Npy1r (neuropeptide Y receptor Y1) - Rat Genome Database

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Gene: Npy1r (neuropeptide Y receptor Y1) Rattus norvegicus
Analyze
Symbol: Npy1r
Name: neuropeptide Y receptor Y1
RGD ID: 3198
Description: Predicted to enable neuropeptide binding activity; pancreatic polypeptide receptor activity; and peptide YY receptor activity. Involved in several processes, including positive regulation of cholesterol biosynthetic process; regulation of presynaptic cytosolic calcium ion concentration; and regulation of secretion by cell. Located in axon and synaptic vesicle. Is active in glutamatergic synapse; neuronal dense core vesicle; and presynaptic membrane. Used to study absence epilepsy; anxiety disorder; depressive disorder; and hypertension. Biomarker of obesity. Human ortholog(s) of this gene implicated in amphetamine abuse; cocaine abuse; heroin dependence; nicotine dependence; and opiate dependence. Orthologous to human NPY1R (neuropeptide Y receptor Y1); INTERACTS WITH 17beta-estradiol; 1D-myo-inositol 1,4,5-trisphosphate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: FC5; MGC109393; Neuropepetide Y1 Receptor; neuropeptide Y receptor type 1; neuropeptide Y1 receptor; NPY-1; NPY1-R
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81627,804,416 - 27,814,070 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1627,804,416 - 27,813,387 (-)EnsemblGRCr8
mRatBN7.21623,037,788 - 23,047,330 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1623,037,789 - 23,046,759 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1626,400,898 - 26,409,918 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01629,835,589 - 29,844,607 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01625,766,507 - 25,775,523 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01624,779,480 - 24,789,131 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1624,779,477 - 24,788,740 (-)Ensemblrn6Rnor6.0
Rnor_5.01624,663,045 - 24,672,508 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41624,747,183 - 24,756,507 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1623,162,089 - 23,171,059 (-)NCBICelera
RGSC_v3.11624,748,298 - 24,749,803 (-)NCBI
Cytogenetic Map16p14NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
1D-myo-inositol 1,4,5-trisphosphate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-methyl-4-chlorophenoxybutyric acid  (EXP)
6-propyl-2-thiouracil  (EXP)
acrylamide  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
all-trans-retinol  (ISO)
alpha-Zearalanol  (EXP)
ammonium acetate  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
Azoxymethane  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
cantharidin  (ISO)
capsaicin  (EXP)
carbon nanotube  (ISO)
chrysene  (ISO)
coumestrol  (ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
cyromazine  (EXP)
DDE  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
Diallyl sulfide  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (EXP)
dioxygen  (ISO)
dorsomorphin  (ISO)
Enterolactone  (ISO)
epoxiconazole  (ISO)
ethanol  (EXP)
fluoxetine  (EXP)
genistein  (EXP,ISO)
ifosfamide  (ISO)
ketamine  (EXP)
lead diacetate  (EXP)
medroxyprogesterone acetate  (ISO)
mercury dichloride  (EXP)
methamphetamine  (ISO)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monobenzyl phthalate  (ISO)
Monobutylphthalate  (ISO)
monoethyl phthalate  (ISO)
morphine  (ISO)
N-Nitrosopyrrolidine  (ISO)
nickel atom  (ISO)
O-methyleugenol  (ISO)
okadaic acid  (ISO)
panobinostat  (ISO)
pentobarbital  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenylmercury acetate  (ISO)
phenylpropanolamine  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
picrotoxin  (EXP)
pioglitazone  (ISO)
pirimicarb  (EXP)
progesterone  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
tamoxifen  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP)
tetraphene  (ISO)
thiram  (EXP,ISO)
titanium dioxide  (ISO)
tribromoethanol  (ISO)
trichostatin A  (ISO)
trifluoroacetic acid  (EXP)
triptonide  (ISO)
valproic acid  (ISO)
zearalenone  (ISO)
ziram  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. NPY modulates epinephrine-induced leukocytosis via Y-1 and Y-5 receptor activation in vivo: sympathetic co-transmission during leukocyte mobilization. Bedoui S, etal., J Neuroimmunol 2002 Nov;132(1-2):25-33.
