Chrnb4 (cholinergic receptor nicotinic beta 4 subunit) - Rat Genome Database

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Gene: Chrnb4 (cholinergic receptor nicotinic beta 4 subunit) Rattus norvegicus
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Symbol: Chrnb4
Name: cholinergic receptor nicotinic beta 4 subunit
RGD ID: 2351
Description: Enables acetylcholine binding activity and heterocyclic compound binding activity. Predicted to be involved in several processes, including membrane depolarization; positive regulation of transmission of nerve impulse; and synaptic signaling. Predicted to act upstream of or within several processes, including behavioral response to nicotine; neuronal action potential; and smooth muscle contraction. Located in plasma membrane. Part of acetylcholine-gated channel complex. Biomarker of depressive disorder. Human ortholog(s) of this gene implicated in cocaine abuse; lung cancer (multiple); nicotine dependence; and oral cavity cancer. Orthologous to human CHRNB4 (cholinergic receptor nicotinic beta 4 subunit); PARTICIPATES IN acetylcholine signaling pathway via nicotinic acetylcholine receptor; INTERACTS WITH (S)-anabasine; (S)-nicotine; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Acetylcholine receptor beta 4; cholinergic receptor, nicotinic beta 4; cholinergic receptor, nicotinic, beta 4; cholinergic receptor, nicotinic, beta 4 (neuronal); cholinergic receptor, nicotinic, beta polypeptide 4; N-alpha 2; neuronal acetylcholine receptor non-alpha-2 chain; neuronal acetylcholine receptor subunit beta-4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Chrnb4em5Mcwi
Genetic Models: LEW-Chrnb4em5Mcwi
Candidate Gene For: Bp273
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8864,312,644 - 64,333,319 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl864,313,669 - 64,333,248 (-)EnsemblGRCr8
mRatBN7.2855,417,583 - 55,437,027 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl855,418,313 - 55,437,027 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx860,959,884 - 60,978,450 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0859,238,885 - 59,257,451 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0857,103,128 - 57,121,694 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0859,610,489 - 59,629,073 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl859,609,693 - 59,629,133 (-)Ensemblrn6Rnor6.0
Rnor_5.0858,192,375 - 58,210,959 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4858,586,961 - 58,605,545 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera854,902,516 - 54,921,100 (-)NCBICelera
RGSC_v3.1858,605,220 - 58,624,659 (-)NCBI
RH 3.4 Map8614.4RGD
Cytogenetic Map8q24NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-anabasine  (EXP)
(S)-nicotine  (EXP,ISO)
1,1-dimethyl-4-phenylpiperazinium iodide  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-nonylphenol  (ISO)
4-octylphenol  (ISO)
acetylcholine  (EXP,ISO)
acrylamide  (ISO)
aldicarb  (EXP)
ammonium chloride  (EXP)
atracurium  (ISO)
barium(0)  (ISO)
bendiocarb  (EXP)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butan-1-ol  (ISO)
butan-2-ol  (ISO)
carbachol  (EXP)
carbaryl  (EXP)
celastrol  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (EXP)
cisatracurium  (ISO)
coumarin  (ISO)
crotyl alcohol  (ISO)
Cuprizon  (EXP)
cytisine  (EXP,ISO)
decabromodiphenyl ether  (ISO)
dieldrin  (EXP)
diethylstilbestrol  (ISO)
dihydro-beta-erythroidine  (EXP)
dopamine  (EXP)
dorsomorphin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
epibatidine  (EXP,ISO)
EPTC  (EXP)
ethanol  (ISO)
fenoxycarb  (EXP)
fluoxetine  (EXP)
folic acid  (ISO)
fulvestrant  (ISO)
gentamycin  (EXP)
Hexamethonium  (EXP)
imidacloprid  (ISO)
isobutanol  (ISO)
lead diacetate  (EXP)
Mecamylamine  (EXP,ISO)
mercury dichloride  (EXP)
Mivacurium  (ISO)
N'-Nitrosonornicotine  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nickel atom  (EXP)
nicotine  (EXP,ISO)
NS-398  (ISO)
pancuronium  (ISO)
paracetamol  (EXP)
pentan-1-ol  (ISO)
propan-1-ol  (ISO)
propan-2-ol  (ISO)
propanal  (ISO)
propoxur  (EXP)
rocuronium  (ISO)
sarin  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
tamoxifen  (ISO)
tert-butanol  (ISO)
testosterone  (EXP)
Tetrachlorobisphenol A  (ISO)
thapsigargin  (ISO)
Triptolide  (ISO)
triptonide  (ISO)
tubocurarine  (EXP,ISO)
tunicamycin  (ISO)
valproic acid  (EXP,ISO)
varenicline  (EXP)
vecuronium bromide  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Mammalian nicotinic acetylcholine receptors: from structure to function. Albuquerque EX, etal., Physiol Rev. 2009 Jan;89(1):73-120. doi: 10.1152/physrev.00015.2008.
