Mbd2 (methyl-CpG binding domain protein 2) - Rat Genome Database

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Gene: Mbd2 (methyl-CpG binding domain protein 2) Rattus norvegicus
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Symbol: Mbd2
Name: methyl-CpG binding domain protein 2
RGD ID: 1595452
Description: Predicted to enable several functions, including C2H2 zinc finger domain binding activity; RNA binding activity; and methyl-CpG binding activity. Involved in several processes, including cellular response to serotonin; maternal behavior; and regulation of gene expression. Located in chromatin. Used to study choline deficiency disease. Biomarker of choline deficiency disease and transient cerebral ischemia. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human MBD2 (methyl-CpG binding domain protein 2); PARTICIPATES IN CHD family mediated chromatin remodeling pathway; DNA modification pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC291525; LOC680172; LOC684150; methyl-CpG-binding domain protein 2; MGC188552; similar to Methyl-CpG-binding domain protein 2 (Methyl-CpG-binding protein MBD2)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81866,449,196 - 66,516,112 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1866,449,358 - 66,516,111 (+)EnsemblGRCr8
mRatBN7.21864,174,002 - 64,240,795 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1864,174,002 - 64,240,794 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1866,250,441 - 66,317,290 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01866,943,914 - 67,010,763 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01864,791,202 - 64,858,194 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01865,814,026 - 65,885,115 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1865,814,026 - 65,885,114 (+)Ensemblrn6Rnor6.0
Rnor_5.01864,990,480 - 65,060,941 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41867,281,440 - 67,348,558 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1862,237,373 - 62,304,615 (+)NCBICelera
RGSC_v3.11867,378,120 - 67,421,847 (+)NCBI
Cytogenetic Map18q12.1NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (EXP)
5-aza-2'-deoxycytidine  (EXP,ISO)
acrolein  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bicalutamide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
cadmium dichloride  (EXP)
caffeine  (ISO)
carbon nanotube  (ISO)
choline  (ISO)
coumarin  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
diethylstilbestrol  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
ethanol  (ISO)
finasteride  (EXP)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
fumonisin B1  (ISO)
genistein  (ISO)
hydroquinone  (ISO)
indometacin  (ISO)
L-methionine  (ISO)
menadione  (ISO)
mercury dibromide  (ISO)
methidathion  (ISO)
methyl methanesulfonate  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
nitrates  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
patulin  (ISO)
permethrin  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
resveratrol  (ISO)
S-adenosyl-L-methioninate  (ISO)
S-adenosyl-L-methionine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sulforaphane  (ISO)
sulindac  (EXP)
testosterone  (EXP)
tetrachloromethane  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
valproic acid  (ISO)
zebularine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
chromatin  (IDA,IEA,ISO)
chromosome  (IEA)
cytoplasm  (IEA,ISO)
heterochromatin  (IEA,ISO)
histone deacetylase complex  (IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IBA,IEA,ISO)
NuRD complex  (IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. The nucleosome remodeling and deacetylase complex in development and disease. Basta J and Rauchman M, Transl Res. 2014 May 10. pii: S1931-5244(14)00166-2. doi: 10.1016/j.trsl.2014.05.003.
2. On how mammalian transcription factors recognize methylated DNA. Buck-Koehntop BA and Defossez PA, Epigenetics. 2013 Feb;8(2):131-7. doi: 10.4161/epi.23632. Epub 2013 Jan 16.
3. Kindling induces the mRNA expression of methyl DNA-binding factors in the adult rat hippocampus. Francis J, etal., Neuroscience. 2002;113(1):79-87.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. A folate- and methyl-deficient diet alters the expression of DNA methyltransferases and methyl CpG binding proteins involved in epigenetic gene silencing in livers of F344 rats. Ghoshal K, etal., J Nutr. 2006 Jun;136(6):1522-7.
6. Differential expression of methyl CpG-binding domain containing factor MBD3 in the developing and adult rat brain. Jung BP, etal., J Neurobiol. 2003 May;55(2):220-32.
7. Transient forebrain ischemia alters the mRNA expression of methyl DNA-binding factors in the adult rat hippocampus. Jung BP, etal., Neuroscience. 2002;115(2):515-24.