2. The antidepressant effects of running and escitalopram are associated with levels of hippocampal NPY and Y1 receptor but not cell proliferation in a rat model of depression. Bjornebekk A, etal., Hippocampus. 2010 Jul;20(7):820-8. doi: 10.1002/hipo.20683.
3. The effect of cardiac ischemic preconditioning on rat left ventricular gene expression profile. Canatan H Cell Biochem Funct. 2007 Jun 11;.
4. Alteration of NPY and Y1 receptor in dorsomedial and ventromedial areas of hypothalamus in anorectic tumor-bearing rats. Chance WT, etal., Peptides. 2007 Feb;28(2):295-301. Epub 2007 Jan 17.
5. NPY stimulates cholesterol synthesis acutely by activating the SREBP2-HMGCR pathway through the Y1 and Y5 receptors in murine hepatocytes. Chen F, etal., Life Sci. 2020 Dec 1;262:118478. doi: 10.1016/j.lfs.2020.118478. Epub 2020 Sep 22.
6. Neuropeptide Y-Y1 receptor antisense oligodeoxynucleotide increases the infarct volume after middle cerebral artery occlusion in rats. Cheung RT and Cechetto DF, Neuroscience. 2000;98(4):771-7.
7. Expression of neuropeptide Y and its receptors Y1 and Y2 in the rat heart and its supplying autonomic and spinal sensory ganglia in experimentally induced diabetes. Chottova Dvorakova M, etal., Neuroscience. 2008 Feb 19;151(4):1016-28. doi: 10.1016/j.neuroscience.2007.07.069. Epub 2007 Dec 8.
8. The anti-inflammatory effect of neuropeptide Y (NPY) in rats is dependent on dipeptidyl peptidase 4 (DP4) activity and age. Dimitrijevic M, etal., Peptides. 2008 Dec;29(12):2179-87. doi: 10.1016/j.peptides.2008.08.017. Epub 2008 Sep 3.
9. Molecular cloning of a novel G protein-coupled receptor that may belong to the neuropeptide receptor family. Eva C, etal., FEBS Lett 1990 Oct 1;271(1-2):81-4.
10. Neuropeptide Y1 and Y5 receptors mediate the effects of neuropeptide Y on the hypothalamic-pituitary-thyroid axis. Fekete C, etal., Endocrinology 2002 Dec;143(12):4513-9.
11. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
12. Neuropeptide Y inhibits capsaicin-sensitive nociceptors via a Y1-receptor-mediated mechanism. Gibbs J, etal., Neuroscience. 2004;125(3):703-9.
13. Neuropeptide Y modulates effects of bradykinin and prostaglandin E2 on trigeminal nociceptors via activation of the Y1 and Y2 receptors. Gibbs JL, etal., Br J Pharmacol. 2007 Jan;150(1):72-9. Epub 2006 Dec 4.
14. Ultrastructural localization of neuropeptide Y Y1 receptors in the rat medial nucleus tractus solitarius: relationships with neuropeptide Y or catecholamine neurons. Glass MJ, etal., J Neurosci Res. 2002 Mar 15;67(6):753-65.
15. Physiological role of neuropeptide Y in the regulation of the ascending phase of the peristaltic reflex. Grider JR and Langdon LE, Am J Physiol Gastrointest Liver Physiol. 2003 Dec;285(6):G1139-46. Epub 2003 Aug 14.
16. Estrogen Induces Neuropeptide Y (NPY) Y1 receptor gene expression and responsiveness to NPY in gonadotrope-enriched pituitary cell cultures. Hill JW, etal., Endocrinology. 2004 May;145(5):2283-90. Epub 2004 Jan 15.
17. Neuropeptide y and neuropeptide y y5 receptor interaction restores impaired growth potential of aging bone marrow stromal cells. Igura K, etal., Rejuvenation Res. 2011 Aug;14(4):393-403. doi: 10.1089/rej.2010.1129. Epub 2011 May 19.