2. Genetic variants in nicotine addiction and alcohol metabolism genes, oral cancer risk and the propensity to smoke and drink alcohol: a replication study in India. Anantharaman D, etal., PLoS One. 2014 Feb 5;9(2):e88240. doi: 10.1371/journal.pone.0088240. eCollection 2014.
3. Alpha 3, alpha 5, and beta 4: three members of the rat neuronal nicotinic acetylcholine receptor-related gene family form a gene cluster. Boulter J, etal., J Biol Chem 1990 Mar 15;265(8):4472-82.
4. Nicotinic cholinergic receptors in esophagus: Early alteration during carcinogenesis and prognostic value. Chianello Nicolau M, etal., World J Gastroenterol. 2016 Aug 21;22(31):7146-56. doi: 10.3748/wjg.v22.i31.7146.
5. Molecular biology and electrophysiology of neuronal nicotinic receptors of rat chromaffin cells. Di Angelantonio S, etal., Eur J Neurosci 2003 Jun;17(11):2313-22.
6. The functional diversity of the neuronal nicotinic acetylcholine receptors is increased by a novel subunit: beta 4. Duvoisin RM, etal., Neuron 1989 Oct;3(4):487-96.
7. Alterations in nicotinic receptor alpha5 subunit gene differentially impact early and later stages of cocaine addiction: a translational study in transgenic rats and patients. Forget B, etal., Prog Neurobiol. 2021 Feb;197:101898. doi: 10.1016/j.pneurobio.2020.101898. Epub 2020 Aug 22.
8. Formation of oligomers containing the beta3 and beta4 subunits of the rat nicotinic receptor. Forsayeth JR and Kobrin E, J Neurosci. 1997 Mar 1;17(5):1531-8.
9. Nicotinic receptor subunit alpha5 modifies assembly, up-regulation, and response to pro-inflammatory cytokines. Gahring LC and Rogers SW, J Biol Chem. 2010 Aug 20;285(34):26049-57. doi: 10.1074/jbc.M110.105346. Epub 2010 Jun 21.
10. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
11. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
12. Rare missense variants in CHRNB4 are associated with reduced risk of nicotine dependence. Haller G, etal., Hum Mol Genet. 2012 Feb 1;21(3):647-55. doi: 10.1093/hmg/ddr498. Epub 2011 Oct 31.
13. Down-regulation of cholinergic signaling in the habenula induces anhedonia-like behavior. Han S, etal., Sci Rep. 2017 Apr 18;7(1):900. doi: 10.1038/s41598-017-01088-6.
14. Fine mapping of chromosome 15q25.1 lung cancer susceptibility in African-Americans. Hansen HM, etal., Hum Mol Genet. 2010 Sep 15;19(18):3652-61. doi: 10.1093/hmg/ddq268. Epub 2010 Jun 29.
15. The nicotinic receptor in the rat pineal gland is an alpha3beta4 subtype. Hernandez SC, etal., Mol Pharmacol. 2004 Oct;66(4):978-87. doi: 10.1124/mol.104.002345. Epub 2004 Jul 9.
16. ASCL1 regulates the expression of the CHRNA5/A3/B4 lung cancer susceptibility locus. Improgo MR, etal., Mol Cancer Res. 2010 Feb;8(2):194-203. doi: 10.1158/1541-7786.MCR-09-0185. Epub 2010 Feb 2.
17. Cloning of a putative neuronal nicotinic acetylcholine receptor subunit. Isenberg KE and Meyer GE, J Neurochem 1989 Mar;52(3):988-91.
18. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
19. Polymorphisms of CHRNA5-CHRNA3-CHRNB4 Gene Cluster and NSCLC Risk in Chinese Population. Li Z, etal., Transl Oncol. 2012 Dec;5(6):448-52. doi: 10.1593/tlo.12304. Epub 2012 Dec 1.
20. Quantitative analysis of the heteromeric neuronal nicotinic receptors in the rat hippocampus. Lomazzo E, etal., J Neurochem. 2010 Nov;115(3):625-34. doi: 10.1111/j.1471-4159.2010.06967.x. Epub 2010 Sep 27.
21. Nicotinic cholinergic receptors in the rat retina: simple and mixed heteromeric subtypes. Marritt AM, etal., Mol Pharmacol. 2005 Dec;68(6):1656-68. Epub 2005 Aug 29.
22. Expression of acetylcholine receptors by experimental rat renal allografts. Meixner M, etal., Biomed Res Int. 2014;2014:289656. doi: 10.1155/2014/289656. Epub 2014 Jul 9.
23. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
24. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
25. UBXD4, a UBX-containing protein, regulates the cell surface number and stability of alpha3-containing nicotinic acetylcholine receptors. Rezvani K, etal., J Neurosci. 2009 May 27;29(21):6883-96. doi: 10.1523/JNEUROSCI.4723-08.2009.
26. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
27. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
28. Epigenetic screen identifies genotype-specific promoter DNA methylation and oncogenic potential of CHRNB4. Scherf DB, etal., Oncogene. 2013 Jul 11;32(28):3329-38. doi: 10.1038/onc.2012.344. Epub 2012 Sep 3.
29. Study on polymorphisms in CHRNA5/CHRNA3/CHRNB4 gene cluster and the associated with the risk of non-small cell lung cancer. Sun Y, etal., Oncotarget. 2017 Dec 20;9(2):2435-2444. doi: 10.18632/oncotarget.23459. eCollection 2018 Jan 5.
30. The comparative pharmacology and up-regulation of rat neuronal nicotinic receptor subtype binding sites stably expressed in transfected mammalian cells. Xiao Y and Kellar KJ, J Pharmacol Exp Ther. 2004 Jul;310(1):98-107. Epub 2004 Mar 11.
31. Unmethylation of the CHRNB4 gene is an unfavorable prognostic factor in non-small cell lung cancer. Yoo SS, etal., Lung Cancer. 2014 Oct;86(1):85-90. doi: 10.1016/j.lungcan.2014.08.002. Epub 2014 Aug 12.
Additional References at PubMed
PMID:8906617   PMID:10531434   PMID:10771006   PMID:11450844   PMID:12606764   PMID:14764595   PMID:15275829   PMID:15537871   PMID:18249185   PMID:18387948   PMID:20043866   PMID:22024738  
PMID:23811311   PMID:25041985   PMID:25453771  


Genomics

Comparative Map Data
Chrnb4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8864,312,644 - 64,333,319 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl864,313,669 - 64,333,248 (-)EnsemblGRCr8
mRatBN7.2855,417,583 - 55,437,027 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl855,418,313 - 55,437,027 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx860,959,884 - 60,978,450 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0859,238,885 - 59,257,451 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0857,103,128 - 57,121,694 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0859,610,489 - 59,629,073 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl859,609,693 - 59,629,133 (-)Ensemblrn6Rnor6.0
Rnor_5.0858,192,375 - 58,210,959 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4858,586,961 - 58,605,545 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera854,902,516 - 54,921,100 (-)NCBICelera
RGSC_v3.1858,605,220 - 58,624,659 (-)NCBI
RH 3.4 Map8614.4RGD
Cytogenetic Map8q24NCBI
CHRNB4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381578,624,111 - 78,661,641 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1578,624,111 - 78,727,754 (-)Ensemblhg38GRCh38
GRCh371578,916,453 - 78,933,552 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361576,703,691 - 76,720,642 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341576,703,690 - 76,720,642NCBI
Celera1555,852,898 - 55,869,734 (-)NCBICelera
Cytogenetic Map15q25.1NCBI
HuRef1555,674,500 - 55,691,566 (-)NCBIHuRef
CHM1_11579,035,191 - 79,052,089 (-)NCBICHM1_1
T2T-CHM13v2.01576,487,585 - 76,519,049 (-)NCBIT2T-CHM13v2.0
Chrnb4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39954,935,438 - 54,956,236 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl954,935,438 - 54,956,063 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38955,028,154 - 55,048,953 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl955,028,154 - 55,048,779 (-)Ensemblmm10GRCm38
MGSCv37954,875,963 - 54,896,351 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36954,826,293 - 54,846,681 (-)NCBIMGSCv36mm8
