Rbl1 (RB transcriptional corepressor like 1) - Rat Genome Database

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Gene: Rbl1 (RB transcriptional corepressor like 1) Rattus norvegicus
Analyze
Symbol: Rbl1
Name: RB transcriptional corepressor like 1
RGD ID: 1595511
Description: Predicted to enable RNA polymerase II transcription regulatory region sequence-specific DNA binding activity and promoter-specific chromatin binding activity. Predicted to be involved in cell differentiation; negative regulation of G1/S transition of mitotic cell cycle; and negative regulation of cellular senescence. Predicted to act upstream of or within negative regulation of gene expression and negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Predicted to be part of transcription regulator complex. Predicted to be active in chromatin. Orthologous to human RBL1 (RB transcriptional corepressor like 1); PARTICIPATES IN G1/S transition pathway; cell cycle pathway, mitotic; transforming growth factor-beta superfamily mediated signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; acetamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC680111; p107; pRb1; retinoblastoma-like 1; retinoblastoma-like 1 (p107); retinoblastoma-like protein 1; similar to Retinoblastoma-like protein 1 (107 kDa retinoblastoma-associated protein) (PRB1) (P107)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83166,226,187 - 166,289,862 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3166,226,198 - 166,289,376 (-)EnsemblGRCr8
mRatBN7.23145,806,160 - 145,869,434 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3145,807,095 - 145,869,330 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3149,633,152 - 149,694,671 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03158,130,942 - 158,195,584 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03155,871,986 - 155,936,707 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03153,263,692 - 153,321,351 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3153,263,692 - 153,321,352 (-)Ensemblrn6Rnor6.0
Rnor_5.03158,398,177 - 158,452,482 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43147,734,622 - 147,796,630 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3144,513,506 - 144,575,032 (-)NCBICelera
Cytogenetic Map3q42NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(S)-nicotine  (ISO)
1,1-dichloroethene  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,4'-trichlorobiphenyl  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-hydroxynon-2-enal  (ISO)
4-nitrophenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alvocidib  (ISO)
amphetamine  (EXP)
antimycin A  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
calyculin A  (ISO)
camptothecin  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloroprene  (ISO)
chlorpyrifos  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cycloheximide  (ISO)
D-mannitol  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
doxorubicin  (ISO)
folic acid  (ISO)
FR900359  (ISO)
furan  (EXP)
genistein  (EXP)
gentamycin  (EXP)
glyphosate  (ISO)
GSK-J4  (ISO)
GW 3965  (ISO)
hydralazine  (ISO)
hydrogen peroxide  (ISO)
irinotecan  (ISO)
lamivudine  (ISO)
Lasiocarpine  (ISO)
lidocaine  (EXP,ISO)
lipopolysaccharide  (ISO)
LY294002  (ISO)
methotrexate  (ISO)
methoxyacetic acid  (EXP)
methylmercury chloride  (ISO)
monocrotaline  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodiethylamine  (ISO)
nicotine  (ISO)
okadaic acid  (ISO)
oxaliplatin  (EXP)
oxybenzone  (ISO)
ozone  (ISO)
palbociclib  (ISO)
paracetamol  (EXP,ISO)
PCB138  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
quercetin  (ISO)
raloxifene  (ISO)
riddelliine  (ISO)
ritonavir  (ISO)
rotenone  (EXP,ISO)
silicon dioxide  (ISO)
silver(1+) nitrate  (ISO)
sirolimus  (ISO)
sodium arsenite  (ISO)
succimer  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
toluene 2,4-diisocyanate  (ISO)
topotecan  (EXP)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
valproic acid  (ISO)
vincristine  (ISO)
zidovudine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
chromatin  (IBA)
nucleoplasm  (IEA,ISO)
nucleus  (IEA,ISO)
transcription regulator complex  (IBA,IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. PP2A-mediated dephosphorylation of p107 plays a critical role in chondrocyte cell cycle arrest by FGF. Kolupaeva V, etal., PLoS One. 2008;3(10):e3447. doi: 10.1371/journal.pone.0003447. Epub 2008 Oct 17.
