Me1 (malic enzyme 1) - Rat Genome Database

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Gene: Me1 (malic enzyme 1) Rattus norvegicus
Analyze
Symbol: Me1
Name: malic enzyme 1
RGD ID: 3074
Description: Enables NADP binding activity and malate dehydrogenase (decarboxylating) (NADP+) activity. Involved in response to hormone. Located in cytosol and mitochondrion. Orthologous to human ME1 (malic enzyme 1); PARTICIPATES IN Leigh disease pathway; primary hyperoxaluria type 2 pathway; pyruvate decarboxylase deficiency pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: cytosolic malic enzyme 1; malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+); Malic enzyme 1 soluble; malic enzyme 1, NADP(+)-dependent, cytosolic; Malic enzyme 1, soluble; MOD1; NADP-dependent malic enzyme; NADP-ME
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8896,429,057 - 96,540,244 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl896,429,057 - 96,540,275 (-)EnsemblGRCr8
mRatBN7.2887,549,043 - 87,660,251 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl887,549,043 - 87,660,304 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx893,229,577 - 93,340,927 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0891,428,778 - 91,540,131 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0889,270,059 - 89,381,778 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0894,256,830 - 94,368,834 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl894,256,839 - 94,368,834 (-)Ensemblrn6Rnor6.0
Rnor_5.0893,769,078 - 93,863,611 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4891,839,845 - 91,955,917 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera887,151,761 - 87,246,579 (-)NCBICelera
RGSC_v3.1891,860,614 - 91,975,372 (-)NCBI
RH 3.4 Map8999.69RGD
Cytogenetic Map8q31NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
(E)-cinnamyl alcohol  (ISO)
(S)-nicotine  (ISO)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,4-phenylenediamine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dimethoxyphenol  (ISO)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5-triiodo-L-thyronine  (EXP)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
9-cis,11-trans-octadecadienoic acid  (ISO)
Actein  (EXP)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
aldrin  (ISO)
all-trans-retinoic acid  (ISO)
alpha-hexachlorocyclohexane  (EXP)
alpha-hexylcinnamaldehyde  (ISO)
alpha-Zearalanol  (EXP)
amiodarone  (EXP)
ammonium chloride  (EXP)
antimycin A  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
Augmentin  (ISO)
azoxystrobin  (ISO)
Bandrowski's base  (ISO)
benazepril  (EXP)
benzbromarone  (EXP)
benzene  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (EXP)
benzoic acid  (ISO)
beta-naphthoflavone  (ISO)
bexarotene  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
buspirone  (EXP)
butanal  (ISO)
cadmium dichloride  (EXP,ISO)
cadmium sulfate  (ISO)
cannabidiol  (ISO)
captan  (ISO)
carbamazepine  (EXP,ISO)
carbon nanotube  (ISO)
celastrol  (ISO)
chloroacetaldehyde  (ISO)
chloroethene  (ISO)
chlorohydrocarbon  (EXP)
cinnamyl alcohol  (ISO)
cisplatin  (ISO)
clavulanic acid  (ISO)
clodronic acid  (ISO)
clofibrate  (EXP,ISO)
cobalt dichloride  (EXP,ISO)
copper(II) sulfate  (ISO)
corticosterone  (EXP)
cyclosporin A  (EXP,ISO)
daidzein  (ISO)
DDE  (ISO)
deguelin  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
Diallyl sulfide  (EXP)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (EXP)
dibenzo[a,l]pyrene  (EXP,ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
dichloroacetic acid  (ISO)
diethyl maleate  (ISO)
