Si (sucrase-isomaltase) - Rat Genome Database

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Gene: Si (sucrase-isomaltase) Rattus norvegicus
Analyze
Symbol: Si
Name: sucrase-isomaltase
RGD ID: 3675
Description: Enables beta-fructofuranosidase activity and oligo-1,6-glucosidase activity. Involved in several processes, including carbohydrate utilization; intestinal epithelial cell maturation; and response to cortisone. Located in several cellular components, including Golgi cisterna; cell projection membrane; and multivesicular body. Biomarker of colitis and exocrine pancreatic insufficiency. Human ortholog(s) of this gene implicated in congenital sucrase-isomaltase deficiency. Orthologous to human SI (sucrase-isomaltase); PARTICIPATES IN congenital sucrase-isomaltase deficiency pathway; glycogen storage disease type III pathway; glycogen storage disease type IV pathway; INTERACTS WITH (S)-naringenin; 17alpha-ethynylestradiol; acetylsalicylic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: SUCIMAL; sucrase-isomaltase (alpha-glucosidase); sucrase-isomaltase, intestinal
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82159,804,568 - 159,884,902 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2159,804,568 - 159,883,934 (-)EnsemblGRCr8
mRatBN7.22157,505,893 - 157,586,228 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2157,506,342 - 157,585,260 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2164,628,371 - 164,709,000 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02162,678,862 - 162,759,493 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02157,311,634 - 157,392,265 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02170,220,794 - 170,301,348 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2170,221,245 - 170,301,348 (-)Ensemblrn6Rnor6.0
Rnor_5.02189,563,145 - 189,643,699 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42163,520,975 - 163,601,280 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2151,764,945 - 151,845,208 (-)NCBICelera
RGSC_v3.12163,470,937 - 163,551,243 (-)NCBI
RH 3.4 Map21027.6RGD
Cytogenetic Map2q32NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Disordered expression of the sucrase-isomaltase complex in the small intestine in Otsuka Long-Evans tokushima fatty rats, a model of non-insulin-dependent diabetes mellitus with insulin resistance. Adachi T, etal., Biochim Biophys Acta. 1999 Jan 4;1426(1):126-32.
2. Morphological changes and increased sucrase and isomaltase activity in small intestines of insulin-deficient and type 2 diabetic rats. Adachi T, etal., Endocr J. 2003 Jun;50(3):271-9.
3. Mucosal function in rat jejunum and ileum is altered by induction of colitis. Amit-Romach E, etal., Int J Mol Med. 2006 Oct;18(4):721-7.
4. Female athlete triad affects rat intestinal morphology and sucrase-isomaltase expression. Aoki K, etal., Br J Nutr. 2023 Jul 14;130(1):1-9. doi: 10.1017/S0007114522003063. Epub 2022 Nov 4.
5. Molecular cloning and characterization of a rat intestinal sucrase-isomaltase cDNA. Regulation of sucrase-isomaltase gene expression by sucrose feeding. Broyart JP, etal., Biochim Biophys Acta. 1990 Sep 10;1087(1):61-7. doi: 10.1016/0167-4781(90)90121-h.
6. Premature stimulation of rat sucrase-isomaltase (SI) by exogenous insulin and the analog B-Asp10 is regulated by a receptor-mediated signal triggering SI gene transcription. Buts JP, etal., Pediatr Res. 1998 May;43(5):585-91.
7. Cloning and sequencing of a full-length rat sucrase-isomaltase-encoding cDNA. Chandrasena G, etal., Gene 1994 Dec 15;150(2):355-60.
8. Sucrase-isomaltase gene expression in suckling rat intestine: hormonal, dietary, and growth factor control. Emvo EN, etal., J Pediatr Gastroenterol Nutr. 1996 Oct;23(3):262-9.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Molecular pathogenicity of novel sucrase-isomaltase mutations found in congenital sucrase-isomaltase deficiency patients. Gericke B, etal., Biochim Biophys Acta Mol Basis Dis. 2017 Mar;1863(3):817-826. doi: 10.1016/j.bbadis.2016.12.017. Epub 2017 Jan 3.
11. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
12. Evidence of degradation process of sucrase-isomaltase in jejunum of adult rats. Goda T and Koldovský O, Biochem J. 1985 Aug 1;229(3):751-8. doi: 10.1042/bj2290751.
