Hsd17b1 (hydroxysteroid (17-beta) dehydrogenase 1) - Rat Genome Database

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Gene: Hsd17b1 (hydroxysteroid (17-beta) dehydrogenase 1) Rattus norvegicus
Analyze
Symbol: Hsd17b1
Name: hydroxysteroid (17-beta) dehydrogenase 1
RGD ID: 2836
Description: Enables estradiol 17-beta-dehydrogenase [NAD(P)+] activity and testosterone dehydrogenase (NAD+) activity. Involved in bone development; cellular response to metal ion; and steroid biosynthetic process. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Orthologous to human HSD17B1 (hydroxysteroid 17-beta dehydrogenase 1); PARTICIPATES IN estradiol biosynthetic pathway; steroid hormone biosynthetic pathway; INTERACTS WITH (+)-taxifolin; (S)-nicotine; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 17-beta-HSD 1; 17-beta-hydroxysteroid dehydrogenase type 1; 17BHD1; estradiol 17-beta-dehydrogenase 1; hydroxysteroid 17-beta dehydrogenase 1; Hydroxysteroid dehydrogenase 17 beta type 1; Hydroxysteroid dehydrogenase 17 beta, type 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Eau3 Pia10 Ciaa2
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81086,510,011 - 86,512,211 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1086,510,011 - 86,512,210 (+)EnsemblGRCr8
mRatBN7.21086,009,728 - 86,011,928 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1086,009,728 - 86,011,927 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1091,046,170 - 91,048,370 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01090,524,986 - 90,527,186 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01085,918,153 - 85,920,353 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01088,987,558 - 88,989,758 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1088,987,558 - 88,989,757 (+)Ensemblrn6Rnor6.0
Rnor_5.01088,786,054 - 88,788,254 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41090,094,249 - 90,096,451 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1084,727,443 - 84,729,643 (+)NCBICelera
RGSC_v3.11090,108,618 - 90,110,820 (+)NCBI
Cytogenetic Map10q31NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-taxifolin  (EXP)
(S)-nicotine  (EXP,ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenol  (ISO)
2,6-dibromophenol  (ISO)
2-bromophenol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
9-cis-retinoic acid  (ISO)
acetaldehyde  (ISO)
acetamiprid  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
aminoglutethimide  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
androst-5-ene-3beta,17beta-diol  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (EXP)
atrazine  (EXP)
Azoxymethane  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzofurans  (ISO)
beta-lapachone  (ISO)
beta-naphthoflavone  (ISO)
bifenthrin  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
bucladesine  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (EXP)
colforsin daropate hydrochloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
coumarin  (ISO)
Cuprizon  (EXP)
cyhexatin  (ISO)
cypermethrin  (ISO)
DDT  (ISO)
decabromodiphenyl ether  (EXP,ISO)
dehydroepiandrosterone  (ISO)
dexamethasone  (EXP)
dextran sulfate  (ISO)
dibutyl phthalate  (EXP,ISO)
diethylstilbestrol  (EXP,ISO)
disodium selenite  (EXP)
dutasteride  (ISO)
endosulfan  (EXP,ISO)
Enterolactone  (ISO)
epoxiconazole  (ISO)
estrone  (ISO)
ethylparaben  (ISO)
fentin chloride  (ISO)
fentin hydroxide  (ISO)
fenvalerate  (EXP,ISO)
Finrozole  (ISO)
flufenoxuron  (ISO)
flutamide  (EXP)
fluvastatin  (EXP)
formaldehyde  (ISO)
formestane  (ISO)
fulvestrant  (ISO)
gamma-hexachlorocyclohexane  (EXP)
genistein  (EXP,ISO)
glutathione  (EXP)
HT-2 toxin  (ISO)
iodoacetic acid  (ISO)
iron dichloride  (ISO)
isoliquiritigenin  (ISO)
L-ascorbic acid  (EXP)
lead diacetate  (ISO)
letrozole  (EXP)
methimazole  (EXP)
methoxychlor  (EXP,ISO)
methylmercury chloride  (ISO)
metyrapone  (ISO)
microcystin-LR  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monobenzyl phthalate  (ISO)
Monobutylphthalate  (ISO)
monoethyl phthalate  (ISO)
NADP zwitterion  (ISO)
NADP(+)  (ISO)
naphthalenes  (ISO)
nicotine  (EXP,ISO)
ochratoxin A  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP)
perflubron  (ISO)
perfluorobutanesulfonic acid  (ISO)
perfluorododecanoic acid  (EXP)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
pregnenolone  (ISO)
procymidone  (ISO)
resveratrol  (ISO)
saccharin  (EXP)
sarin  (EXP)
silicon dioxide  (ISO)
sodium arsenite  (EXP,ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
taurine  (EXP)
testosterone  (ISO)
tetracycline  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
tributylstannane  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (EXP)
triphenyl phosphate  (ISO)
triptonide  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zearalenone  (ISO)
zinc oxide  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
cytosol  (IBA,IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Cloning of rat 17 beta-hydroxysteroid dehydrogenase type 2 and characterization of tissue distribution and catalytic activity of rat type 1 and type 2 enzymes. Akinola LA, etal., Endocrinology 1996 May;137(5):1572-9.