dioxygen  (ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
diquat  (ISO)
disulfiram  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
equol  (ISO)
ethanol  (EXP,ISO)
eugenol  (EXP,ISO)
felbamate  (EXP)
fenofibrate  (EXP,ISO)
fenpyroximate  (ISO)
finasteride  (EXP)
fipronil  (EXP)
fluoranthene  (EXP)
flutamide  (EXP)
folic acid  (ISO)
folpet  (ISO)
formaldehyde  (ISO)
fructose  (ISO)
furan  (EXP)
furfural  (ISO)
gedunin  (ISO)
genistein  (ISO)
glafenine  (EXP)
glutathione  (EXP)
GW 7647  (ISO)
hexadecanoic acid  (ISO)
hexane  (ISO)
hydrogen peroxide  (ISO)
hydrogen sulfide  (ISO)
hypochlorous acid  (ISO)
ibuprofen  (EXP)
ifosfamide  (ISO)
indinavir  (ISO)
indole-3-methanol  (EXP)
indometacin  (EXP,ISO)
inulin  (ISO)
iron atom  (ISO)
iron(0)  (ISO)
isoeugenol  (ISO)
isoflavones  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
ketoconazole  (EXP)
L-ethionine  (EXP)
lamivudine  (ISO)
lead diacetate  (ISO)
leflunomide  (EXP)
lipopolysaccharide  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
melatonin  (EXP)
menadione  (ISO)
mercury dibromide  (ISO)
mercury dichloride  (ISO)
Mesaconitine  (EXP)
metformin  (EXP,ISO)
methoxychlor  (EXP)
methyl salicylate  (ISO)
methylmercury chloride  (EXP,ISO)
methylseleninic acid  (ISO)
N-acetyl-L-cysteine  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (EXP)
nefazodone  (EXP)
nelfinavir  (ISO)
nickel sulfate  (ISO)
nicotine  (ISO)
ochratoxin A  (EXP,ISO)
omeprazole  (EXP)
organophosphorus compound  (EXP)
oxfendazole  (EXP)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
permethrin  (ISO)
phenethyl caffeate  (EXP)
phenobarbital  (EXP,ISO)
phenylmercury acetate  (ISO)
phenytoin  (EXP)
phytoestrogen  (ISO)
picoxystrobin  (ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP,ISO)
potassium bromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
procymidone  (EXP)
propan-2-ol  (ISO)
pyrazinecarboxamide  (EXP)
pyrimidifen  (ISO)
quercetin 3-O-beta-D-glucofuranoside  (EXP)
quercetin 3-O-beta-D-glucopyranoside  (EXP)
rac-lactic acid  (ISO)
Rebamipide  (EXP)
resveratrol  (ISO)
rotenone  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
saquinavir  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
sodium dichromate  (EXP,ISO)
sodium dodecyl sulfate  (ISO)
stavudine  (ISO)
sulforaphane  (ISO)
sulindac  (EXP)
sunitinib  (ISO)
tebufenpyrad  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP)
tetracycline  (EXP)
thapsigargin  (EXP)
thifluzamide  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
topiramate  (EXP)
Torularhodin  (ISO)
trans-isoeugenol  (ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
triphenyl phosphate  (EXP)
Triptolide  (ISO)
troglitazone  (EXP)
trovafloxacin  (EXP)
tunicamycin  (ISO)
valdecoxib  (EXP)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
vitamin D  (ISO)
vitamin E  (EXP)
zidovudine  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA,ISO)
cytosol  (IDA,IEA,ISO)
mitochondrion  (IBA,IDA)

References

References - curated
# Reference Title Reference Citation
1. Tissue-specific regulation of two functional malic enzyme mRNAs by triiodothyronine. Dozin B, etal., Biochemistry. 1985 Sep 24;24(20):5581-6.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Cloning, sequencing and functional expression of a cDNA encoding a NADP-dependent malic enzyme from human liver. Gonzalez-Manchon C, etal., Gene. 1995 Jul 4;159(2):255-60.
5. Dietary lipoic acid-dependent changes in the activity and mRNA levels of hepatic lipogenic enzymes in rats. Huong DT and Ide T, Br J Nutr. 2008 Jul;100(1):79-87. Epub 2007 Dec 7.
6. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
7. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
8. Characterization of cytosolic malic enzyme in human tumor cells. Loeber G, etal., FEBS Lett. 1994 May 16;344(2-3):181-6.
9. Coding nucleotide sequence of rat liver malic enzyme mRNA. Magnuson MA, etal., J Biol Chem 1986 Jan 25;261(3):1183-6.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Structural characterization of the rat malic enzyme gene. Morioka H, etal., Proc Natl Acad Sci U S A 1989 Jul;86(13):4912-6.
12. Effect of cold acclimation on brown adipose tissue fatty acid synthesis in rats adapted to a high-protein, carbohydrate-free diet. Moura MA, etal., Metabolism. 2001 Dec;50(12):1493-8.
13. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
14. Cardiac glutaminolysis: a maladaptive cancer metabolism pathway in the right ventricle in pulmonary hypertension. Piao L, etal., J Mol Med (Berl). 2013 Oct;91(10):1185-97. doi: 10.1007/s00109-013-1064-7. Epub 2013 Jun 21.
15. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
16. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
17. GOA pipeline RGD automated data pipeline
18. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. Kinetics of induction by thyroid hormone of the two hepatic mRNAs coding for cytosolic malic enzyme in the hypothyroid and euthyroid states. Evidence against an obligatory role of S14 protein in malic enzyme gene expression. Strait KA, etal., J Biol Chem 1989 Nov 25;264(33):19784-9.
21. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
22. Effect of Anabolic Steroid Nandrolone Decanoate on the Properties of Certain Enzymes in the Heart, Liver, and Muscle of Rats, and their Effect on Rats' Cardiac Electrophysiology. Tylicki A, etal., Horm Metab Res. 2007 Apr;39(4):268-72.
23. Mitochondrial malic enzyme: purification from bovine brain, generation of an antiserum, and immunocytochemical localization in neurons of rat brain. Vogel R, etal., J Neurochem. 1998 Aug;71(2):844-52.
Additional References at PubMed
PMID:2699453   PMID:3211151   PMID:4385090   PMID:6838491   PMID:7667285   PMID:18614015   PMID:18755687   PMID:18802677   PMID:19293334   PMID:22871113   PMID:23334421  


Genomics

Comparative Map Data
Me1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8896,429,057 - 96,540,244 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl896,429,057 - 96,540,275 (-)EnsemblGRCr8
mRatBN7.2887,549,043 - 87,660,251 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl887,549,043 - 87,660,304 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx893,229,577 - 93,340,927 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0891,428,778 - 91,540,131 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0889,270,059 - 89,381,778 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0894,256,830 - 94,368,834 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl894,256,839 - 94,368,834 (-)Ensemblrn6Rnor6.0
Rnor_5.0893,769,078 - 93,863,611 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4891,839,845 - 91,955,917 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera887,151,761 - 87,246,579 (-)NCBICelera
RGSC_v3.1891,860,614 - 91,975,372 (-)NCBI
RH 3.4 Map8999.69RGD
Cytogenetic Map8q31NCBI
ME1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38683,210,402 - 83,431,051 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl683,210,393 - 83,431,208 (-)Ensemblhg38GRCh38
GRCh37683,920,121 - 84,140,770 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36683,976,827 - 84,197,498 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34683,977,975 - 84,197,499NCBI
Celera684,353,414 - 84,574,177 (-)NCBICelera
Cytogenetic Map6q14.2NCBI
HuRef681,148,328 - 81,370,879 (-)NCBIHuRef
CHM1_1684,017,801 - 84,238,482 (-)NCBICHM1_1
T2T-CHM13v2.0684,433,644 - 84,654,257 (-)NCBIT2T-CHM13v2.0
Me1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39986,463,416 - 86,577,967 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl986,463,424 - 86,578,006 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38986,581,363 - 86,695,914 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl986,581,371 - 86,695,953 (-)Ensemblmm10GRCm38