13. Effects of a high-protein, low-carbohydrate diet on degradation of sucrase-isomaltase in rat jejunoileum. Goda T, etal., Am J Physiol. 1988 Jun;254(6 Pt 1):G907-12. doi: 10.1152/ajpgi.1988.254.6.G907.
14. Intestinal disaccharidase activity following pancreatic duct occlusion in the rat. Hauer-Jensen M, etal., Pancreas. 1987;2(3):295-302. doi: 10.1097/00006676-198705000-00008.
15. Biosynthesis of sucrase-isomaltase. Purification and NH2-terminal amino acid sequence of the rat sucrase-isomaltase precursor (pro-sucrase-isomaltase) from fetal intestinal transplants. Hauri HP, etal., J Biol Chem. 1982 Apr 25;257(8):4522-8.
16. Monoclonal antibodies to sucrase/isomaltase: probes for the study of postnatal development and biogenesis of the intestinal microvillus membrane. Hauri HP, etal., Proc Natl Acad Sci U S A. 1980 Nov;77(11):6629-33. doi: 10.1073/pnas.77.11.6629.
17. Enhancement of brush border membrane peptidase activity in rat jejunum induced by starvation. Ihara T, etal., Pflugers Arch. 2000 May;440(1):75-83.
18. Induction of histone H3K4 methylation at the promoter, enhancer, and transcribed regions of the Si and Sglt1 genes in rat jejunum in response to a high-starch/low-fat diet. Inoue S, etal., Nutrition. 2015 Feb;31(2):366-72. doi: 10.1016/j.nut.2014.07.017. Epub 2014 Aug 6.
19. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
20. Enhancement of sucrase-isomaltase gene expression induced by luminally administered fructose in rat jejunum. Kishi K, etal., J Nutr Biochem. 1999 Jan;10(1):8-12.
21. Glucagon-like peptide-2 increases sucrase-isomaltase but not caudal-related homeobox protein-2 gene expression. Kitchen PA, etal., Am J Physiol Gastrointest Liver Physiol. 2000 Mar;278(3):G425-8. doi: 10.1152/ajpgi.2000.278.3.G425.
22. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
23. Contribution of the Individual Small Intestinal α-Glucosidases to Digestion of Unusual α-Linked Glycemic Disaccharides. Lee BH, etal., J Agric Food Chem. 2016 Aug 24;64(33):6487-94. doi: 10.1021/acs.jafc.6b01816. Epub 2016 Aug 9.
24. Total intestinal lactase and sucrase activities are reduced in aged rats. Lee MF, etal., J Nutr. 1997 Jul;127(7):1382-7.
25. Sucrase-isomaltase ontogeny: synergism between glucocorticoids and thyroxine reflects increased mRNA and no change in cell migration. Leeper LL, etal., Biochem Biophys Res Commun. 1998 May 29;246(3):765-70.
26. Localization of sucrase-isomaltase in the rat enterocyte. Lorenzsonn V, etal., Gastroenterology. 1987 Jan;92(1):98-105. doi: 10.1016/0016-5085(87)90844-4.
27. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
28. Immunoelectron microscopic localization of sucrase-isomaltase in rat small intestine. Noda S and Goda T, J Nutr Sci Vitaminol (Tokyo). 1993 Apr;39(2):201-5. doi: 10.3177/jnsv.39.201.
29. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
30. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
31. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
32. GOA pipeline RGD automated data pipeline
33. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
34. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
35. Feeding medium-chain triglycerides to rats decreases degradation of sucrase-isomaltase complex in the jejunum. Shinohara H, etal., J Nutr. 1993 Jun;123(6):1161-7. doi: 10.1093/jn/123.6.1161.
36. Characteristics and structural requirements of apical sorting of the rat growth hormone through the O-glycosylated stalk region of intestinal sucrase-isomaltase. Spodsberg N, etal., J Biol Chem 2001 Dec 7;276(49):46597-604.
37. Histone H3 modifications and Cdx-2 binding to the sucrase-isomaltase (SI) gene is involved in induction of the gene in the transition from the crypt to villus in the small intestine of rats. Suzuki T, etal., Biochem Biophys Res Commun. 2008 May 2;369(2):788-93. doi: 10.1016/j.bbrc.2008.02.101. Epub 2008 Feb 29.
38. Regulation of sucrase-isomaltase gene expression along the crypt-villus axis of rat small intestine. Traber PG Biochem Biophys Res Commun 1990 Dec 31;173(3):765-73.