8. Epigenetic regulation of neonatal cardiomyocytes differentiation. Kou CY, etal., Biochem Biophys Res Commun. 2010 Sep 17;400(2):278-83. doi: 10.1016/j.bbrc.2010.08.064. Epub 2010 Aug 22.
9. Gestational choline deficiency causes global and Igf2 gene DNA hypermethylation by up-regulation of Dnmt1 expression. Kovacheva VP, etal., J Biol Chem. 2007 Oct 26;282(43):31777-88. Epub 2007 Aug 27.
10. Global DNA methylation, DNMT1, and MBD2 in patients with rheumatoid arthritis. Liu CC, etal., Immunol Lett. 2011 Mar 30;135(1-2):96-9. doi: 10.1016/j.imlet.2010.10.003. Epub 2010 Oct 16.
11. Effect of Methyl-CpG binding domain protein 2 (MBD2) on AMD-like lesions in ApoE-deficient mice. Pan JR, etal., J Huazhong Univ Sci Technolog Med Sci. 2014 Jun;34(3):408-14. doi: 10.1007/s11596-014-1292-2. Epub 2014 Jun 18.
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Neonatal exposure to estradiol/bisphenol A alters promoter methylation and expression of Nsbp1 and Hpcal1 genes and transcriptional programs of Dnmt3a/b and Mbd2/4 in the rat prostate gland throughout life. Tang WY, etal., Endocrinology. 2012 Jan;153(1):42-55. doi: 10.1210/en.2011-1308. Epub 2011 Nov 22.
14. The methylated-DNA binding protein MBD2 enhances NGFI-A (egr-1)-mediated transcriptional activation of the glucocorticoid receptor. Weaver IC, etal., Philos Trans R Soc Lond B Biol Sci. 2014 Sep 26;369(1652). pii: 20130513. doi: 10.1098/rstb.2013.0513.
15. Chronic cerebrovascular hypoperfusion affects global DNA methylation and histone acetylation in rat brain. Wu X, etal., Neurosci Bull. 2013 Dec;29(6):685-92. doi: 10.1007/s12264-013-1345-8. Epub 2013 May 28.
16. Genetic association study between methyl-CpG-binding domain genes and schizophrenia among Chinese family trios. Xie B, etal., Psychiatr Genet. 2014 Oct;24(5):221-4. doi: 10.1097/YPG.0000000000000042.
Additional References at PubMed
PMID:9774669   PMID:11242117   PMID:11274056   PMID:11553631   PMID:11984006   PMID:12477932   PMID:14519686   PMID:14643676   PMID:15342650   PMID:16217013   PMID:16608912   PMID:17546630  
PMID:18644872   PMID:21029866   PMID:23770133   PMID:24307175  


Genomics

Comparative Map Data
Mbd2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81866,449,196 - 66,516,112 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1866,449,358 - 66,516,111 (+)EnsemblGRCr8
mRatBN7.21864,174,002 - 64,240,795 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1864,174,002 - 64,240,794 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1866,250,441 - 66,317,290 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01866,943,914 - 67,010,763 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01864,791,202 - 64,858,194 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01865,814,026 - 65,885,115 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1865,814,026 - 65,885,114 (+)Ensemblrn6Rnor6.0
Rnor_5.01864,990,480 - 65,060,941 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41867,281,440 - 67,348,558 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1862,237,373 - 62,304,615 (+)NCBICelera
RGSC_v3.11867,378,120 - 67,421,847 (+)NCBI
Cytogenetic Map18q12.1NCBI
MBD2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381854,151,606 - 54,224,669 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1854,151,606 - 54,224,669 (-)Ensemblhg38GRCh38
GRCh371851,677,976 - 51,751,039 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361849,934,573 - 50,005,156 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341849,983,044 - 50,005,156NCBI
Celera1848,536,865 - 48,607,453 (-)NCBICelera
Cytogenetic Map18q21.2NCBI
HuRef1848,533,225 - 48,606,305 (-)NCBIHuRef
CHM1_11851,672,993 - 51,746,130 (-)NCBICHM1_1
T2T-CHM13v2.01854,354,681 - 54,427,744 (-)NCBIT2T-CHM13v2.0
Mbd2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391870,701,298 - 70,761,769 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1870,701,260 - 70,759,202 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381870,568,225 - 70,629,134 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1870,568,189 - 70,626,131 (+)Ensemblmm10GRCm38
MGSCv371870,727,946 - 70,785,785 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361870,693,557 - 70,751,499 (+)NCBIMGSCv36mm8
Celera1871,855,127 - 71,913,052 (+)NCBICelera
Cytogenetic Map18E2NCBI
cM Map1844.54NCBI
Mbd2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540238,767,419 - 38,830,204 (-)Ensembl
ChiLan1.0NW_00495540238,761,668 - 38,829,830 (-)NCBIChiLan1.0ChiLan1.0