2. Characterization of rat 17 beta-hydroxysteroid dehydrogenase type 1 gene and mRNA transcripts. Akinola LA, etal., Gene 1998 Feb 27;208(2):229-38.
3. Lactational exposure to hexavalent chromium delays puberty by impairing ovarian development, steroidogenesis and pituitary hormone synthesis in developing Wistar rats. Banu SK, etal., Toxicol Appl Pharmacol. 2008 Oct 15;232(2):180-9. Epub 2008 Jun 17.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat 17 beta-hydroxysteroid dehydrogenase type 1: primary structure and regulation of enzyme expression in rat ovary by diethylstilbestrol and gonadotropins in vivo. Ghersevich S, etal., Endocrinology 1994 Oct;135(4):1477-87.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Aging reduces the efficacy of estrogen substitution to attenuate cardiac hypertrophy in female spontaneously hypertensive rats. Jazbutyte V, etal., Hypertension. 2006 Oct;48(4):579-86. Epub 2006 Aug 28.
8. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
9. FSH and FOXO1 regulate genes in the sterol/steroid and lipid biosynthetic pathways in granulosa cells. Liu Z, etal., Mol Endocrinol. 2009 May;23(5):649-61. Epub 2009 Feb 5.
10. Androgen synthesis in adrenarche. Miller WL Rev Endocr Metab Disord. 2009 Mar;10(1):3-17.
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. Overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormones. Payne AH and Hales DB, Endocr Rev. 2004 Dec;25(6):947-70.
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. GOA pipeline RGD automated data pipeline
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Identification of genomic regions controlling experimental autoimmune uveoretinitis in rats. Sun SH, etal., Int Immunol 1999 Apr;11(4):529-34
17. 17Beta-hydroxysteroid dehydrogenase type 1 and type 2 in human breast carcinoma: a correlation to clinicopathological parameters. Suzuki T, etal., Br J Cancer. 2000 Feb;82(3):518-23.
18. Expression of estrogen receptors and enzymes involved in sex steroid metabolism in the rat tibia during sexual maturation. van der Eerden BC, etal., J Endocrinol. 2004 Mar;180(3):457-67.
19. Disruption in the expression and immunolocalisation of steroid receptors and steroidogenic enzymes in letrozole-induced polycystic ovaries in rat. Zurvarra FM, etal., Reprod Fertil Dev. 2009;21(7):827-39.