Celera952,271,558 - 52,291,872 (-)NCBICelera
Cytogenetic Map9BNCBI
cM Map929.84NCBI
Chrnb4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554501,013,607 - 1,030,282 (-)Ensembl
ChiLan1.0NW_0049554501,013,897 - 1,030,232 (-)NCBIChiLan1.0ChiLan1.0
CHRNB4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21667,837,116 - 67,880,179 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11572,003,030 - 72,045,815 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01557,552,697 - 57,570,828 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11576,515,683 - 76,532,905 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1576,515,455 - 76,532,712 (-)EnsemblpanPan2panpan1.1
CHRNB4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11338,312,537 - 38,327,242 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1338,312,173 - 38,328,341 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1338,273,110 - 38,288,065 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01338,786,382 - 38,801,494 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1338,786,222 - 38,800,419 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11338,477,587 - 38,492,683 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01338,586,959 - 38,602,041 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01339,061,951 - 39,077,068 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Chrnb4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640118,560,402 - 118,577,508 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647136,408,447 - 36,426,021 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647136,408,471 - 36,425,571 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CHRNB4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1747,338,819 - 47,359,064 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2752,808,908 - 52,829,172 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CHRNB4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1264,700,217 - 4,717,363 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl264,701,321 - 4,719,319 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666048137,078,808 - 137,095,082 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Chrnb4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248942,305,820 - 2,322,505 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248942,305,815 - 2,322,264 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Chrnb4
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1849,105,759 - 49,124,647 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Chrnb4
192 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:127
Count of miRNA genes:74
Interacting mature miRNAs:77
Transcripts:ENSRNOT00000019458, ENSRNOT00000040753
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83975280384752803Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)849849908118871671Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)839106363103375781Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)85076395195763951Rat
11556286Cm81Cardiac mass QTL 810.01heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)83910625884106258Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)85158969999045312Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)839106363103375781Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)84447792689477926Rat
4889938Bss89Bone structure and strength QTL 893.8tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)85899169791341052Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)839106258103375958Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83910625891341052Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)861019838121662124Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)863404444108404444Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)835464071107982864Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)84754141992541419Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83910625884106258Rat
631842Inf1Infertility severity QTL 14.10.001seminal gland mass (VT:0010524)seminal vesicle wet weight (CMO:0001603)83154366176543661Rat
737824Hcar10Hepatocarcinoma resistance QTL 102.9liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)84961020468373388Rat
1359033Bp273Blood pressure QTL 273arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83910625884106258Rat
1331769Rf39Renal function QTL 393.871urine output (VT:0003620)timed urine volume (CMO:0000260)850763951107970527Rat
61358Bp39Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84444783789447837Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)84961020494610204Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)835464071107982864Rat