MBD2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21771,682,971 - 71,755,813 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11857,372,347 - 57,448,428 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01847,534,356 - 47,609,481 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11850,876,490 - 50,946,077 (-)NCBIPanPan1.1PanPan1.1panPan2
MBD2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1121,232,260 - 21,283,687 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl121,235,967 - 21,283,346 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha122,214,129 - 22,277,156 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0121,116,138 - 21,179,161 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl121,116,177 - 21,179,029 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1121,172,397 - 21,235,448 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0121,064,613 - 21,127,587 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0121,336,222 - 21,399,248 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Mbd2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494434,305,611 - 34,380,215 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364979,545,907 - 9,619,267 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364979,512,350 - 9,619,250 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MBD2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1103,735,192 - 103,752,402 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11103,683,077 - 103,768,372 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21113,947,945 - 113,959,372 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MBD2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11826,714,610 - 26,785,028 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666050632,587 - 703,065 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mbd2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477817,883,933 - 17,959,880 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462477817,880,480 - 17,959,879 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Mbd2
531 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:32
Count of miRNA genes:30
Interacting mature miRNAs:31
Transcripts:ENSRNOT00000016112
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331733Bp233Blood pressure QTL 2333.97196arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182507112683910656Rat
1331730Scl27Serum cholesterol level QTL 273.826blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)185449080186134022Rat
1331741Bp232Blood pressure QTL 2323.59112arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)182349405785487725Rat
1331742Bp228Blood pressure QTL 2283.88752arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050577371277Rat
1298072Cia26Collagen induced arthritis QTL 263.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)186438376279484311Rat
1300125Rf26Renal function QTL 263.2urine potassium amount (VT:0010539)urine potassium excretion rate (CMO:0000761)185335052168120379Rat
631834Sach3Saccharin preference QTL 33.90.01consumption behavior trait (VT:0002069)calculated saccharin drink intake volume (CMO:0001600)183857591983575919Rat
12904668Bw188Body weight QTL 1880.03body mass (VT:0001259)body weight (CMO:0000012)182682218671822186Rat
12904669Cm125Cardiac mass QTL 1250.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)182682218671822186Rat
6893683Bw110Body weight QTL 1102.70.002body mass (VT:0001259)body weight (CMO:0000012)184562030686134022Rat
12904670Cm126Cardiac mass QTL 1260.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)182682218671822186Rat
7794793Mcs34Mammary carcinoma susceptibility QTL 341.54mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)186563556785897775Rat
12904677Kidm72Kidney mass QTL 720.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)182682218671822186Rat
9589041Epfw12Epididymal fat weight QTL 1217.080.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)184891573786134022Rat
8694432Bw165Body weight QTL 1653.810.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)184891573786134022Rat
12904673Cm127Cardiac mass QTL 1270.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)182682218671822186Rat
12904675Am19Aortic mass QTL 190.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)182682218671822186Rat
1331774Bp226Blood pressure QTL 2264.41065arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050577371277Rat
