Inpp5d (inositol polyphosphate-5-phosphatase D) - Rat Genome Database

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Gene: Inpp5d (inositol polyphosphate-5-phosphatase D) Rattus norvegicus
Analyze
Symbol: Inpp5d
Name: inositol polyphosphate-5-phosphatase D
RGD ID: 2914
Description: Enables inositol-4,5-bisphosphate 5-phosphatase activity. Predicted to be involved in several processes, including negative regulation of bone resorption; negative regulation of natural killer cell mediated cytotoxicity; and regulation of leukocyte differentiation. Predicted to act upstream of or within several processes, including determination of adult lifespan; negative regulation of B cell proliferation; and regulation of hemopoiesis. Located in actin filament and cortical cytoskeleton. Orthologous to human INPP5D (inositol polyphosphate-5-phosphatase D); PARTICIPATES IN erythropoietin signaling pathway; Fc epsilon receptor mediated signaling pathway; granulocyte-macrophage colony-stimulating factor signaling pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: inositol polyphosphate-5-phosphatase; Inositol polyphosphate-5-phosphatase 145 kDa; Inositol polyphosphate-5-phosphatase, 145 kDa; phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1; phosphatidylinositol-4,5-bisphosphate 5-phosphatase; SH2 domain-containing inositol 5'-phosphatase 1; SH2 domain-containing inositol phosphatase 1; SH2 domain-containing inositol-5'-phosphatase 1; SHIP-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8995,735,533 - 95,840,584 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl995,735,530 - 95,840,589 (+)EnsemblGRCr8
mRatBN7.2988,287,680 - 88,392,748 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl988,287,677 - 88,392,746 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx996,712,335 - 96,817,268 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09101,848,406 - 101,953,467 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.09100,215,907 - 100,320,982 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0994,745,220 - 94,850,778 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl994,745,217 - 94,850,771 (+)Ensemblrn6Rnor6.0
Rnor_5.0994,464,380 - 94,569,984 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4986,576,742 - 86,682,240 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera985,697,060 - 85,801,952 (+)NCBICelera
RGSC_v3.1986,760,159 - 86,865,657 (+)NCBI
Cytogenetic Map9q35NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aripiprazole  (ISO)
Azoxymethane  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
camptothecin  (ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
chlorpyrifos  (EXP,ISO)
choline  (ISO)
cisplatin  (ISO)
clotrimazole  (EXP)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
deoxynivalenol  (ISO)
dextran sulfate  (ISO)
diazinon  (EXP)
dicrotophos  (ISO)
dieldrin  (EXP)
dimethyl sulfoxide  (ISO)
dorsomorphin  (ISO)
ellagic acid  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
ethanol  (ISO)
folic acid  (ISO)
folpet  (ISO)
formaldehyde  (ISO)
gentamycin  (EXP)
ketamine  (EXP)
L-methionine  (ISO)
Lasiocarpine  (ISO)
lipopolysaccharide  (ISO)
lithium atom  (ISO)
lithium hydride  (ISO)
maneb  (ISO)
MeIQx  (ISO)
mercury dibromide  (ISO)
methapyrilene  (ISO)
methimazole  (EXP)
methylmercury chloride  (ISO)
N-ethyl-N-nitrosourea  (ISO)
N-nitrosodimethylamine  (EXP)
nickel atom  (ISO)
nickel dichloride  (EXP)
nitrates  (ISO)
Nutlin-3  (ISO)
okadaic acid  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
quercitrin  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
sotorasib  (ISO)
succimer  (ISO)
sunitinib  (ISO)
testosterone  (EXP)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trametinib  (ISO)
tricetin  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
tungsten  (ISO)
urethane  (ISO)
valproic acid  (ISO)
zinc protoporphyrin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Metabolic switching of PI3K-dependent lipid signals. Downes CP, etal., Biochem Soc Trans. 2007 Apr;35(Pt 2):188-92.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Dynamic interactions of Fc gamma receptor IIB with filamin-bound SHIP1 amplify filamentous actin-dependent negative regulation of Fc epsilon receptor I signaling. Lesourne R, etal., J Immunol. 2005 Feb 1;174(3):1365-73.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
8. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
9. GOA pipeline RGD automated data pipeline
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Comprehensive gene review and curation RGD comprehensive gene curation
12. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
13. Frequency and amplitude control of cortical oscillations by phosphoinositide waves. Xiong D, etal., Nat Chem Biol. 2016 Mar;12(3):159-66. doi: 10.1038/nchembio.2000. Epub 2016 Jan 11.