3. Mammalian cyclin-dependent kinases. Malumbres M and Barbacid M, Trends Biochem Sci. 2005 Nov;30(11):630-41. Epub 2005 Oct 19.
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:7797074   PMID:8245034   PMID:10082561   PMID:12853964   PMID:15701640   PMID:16286473   PMID:16360038   PMID:18818403   PMID:23716589   PMID:23775125   PMID:25100735   PMID:28595801  


Genomics

Comparative Map Data
Rbl1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83166,226,187 - 166,289,862 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3166,226,198 - 166,289,376 (-)EnsemblGRCr8
mRatBN7.23145,806,160 - 145,869,434 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3145,807,095 - 145,869,330 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3149,633,152 - 149,694,671 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03158,130,942 - 158,195,584 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03155,871,986 - 155,936,707 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03153,263,692 - 153,321,351 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3153,263,692 - 153,321,352 (-)Ensemblrn6Rnor6.0
Rnor_5.03158,398,177 - 158,452,482 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43147,734,622 - 147,796,630 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3144,513,506 - 144,575,032 (-)NCBICelera
Cytogenetic Map3q42NCBI
RBL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382036,996,349 - 37,095,997 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2036,996,349 - 37,095,999 (-)Ensemblhg38GRCh38
GRCh372035,624,752 - 35,724,400 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362035,059,592 - 35,157,824 (-)NCBIBuild 36Build 36hg18NCBI36
Build 342035,065,390 - 35,157,824NCBI
Celera2032,333,780 - 32,432,015 (-)NCBICelera
Cytogenetic Map20q11.23NCBI
HuRef2032,360,436 - 32,458,763 (-)NCBIHuRef
CHM1_12035,527,068 - 35,627,333 (-)NCBICHM1_1
T2T-CHM13v2.02038,720,692 - 38,820,363 (-)NCBIT2T-CHM13v2.0
Rbl1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392156,987,813 - 157,046,454 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2156,987,813 - 157,046,454 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm382157,145,893 - 157,204,534 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2157,145,893 - 157,204,534 (-)Ensemblmm10GRCm38
MGSCv372156,971,629 - 157,030,270 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv362156,837,339 - 156,895,960 (-)NCBIMGSCv36mm8
Celera2163,079,752 - 163,138,173 (-)NCBICelera
Cytogenetic Map2H1NCBI
cM Map278.05NCBI
Rbl1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542224,620,078 - 24,695,229 (+)Ensembl
ChiLan1.0NW_00495542224,620,068 - 24,695,203 (+)NCBIChiLan1.0ChiLan1.0
RBL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22142,730,094 - 42,825,356 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12042,722,411 - 42,818,447 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02033,324,663 - 33,419,891 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12034,442,865 - 34,535,248 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2034,443,203 - 34,534,109 (-)EnsemblpanPan2panpan1.1
RBL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12425,698,313 - 25,757,358 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2425,699,638 - 25,757,229 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2425,346,666 - 25,405,658 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02426,395,755 - 26,454,244 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2426,395,763 - 26,454,227 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12425,673,462 - 25,732,016 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02425,777,693 - 25,836,916 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02426,267,110 - 26,325,939 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Rbl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640174,589,725 - 174,641,443 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365614,107,861 - 4,157,647 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365614,108,393 - 4,157,993 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RBL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1740,194,950 - 40,279,156 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11740,201,214 - 40,279,318 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21745,641,172 - 45,716,781 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103246453