9589816Gluco68Glucose level QTL 687.250.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)183199089176990891Rat
1331770Bp234Blood pressure QTL 2343.807arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)184562030686134022Rat
2301969Bp324Blood pressure QTL 3244.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)186198220476619168Rat
2303120Mamtr8Mammary tumor resistance QTL 80.001mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)183161050585493247Rat
1578667Bss21Bone structure and strength QTL 213.5femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)181206648285493247Rat
12880368Bw187Body weight QTL 1870.045body mass (VT:0001259)body weight (CMO:0000012)183337915878379158Rat
724542Kidm2Kidney mass QTL 22.6kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)186144685386134022Rat
61367Iddm4Insulin dependent diabetes mellitus QTL 42.330.0074blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)184046238385462383Rat
1359020Ppulsi2Prepulse inhibition QTL 22.71prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)185449080176272247Rat
2312600Bp341Blood pressure QTL 3410.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)186160038472538878Rat
1331752Bw27Body weight QTL 272.963body mass (VT:0001259)body weight (CMO:0000012)185449080168120379Rat
9590318Scort22Serum corticosterone level QTL 227.640.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)183199089176990891Rat
1578661Bss20Bone structure and strength QTL 203.7femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)181206648285493247Rat
1331754Bp230Blood pressure QTL 2304.61609arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)181564228086134022Rat
12904069Cm123Cardiac mass QTL 1230.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)183337915878379158Rat
1331798Bp224Blood pressure QTL 2243.53873arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050577371277Rat
12904070Cm124Cardiac mass QTL 1240.01heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)183337915878379158Rat
2303584Gluco55Glucose level QTL 552blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)185079521286134022Rat
12904071Am18Aortic mass QTL 180.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)183337915878379158Rat
2301413Bp318Blood pressure QTL 3180.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182682218671822186Rat
61383Bp47Blood pressure QTL 4717.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)183152278376522783Rat
12904067Cm122Cardiac mass QTL 1220.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)183337915878379158Rat
61384Bp48Blood pressure QTL 4819.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)186289225779484461Rat
2301417Bp319Blood pressure QTL 3190.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183337915878379158Rat
12904073Kidm71Kidney mass QTL 710.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)183337915878379158Rat
738008Hcar14Hepatocarcinoma resistance QTL 144.3liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion number (CMO:0001462)185782524385493247Rat
1331776Bp225Blood pressure QTL 2252.829arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)183161050577371277Rat
631518Bw11Body weight QTL 112.8body mass (VT:0001259)body weight (CMO:0000012)183612162681121626Rat
1641923Colcr8Colorectal carcinoma resistance QTL 83.10.0014intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)183199089176990891Rat
8694366Abfw8Abdominal fat weight QTL 86.380.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)184891573786134022Rat
631509Sald2Serum aldosterone level QTL 22.9blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)182641582171415821Rat
631274Sprol1Serum protein level QTL 15.3blood total protein amount (VT:0005567)serum total protein level (CMO:0000661)183164450879484311Rat
1358193Emca2Estrogen-induced mammary cancer QTL 21.6mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)186584644786134022Rat
1598832Glom11Glomerulus QTL 112.9kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)185326667186134022Rat
1600373Mamtr6Mammary tumor resistance QTL 6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)181955353285493247Rat
8694378Bw157Body weight QTL 1573.590.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)183199089176990891Rat
2303571Bw92Body weight QTL 923body mass (VT:0001259)body weight (CMO:0000012)185079521286134022Rat
631675Iddm15Insulin dependent diabetes mellitus QTL 15urine glucose amount (VT:0001758)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)186289225779484461Rat