MGSCv37986,474,970 - 86,589,947 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36987,524,432 - 87,639,643 (-)NCBIMGSCv36mm8
MGSCv36986,378,094 - 86,492,941 (-)NCBIMGSCv36mm8
Celera983,658,088 - 83,772,920 (-)NCBICelera
Cytogenetic Map9E3.1NCBI
cM Map946.58NCBI
Me1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541110,938,944 - 11,065,085 (-)Ensembl
ChiLan1.0NW_00495541110,938,580 - 11,084,171 (-)NCBIChiLan1.0ChiLan1.0
ME1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25103,312,102 - 103,524,703 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16101,204,935 - 101,421,593 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0681,107,569 - 81,320,050 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1684,382,732 - 84,595,701 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl684,382,732 - 84,595,701 (-)EnsemblpanPan2panpan1.1
ME1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11243,623,413 - 43,793,590 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1243,624,945 - 43,828,775 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1243,436,816 - 43,632,406 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01244,390,732 - 44,586,598 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1244,390,736 - 44,586,656 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11243,730,159 - 43,925,658 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01243,679,098 - 43,858,889 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01243,840,059 - 44,036,221 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Me1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494678,899,805 - 79,044,563 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365107,426,347 - 7,571,553 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365107,425,983 - 7,571,090 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ME1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl182,799,684 - 82,991,085 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1182,799,878 - 82,989,895 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2193,051,393 - 93,241,425 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap1p12NCBI
ME1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1137,889,211 - 8,112,793 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl137,887,984 - 8,112,533 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666040184,102,580 - 184,333,948 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Me1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462479911,166,398 - 11,382,662 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Me1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1880,629,671 - 80,743,131 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Me1
380 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:174
Count of miRNA genes:127
Interacting mature miRNAs:150
Transcripts:ENSRNOT00000013244
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300177Cm2Cardiac mass QTL 23.65heart mass (VT:0007028)heart weight (CMO:0000017)863141536109261840Rat
1549909Stresp11Stress response QTL 116.830.0019stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)882352698127352698Rat
12879878Bw183Body weight QTL 1830.001body mass (VT:0001259)body weight (CMO:0000012)862848139107848139Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)858337123103337123Rat
12879879Cm99Cardiac mass QTL 990.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)862848139107848139Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)849849908118871671Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)880768445125768445Rat
1331804Cm30Cardiac mass QTL 303.77443heart mass (VT:0007028)heart wet weight (CMO:0000069)862970527107970527Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)839106363103375781Rat
12879880Cm100Cardiac mass QTL 1000.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)862848139107848139Rat
12879881Cm101Cardiac mass QTL 1010.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)862848139107848139Rat
12879882Am8Aortic mass QTL 80.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)862848139107848139Rat
12879883Kidm65Kidney mass QTL 650.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)862848139107848139Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)85158969999045312Rat