14. SH2 domain-containing inositol polyphosphate 5'-phosphatase is the main mediator of the inhibitory action of the mast cell function-associated antigen. Xu R, etal., J Immunol 2001 Dec 1;167(11):6394-402.
Additional References at PubMed
PMID:8643691   PMID:8654924   PMID:8890215   PMID:9620849   PMID:10704460   PMID:11970986   PMID:12008030   PMID:12161749  


Genomics

Comparative Map Data
Inpp5d
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8995,735,533 - 95,840,584 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl995,735,530 - 95,840,589 (+)EnsemblGRCr8
mRatBN7.2988,287,680 - 88,392,748 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl988,287,677 - 88,392,746 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx996,712,335 - 96,817,268 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09101,848,406 - 101,953,467 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.09100,215,907 - 100,320,982 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0994,745,220 - 94,850,778 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl994,745,217 - 94,850,771 (+)Ensemblrn6Rnor6.0
Rnor_5.0994,464,380 - 94,569,984 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4986,576,742 - 86,682,240 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera985,697,060 - 85,801,952 (+)NCBICelera
RGSC_v3.1986,760,159 - 86,865,657 (+)NCBI
Cytogenetic Map9q35NCBI
INPP5D
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382233,060,342 - 233,207,903 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2233,059,967 - 233,207,903 (+)Ensemblhg38GRCh38
GRCh372233,925,052 - 234,116,549 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362233,633,280 - 233,703,602 (+)NCBIBuild 36Build 36hg18NCBI36
Build 362233,734,415 - 233,781,288 (+)NCBIBuild 36Build 36hg18NCBI36
Build 342233,851,680 - 233,898,543NCBI
Celera2227,689,229 - 227,838,082 (+)NCBICelera
Cytogenetic Map2q37.1NCBI
HuRef2225,771,888 - 225,851,574 (+)NCBIHuRef
HuRef2225,855,510 - 225,917,438 (+)NCBIHuRef
CHM1_12233,930,801 - 234,001,504 (+)NCBICHM1_1
CHM1_12234,060,594 - 234,122,681 (+)NCBICHM1_1
T2T-CHM13v2.02233,547,692 - 233,695,995 (+)NCBIT2T-CHM13v2.0
Inpp5d
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39187,548,034 - 87,648,232 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl187,548,034 - 87,648,229 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38187,620,312 - 87,720,510 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl187,620,312 - 87,720,507 (+)Ensemblmm10GRCm38
MGSCv37189,516,887 - 89,617,083 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36189,451,550 - 89,551,673 (+)NCBIMGSCv36mm8
Celera190,584,657 - 90,684,696 (+)NCBICelera
Cytogenetic Map1DNCBI
cM Map144.44NCBI
Inpp5d
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554532,938,659 - 3,037,211 (-)Ensembl
ChiLan1.0NW_0049554532,938,659 - 3,037,211 (-)NCBIChiLan1.0ChiLan1.0
INPP5D
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213135,661,459 - 135,810,426 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B135,676,418 - 135,825,387 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B120,287,606 - 120,436,526 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B239,201,762 - 239,350,190 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B239,201,762 - 239,350,190 (+)EnsemblpanPan2panpan1.1
INPP5D
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12544,612,146 - 44,731,347 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2544,611,523 - 44,730,200 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2545,107,368 - 45,226,924 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02544,871,607 - 44,991,203 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2544,871,613 - 44,991,203 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12544,796,019 - 44,915,638 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02544,642,212 - 44,761,876 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02544,797,422 - 44,916,878 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Inpp5d