18. Infusion of neuropeptide Y into CA3 region of hippocampus produces antidepressant-like effect via Y1 receptor. Ishida H, etal., Hippocampus. 2007;17(4):271-80.
19. Electroconvulsive stimuli selectively affect behavior and neuropeptide Y (NPY) and NPY Y(1) receptor gene expressions in hippocampus and hypothalamus of Flinders Sensitive Line rat model of depression. Jiménez-Vasquez PA, etal., Eur Neuropsychopharmacol. 2007 Mar;17(4):298-308. doi: 10.1016/j.euroneuro.2006.06.011. Epub 2006 Aug 9.
20. Differential regulation of mRNAs for neuropeptide Y and its receptor subtypes in widespread areas of the rat limbic system during kindling epileptogenesis. Kopp J, etal., Brain Res Mol Brain Res. 1999 Sep 8;72(1):17-29.
21. Obesity and mild hyperinsulinemia found in neuropeptide Y-Y1 receptor-deficient mice. Kushi A, etal., Proc Natl Acad Sci U S A. 1998 Dec 22;95(26):15659-64.
22. Genetic variations in genes of the stress response pathway are associated with prolonged abstinence from heroin. Levran O, etal., Pharmacogenomics. 2018 Mar;19(4):333-341. doi: 10.2217/pgs-2017-0179. Epub 2018 Feb 21.
23. A 3' UTR SNP rs885863, a cis-eQTL for the circadian gene VIPR2 and lincRNA 689, is associated with opioid addiction. Levran O, etal., PLoS One. 2019 Nov 5;14(11):e0224399. doi: 10.1371/journal.pone.0224399. eCollection 2019.
24. Stress-related genes and heroin addiction: a role for a functional FKBP5 haplotype. Levran O, etal., Psychoneuroendocrinology. 2014 Jul;45:67-76. doi: 10.1016/j.psyneuen.2014.03.017. Epub 2014 Apr 6.
25. Of mice and men: neuropeptide Y and its receptors are associated with atherosclerotic lesion burden and vulnerability. Li L, etal., J Cardiovasc Transl Res. 2011 Jun;4(3):351-62. doi: 10.1007/s12265-011-9271-5. Epub 2011 Apr 6.
26. Gene Expression Changes in Glutamate and GABA-A Receptors, Neuropeptides, Ion Channels, and Cholesterol Synthesis in the Periaqueductal Gray Following Binge-Like Alcohol Drinking by Adolescent Alcohol-Preferring (P) Rats. McClintick JN, etal., Alcohol Clin Exp Res. 2016 May;40(5):955-68. doi: 10.1111/acer.13056. Epub 2016 Apr 8.
27. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
28. Central neuropeptide Y signaling ameliorates N(omega)-nitro-L-arginine methyl ester hypertension in the rat through a Y1 receptor mechanism. Michalkiewicz M, etal., Hypertension 2005 Apr;45(4):780-5. Epub 2005 Feb 7.
29. Role of neuropeptide Y Y(1) and Y(2) receptors on behavioral despair in a rat model of depression with co-morbid anxiety. Morales-Medina JC, etal., Neuropharmacology. 2012 Jan;62(1):200-8. doi: 10.1016/j.neuropharm.2011.06.030. Epub 2011 Jul 23.
30. Neuropeptide Y suppresses absence seizures in a genetic rat model primarily through effects on Y receptors. Morris MJ, etal., Eur J Neurosci. 2007 Feb;25(4):1136-43.
31. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
32. The neuropeptide Y receptors, Y1 and Y2, are transiently and differentially expressed in the developing cerebellum. Neveu I, etal., Neuroscience 2002;113(4):767-77.
33. Association between neuropeptide Y gene and its receptor Y1 gene and methamphetamine dependence. Okahisa Y, etal., Psychiatry Clin Neurosci. 2009 Jun;63(3):417-22. doi: 10.1111/j.1440-1819.2009.01961.x.