71120Niddm21Non-insulin dependent diabetes mellitus QTL 213.73blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)866992095111992095Rat
1358912Bw51Body weight QTL 512.95body mass (VT:0001259)body weight (CMO:0000012)860248093105248093Rat
634332Pia18Pristane induced arthritis QTL 184joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)884192326132782436Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)839106363103375781Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)879394435132782436Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)839106258103375958Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)861019838121662124Rat
2293697Bmd39Bone mineral density QTL 39femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)862848139107848139Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)863404444108404444Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)835464071107982864Rat
1331837Bw23Body weight QTL 234.190.00007body mass (VT:0001259)body weight (CMO:0000012)855428416107963099Rat
1331838Niddm61Non-insulin dependent diabetes mellitus QTL 613.530.0004blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)862963099107963099Rat
8694446Bw170Body weight QTL 17012.070.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)880768445125768445Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)870041301121080908Rat
1331769Rf39Renal function QTL 393.871urine output (VT:0003620)timed urine volume (CMO:0000260)850763951107970527Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)868690349119799881Rat
10450865Bw175Body weight QTL 1754.1total fat pad mass (VT:0015008)adipose tissue molecular composition measurement (CMO:0000484)884192326129192326Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)835464071107982864Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)855428333127966348Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)839106363114525825Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)885348065130348065Rat
724540Uae8Urinary albumin excretion QTL 85urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)839106258103375958Rat
10402857Bp380Blood pressure QTL 3800.95arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)862848139107848139Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)835464071107982864Rat
631664Hcar3Hepatocarcinoma resistance QTL 32.90.0005liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)862982864107982864Rat
2301402Bp316Blood pressure QTL 3160.005arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)862848139107848139Rat
8694200Abfw4Abdominal fat weight QTL 49.070.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)880768445125768445Rat
8694392Bw161Body weight QTL 1618.060.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)880768445125768445Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)891340911131690273Rat

Markers in Region
RH129138  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2887,549,163 - 87,549,352 (+)MAPPERmRatBN7.2
Rnor_6.0894,256,960 - 94,257,148NCBIRnor6.0
Rnor_5.0893,769,199 - 93,769,387UniSTSRnor5.0
RGSC_v3.4891,839,966 - 91,840,154UniSTSRGSC3.4
Celera887,151,882 - 87,152,070UniSTS
Cytogenetic Map8q31UniSTS
AU048158  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2887,639,285 - 87,639,421 (+)MAPPERmRatBN7.2
Rnor_6.0894,347,354 - 94,347,489NCBIRnor6.0
Rnor_5.0893,858,715 - 93,858,850UniSTSRnor5.0
Celera887,241,607 - 87,241,743UniSTS
Cytogenetic Map8q31UniSTS
ME1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2887,614,953 - 87,615,108 (+)MAPPERmRatBN7.2
Rnor_6.0894,322,488 - 94,322,642NCBIRnor6.0
Rnor_5.0893,834,727 - 93,834,881UniSTSRnor5.0
RGSC_v3.4891,905,747 - 91,905,901UniSTSRGSC3.4
Celera887,217,631 - 87,217,785UniSTS
Cytogenetic Map8q31UniSTS
RH130391  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2887,550,091 - 87,550,287 (+)MAPPERmRatBN7.2
Rnor_6.0894,257,888 - 94,258,083NCBIRnor6.0
Rnor_5.0893,770,127 - 93,770,322UniSTSRnor5.0
RGSC_v3.4891,840,894 - 91,841,089UniSTSRGSC3.4
Celera887,152,810 - 87,153,005UniSTS
RH 3.4 Map8998.59UniSTS
Cytogenetic Map8q31UniSTS
RH94870  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8896,430,278 - 96,430,541 (+)Marker Load Pipeline
mRatBN7.2887,550,264 - 87,550,527 (+)MAPPERmRatBN7.2
