Gcgr (glucagon receptor) - Rat Genome Database

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Gene: Gcgr (glucagon receptor) Rattus norvegicus
Analyze
Symbol: Gcgr
Name: glucagon receptor
RGD ID: 2669
Description: Enables glucagon receptor activity and peptide hormone binding activity. Involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway; exocytosis; and hormone-mediated signaling pathway. Located in endosome. Human ortholog(s) of this gene implicated in Mahvash Disease and type 2 diabetes mellitus. Orthologous to human GCGR (glucagon receptor); PARTICIPATES IN G protein mediated signaling pathway via Galphas family; glucagon signaling pathway; INTERACTS WITH 1,3,5-trinitro-1,3,5-triazinane; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: GL-R; glucagon receptor perhaps same as Niddm3; MGC93090
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810106,306,803 - 106,314,970 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl10106,306,559 - 106,314,969 (+)EnsemblGRCr8
mRatBN7.210105,808,474 - 105,816,641 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10105,808,473 - 105,816,640 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx10110,912,618 - 110,920,789 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010110,375,645 - 110,383,816 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010105,728,922 - 105,737,089 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.010109,707,863 - 109,716,253 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10109,707,962 - 109,716,128 (+)Ensemblrn6Rnor6.0
Rnor_5.010109,301,000 - 109,309,259 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.410109,921,411 - 109,929,577 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera10104,352,017 - 104,360,184 (+)NCBICelera
RGSC_v3.110109,935,913 - 109,944,081 (+)NCBI
Cytogenetic Map10q32.3NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3,5-trinitro-1,3,5-triazinane  (EXP)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-acetamidofluorene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
benzo[e]pyrene  (ISO)
beta-naphthoflavone  (ISO)
bexarotene  (EXP)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP)
bisphenol F  (ISO)
buta-1,3-diene  (ISO)
butanal  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
carbon nanotube  (EXP)
chlorpromazine  (ISO)
chrysene  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
D-glucose  (ISO)
dibutyl phthalate  (EXP)
dichlorine  (EXP)
dimethylarsinic acid  (EXP)
disulfiram  (ISO)
endosulfan  (EXP)
fenthion  (ISO)
gatifloxacin  (EXP)
genistein  (EXP)
gentamycin  (EXP)
glucagon  (ISO)
glucose  (ISO)
graphite  (EXP)
lipopolysaccharide  (ISO)
manganese(II) chloride  (EXP)
methapyrilene  (ISO)
methidathion  (ISO)
methimazole  (EXP)
methoxychlor  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP)
N-nitrosodiethylamine  (EXP)
naphthalene  (ISO)
O-methyleugenol  (ISO)
okadaic acid  (ISO)
ozone  (EXP)
paracetamol  (ISO)
paraquat  (EXP)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenacetin  (EXP)
phenylhydrazine  (EXP)
pirinixic acid  (EXP)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
propanal  (ISO)
rotenone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
sodium arsenite  (ISO)
temozolomide  (ISO)
Tesaglitazar  (EXP)
tetrachloromethane  (ISO)
tetraphene  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tributylstannane  (ISO)
triptonide  (ISO)
troglitazone  (EXP)
trovafloxacin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
endosome  (IDA)
membrane  (IEA)
plasma membrane  (IBA,IEA,ISO,ISS)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Alterations in hepatic glucagon receptor density and in Gsalpha and Gialpha2 protein content with diet-induced hepatic steatosis: effects of acute exercise. Charbonneau A, etal., Am J Physiol Endocrinol Metab. 2005 Jul;289(1):E8-14. Epub 2005 Feb 1.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Structural and functional characterizations of the 5'-flanking region of the mouse glucagon receptor gene: comparison with the rat gene. Geiger A, etal., Biochem Biophys Res Commun 2000 Jun 16;272(3):912-21.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. A missense mutation in the glucagon receptor gene is associated with non-insulin-dependent diabetes mellitus. Hager J, etal., Nat Genet. 1995 Mar;9(3):299-304.
6. Expression cloning and signaling properties of the rat glucagon receptor. Jelinek LJ, etal., Science 1993 Mar 12;259(5101):1614-6.
7. Glucagon stimulates exocytosis in mouse and rat pancreatic alpha-cells by binding to glucagon receptors. Ma X, etal., Mol Endocrinol. 2005 Jan;19(1):198-212. Epub 2004 Sep 30.
8. Glucagon-mediated internalization of serine-phosphorylated glucagon receptor and Gsalpha in rat liver. Merlen C, etal., FEBS Lett. 2006 Oct 16;580(24):5697-704. Epub 2006 Sep 20.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
12. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
13. Functional analysis of the glucose response element of the rat glucagon receptor gene in insulin-producing INS-1 cells. Portois L, etal., Biochim Biophys Acta 2002 Mar 19;1574(2):175-86.