1331744Bp217Blood pressure QTL 2173.398arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83910625867378345Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)855428333127966348Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)839106363114525825Rat
1582254Kidm31Kidney mass QTL 313kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)84924517894245178Rat
724540Uae8Urinary albumin excretion QTL 85urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)839106258103375958Rat
10402857Bp380Blood pressure QTL 3800.95arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)862848139107848139Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)835464071107982864Rat
631216Stl9Serum triglyceride level QTL 94.710.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)85076395167219641Rat
1582243Bw66Body weight QTL 663.40.0048body mass (VT:0001259)body weight (CMO:0000012)84924517894245178Rat
5684973Bss100Bone structure and strength QTL 1004.7tibia area (VT:1000281)tibia area measurement (CMO:0001382)85899169791341052Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)84447504389475043Rat
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83910625891341052Rat
12879878Bw183Body weight QTL 1830.001body mass (VT:0001259)body weight (CMO:0000012)862848139107848139Rat
1300177Cm2Cardiac mass QTL 23.65heart mass (VT:0007028)heart weight (CMO:0000017)863141536109261840Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)858337123103337123Rat
12879879Cm99Cardiac mass QTL 990.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)862848139107848139Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83910625891341052Rat
1331804Cm30Cardiac mass QTL 303.77443heart mass (VT:0007028)heart wet weight (CMO:0000069)862970527107970527Rat
12879880Cm100Cardiac mass QTL 1000.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)862848139107848139Rat
12879881Cm101Cardiac mass QTL 1010.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)862848139107848139Rat
12879882Am8Aortic mass QTL 80.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)862848139107848139Rat
12879883Kidm65Kidney mass QTL 650.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)862848139107848139Rat
1358912Bw51Body weight QTL 512.95body mass (VT:0001259)body weight (CMO:0000012)860248093105248093Rat
2313086Bss60Bone structure and strength QTL 604.10.0001tibia length (VT:0004357)tibia length (CMO:0000450)85899169791341052Rat
2293697Bmd39Bone mineral density QTL 39femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)862848139107848139Rat
631648Stl5Serum triglyceride level QTL 540.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)83546407171842899Rat
1331837Bw23Body weight QTL 234.190.00007body mass (VT:0001259)body weight (CMO:0000012)855428416107963099Rat
1331838Niddm61Non-insulin dependent diabetes mellitus QTL 613.530.0004blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)862963099107963099Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83910625891341052Rat
2301402Bp316Blood pressure QTL 3160.005arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)862848139107848139Rat
631664Hcar3Hepatocarcinoma resistance QTL 32.90.0005liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)862982864107982864Rat

Markers in Region
Chrnb4  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2855,423,273 - 55,424,861 (+)MAPPERmRatBN7.2
Rnor_6.0859,615,383 - 59,616,969NCBIRnor6.0
Rnor_5.0858,197,269 - 58,198,855UniSTSRnor5.0
RGSC_v3.4858,591,855 - 58,593,441UniSTSRGSC3.4
Celera854,907,410 - 54,908,996UniSTS
RH 3.4 Map8614.4UniSTS
Cytogenetic Map8q24UniSTS
PMC312758P4  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2855,437,250 - 55,437,355 (+)MAPPERmRatBN7.2
Rnor_6.0859,629,357 - 59,629,461NCBIRnor6.0
Rnor_5.0858,211,243 - 58,211,347UniSTSRnor5.0
RGSC_v3.4858,605,829 - 58,605,933UniSTSRGSC3.4
Celera854,921,384 - 54,921,488UniSTS
Cytogenetic Map8q24UniSTS
Chrnb4  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8864,313,845 - 64,314,073 (+)Marker Load Pipeline
mRatBN7.2855,417,759 - 55,417,987 (+)MAPPERmRatBN7.2
Rnor_6.0859,609,870 - 59,610,097NCBIRnor6.0
Rnor_5.0858,191,756 - 58,191,983UniSTSRnor5.0
RGSC_v3.4858,586,342 - 58,586,569UniSTSRGSC3.4
Celera854,901,897 - 54,902,124UniSTS
RH 3.4 Map8614.4UniSTS
Cytogenetic Map8q24UniSTS


Genetic Models
This gene Chrnb4 is modified in the following models/strains:
LEW-Chrnb4em5Mcwi    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
11 26 135 47 43 16 30 16 6 162 74 2 113 61 73 27 14 14