39. A role for myosin-1A in the localization of a brush border disaccharidase. Tyska MJ and Mooseker MS, J Cell Biol. 2004 May 10;165(3):395-405.
40. Dietary regulation of sucrase-isomaltase gene expression in rat jejunum. Yasutake H, etal., Biochim Biophys Acta. 1995 Feb 23;1243(2):270-6.
41. Expression of intestinal brush-border membrane hydrolases and ferritin after segmental ischemia-reperfusion in rats. Yeh KY, etal., Am J Physiol. 1998 Sep;275(3 Pt 1):G572-83.
42. Vitamin A exerts its activity at the transcriptional level in the small intestine. Zaiger G, etal., Eur J Nutr. 2004 Oct;43(5):259-66. Epub 2004 Jan 28.
Additional References at PubMed
PMID:17272516   PMID:17673438   PMID:18617558   PMID:19352013   PMID:20356844   PMID:22896899   PMID:23533145  


Genomics

Comparative Map Data
Si
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82159,804,568 - 159,884,902 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2159,804,568 - 159,883,934 (-)EnsemblGRCr8
mRatBN7.22157,505,893 - 157,586,228 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2157,506,342 - 157,585,260 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2164,628,371 - 164,709,000 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02162,678,862 - 162,759,493 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02157,311,634 - 157,392,265 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02170,220,794 - 170,301,348 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2170,221,245 - 170,301,348 (-)Ensemblrn6Rnor6.0
Rnor_5.02189,563,145 - 189,643,699 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42163,520,975 - 163,601,280 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2151,764,945 - 151,845,208 (-)NCBICelera
RGSC_v3.12163,470,937 - 163,551,243 (-)NCBI
RH 3.4 Map21027.6RGD
Cytogenetic Map2q32NCBI
SI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383164,978,898 - 165,090,232 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3164,978,898 - 165,078,496 (-)Ensemblhg38GRCh38
GRCh373164,696,686 - 164,796,284 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363166,179,380 - 166,278,976 (-)NCBIBuild 36Build 36hg18NCBI36
Build 343166,179,388 - 166,278,984NCBI
Celera3163,095,850 - 163,195,264 (-)NCBICelera
Cytogenetic Map3q26.1NCBI
HuRef3162,066,552 - 162,166,109 (-)NCBIHuRef
CHM1_13164,659,546 - 164,759,127 (-)NCBICHM1_1
T2T-CHM13v2.03167,761,814 - 167,873,135 (-)NCBIT2T-CHM13v2.0
Sis
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39372,795,890 - 72,875,196 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl372,795,890 - 72,875,196 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38372,888,557 - 72,967,863 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl372,888,557 - 72,967,863 (-)Ensemblmm10GRCm38
MGSCv37372,692,482 - 72,770,788 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36372,976,489 - 73,055,789 (-)NCBIMGSCv36mm8
Celera373,012,488 - 73,086,863 (-)NCBICelera
Cytogenetic Map3E3NCBI
cM Map332.59NCBI
Si
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544814,685,963 - 14,777,338 (-)Ensembl
ChiLan1.0NW_00495544814,686,315 - 14,777,298 (-)NCBIChiLan1.0ChiLan1.0
SI
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22162,877,001 - 162,976,815 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13162,881,729 - 162,981,543 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03161,961,038 - 162,104,054 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13170,057,282 - 170,156,983 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3170,057,750 - 170,154,502 (-)EnsemblpanPan2panpan1.1
SI
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13430,284,869 - 30,373,749 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3430,284,858 - 30,373,780 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3439,346,430 - 39,434,804 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03430,347,263 - 30,435,400 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3430,346,966 - 30,434,636 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13430,290,443 - 30,378,872 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03430,241,911 - 30,330,433 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03430,511,922 - 30,599,883 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Si
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560296,367,610 - 96,445,267 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367071,153,538 - 1,228,220 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049367071,153,538 - 1,228,220 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SI
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13104,296,283 - 104,379,478 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.113104,296,281 - 104,379,558 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213112,716,702 - 112,812,308 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SI
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11524,480,060 - 24,582,468 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1524,482,865 - 24,582,394 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366606333,458,175 - 33,557,570 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Si