14. Identification of a glucose response element in the promoter of the rat glucagon receptor gene. Portois L, etal., J Biol Chem 1999 Mar 19;274(12):8181-90.
15. GOA pipeline RGD automated data pipeline
16. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
19. A cDNA construct allowing the expression of rat hepatic glucagon receptors. Svoboda M, etal., Biochem Biophys Res Commun 1993 Apr 15;192(1):135-42.
20. Small introns in a hepatic cDNA encoding a new glucagon-like peptide 1-type receptor. Svoboda M, etal., Biochem Biophys Res Commun 1993 Mar 15;191(2):479-86.
21. Localization of the rat genes encoding glucagon, glucagon receptor, and insulin receptor, candidates for diabetes mellitus susceptibility loci. Szpirer C, etal., Mamm Genome 1997 Aug;8(8):586-8
22. Roles of specific extracellular domains of the glucagon receptor in ligand binding and signaling. Unson CG, etal., Biochemistry 2002 Oct 1;41(39):11795-803.
23. Antibodies against specific extracellular epitopes of the glucagon receptor block glucagon binding. Unson CG, etal., Proc Natl Acad Sci U S A. 1996 Jan 9;93(1):310-5.
Additional References at PubMed
PMID:8082779   PMID:9287038   PMID:11853547   PMID:12552113   PMID:17053032   PMID:17462598   PMID:18787074   PMID:19046568   PMID:23209793   PMID:23918690   PMID:26975347   PMID:28514451  


Genomics

Comparative Map Data
Gcgr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810106,306,803 - 106,314,970 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl10106,306,559 - 106,314,969 (+)EnsemblGRCr8
mRatBN7.210105,808,474 - 105,816,641 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10105,808,473 - 105,816,640 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx10110,912,618 - 110,920,789 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010110,375,645 - 110,383,816 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010105,728,922 - 105,737,089 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.010109,707,863 - 109,716,253 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10109,707,962 - 109,716,128 (+)Ensemblrn6Rnor6.0
Rnor_5.010109,301,000 - 109,309,259 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.410109,921,411 - 109,929,577 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera10104,352,017 - 104,360,184 (+)NCBICelera
RGSC_v3.110109,935,913 - 109,944,081 (+)NCBI
Cytogenetic Map10q32.3NCBI
GCGR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381781,804,150 - 81,814,008 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1781,803,105 - 81,814,023 (+)Ensemblhg38GRCh38
GRCh371779,762,026 - 79,771,884 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 34171,860,193 - 1,870,113NCBI
Celera1776,365,499 - 76,375,377 (+)NCBICelera
Cytogenetic Map17q25.3NCBI
HuRef1775,168,495 - 75,173,668 (+)NCBIHuRef
CHM1_11779,848,214 - 79,858,084 (+)NCBICHM1_1
T2T-CHM13v2.01782,671,316 - 82,681,173 (+)NCBIT2T-CHM13v2.0
Gcgr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911120,420,011 - 120,429,815 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11120,421,525 - 120,429,812 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm3811120,529,185 - 120,538,989 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11120,530,699 - 120,538,986 (+)Ensemblmm10GRCm38
MGSCv3711120,392,041 - 120,400,298 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3611120,345,362 - 120,355,178 (+)NCBIMGSCv36mm8
Celera11132,266,137 - 132,274,394 (+)NCBICelera
Cytogenetic Map11E2NCBI
cM Map1184.24NCBI
Gcgr
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555061,340,689 - 1,344,260 (-)Ensembl
ChiLan1.0NW_0049555061,340,410 - 1,348,028 (-)NCBIChiLan1.0ChiLan1.0
GCGR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21998,339,489 - 98,350,188 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan117103,240,205 - 103,250,716 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01776,205,023 - 76,220,171 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11781,911,915 - 81,922,906 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1781,912,135 - 81,922,906 (+)EnsemblpanPan2panpan1.1
GCGR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.19455,744 - 463,070 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl9344,438 - 459,925 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha91,057,897 - 1,065,209 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.091,048,891 - 1,056,220 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl91,048,304 - 1,056,213 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.191,074,261 - 1,081,570 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.091,200,838 - 1,208,113 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.091,279,553 - 1,286,873 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Gcgr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244056021,060,107 - 1,068,224 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365945,343,740 - 5,351,923 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365945,347,789 - 5,351,852 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GCGR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl121,146,069 - 1,157,234 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1121,149,589 - 1,157,234 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