Sequence


Ensembl Acc Id: ENSRNOT00000019458   ⟹   ENSRNOP00000019458
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl864,313,669 - 64,333,109 (-)Ensembl
mRatBN7.2 Ensembl855,418,313 - 55,437,027 (-)Ensembl
Rnor_6.0 Ensembl859,609,693 - 59,629,133 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000101543   ⟹   ENSRNOP00000077477
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl864,313,669 - 64,328,578 (-)Ensembl
mRatBN7.2 Ensembl855,418,313 - 55,432,496 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000138086   ⟹   ENSRNOP00000104050
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl864,313,669 - 64,333,248 (-)Ensembl
RefSeq Acc Id: NM_052806   ⟹   NP_434693
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8864,313,669 - 64,333,109 (-)NCBI
mRatBN7.2855,417,583 - 55,437,027 (-)NCBI
Rnor_6.0859,610,489 - 59,629,073 (-)NCBI
Rnor_5.0858,192,375 - 58,210,959 (-)NCBI
RGSC_v3.4858,586,961 - 58,605,545 (-)RGD
Celera854,902,516 - 54,921,100 (-)RGD
Sequence:
RefSeq Acc Id: XM_063264942   ⟹   XP_063121012
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8864,312,644 - 64,333,319 (-)NCBI
RefSeq Acc Id: XM_063264943   ⟹   XP_063121013
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8864,312,644 - 64,328,246 (-)NCBI
RefSeq Acc Id: NP_434693   ⟸   NM_052806
- Peptide Label: precursor
- UniProtKB: Q63361 (UniProtKB/Swiss-Prot),   P12392 (UniProtKB/Swiss-Prot),   A6J4N9 (UniProtKB/TrEMBL),   A0A8I5Y7T1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000019458   ⟸   ENSRNOT00000019458
Ensembl Acc Id: ENSRNOP00000077477   ⟸   ENSRNOT00000101543
RefSeq Acc Id: XP_063121012   ⟸   XM_063264942
- Peptide Label: isoform X1
- UniProtKB: A0A8I5Y7T1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063121013   ⟸   XM_063264943
- Peptide Label: isoform X2
Ensembl Acc Id: ENSRNOP00000104050   ⟸   ENSRNOT00000138086
Protein Domains
Neurotransmitter-gated ion-channel ligand-binding   Neurotransmitter-gated ion-channel transmembrane

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P12392-F1-model_v2 AlphaFold P12392 1-495 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2351 AgrOrtholog
BioCyc Gene G2FUF-30379 BioCyc
Ensembl Genes ENSRNOG00000014427 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000019458 ENTREZGENE
  ENSRNOT00000019458.6 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.58.390 UniProtKB/Swiss-Prot
  2.70.170.10 UniProtKB/Swiss-Prot
InterPro Neur_chan_lig-bd UniProtKB/Swiss-Prot
  Neur_chan_lig-bd_sf UniProtKB/Swiss-Prot
  Neur_channel UniProtKB/Swiss-Prot
  Neuro-gated_channel_TM_sf UniProtKB/Swiss-Prot
  Neuro_actylchol_rec UniProtKB/Swiss-Prot
  Neurotrans-gated_channel_TM UniProtKB/Swiss-Prot
  Neurotransmitter_ion_chnl_CS UniProtKB/Swiss-Prot
  Nicotinic_acetylcholine_rcpt UniProtKB/Swiss-Prot
KEGG Report rno:25103 UniProtKB/Swiss-Prot
NCBI Gene 25103 ENTREZGENE
PANTHER PTHR18945 UniProtKB/Swiss-Prot
Pfam Neur_chan_LBD UniProtKB/Swiss-Prot
  Neur_chan_memb UniProtKB/Swiss-Prot
PharmGKB CHRNB4 RGD
PhenoGen Chrnb4 PhenoGen
PRINTS NICOTINICR UniProtKB/Swiss-Prot
  NRIONCHANNEL UniProtKB/Swiss-Prot
PROSITE NEUROTR_ION_CHANNEL UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000014427 RatGTEx
Superfamily-SCOP SSF63712 UniProtKB/Swiss-Prot
  SSF90112 UniProtKB/Swiss-Prot
UniProt A0A8I5Y7T1 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0L3T5_RAT UniProtKB/TrEMBL
  A6J4N9 ENTREZGENE, UniProtKB/TrEMBL
  ACHB4_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q63361 ENTREZGENE
UniProt Secondary Q63361 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Chrnb4  cholinergic receptor nicotinic beta 4 subunit  Chrnb4  cholinergic receptor, nicotinic beta 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-12-09 Chrnb4  cholinergic receptor, nicotinic beta 4  Chrnb4  cholinergic receptor, nicotinic, beta 4 (neuronal)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-16 Chrnb4  cholinergic receptor, nicotinic, beta 4 (neuronal)  Chrnb4  cholinergic receptor, nicotinic, beta 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-29 Chrnb4  cholinergic receptor, nicotinic, beta 4  Chrnb4  cholinergic receptor, nicotinic, beta polypeptide 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2001-07-23 Chrnb4  Acetylcholine receptor beta 4      Name withdrawn 67952 WITHDRAWN
2001-07-23 Chrnb4  cholinergic receptor, nicotinic, beta polypeptide 4      Name updated to reflect Human and Mouse nomenclature 67952 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains contains a potential N-glycosylation site 727601