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303186,769,492 - 186,893,121 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365254,048,492 - 4,154,618 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365254,046,609 - 4,154,715 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
INPP5D
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15133,501,092 - 133,626,644 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.115133,501,067 - 133,626,647 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215147,601,906 - 147,670,776 (+)NCBISscrofa10.2Sscrofa10.2susScr3
INPP5D
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110119,093,160 - 119,244,128 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl10119,093,781 - 119,244,123 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604080,260,665 - 80,414,305 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Inpp5d
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248435,685,502 - 5,773,469 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248435,685,409 - 5,774,459 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Inpp5d
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v14159,740,868 - 159,845,330 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Inpp5d
1186 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:156
Count of miRNA genes:118
Interacting mature miRNAs:138
Transcripts:ENSRNOT00000051338
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)956047863101047863Rat
1582203Gluco19Glucose level QTL 193.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)963376862108376862Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)965657365108376720Rat
724547Cm21Cardiac mass QTL 212.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)986720043110356905Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)94445825699506504Rat
2303178Bp334Blood pressure QTL 3343.70.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)986720043121768150Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)964220169109220169Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)964220169109220169Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)944458256121768150Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)964220169109220169Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)968875497121768150Rat
1354626Bvd1Brain ventricular dilatation QTL 13.730.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)983161999118999486Rat
4889852Pur26Proteinuria QTL 26150.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)985262459109044727Rat
7794784Mcs31Mammary carcinoma susceptibility QTL 312.98mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)985262459118999486Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)948718864108376862Rat
1578757Pur6Proteinuria QTL 63.30.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)964220169109220169Rat
4889943Bss90Bone structure and strength QTL 904.1tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)95450650499506504Rat

Markers in Region
D9Rat67  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2988,387,943 - 88,388,152 (+)MAPPERmRatBN7.2
Rnor_6.0994,845,971 - 94,846,179NCBIRnor6.0
Rnor_5.0994,565,182 - 94,565,390UniSTSRnor5.0
RGSC_v3.4986,677,437 - 86,677,646RGDRGSC3.4
RGSC_v3.4986,677,438 - 86,677,646UniSTSRGSC3.4
Celera985,797,206 - 85,797,414UniSTS
RGSC_v3.1986,860,856 - 86,861,065RGD
SHRSP x BN Map956.8299UniSTS
SHRSP x BN Map956.8299RGD
FHH x ACI Map959.98RGD
Cytogenetic Map9q35UniSTS
D9Got236  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2988,317,849 - 88,318,080 (+)MAPPERmRatBN7.2
Rnor_6.0994,775,679 - 94,775,909NCBIRnor6.0
Rnor_5.0994,494,839 - 94,495,069UniSTSRnor5.0
RGSC_v3.4986,606,909 - 86,607,139UniSTSRGSC3.4
Celera985,727,224 - 85,727,454UniSTS
Cytogenetic Map9q35UniSTS
RH133650  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2988,392,559 - 88,392,741 (+)MAPPERmRatBN7.2
Rnor_6.0994,850,585 - 94,850,766NCBIRnor6.0
Rnor_5.0994,569,796 - 94,569,977UniSTSRnor5.0
RGSC_v3.4986,682,052 - 86,682,233UniSTSRGSC3.4
Celera985,801,764 - 85,801,945UniSTS
RH 3.4 Map4985.9UniSTS
Cytogenetic Map9q35UniSTS