34. Gene expression in the neuropeptide Y system during ethanol withdrawal kindling in rats. Olling JD, etal., Alcohol Clin Exp Res. 2010 Mar 1;34(3):462-70. doi: 10.1111/j.1530-0277.2009.01110.x. Epub 2009 Dec 17.
35. Complex plastic changes in the neuropeptide Y system during ethanol intoxication and withdrawal in the rat brain. Olling JD, etal., J Neurosci Res. 2009 Aug 1;87(10):2386-97. doi: 10.1002/jnr.22049.
36. Polymorphisms in Stress-Related Genes Are Associated with Reduced Cocaine Abuse and Longer Retention in Methadone Maintenance Treatment for Opioid Use Disorder. Peles E, etal., Eur Addict Res. 2021;27(3):198-205. doi: 10.1159/000511898. Epub 2020 Nov 26.
37. An immunohistochemical marker for Wallerian degeneration of fibers in the central and peripheral nervous system. Pesini P, etal., Brain Res. 1999 May 15;828(1-2):41-59.
38. Characterization of NPY receptors mediating contraction in rat intramyocardial coronary arteries. Prieto D, etal., Regul Pept. 1998 Sep 25;75-76:155-60.
39. Further evidence for the association of GAL, GALR1 and NPY1R variants with opioid dependence. Randesi M, etal., Pharmacogenomics. 2020 Aug;21(13):903-917. doi: 10.2217/pgs-2020-0045. Epub 2020 Aug 6.
40. GOA pipeline RGD automated data pipeline
41. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
42. Comprehensive gene review and curation RGD comprehensive gene curation
43. Medial prefrontal cortex neuropeptide Y modulates binge-like ethanol consumption in C57BL/6J mice. Robinson SL, etal., Neuropsychopharmacology. 2019 May;44(6):1132-1140. doi: 10.1038/s41386-018-0310-7. Epub 2019 Jan 7.
44. Impact of intermittent voluntary ethanol consumption during adolescence on the expression of endocannabinoid system and neuroinflammatory mediators. Sanchez-Marin L, etal., Eur Neuropsychopharmacol. 2020 Apr;33:126-138. doi: 10.1016/j.euroneuro.2020.01.012. Epub 2020 Feb 10.
45. Neuropeptide Y Y1 receptors mediate morphine-induced reductions of natural killer cell activity. Saurer TB, etal., J Neuroimmunol. 2006 Aug;177(1-2):18-26. doi: 10.1016/j.jneuroim.2006.05.002.
46. Modulation of intracellular calcium changes and glutamate release by neuropeptide Y1 and Y2 receptors in the rat hippocampus: differential effects in CA1, CA3 and dentate gyrus. Silva AP, etal., J Neurochem. 2001 Oct;79(2):286-96. doi: 10.1046/j.1471-4159.2001.00560.x.
47. Antisense mRNA for NPY-Y1 receptor in the medial preoptic area increases prolactin secretion. Silveira NA and Franci CR, Braz J Med Biol Res. 1999 Sep;32(9):1161-5.
48. Differential roles for neuropeptide Y Y1 and Y5 receptors in anxiety and sedation. Sorensen G, etal., J Neurosci Res. 2004 Sep 1;77(5):723-9.
49. Central neuropeptide Y modulates binge-like ethanol drinking in C57BL/6J mice via Y1 and Y2 receptors. Sparrow AM, etal., Neuropsychopharmacology. 2012 May;37(6):1409-21. doi: 10.1038/npp.2011.327. Epub 2012 Jan 4.
50. Acute stress and alcohol exposure during adolescence result in an anxious phenotype in adulthood: Role of altered glutamate/endocannabinoid transmission mechanisms. Sánchez-Marín L, etal., Prog Neuropsychopharmacol Biol Psychiatry. 2022 Mar 8;113:110460. doi: 10.1016/j.pnpbp.2021.110460. Epub 2021 Oct 22.