Additional References at PubMed
PMID:4396689   PMID:8805577   PMID:9525918   PMID:10625652   PMID:12477932   PMID:15489334   PMID:34038751  


Genomics

Comparative Map Data
Hsd17b1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81086,510,011 - 86,512,211 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1086,510,011 - 86,512,210 (+)EnsemblGRCr8
mRatBN7.21086,009,728 - 86,011,928 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1086,009,728 - 86,011,927 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1091,046,170 - 91,048,370 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01090,524,986 - 90,527,186 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01085,918,153 - 85,920,353 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01088,987,558 - 88,989,758 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1088,987,558 - 88,989,757 (+)Ensemblrn6Rnor6.0
Rnor_5.01088,786,054 - 88,788,254 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41090,094,249 - 90,096,451 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1084,727,443 - 84,729,643 (+)NCBICelera
RGSC_v3.11090,108,618 - 90,110,820 (+)NCBI
Cytogenetic Map10q31NCBI
HSD17B1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381742,552,923 - 42,555,214 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1742,552,922 - 42,555,214 (+)Ensemblhg38GRCh38
GRCh371740,704,941 - 40,707,232 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361737,957,510 - 37,960,757 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341737,957,509 - 37,960,757NCBI
Celera1737,359,920 - 37,363,168 (+)NCBICelera
Cytogenetic Map17q21.2NCBI
HuRef1736,468,996 - 36,472,244 (+)NCBIHuRef
CHM1_11740,939,828 - 40,943,076 (+)NCBICHM1_1
T2T-CHM13v2.01743,410,112 - 43,412,403 (+)NCBIT2T-CHM13v2.0
Hsd17b1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911100,968,792 - 100,972,014 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11100,969,237 - 100,971,353 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm3811101,077,968 - 101,081,188 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11101,078,411 - 101,080,527 (+)Ensemblmm10GRCm38
MGSCv3711100,939,725 - 100,941,819 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3611100,894,501 - 100,896,595 (+)NCBIMGSCv36mm8
Celera11112,374,513 - 112,376,607 (+)NCBICelera
Cytogenetic Map11DNCBI
cM Map1164.17NCBI
Hsd17b1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545116,449,683 - 16,451,945 (+)Ensembl
ChiLan1.0NW_00495545116,449,333 - 16,452,036 (+)NCBIChiLan1.0ChiLan1.0
HSD17B1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21922,429,368 - 22,431,647 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11724,319,367 - 24,325,778 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01714,760,856 - 14,763,584 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11714,986,538 - 14,989,741 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1714,986,814 - 14,988,820 (-)EnsemblpanPan2panpan1.1
HSD17B1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1920,402,124 - 20,407,143 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl920,405,019 - 20,406,792 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha919,866,871 - 19,868,985 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0921,123,971 - 21,126,087 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl921,123,971 - 21,125,745 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1919,909,803 - 19,911,916 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0920,175,037 - 20,177,147 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0920,279,091 - 20,281,208 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Hsd17b1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560219,760,718 - 19,762,826 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649017,312,390 - 17,314,409 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493649017,312,390 - 17,314,423 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HSD17B1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1220,269,056 - 20,271,548 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11220,269,468 - 20,271,349 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21220,482,373 - 20,484,253 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HSD17B1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11663,730,303 - 63,733,974 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1663,728,777 - 63,732,411 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607734,525,962 - 34,529,030 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hsd17b1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247951,551,311 - 1,553,493 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247951,551,311 - 1,553,432 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Hsd17b1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1960,372,151 - 60,374,534 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Hsd17b1
10 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:182
Count of miRNA genes:132
Interacting mature miRNAs:147
Transcripts:ENSRNOT00000026878
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105107189796071897Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102702353598502431Rat