RH144552  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2988,304,395 - 88,304,502 (+)MAPPERmRatBN7.2
Rnor_6.0994,762,329 - 94,762,435NCBIRnor6.0
Rnor_5.0994,481,489 - 94,481,595UniSTSRnor5.0
RGSC_v3.4986,593,456 - 86,593,562UniSTSRGSC3.4
Celera985,713,771 - 85,713,877UniSTS
Cytogenetic Map9q35UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 142 81 92 31 16 16

Sequence


Ensembl Acc Id: ENSRNOT00000051338   ⟹   ENSRNOP00000040111
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl995,735,530 - 95,840,582 (+)Ensembl
mRatBN7.2 Ensembl988,287,677 - 88,392,746 (+)Ensembl
Rnor_6.0 Ensembl994,745,217 - 94,850,771 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000139676   ⟹   ENSRNOP00000112261
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl995,735,593 - 95,840,589 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000147470   ⟹   ENSRNOP00000105195
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl995,735,593 - 95,840,589 (+)Ensembl
RefSeq Acc Id: NM_019311   ⟹   NP_062184
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8995,735,533 - 95,840,584 (+)NCBI
mRatBN7.2988,287,680 - 88,392,748 (+)NCBI
Rnor_6.0994,745,220 - 94,850,773 (+)NCBI
Rnor_5.0994,464,380 - 94,569,984 (+)NCBI
RGSC_v3.4986,576,742 - 86,682,240 (+)RGD
Celera985,697,060 - 85,801,952 (+)RGD
Sequence:
RefSeq Acc Id: NP_062184   ⟸   NM_019311
- UniProtKB: P97573 (UniProtKB/Swiss-Prot),   F1M981 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000040111   ⟸   ENSRNOT00000051338
Ensembl Acc Id: ENSRNOP00000112261   ⟸   ENSRNOT00000139676
Ensembl Acc Id: ENSRNOP00000105195   ⟸   ENSRNOT00000147470
Protein Domains
Inositol polyphosphate-related phosphatase   SH2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P97573-F1-model_v2 AlphaFold P97573 1-1190 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696839
Promoter ID:EPDNEW_R7363
Type:initiation region
Name:Inpp5d_1
Description:inositol polyphosphate-5-phosphatase D
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0994,745,292 - 94,745,352EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2914 AgrOrtholog
BioCyc Gene G2FUF-26836 BioCyc
BioCyc Pathway PWY-6368 [3-phosphoinositide degradation] BioCyc
BioCyc Pathway Image PWY-6368 BioCyc
Ensembl Genes ENSRNOG00000017020 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000051338 ENTREZGENE
Gene3D-CATH 3.30.505.10 UniProtKB/Swiss-Prot
  3.60.10.10 UniProtKB/Swiss-Prot
InterPro Endo/exonu/phosph_ase_sf UniProtKB/Swiss-Prot
  IPPc UniProtKB/Swiss-Prot
  SH2 UniProtKB/Swiss-Prot
  SH2_dom_sf UniProtKB/Swiss-Prot
KEGG Report rno:54259 UniProtKB/Swiss-Prot
NCBI Gene 54259 ENTREZGENE
PANTHER PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 5-PHOSPHATASE 1 UniProtKB/Swiss-Prot
  SH2 DOMAIN-CONTAINING PROTEIN UniProtKB/Swiss-Prot
Pfam C2_SHIP1-2_2nd UniProtKB/Swiss-Prot
  C2_SHIP1-2_first UniProtKB/Swiss-Prot
  Exo_endo_phos2 UniProtKB/Swiss-Prot
  SH2 UniProtKB/Swiss-Prot
PhenoGen Inpp5d PhenoGen
PRINTS SH2DOMAIN UniProtKB/Swiss-Prot
PROSITE SH2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000017020 RatGTEx
SMART IPPc UniProtKB/Swiss-Prot
  SH2 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF55550 UniProtKB/Swiss-Prot
  SSF56219 UniProtKB/Swiss-Prot
TIGR TC221321
UniProt A0ABK0LMV9_RAT UniProtKB/TrEMBL
  A0ABK0LWM9_RAT UniProtKB/TrEMBL
  A6JWN9_RAT UniProtKB/TrEMBL
  A6JWP0_RAT UniProtKB/TrEMBL
  A6JWP1_RAT UniProtKB/TrEMBL
  A6JWP2_RAT UniProtKB/TrEMBL
  A6JWP3_RAT UniProtKB/TrEMBL
  A6JWP4_RAT UniProtKB/TrEMBL
  A6JWP5_RAT UniProtKB/TrEMBL
  A6JWP6_RAT UniProtKB/TrEMBL
  F1M981 ENTREZGENE, UniProtKB/TrEMBL
  P97573 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-11-06 Inpp5d  inositol polyphosphate-5-phosphatase D    Inositol polyphosphate-5-phosphatase, 145 kDa  Name updated 625702 APPROVED
2001-05-08 Inpp5d  Inositol polyphosphate-5-phosphatase      Name withdrawn, does not match Human and Mouse nomenclature 62408 WITHDRAWN
2001-05-08 Inpp5d  Inositol polyphosphate-5-phosphatase, 145 kDa      Name changed to reflect Human and Mouse nomenclature 62408 APPROVED