Rnor_6.0894,258,061 - 94,258,323NCBIRnor6.0
Rnor_5.0893,770,300 - 93,770,562UniSTSRnor5.0
RGSC_v3.4891,841,067 - 91,841,329UniSTSRGSC3.4
Celera887,152,983 - 87,153,245UniSTS
RH 3.4 Map8999.69UniSTS
Cytogenetic Map8q31UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 91 59 6 355 191 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000013244   ⟹   ENSRNOP00000013244
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl896,429,062 - 96,540,275 (-)Ensembl
mRatBN7.2 Ensembl887,549,048 - 87,660,304 (-)Ensembl
Rnor_6.0 Ensembl894,256,839 - 94,352,246 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000078977   ⟹   ENSRNOP00000071968
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl896,429,057 - 96,539,934 (-)Ensembl
mRatBN7.2 Ensembl887,549,043 - 87,659,923 (-)Ensembl
Rnor_6.0 Ensembl894,258,198 - 94,368,834 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000150972   ⟹   ENSRNOP00000110118
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl896,429,062 - 96,540,275 (-)Ensembl
RefSeq Acc Id: NM_012600   ⟹   NP_036732
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8896,429,057 - 96,540,244 (-)NCBI
mRatBN7.2887,549,043 - 87,660,251 (-)NCBI
Rnor_6.0894,256,839 - 94,368,834 (-)NCBI
Rnor_5.0893,769,078 - 93,863,611 (-)NCBI
RGSC_v3.4891,839,845 - 91,955,917 (-)RGD
Celera887,151,761 - 87,246,579 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_036732 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41563 (Get FASTA)   NCBI Sequence Viewer  
  AAA41564 (Get FASTA)   NCBI Sequence Viewer  
  EDL77625 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000013244
GenBank Protein P13697 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_036732   ⟸   NM_012600
- UniProtKB: P13697 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000013244   ⟸   ENSRNOT00000013244
Ensembl Acc Id: ENSRNOP00000071968   ⟸   ENSRNOT00000078977
Ensembl Acc Id: ENSRNOP00000110118   ⟸   ENSRNOT00000150972
Protein Domains
Malic enzyme N-terminal   Malic enzyme NAD-binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P13697-F1-model_v2 AlphaFold P13697 1-572 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696161
Promoter ID:EPDNEW_R6686
Type:initiation region
Name:Me1_1
Description:malic enzyme 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0894,368,867 - 94,368,927EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3074 AgrOrtholog
BioCyc Gene G2FUF-29639 BioCyc
Ensembl Genes ENSRNOG00000009715 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000013244 ENTREZGENE
Gene3D-CATH 3.40.50.10380 UniProtKB/Swiss-Prot
  NAD(P)-binding Rossmann-like Domain UniProtKB/Swiss-Prot
InterPro Aminiacid_DH-like_N_sf UniProtKB/Swiss-Prot
  Malic_enzyme_CS UniProtKB/Swiss-Prot
  Malic_N_dom UniProtKB/Swiss-Prot
  Malic_N_dom_sf UniProtKB/Swiss-Prot
  Malic_NAD-bd UniProtKB/Swiss-Prot
  Malic_OxRdtase UniProtKB/Swiss-Prot
  NAD(P)-bd_dom_sf UniProtKB/Swiss-Prot
NCBI Gene 24552 ENTREZGENE
PANTHER MALIC ENZYME-RELATED UniProtKB/Swiss-Prot
  NADP-DEPENDENT MALIC ENZYME UniProtKB/Swiss-Prot
Pfam malic UniProtKB/Swiss-Prot
  Malic_M UniProtKB/Swiss-Prot
PhenoGen Me1 PhenoGen
PIRSF PIRSF000106 UniProtKB/Swiss-Prot
PRINTS MALOXRDTASE UniProtKB/Swiss-Prot
PROSITE MALIC_ENZYMES UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000009715 RatGTEx
SMART malic UniProtKB/Swiss-Prot
  Malic_M UniProtKB/Swiss-Prot
Superfamily-SCOP SSF51735 UniProtKB/Swiss-Prot
  SSF53223 UniProtKB/Swiss-Prot
TIGR TC217846
UniProt A0A0G2K1S6_RAT UniProtKB/TrEMBL
  A0ABK0LH34_RAT UniProtKB/TrEMBL
  A6I1V2_RAT UniProtKB/TrEMBL
  F1LQQ1_RAT UniProtKB/TrEMBL
  MAOX_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-14 Me1  malic enzyme 1  Me1  malic enzyme 1, NADP(+)-dependent, cytosolic  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-15 Me1  malic enzyme 1, NADP(+)-dependent, cytosolic  Me1  malic enzyme 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-11-06 Me1  malic enzyme 1    Malic enzyme 1, soluble  Name updated 625702 APPROVED
2002-06-10 Me1  Malic enzyme 1, soluble      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_homology putative NADP-binding site is similar to the fatty acid synthetase enoyl reductase NADP-binding domain 633307