8657410Bp374Blood pressure QTL 374heart left ventricle size trait (VT:0002753)heart left ventricle end-diastolic diameter (CMO:0000982)1067476608107713808Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063719161107713808Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)103550938391417879Rat
631555Bp134Blood pressure QTL 1340.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)108101207791729860Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042546145107713808Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1058073360103073360Rat
12903252Cm113Cardiac mass QTL 1130.047heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105429633699451733Rat
4889948Bss91Bone structure and strength QTL 914tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)108306123692869129Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1064939013107713808Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104183127886831278Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076951790107713808Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105046480295464802Rat
1300107Rf18Renal function QTL 183.41urine output (VT:0003620)timed urine volume (CMO:0000260)1079272424102982300Rat
70168Eae12Experimental allergic encephalomyelitis QTL 120.0009nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)1073599825107713808Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104552916496099749Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104493935989939359Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1054296227107713808Rat
10450495Bp383Blood pressure QTL 3830.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107674313395464802Rat
12903269Am15Aortic mass QTL 150.042aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
10450493Bp382Blood pressure QTL 3820.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105086028895860288Rat
12903266Cm114Cardiac mass QTL 1140.02heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)1066817119107713808Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2292617Ept18Estrogen-induced pituitary tumorigenesis QTL 183.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107395035396620293Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101499153586964295Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062556066107556066Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14282327487823274Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
12880372Am12Aortic mass QTL 120.003aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062556066107556066Rat
12880375Kidm66Kidney mass QTL 660.009kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
1357344Bp249Blood pressure QTL 2490.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106724133498502431Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104493935989939359Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
12880370Cm105Cardiac mass QTL 1050.008heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104282327487823274Rat
12880371Cm106Cardiac mass QTL 1060.007heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106184349698710773Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)107369533997272278Rat
11565453Kidm58Kidney mass QTL 580.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
7387312Bw125Body weight QTL 12530.0047retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight (CMO:0000356)1065390777107713808Rat
6893357Bw102Body weight QTL 1020.50.36body mass (VT:0001259)body weight (CMO:0000012)1081012077101828297Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102293137391127454Rat
2306793Ean5Experimental allergic neuritis QTL 54.7nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)107304965694495280Rat
2306792Ean4Experimental allergic neuritis QTL 44nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)104949549294495492Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1052269185107713808Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068920187107713808Rat
1358915Stresp7Stress response QTL 73.52blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)1065307813107713808Rat
70363Bp71Blood pressure QTL 710.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1061843496106843496Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)102980091091417879Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070698731107713808Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)102758722696099902Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105530797293608131Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)1061843496100198886Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104360879388608793Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040535708107713808Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
7207811Bmd90Bone mineral density QTL 905.2femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)104994371094943710Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1581559Eae18Experimental allergic encephalomyelitis QTL 180.00002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1066108888107555881Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104493935989939359Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1061843496100198886Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104786912992869129Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
12880055Am11Aortic mass QTL 110.004aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)108450348796432422Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107674313395604677Rat