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1226,593,657 - 26,601,041 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666054222,711 - 309,667 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rbl1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248422,494,911 - 2,563,421 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248422,495,015 - 2,565,220 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Rbl1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v15136,487,609 - 136,550,989 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Rbl1
291 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:94
Count of miRNA genes:83
Interacting mature miRNAs:84
Transcripts:ENSRNOT00000064824
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12879876Bw182Body weight QTL 1820.003body mass (VT:0001259)body weight (CMO:0000012)3141555229186555229Rat
2301411Bp320Blood pressure QTL 3200.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3141555229186555229Rat
1582233Insul10Insulin level QTL 105.40.0015blood insulin amount (VT:0001560)serum insulin level times blood glucose level (CMO:0002040)3133259579178259579Rat
12879872Cm97Cardiac mass QTL 970.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3141555229186555229Rat
12879873Cm96Cardiac mass QTL 960.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)3141555229186555229Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3151075912189428310Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)3129154923182114333Rat
12879874Cm98Cardiac mass QTL 980.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)3141555229186555229Rat
12879875Kidm64Kidney mass QTL 640.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3141555229186555229Rat
1298068Bp167Blood pressure QTL 1670.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3161492708189428310Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)367641776167835660Rat
61335Bp20Blood pressure QTL 203arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3161799493176036425Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3133134628178134628Rat
1331726Bp208Blood pressure QTL 2083.129arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3161799270187311134Rat
1582213Insul6Insulin level QTL 63.70.0009blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)3155759447189428310Rat
1300173Rf11Renal function QTL 113.38renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)3141508991166376254Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3152055202189428310Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3142898802187898802Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)379649560177741895Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)3145335553189428310Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3125116475170116475Rat
1582256Insul9Insulin level QTL 94.40.0016blood insulin amount (VT:0001560)absolute change in serum insulin level (CMO:0002038)3155759447189428310Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3139299381184299381Rat
5686842Rf59Renal function QTL 59urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)3122395989167395989Rat
1300159Kidm4Kidney mass QTL 43.83kidney mass (VT:0002707)right kidney wet weight to body weight ratio (CMO:0001953)3141508991177728348Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)3131036586176036586Rat
631673Iddm13Insulin dependent diabetes mellitus QTL 131.30.663blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)3137114333182114333Rat
1582248Insul7Insulin level QTL 73.90.0041blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)3155759447189428310Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)3131036586176036586Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)398651826167012663Rat
1578666Vnigr1Vascular neointimal growth QTL 14.6artery morphology trait (VT:0002191)artery lumen area (CMO:0001409)3151075912189428310Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3151075912189428310Rat
12879871Am7Aortic mass QTL 70.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)3141555229186555229Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3144575244189428310Rat
2293087Iddm27Insulin dependent diabetes mellitus QTL 272.68blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)3160357340167835660Rat

Markers in Region
D3Uwm1  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr83166,284,097 - 166,284,258 (+)Marker Load Pipeline
mRatBN7.23145,864,084 - 145,864,245 (+)MAPPERmRatBN7.2
Rnor_6.03153,320,686 - 153,320,846NCBIRnor6.0
Rnor_5.03158,398,682 - 158,398,842UniSTSRnor5.0
RGSC_v3.43147,791,421 - 147,791,581UniSTSRGSC3.4
Celera3144,569,830 - 144,569,990UniSTS
RGSC_v3.13147,697,329 - 147,697,490RGD
Cytogenetic Map3q42UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 11 67 165 91 90 59 92 59 6 355 191 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000064824   ⟹   ENSRNOP00000063017