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473042,984,431 - 43,112,819 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473042,984,277 - 43,112,819 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Si
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1383,222,673 - 83,303,117 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Si
545 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:89
Count of miRNA genes:74
Interacting mature miRNAs:78
Transcripts:ENSRNOT00000046681
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631566Bp90Blood pressure QTL 900.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2149957381221199885Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845370229470703Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)283465462229820014Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2138595962205135428Rat
1581576Pur7Proteinuria QTL 70.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)280396178220931218Rat
152025245Scl81Serum cholesterol level QTL 813.49blood cholesterol amount (VT:0000180)2124537199209621565Rat
1581578Cm49Cardiac mass QTL 494.90.01heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2145807215220931416Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)278269809208420281Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2122597372215234002Rat
12879836Kidm61Kidney mass QTL 610.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2154723085199723085Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)280396178220931218Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2145807215190807215Rat
12879837Am2Aortic mass QTL 20.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2154723085199723085Rat
10043139Iddm55Insulin dependent diabetes mellitus QTL 553.10.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2150313808195313808Rat
12879838Cm86Cardiac mass QTL 860.002heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2154723085199723085Rat
1302793Bw16Body weight QTL 1650.0001body mass (VT:0001259)body weight (CMO:0000012)2159440891205135267Rat
12879839Cm85Cardiac mass QTL 850.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2154723085199723085Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2159440891220931218Rat
12879845Cm89Cardiac mass QTL 890.008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2154723085178247591Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2143565208188565208Rat
12879846Cm90Cardiac mass QTL 900.011heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)2154723085178247591Rat
12879847Am4Aortic mass QTL 40.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2154723085178247591Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24265106205135428Rat
12879840Bw179Body weight QTL 1790.005body mass (VT:0001259)body weight (CMO:0000012)2154723085199723085Rat
1581502Esta3Estrogen-induced thymic atrophy QTL 3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2139067258192287892Rat
1359032Hrtrt18Heart rate QTL 18heart pumping trait (VT:2000009)heart rate (CMO:0000002)2159440760195313808Rat
2301966Bp322Blood pressure QTL 3223.58arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2144882354205135428Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845182205135428Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)283400752223709938Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2139067258184067258Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660251712708Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)280396034220931416Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)278269809205135428Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2159440760228950743Rat
2301415Cm67Cardiac mass QTL 670.003heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2154723085178247591Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2143344967251712708Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2143746578205135428Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2143344967251712708Rat
11565180Kidm56Kidney mass QTL 560.003kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2154723085178247591Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2114384617215381366Rat
1598805Memor8Memory QTL 83exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2150096616195096616Rat
11565181Bw176Body weight QTL 1760.002body mass (VT:0001259)body weight (CMO:0000012)2154723085178247591Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2145306936212705578Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2113746222205135428Rat
61401Niddm2Non-insulin dependent diabetes mellitus QTL 24.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2147287892192287892Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2114384617215381366Rat
738007Anxrr7Anxiety related response QTL 74.4exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2120339555165339555Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660223841096Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2117415288205135428Rat
631520Bp73Blood pressure QTL 730.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2149806826170653323Rat