GCGR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11673,672,490 - 73,693,297 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1673,681,571 - 73,693,299 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607745,089,536 - 45,141,103 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gcgr
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462480110,678,944 - 10,682,362 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462480110,674,854 - 10,682,619 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Gcgr
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1963,482,625 - 63,491,025 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Gcgr
129 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:53
Count of miRNA genes:51
Interacting mature miRNAs:53
Transcripts:ENSRNOT00000054962
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7387312Bw125Body weight QTL 12530.0047retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight (CMO:0000356)1065390777107713808Rat
1354641Bvd2Brain ventricular dilatation QTL 26.360.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)1093723381107556066Rat
8657410Bp374Blood pressure QTL 374heart left ventricle size trait (VT:0002753)heart left ventricle end-diastolic diameter (CMO:0000982)1067476608107713808Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063719161107713808Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1052269185107713808Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042546145107713808Rat
12903252Cm113Cardiac mass QTL 1130.047heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068920187107713808Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1064939013107713808Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076951790107713808Rat
1358915Stresp7Stress response QTL 73.52blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)1065307813107713808Rat
70168Eae12Experimental allergic encephalomyelitis QTL 120.0009nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)1073599825107713808Rat
634320Niddm49Non-insulin dependent diabetes mellitus QTL 494.41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1089039175107713808Rat
70363Bp71Blood pressure QTL 710.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1061843496106843496Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1054296227107713808Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070698731107713808Rat
1576313Pia25Pristane induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1096620293107713808Rat
12903269Am15Aortic mass QTL 150.042aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
12903266Cm114Cardiac mass QTL 1140.02heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)1066817119107713808Rat
1578672Bmd16Bone mineral density QTL 166.2femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)1097202388107556066Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
1576307Cia28Collagen induced arthritis QTL 28joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1096620293107713808Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040535708107713808Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062556066107556066Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1581559Eae18Experimental allergic encephalomyelitis QTL 180.00002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1066108888107555881Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
12880372Am12Aortic mass QTL 120.003aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062556066107556066Rat
61363Oia3Oil induced arthritis QTL 30.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087807758107713808Rat
12880375Kidm66Kidney mass QTL 660.009kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
12880370Cm105Cardiac mass QTL 1050.008heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
1600367Mcs15Mammary carcinoma susceptibility QTL 154.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
12880371Cm106Cardiac mass QTL 1060.007heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
631537Oia4Oil induced arthritis QTL 4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1076128947107713808Rat
1300137Bp186Blood pressure QTL 1863.57arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1091127270107556066Rat
634354Rends3Renal damage susceptibility QTL 30.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)1061997479106997479Rat
61436Cia5Collagen induced arthritis QTL 54.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1091727883107713808Rat
11565453Kidm58Kidney mass QTL 580.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
2301405Cm69Cardiac mass QTL 690.031heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
1578663Bss18Bone structure and strength QTL 183.6femur width (VT:1000666)femoral neck width (CMO:0001695)1097202388107556066Rat

Markers in Region
D10Mcw1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.210105,813,290 - 105,813,458 (+)MAPPERmRatBN7.2
Rnor_6.010109,712,779 - 109,712,946NCBIRnor6.0
Rnor_5.010109,305,909 - 109,306,076UniSTSRnor5.0
RGSC_v3.410109,926,227 - 109,926,395RGDRGSC3.4
RGSC_v3.410109,926,228 - 109,926,395UniSTSRGSC3.4
