome Database

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Leptin promotes dopamine transporter and tyrosine hydroxylase activity in the nucleus accumbens of Sprague-Dawley rats.

Authors: Perry, ML  Leinninger, GM  Chen, R  Luderman, KD  Yang, H  Gnegy, ME  Myers MG, JR  Kennedy, RT 
Citation: Perry ML, etal., J Neurochem. 2010 Aug;114(3):666-74. Epub 2010 Apr 20.
RGD ID: 4139887
Pubmed: PMID:20412389   (View Abstract at PubMed)
PMCID: PMC2910163   (View Article at PubMed Central)
DOI: DOI:10.1111/j.1471-4159.2010.06757.x   (Journal Full-text)

Adipocytes produce the hormone, leptin, in proportion to fat mass to signal the status of body energy stores to the central nervous system, thereby modulating food intake and energy homeostasis. In addition to controlling satiety, leptin suppresses the reward value of food, which is controlled by the mesolimbic dopamine (DA) system. Previous results from leptin-deficient ob/ob animals suggest that chronic leptin deficiency decreases DA content in the mesolimbic DA system, thereby decreasing the response to amphetamine (AMPH). The extent to which these alterations in the mesolimbic DA system of ob/ob animals may mirror the leptin response of normal animals has remained unclear, however. We therefore examined the potential short-term modulation of the mesolimbic DA system by leptin in normal animals. We show that 4 h of systemic leptin treatment enhances AMPH-stimulated DA efflux in the nucleus accumbens (NAc) of Sprague-Dawley rats. While acute leptin treatment increased NAc tyrosine hydroxylase activity, total tyrosine hydroxylase and DA content were unchanged at this early time point. Leptin also increased NAc DA transporter activity in the absence of changes in cell surface or total DA transporter. Thus, leptin modulates the mesolimbic DA system via multiple acute mechanisms, and increases AMPH-mediated DA efflux in normal animals.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
dopamine transport  IDA 4139887 RGD 

Molecular Function
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
dopamine:sodium symporter activity  IDA 4139887 RGD 
tyrosine 3-monooxygenase activity  IDA 4139887 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Slc6a3  (solute carrier family 6 member 3)
Th  (tyrosine hydroxylase)


Additional Information