2301398Kidm38Kidney mass QTL 380.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)108450348796432422Rat
2292436Bp310Blood pressure QTL 310arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105060467795604677Rat
1600367Mcs15Mammary carcinoma susceptibility QTL 154.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)103550938388177745Rat
631537Oia4Oil induced arthritis QTL 4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1076128947107713808Rat
1358188Ept9Estrogen-induced pituitary tumorigenesis QTL 93.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107395035396620293Rat
634354Rends3Renal damage susceptibility QTL 30.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)1061997479106997479Rat
2301405Cm69Cardiac mass QTL 690.031heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102702353599451848Rat

Markers in Region
D10Wox46  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81086,512,483 - 86,512,677 (+)Marker Load Pipeline
mRatBN7.21086,012,200 - 86,012,394 (+)MAPPERmRatBN7.2
Rnor_6.01088,990,031 - 88,990,224NCBIRnor6.0
Rnor_5.01088,788,527 - 88,788,720UniSTSRnor5.0
RGSC_v3.41090,096,724 - 90,096,917UniSTSRGSC3.4
Celera1084,729,916 - 84,730,103UniSTS
Cytogenetic Map10q32.1UniSTS
RH134495  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21086,008,718 - 86,008,899 (+)MAPPERmRatBN7.2
Rnor_6.01088,986,549 - 88,986,729NCBIRnor6.0
Rnor_5.01088,785,045 - 88,785,225UniSTSRnor5.0
RGSC_v3.41090,093,240 - 90,093,420UniSTSRGSC3.4
Celera1084,726,434 - 84,726,614UniSTS
RH 3.4 Map10877.1UniSTS
Cytogenetic Map10q32.1UniSTS
RH142272  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81086,509,029 - 86,509,221 (+)Marker Load Pipeline
mRatBN7.21086,008,746 - 86,008,938 (+)MAPPERmRatBN7.2
Rnor_6.01088,986,577 - 88,986,768NCBIRnor6.0
Rnor_5.01088,785,073 - 88,785,264UniSTSRnor5.0
RGSC_v3.41090,093,268 - 90,093,459UniSTSRGSC3.4
Celera1084,726,462 - 84,726,653UniSTS
RH 3.4 Map10875.29UniSTS
Cytogenetic Map10q32.1UniSTS
Hsd17b1  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81086,510,809 - 86,511,604 (+)Marker Load Pipeline
mRatBN7.21086,010,526 - 86,011,321 (+)MAPPERmRatBN7.2
Rnor_6.01088,988,357 - 88,989,151NCBIRnor6.0
Rnor_5.01088,786,853 - 88,787,647UniSTSRnor5.0
RGSC_v3.41090,095,050 - 90,095,844UniSTSRGSC3.4
Celera1084,728,242 - 84,729,036UniSTS
Cytogenetic Map10q32.1UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 160 91 90 59 88 59 6 352 188 11 139 81 92 31 16 16

Sequence


Ensembl Acc Id: ENSRNOT00000026878   ⟹   ENSRNOP00000026878
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1086,510,011 - 86,512,210 (+)Ensembl
mRatBN7.2 Ensembl1086,009,728 - 86,011,927 (+)Ensembl
Rnor_6.0 Ensembl1088,987,558 - 88,989,757 (+)Ensembl
RefSeq Acc Id: NM_012851   ⟹   NP_036983
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81086,510,011 - 86,512,211 (+)NCBI
mRatBN7.21086,009,728 - 86,011,928 (+)NCBI
Rnor_6.01088,987,558 - 88,989,758 (+)NCBI
Rnor_5.01088,786,054 - 88,788,254 (+)NCBI
RGSC_v3.41090,094,249 - 90,096,451 (+)RGD
Celera1084,727,443 - 84,729,643 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_036983 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH86365 (Get FASTA)   NCBI Sequence Viewer  
  CAA55389 (Get FASTA)   NCBI Sequence Viewer  
  CAA66349 (Get FASTA)   NCBI Sequence Viewer  
  CAA66657 (Get FASTA)   NCBI Sequence Viewer  
  EDM06082 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000026878
  ENSRNOP00000026878.5
GenBank Protein P51657 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_036983   ⟸   NM_012851
- UniProtKB: P51657 (UniProtKB/Swiss-Prot),   A6HJ77 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000026878   ⟸   ENSRNOT00000026878

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P51657-F1-model_v2 AlphaFold P51657 1-344 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2836 AgrOrtholog
BioCyc Gene G2FUF-23203 BioCyc
Ensembl Genes ENSRNOG00000019830 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000026878 ENTREZGENE
  ENSRNOT00000026878.6 UniProtKB/Swiss-Prot
Gene3D-CATH NAD(P)-binding Rossmann-like Domain UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7305002 IMAGE-MGC_LOAD
InterPro 17beta_DH UniProtKB/Swiss-Prot
  NAD(P)-bd_dom_sf UniProtKB/Swiss-Prot
  Sc_DH/Rdtase_CS UniProtKB/Swiss-Prot
  SDR_fam UniProtKB/Swiss-Prot
KEGG Report rno:25322 UniProtKB/Swiss-Prot
MGC_CLONE MGC:105495 IMAGE-MGC_LOAD
NCBI Gene 25322 ENTREZGENE
PANTHER 17-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 UniProtKB/Swiss-Prot
  RETINOL DEHYDROGENASE-RELATED UniProtKB/Swiss-Prot
Pfam adh_short UniProtKB/Swiss-Prot
PhenoGen Hsd17b1 PhenoGen
PIRSF 17beta-HSD UniProtKB/Swiss-Prot
PRINTS GDHRDH UniProtKB/Swiss-Prot
  SDRFAMILY UniProtKB/Swiss-Prot
PROSITE ADH_SHORT UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000019830 RatGTEx
Superfamily-SCOP SSF51735 UniProtKB/Swiss-Prot
UniProt A6HJ77 ENTREZGENE, UniProtKB/TrEMBL
  DHB1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Hsd17b1  hydroxysteroid (17-beta) dehydrogenase 1    hydroxysteroid 17-beta dehydrogenase 1  Name updated 1299863 APPROVED
2003-04-09 Hsd17b1  hydroxysteroid 17-beta dehydrogenase 1    Hydroxysteroid dehydrogenase 17 beta, type 1  Name updated 629478 APPROVED
2002-06-10 Hsd17b1  Hydroxysteroid dehydrogenase 17 beta, type 1      Symbol and Name status set to approved 70586 APPROVED