Celera10104,356,834 - 104,357,001UniSTS
RGSC_v3.110109,940,731 - 109,940,899RGD
Cytogenetic Map10q32.3UniSTS
RH142644  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.210105,807,925 - 105,808,092 (+)MAPPERmRatBN7.2
Rnor_6.010109,707,414 - 109,707,580NCBIRnor6.0
Rnor_5.010109,300,544 - 109,300,710UniSTSRnor5.0
RGSC_v3.410109,920,896 - 109,921,062UniSTSRGSC3.4
Celera10104,351,294 - 104,351,460UniSTS
Cytogenetic Map10q32.3UniSTS
RH142648  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.210105,807,953 - 105,808,117 (+)MAPPERmRatBN7.2
Rnor_6.010109,707,442 - 109,707,605NCBIRnor6.0
Rnor_5.010109,300,572 - 109,300,735UniSTSRnor5.0
RGSC_v3.410109,920,924 - 109,921,087UniSTSRGSC3.4
Celera10104,351,322 - 104,351,485UniSTS
Cytogenetic Map10q32.3UniSTS
RH141343  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.210105,816,456 - 105,816,636 (+)MAPPERmRatBN7.2
Rnor_6.010109,715,945 - 109,716,124NCBIRnor6.0
Rnor_5.010109,309,075 - 109,309,254UniSTSRnor5.0
RGSC_v3.410109,929,394 - 109,929,573UniSTSRGSC3.4
Celera10104,360,000 - 104,360,179UniSTS
Cytogenetic Map10q32.3UniSTS
Gcgr  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr810106,313,725 - 106,314,614 (+)Marker Load Pipeline
mRatBN7.210105,815,396 - 105,816,285 (+)MAPPERmRatBN7.2
Rnor_6.010109,714,885 - 109,715,773NCBIRnor6.0
Rnor_5.010109,308,015 - 109,308,903UniSTSRnor5.0
RGSC_v3.410109,928,334 - 109,929,222UniSTSRGSC3.4
Celera10104,358,940 - 104,359,828UniSTS
Cytogenetic Map10q32.3UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
14 12 67 136 91 90 59 79 59 6 341 179 11 109 81 91 31 16 16

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001430043 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001430044 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001430045 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_172091 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_172092 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_073147 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_190841 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006247876 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006247877 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008768468 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008768469 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039085243 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039085245 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039085247 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC131537 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF229080 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH003671 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC081700 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB735411 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CV117246 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L04796 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M96674 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X68692 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000054962   ⟹   ENSRNOP00000051845
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl10106,306,741 - 106,314,969 (+)Ensembl
mRatBN7.2 Ensembl10105,808,473 - 105,816,640 (+)Ensembl
Rnor_6.0 Ensembl10109,707,962 - 109,716,128 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000083601   ⟹   ENSRNOP00000074929
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl10109,708,755 - 109,716,128 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000088898   ⟹   ENSRNOP00000074632
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl10106,310,980 - 106,314,969 (+)Ensembl
mRatBN7.2 Ensembl10105,808,510 - 105,816,640 (+)Ensembl
Rnor_6.0 Ensembl10109,707,998 - 109,716,128 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000153208   ⟹   ENSRNOP00000107799
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl10106,306,559 - 106,314,969 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000164345   ⟹   ENSRNOP00000110586
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl10106,306,559 - 106,314,969 (+)Ensembl
RefSeq Acc Id: NM_172091   ⟹   NP_742088
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810106,307,596 - 106,314,970 (+)NCBI
mRatBN7.210105,809,267 - 105,816,641 (+)NCBI
Rnor_6.010109,708,755 - 109,716,129 (+)NCBI
Rnor_5.010109,301,000 - 109,309,259 (+)NCBI
RGSC_v3.410109,921,411 - 109,929,577 (+)RGD
Celera10104,352,810 - 104,360,184 (+)NCBI
Sequence:
RefSeq Acc Id: NM_172092   ⟹   NP_742089
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810106,306,803 - 106,314,970 (+)NCBI
mRatBN7.210105,808,474 - 105,816,641 (+)NCBI
Rnor_6.010109,707,962 - 109,716,129 (+)NCBI
Rnor_5.010109,301,000 - 109,309,259 (+)NCBI
RGSC_v3.410109,921,411 - 109,929,577 (+)RGD
Celera10104,352,017 - 104,360,184 (+)NCBI
Sequence:
RefSeq Acc Id: NR_073147
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810106,306,803 - 106,314,970 (+)NCBI
mRatBN7.210105,808,474 - 105,816,641 (+)NCBI
Rnor_6.010109,707,962 - 109,716,129 (+)NCBI
Rnor_5.010109,301,000 - 109,309,259 (+)NCBI
Celera10104,352,017 - 104,360,184 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006247877   ⟹   XP_006247939