51. Ultrastructural Characterization of Corticotropin-Releasing Factor and Neuropeptide Y in the Rat Locus Coeruleus: Anatomical Evidence for Putative Interactions. Theisen CC, etal., Neuroscience. 2018 Aug 1;384:21-40. doi: 10.1016/j.neuroscience.2018.04.043. Epub 2018 May 22.
52. Influence of dehydration on the expression of neuropeptide Y Y1 receptors in hypothalamic magnocellular neurons. Urban JH, etal., Endocrinology. 2006 Sep;147(9):4122-31. Epub 2006 May 25.
53. Overexpression of NPY and Y2 receptors in epileptic brain tissue: an endogenous neuroprotective mechanism in temporal lobe epilepsy? Vezzani A and Sperk G, Neuropeptides. 2004 Aug;38(4):245-52.
54. Difference of NPY and its receptor gene expressions between obesity and obesity-resistant rats in response to high-fat diet. Wang C, etal., Horm Metab Res. 2007 Apr;39(4):262-7.
55. Activation of neuropeptide Y Y1 receptors inhibits glutamate release through reduction of voltage-dependent Ca2+ entry in the rat cerebral cortex nerve terminals: suppression of this inhibitory effect by the protein kinase C-dependent facilitatory pathway. Wang SJ, Neuroscience. 2005;134(3):987-1000. doi: 10.1016/j.neuroscience.2005.04.053.
56. Association study of 45 candidate genes in nicotine dependence in Han Chinese. Wei J, etal., Addict Behav. 2012 May;37(5):622-6. doi: 10.1016/j.addbeh.2012.01.009. Epub 2012 Jan 18.
Additional References at PubMed
PMID:9623984   PMID:10698177   PMID:11206547   PMID:12429884   PMID:12477932   PMID:12535945   PMID:12855401   PMID:12900925   PMID:14615027   PMID:14688445   PMID:15044185   PMID:15123022  
PMID:15295007   PMID:15544855   PMID:15576634   PMID:15623437   PMID:15690487   PMID:15720710   PMID:16051880   PMID:16448775   PMID:17463058   PMID:17510186   PMID:18323405   PMID:18535365  
PMID:19138726   PMID:19593212   PMID:19731317   PMID:20219870   PMID:20536577   PMID:21629996   PMID:22210742   PMID:22659471   PMID:22713926   PMID:22732442   PMID:23052195   PMID:23071607  
PMID:23074243   PMID:23179670   PMID:23548582   PMID:23825421   PMID:24225225   PMID:24444822   PMID:24779394   PMID:25241802   PMID:26330345   PMID:26490304   PMID:26666529   PMID:28239793  
PMID:28438668   PMID:29157796   PMID:30227410   PMID:30700376   PMID:31076578   PMID:31622603   PMID:38622072  


Genomics

Comparative Map Data
Npy1r
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81627,804,416 - 27,814,070 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1627,804,416 - 27,813,387 (-)EnsemblGRCr8
mRatBN7.21623,037,788 - 23,047,330 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1623,037,789 - 23,046,759 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1626,400,898 - 26,409,918 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01629,835,589 - 29,844,607 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01625,766,507 - 25,775,523 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01624,779,480 - 24,789,131 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1624,779,477 - 24,788,740 (-)Ensemblrn6Rnor6.0
Rnor_5.01624,663,045 - 24,672,508 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41624,747,183 - 24,756,507 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1623,162,089 - 23,171,059 (-)NCBICelera
RGSC_v3.11624,748,298 - 24,749,803 (-)NCBI
Cytogenetic Map16p14NCBI
NPY1R
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384163,323,962 - 163,344,689 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4163,323,962 - 163,344,852 (-)Ensemblhg38GRCh38
GRCh374164,245,114 - 164,253,748 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364164,464,567 - 164,473,198 (-)NCBIBuild 36Build 36hg18NCBI36
Build 344164,602,721 - 164,611,353NCBI
Celera4161,577,336 - 161,585,966 (-)NCBICelera
Cytogenetic Map4q32.2NCBI
HuRef4159,999,060 - 160,008,005 (-)NCBIHuRef
CHM1_14164,221,563 - 164,230,393 (-)NCBICHM1_1
T2T-CHM13v2.04166,671,793 - 166,692,717 (-)NCBIT2T-CHM13v2.0
Npy1r
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39867,149,595 - 67,159,452 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl867,149,844 - 67,159,444 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38866,697,149 - 66,706,800 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl866,697,192 - 66,706,792 (+)Ensemblmm10GRCm38
MGSCv37869,221,321 - 69,230,697 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36869,632,837 - 69,635,097 (+)NCBIMGSCv36mm8