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3166,226,198 - 166,289,376 (-)Ensembl
mRatBN7.2 Ensembl3145,807,095 - 145,869,330 (-)Ensembl
Rnor_6.0 Ensembl3153,263,692 - 153,321,352 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000100752   ⟹   ENSRNOP00000093339
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3166,226,198 - 166,289,376 (-)Ensembl
mRatBN7.2 Ensembl3145,807,095 - 145,869,330 (-)Ensembl
RefSeq Acc Id: NM_001191066   ⟹   NP_001177995
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83166,226,187 - 166,289,376 (-)NCBI
mRatBN7.23145,806,160 - 145,869,363 (-)NCBI
Rnor_6.03153,263,692 - 153,321,351 (-)NCBI
Rnor_5.03158,398,177 - 158,452,482 (+)NCBI
Celera3144,513,506 - 144,575,032 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039105840   ⟹   XP_038961768
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83166,226,187 - 166,289,862 (-)NCBI
mRatBN7.23145,806,160 - 145,869,434 (-)NCBI
RefSeq Acc Id: XM_039105841   ⟹   XP_038961769
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83166,226,187 - 166,274,917 (-)NCBI
mRatBN7.23145,806,160 - 145,854,904 (-)NCBI
RefSeq Acc Id: XR_010064693
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83166,246,449 - 166,289,862 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001177995 (Get FASTA)   NCBI Sequence Viewer  
  XP_038961768 (Get FASTA)   NCBI Sequence Viewer  
  XP_038961769 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein D3ZS28 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000063017
  ENSRNOP00000093339
RefSeq Acc Id: NP_001177995   ⟸   NM_001191066
- UniProtKB: D3ZS28 (UniProtKB/Swiss-Prot),   A0A573VVF2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000063017   ⟸   ENSRNOT00000064824
RefSeq Acc Id: XP_038961768   ⟸   XM_039105840
- Peptide Label: isoform X1
- UniProtKB: D3ZS28 (UniProtKB/Swiss-Prot),   A0A8I6AK71 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038961769   ⟸   XM_039105841
- Peptide Label: isoform X2
Ensembl Acc Id: ENSRNOP00000093339   ⟸   ENSRNOT00000100752
Protein Domains
Cyclin-like   Retinoblastoma-associated protein A-box   Retinoblastoma-associated protein C-terminal   Retinoblastoma-associated protein N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZS28-F1-model_v2 AlphaFold D3ZS28 1-1049 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1595511 AgrOrtholog
BioCyc Gene G2FUF-47064 BioCyc
Ensembl Genes ENSRNOG00000006921 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000064824 ENTREZGENE
  ENSRNOT00000100752 ENTREZGENE
Gene3D-CATH 1.10.472.140 UniProtKB/Swiss-Prot
  Cyclin-like UniProtKB/Swiss-Prot
InterPro Cyclin-like UniProtKB/Swiss-Prot
  Cyclin-like_sf UniProtKB/Swiss-Prot
  RB_A UniProtKB/Swiss-Prot
  RB_B UniProtKB/Swiss-Prot
  RB_C UniProtKB/Swiss-Prot
  RB_fam UniProtKB/Swiss-Prot
  RB_N UniProtKB/Swiss-Prot
KEGG Report rno:680111 UniProtKB/Swiss-Prot
NCBI Gene 680111 ENTREZGENE
PANTHER PTHR13742 UniProtKB/Swiss-Prot
  PTHR13742:SF20 UniProtKB/Swiss-Prot
Pfam DUF3452 UniProtKB/Swiss-Prot
  RB_A UniProtKB/Swiss-Prot
  RB_B UniProtKB/Swiss-Prot
PhenoGen Rbl1 PhenoGen
RatGTEx ENSRNOG00000006921 RatGTEx
SMART CYCLIN UniProtKB/Swiss-Prot
  DUF3452 UniProtKB/Swiss-Prot
  RB_A UniProtKB/Swiss-Prot
  Rb_C UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47954 UniProtKB/Swiss-Prot
UniProt A0A573VVF2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AK71 ENTREZGENE, UniProtKB/TrEMBL
  D3ZS28 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-03 Rbl1  RB transcriptional corepressor like 1  Rbl1  retinoblastoma-like 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-03-24 Rbl1  retinoblastoma-like 1  Rbl1  retinoblastoma-like 1 (p107)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-05 Rbl1  retinoblastoma-like 1 (p107)  LOC680111  similar to Retinoblastoma-like protein 1 (107 kDa retinoblastoma-associated protein) (PRB1) (P107)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-01-09 LOC680111  similar to Retinoblastoma-like protein 1 (107 kDa retinoblastoma-associated protein) (PRB1) (P107)  LOC683869  similar to Retinoblastoma-like protein 1 (107 kDa retinoblastoma-associated protein) (PRB1) (P107)  Data merged from RGD:1597810 1643240 APPROVED
2006-11-20 LOC680111  similar to Retinoblastoma-like protein 1 (107 kDa retinoblastoma-associated protein) (PRB1) (P107)      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-20 LOC683869  similar to Retinoblastoma-like protein 1 (107 kDa retinoblastoma-associated protein) (PRB1) (P107)      Symbol and Name status set to provisional 70820 PROVISIONAL