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810106,310,748 - 106,314,970 (+)NCBI
mRatBN7.210105,812,419 - 105,816,641 (+)NCBI
Rnor_6.010109,708,719 - 109,716,129 (+)NCBI
Rnor_5.010109,301,000 - 109,309,259 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008768468   ⟹   XP_008766690
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810106,310,213 - 106,314,970 (+)NCBI
mRatBN7.210105,811,849 - 105,816,641 (+)NCBI
Rnor_6.010109,711,347 - 109,716,253 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008768469   ⟹   XP_008766691
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810106,310,213 - 106,314,819 (+)NCBI
mRatBN7.210105,811,849 - 105,816,641 (+)NCBI
Rnor_6.010109,711,344 - 109,716,253 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039085243   ⟹   XP_038941171
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810106,310,271 - 106,314,970 (+)NCBI
mRatBN7.210105,811,938 - 105,816,641 (+)NCBI
RefSeq Acc Id: XM_039085245   ⟹   XP_038941173
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810106,311,058 - 106,314,970 (+)NCBI
mRatBN7.210105,812,737 - 105,816,641 (+)NCBI
RefSeq Acc Id: XM_039085247   ⟹   XP_038941175
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810106,310,213 - 106,313,401 (+)NCBI
mRatBN7.210105,811,849 - 105,815,075 (+)NCBI
RefSeq Acc Id: NP_742089   ⟸   NM_172092
- Peptide Label: precursor
- UniProtKB: P30082 (UniProtKB/Swiss-Prot),   A6HLE4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_742088   ⟸   NM_172091
- Peptide Label: precursor
- UniProtKB: P30082 (UniProtKB/Swiss-Prot),   A6HLE4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006247939   ⟸   XM_006247877
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_008766691   ⟸   XM_008768469
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_008766690   ⟸   XM_008768468
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000074929   ⟸   ENSRNOT00000083601
Ensembl Acc Id: ENSRNOP00000074632   ⟸   ENSRNOT00000088898
Ensembl Acc Id: ENSRNOP00000051845   ⟸   ENSRNOT00000054962
RefSeq Acc Id: XP_038941175   ⟸   XM_039085247
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038941171   ⟸   XM_039085243
- Peptide Label: isoform X2
- UniProtKB: P30082 (UniProtKB/Swiss-Prot),   A6HLE4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038941173   ⟸   XM_039085245
- Peptide Label: isoform X5
- UniProtKB: Q66HT0 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000107799   ⟸   ENSRNOT00000153208
Ensembl Acc Id: ENSRNOP00000110586   ⟸   ENSRNOT00000164345
Protein Domains
G-protein coupled receptors family 2 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P30082-F1-model_v2 AlphaFold P30082 1-485 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697961
Promoter ID:EPDNEW_R8485
Type:initiation region
Name:Gcgr_1
Description:glucagon receptor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.010109,707,882 - 109,707,942EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2669 AgrOrtholog
BioCyc Gene G2FUF-22413 BioCyc
Ensembl Genes ENSRNOG00000036692 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000054962 ENTREZGENE
  ENSRNOT00000054962.3 UniProtKB/Swiss-Prot
  ENSRNOT00000088898 ENTREZGENE
  ENSRNOT00000153208 ENTREZGENE
Gene3D-CATH 4.10.1240.10 UniProtKB/Swiss-Prot
  Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7192550 IMAGE-MGC_LOAD
InterPro GPCR_2 UniProtKB/Swiss-Prot
  GPCR_2-like UniProtKB/Swiss-Prot
  GPCR_2_extracell_dom_sf UniProtKB/Swiss-Prot
  GPCR_2_extracellular_dom UniProtKB/Swiss-Prot
  GPCR_2_GLP1/glucagon_rcpt UniProtKB/Swiss-Prot
  GPCR_2_glucagon_rcpt UniProtKB/Swiss-Prot
  GPCR_2_secretin-like UniProtKB/Swiss-Prot
  GPCR_2_secretin-like_CS UniProtKB/Swiss-Prot
KEGG Report rno:24953 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93090 IMAGE-MGC_LOAD
NCBI Gene 24953 ENTREZGENE
PANTHER GLUCAGON RECEPTOR UniProtKB/Swiss-Prot
  PDF RECEPTOR-LIKE PROTEIN-RELATED UniProtKB/Swiss-Prot
Pfam 7tm_2 UniProtKB/Swiss-Prot
  HRM UniProtKB/Swiss-Prot
PhenoGen Gcgr PhenoGen
PRINTS GLUCAGNFAMLY UniProtKB/Swiss-Prot
  GLUCAGONR UniProtKB/Swiss-Prot
  GPCRSECRETIN UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F2_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F2_2 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F2_3 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F2_4 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000036692 RatGTEx
SMART HormR UniProtKB/Swiss-Prot
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot
  SSF111418 UniProtKB/Swiss-Prot
UniProt A0A0G2K8J6_RAT UniProtKB/TrEMBL
  A0ABK0M7X4_RAT UniProtKB/TrEMBL
  A6HLE4 ENTREZGENE, UniProtKB/TrEMBL
  A6HLE5_RAT UniProtKB/TrEMBL
  GLR_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q66HT0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Gcgr  glucagon receptor      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function transduces signals leading to the accumulation of cAMP and calcium 61488
gene_other may be a candidate gene for Niddm3 61488
gene_process participates in glucose stimulation 625576
gene_process controls blood glucose concentrations 61488
gene_transcript non-coding domain from -545 and -527 nucleotides has a 19 nucleotide centered 2 G boxes 625576