Celera869,251,576 - 69,260,940 (+)NCBICelera
Cytogenetic Map8B3.1NCBI
cM Map833.15NCBI
Npy1r
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540341,681,728 - 41,694,020 (+)Ensembl
ChiLan1.0NW_00495540341,681,834 - 41,693,094 (+)NCBIChiLan1.0ChiLan1.0
NPY1R
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23161,132,638 - 161,153,546 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14161,495,180 - 161,516,073 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04155,583,870 - 155,604,336 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14167,372,306 - 167,392,716 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4167,372,310 - 167,381,597 (-)EnsemblpanPan2panpan1.1
NPY1R
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11559,580,546 - 59,587,753 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1559,580,809 - 59,583,237 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1559,946,494 - 59,947,746 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01560,338,999 - 60,348,168 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1560,339,001 - 60,348,197 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11559,574,468 - 59,575,720 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01559,665,153 - 59,666,405 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01560,034,141 - 60,035,393 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Npy1r
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494316,293,825 - 16,314,919 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365552,267,669 - 2,276,778 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365552,267,727 - 2,276,673 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NPY1R
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl852,152,646 - 52,162,328 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1852,152,649 - 52,163,080 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2855,280,107 - 55,290,551 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NPY1R
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.17109,774,700 - 109,794,543 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl7109,774,918 - 109,776,905 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603789,580,043 - 89,600,565 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Npy1r
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475813,536,493 - 13,545,599 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462475813,542,467 - 13,545,106 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Npy1r
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11322,588,233 - 22,591,920 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Npy1r
166 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:402
Count of miRNA genes:218
Interacting mature miRNAs:258
Transcripts:ENSRNOT00000018952
Prediction methods:Microtar, Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411664Foco30Food consumption QTL 30110.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)16435482249354822Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)1638712345387123Rat
1549842Bp248Blood pressure QTL 2480.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1638712345387123Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)16423421249757901Rat
2307172Activ4Activity QTL 43.710.00023locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)16133425095Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16423421266955197Rat
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16139568015Rat
2303566Bw90Body weight QTL 902body mass (VT:0001259)body weight (CMO:0000012)16139568015Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16423421253708481Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683908666195506Rat
2306902Bp339Blood pressure QTL 3390.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16338679049757901Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16474422249744222Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683908666195506Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683908666195506Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161773081872536785Rat
2293343Glom16Glomerulus QTL 167.4kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1683908652786090Rat
2301406Kidm39Kidney mass QTL 390.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)161590580260905802Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683908666195506Rat