1598833Bp295Blood pressure QTL 2953.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150096616195096616Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)283465462225110681Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)247856345205135428Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979184731399Rat
1354594Despr10Despair related QTL 102e-06locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)2116804572161804572Rat
152025206Hrtrt23Heart rate QTL 235.98heart pumping trait (VT:2000009)230219200171802126Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)276328396209350714Rat
6903312Bw112Body weight QTL 1123.20.0013body mass (VT:0001259)body weight (CMO:0000012)2145807215173074435Rat
152025204Hrtrt22Heart rate QTL 225.6heart pumping trait (VT:2000009)230219200171802126Rat

Markers in Region
RH94508  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22157,506,068 - 157,506,194 (+)MAPPERmRatBN7.2
Rnor_6.02170,220,969 - 170,221,094NCBIRnor6.0
Rnor_5.02189,563,320 - 189,563,445UniSTSRnor5.0
RGSC_v3.42163,521,150 - 163,521,275UniSTSRGSC3.4
Celera2151,765,120 - 151,765,245UniSTS
RH 3.4 Map21027.6UniSTS
Cytogenetic Map2q32UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
4 22 62 6 6 2 2 2 1 35 25 60 4 10 4 7 7

Sequence


Ensembl Acc Id: ENSRNOT00000046681   ⟹   ENSRNOP00000045106
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2159,804,568 - 159,883,934 (-)Ensembl
mRatBN7.2 Ensembl2157,506,342 - 157,585,260 (-)Ensembl
Rnor_6.0 Ensembl2170,221,245 - 170,300,408 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000088131   ⟹   ENSRNOP00000072960
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2159,804,568 - 159,883,934 (-)Ensembl
mRatBN7.2 Ensembl2157,506,342 - 157,585,260 (-)Ensembl
Rnor_6.0 Ensembl2170,240,644 - 170,301,348 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000163788   ⟹   ENSRNOP00000098943
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2159,804,568 - 159,883,934 (-)Ensembl
RefSeq Acc Id: NM_001389226   ⟹   NP_001376155
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82159,804,568 - 159,884,902 (-)NCBI
mRatBN7.22157,505,893 - 157,586,228 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001376155 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA42144 (Get FASTA)   NCBI Sequence Viewer  
  AAA65097 (Get FASTA)   NCBI Sequence Viewer  
  CAA33552 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000045106
GenBank Protein P23739 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Acc Id: ENSRNOP00000045106   ⟸   ENSRNOT00000046681
Ensembl Acc Id: ENSRNOP00000072960   ⟸   ENSRNOT00000088131
RefSeq Acc Id: NP_001376155   ⟸   NM_001389226
- UniProtKB: F1M792 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000098943   ⟸   ENSRNOT00000163788
Protein Domains
P-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P23739-F1-model_v2 AlphaFold P23739 1-1841 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691378
Promoter ID:EPDNEW_R1901
Type:multiple initiation site
Name:Si_1
Description:sucrase-isomaltase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02170,301,376 - 170,301,436EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3675 AgrOrtholog
BioCyc Gene G2FUF-52801 BioCyc
Ensembl Genes ENSRNOG00000031067 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000046681 ENTREZGENE
Gene3D-CATH 2.60.40.1180 UniProtKB/Swiss-Prot
  4.10.110.10 UniProtKB/Swiss-Prot
  Glycosidases UniProtKB/Swiss-Prot
  glycosyl hydrolase (family 31) UniProtKB/Swiss-Prot
InterPro Gal_mutarotase_sf_dom UniProtKB/Swiss-Prot
  Glyco_hydro_31 UniProtKB/Swiss-Prot
  Glyco_hydro_31_AS UniProtKB/Swiss-Prot
  Glyco_hydro_31_C UniProtKB/Swiss-Prot
  Glyco_hydro_31_CS UniProtKB/Swiss-Prot
  Glyco_hydro_31_N_dom UniProtKB/Swiss-Prot
  Glyco_hydro_b UniProtKB/Swiss-Prot
  Glycoside_hydrolase_SF UniProtKB/Swiss-Prot
  P_trefoil_CS UniProtKB/Swiss-Prot
  P_trefoil_dom UniProtKB/Swiss-Prot
  P_trefoil_dom_sf UniProtKB/Swiss-Prot
NCBI Gene Si ENTREZGENE
PANTHER ALPHA-GLUCOSIDASE UniProtKB/Swiss-Prot
  P-TYPE DOMAIN-CONTAINING PROTEIN UniProtKB/Swiss-Prot
Pfam Gal_mutarotas_2 UniProtKB/Swiss-Prot
  Glyco_hydro_31 UniProtKB/Swiss-Prot
  Glyco_hydro_31_3rd UniProtKB/Swiss-Prot
  Trefoil UniProtKB/Swiss-Prot
PhenoGen Si PhenoGen
PROSITE GLYCOSYL_HYDROL_F31_1 UniProtKB/Swiss-Prot
  GLYCOSYL_HYDROL_F31_2 UniProtKB/Swiss-Prot
  P_TREFOIL_1 UniProtKB/Swiss-Prot
  P_TREFOIL_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000031067 RatGTEx
SMART SM00018 UniProtKB/Swiss-Prot
Superfamily-SCOP Glycosyl hydrolase domain UniProtKB/Swiss-Prot
  SSF51445 UniProtKB/Swiss-Prot
  SSF57492 UniProtKB/Swiss-Prot
  SSF74650 UniProtKB/Swiss-Prot
UniProt A0A0G2K499_RAT UniProtKB/TrEMBL
  A0ABK0LCM4_RAT UniProtKB/TrEMBL
  F1M792 ENTREZGENE, UniProtKB/TrEMBL
  P23739 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-13 Si  sucrase-isomaltase  Si  sucrase-isomaltase (alpha-glucosidase)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-15 Si  sucrase-isomaltase (alpha-glucosidase)  Si  Sucrase-isomaltase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Si  Sucrase-isomaltase      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization sorted to apical pole of cell 70229
gene_expression expressed in intestine 70229