6903319Bw114Body weight QTL 1142.70.0037body mass (VT:0001259)body weight (CMO:0000012)16330168348301683Rat

Markers in Region
UniSTS:256984  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21623,039,172 - 23,039,540 (+)MAPPERmRatBN7.2
Rnor_6.01624,780,864 - 24,781,231NCBIRnor6.0
Rnor_5.01624,664,429 - 24,664,796UniSTSRnor5.0
RGSC_v3.41624,748,567 - 24,748,934UniSTSRGSC3.4
Celera1623,163,473 - 23,163,840UniSTS
Cytogenetic Map16p14UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 61 146 62 61 30 63 30 6 283 157 11 125 72 90 31 14 14

Sequence


Ensembl Acc Id: ENSRNOT00000018952   ⟹   ENSRNOP00000018952
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1627,804,416 - 27,813,387 (-)Ensembl
mRatBN7.2 Ensembl1623,037,789 - 23,046,759 (-)Ensembl
Rnor_6.0 Ensembl1624,779,477 - 24,788,740 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000079412   ⟹   ENSRNOP00000068980
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1627,804,417 - 27,813,387 (-)Ensembl
mRatBN7.2 Ensembl1623,037,790 - 23,046,759 (-)Ensembl
Rnor_6.0 Ensembl1624,779,481 - 24,788,456 (-)Ensembl
RefSeq Acc Id: NM_001113357   ⟹   NP_001106828
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81627,804,416 - 27,813,387 (-)NCBI
mRatBN7.21623,037,789 - 23,046,759 (-)NCBI
Rnor_6.01624,779,480 - 24,788,456 (-)NCBI
Rnor_5.01624,663,045 - 24,672,508 (-)NCBI
RGSC_v3.41624,747,183 - 24,756,507 (-)RGD
Celera1623,162,089 - 23,171,059 (-)RGD
Sequence:
RefSeq Acc Id: XM_006253024   ⟹   XP_006253086
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81627,804,416 - 27,814,070 (-)NCBI
mRatBN7.21623,037,788 - 23,047,330 (-)NCBI
Rnor_6.01624,779,480 - 24,789,131 (-)NCBI
Rnor_5.01624,663,045 - 24,672,508 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006253025   ⟹   XP_006253087
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81627,804,416 - 27,814,070 (-)NCBI
mRatBN7.21623,037,788 - 23,047,330 (-)NCBI
Rnor_6.01624,779,480 - 24,789,131 (-)NCBI
Rnor_5.01624,663,045 - 24,672,508 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063275269   ⟹   XP_063131339
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81627,804,416 - 27,814,066 (-)NCBI
RefSeq Acc Id: NP_001106828   ⟸   NM_001113357
- UniProtKB: P21555 (UniProtKB/Swiss-Prot),   G3V7T1 (UniProtKB/TrEMBL),   A6KFL5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006253087   ⟸   XM_006253025
- Peptide Label: isoform X1
- UniProtKB: P21555 (UniProtKB/Swiss-Prot),   G3V7T1 (UniProtKB/TrEMBL),   A6KFL5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006253086   ⟸   XM_006253024
- Peptide Label: isoform X1
- UniProtKB: P21555 (UniProtKB/Swiss-Prot),   G3V7T1 (UniProtKB/TrEMBL),   A6KFL5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000068980   ⟸   ENSRNOT00000079412
Ensembl Acc Id: ENSRNOP00000018952   ⟸   ENSRNOT00000018952
RefSeq Acc Id: XP_063131339   ⟸   XM_063275269
- Peptide Label: isoform X2
- UniProtKB: Q5FVH5 (UniProtKB/TrEMBL)
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P21555-F1-model_v2 AlphaFold P21555 1-382 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3198 AgrOrtholog
BioCyc Gene G2FUF-11662 BioCyc
Ensembl Genes ENSRNOG00000014149 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000018952 ENTREZGENE
  ENSRNOT00000079412 ENTREZGENE
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7317839 IMAGE-MGC_LOAD
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
  NPY1_rcpt UniProtKB/Swiss-Prot
  NPY_rcpt UniProtKB/Swiss-Prot
MGC_CLONE MGC:109393 IMAGE-MGC_LOAD
NCBI Gene 29358 ENTREZGENE
PANTHER NEUROPEPTIDE Y RECEPTOR UniProtKB/Swiss-Prot
  PTHR24235:SF24 UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot
PhenoGen Npy1r PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot
  NRPEPTIDEY1R UniProtKB/Swiss-Prot
  NRPEPTIDEYR UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000014149 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot
UniProt A6KFL5 ENTREZGENE, UniProtKB/TrEMBL
  G3V7T1 ENTREZGENE, UniProtKB/TrEMBL
  NPY1R_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q5FVH5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-11-06 Npy1r  neuropeptide Y receptor Y1    neuropeptide Y1 receptor  Name updated 625702 APPROVED
2002-06-10 Npy1r  neuropeptide Y1 receptor      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in thalamus, cerebral cortex and hippocampus 69907