61429Cia17Collagen induced arthritis QTL 174.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)183161050572538878Rat
7411719Strs5Sensitivity to stroke QTL 59.4cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)185219805968120379Rat

Markers in Region
RH129492  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21864,240,637 - 64,240,852 (+)MAPPERmRatBN7.2
Rnor_6.01865,884,958 - 65,885,172NCBIRnor6.0
Rnor_5.01865,060,784 - 65,060,998UniSTSRnor5.0
RGSC_v3.41867,348,401 - 67,348,615UniSTSRGSC3.4
Celera1862,304,458 - 62,304,672UniSTS
RH 3.4 Map18663.5UniSTS
Cytogenetic Map18q12.1UniSTS
BE107285  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81866,463,162 - 66,463,316 (+)Marker Load Pipeline
mRatBN7.21864,187,808 - 64,187,962 (+)MAPPERmRatBN7.2
Rnor_6.01865,827,833 - 65,827,986NCBIRnor6.0
Rnor_5.01865,004,287 - 65,004,440UniSTSRnor5.0
RGSC_v3.41867,295,202 - 67,295,355UniSTSRGSC3.4
Celera1862,251,267 - 62,251,420UniSTS
RH 3.4 Map18662.8UniSTS
Cytogenetic Map18q12.1UniSTS
AU049630  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21864,192,935 - 64,193,083 (+)MAPPERmRatBN7.2
Rnor_6.01865,832,960 - 65,833,107NCBIRnor6.0
Rnor_5.01865,009,414 - 65,009,561UniSTSRnor5.0
RGSC_v3.41867,300,329 - 67,300,476UniSTSRGSC3.4
Celera1862,256,394 - 62,256,541UniSTS
Cytogenetic Map18q12.1UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000016112   ⟹   ENSRNOP00000016112
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1866,449,358 - 66,516,111 (+)Ensembl
mRatBN7.2 Ensembl1864,174,002 - 64,240,794 (+)Ensembl
Rnor_6.0 Ensembl1865,814,026 - 65,885,114 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000113824   ⟹   ENSRNOP00000086975
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1864,174,002 - 64,187,615 (+)Ensembl
RefSeq Acc Id: NM_001115025   ⟹   NP_001108497
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81866,449,358 - 66,516,112 (+)NCBI
mRatBN7.21864,174,002 - 64,240,795 (+)NCBI
Rnor_6.01865,814,026 - 65,885,115 (+)NCBI
Rnor_5.01864,990,480 - 65,060,941 (+)NCBI
RGSC_v3.41867,281,440 - 67,348,558 (+)RGD
Celera1862,237,373 - 62,304,615 (+)RGD
Sequence:
RefSeq Acc Id: XM_063277586   ⟹   XP_063133656
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81866,449,202 - 66,507,200 (+)NCBI
RefSeq Acc Id: XM_063277587   ⟹   XP_063133657
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81866,449,196 - 66,463,352 (+)NCBI
RefSeq Acc Id: NP_001108497   ⟸   NM_001115025
- UniProtKB: B0BNM2 (UniProtKB/TrEMBL),   D4A986 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000016112   ⟸   ENSRNOT00000016112
Ensembl Acc Id: ENSRNOP00000086975   ⟸   ENSRNOT00000113824
RefSeq Acc Id: XP_063133657   ⟸   XM_063277587
- Peptide Label: isoform X2
- UniProtKB: A0A8I6AFM4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063133656   ⟸   XM_063277586
- Peptide Label: isoform X1
Protein Domains
MBD

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A986-F1-model_v2 AlphaFold D4A986 1-412 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700855
Promoter ID:EPDNEW_R11378
Type:initiation region
Name:Mbd2_1
Description:methyl-CpG binding domain protein 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01865,814,057 - 65,814,117EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1595452 AgrOrtholog
BioCyc Gene G2FUF-7071 BioCyc
Ensembl Genes ENSRNOG00000011853 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000016112 ENTREZGENE
  ENSRNOT00000016112.9 UniProtKB/TrEMBL
Gene3D-CATH Methyl-cpg-binding Protein 2, Chain A UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7934371 IMAGE-MGC_LOAD
InterPro DNA-bd_integrase-typ UniProtKB/TrEMBL
  MBD2/MBD3_p55-bd UniProtKB/TrEMBL
  MeCpG-bd_2/3_C_dom UniProtKB/TrEMBL
  Methyl_CpG_DNA-bd UniProtKB/TrEMBL
KEGG Report rno:680172 UniProtKB/TrEMBL
MGC_CLONE MGC:188552 IMAGE-MGC_LOAD
NCBI Gene 680172 ENTREZGENE
PANTHER METHYL-CPG BINDING PROTEIN, MBD UniProtKB/TrEMBL
  METHYL-CPG-BINDING DOMAIN PROTEIN 2 UniProtKB/TrEMBL
Pfam MBD UniProtKB/TrEMBL
  MBD_C UniProtKB/TrEMBL
  MBDa UniProtKB/TrEMBL
PhenoGen Mbd2 PhenoGen
PROSITE MBD UniProtKB/TrEMBL
RatGTEx ENSRNOG00000011853 RatGTEx
SMART MBD UniProtKB/TrEMBL
Superfamily-SCOP DNA-binding_integrase-type UniProtKB/TrEMBL
UniProt A0A8I6AFM4 ENTREZGENE
  B0BNM2 ENTREZGENE, UniProtKB/TrEMBL
  D4A986 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-05-01 Mbd2  methyl-CpG binding domain protein 2  LOC684150  similar to Methyl-CpG-binding domain protein 2 (Methyl-CpG-binding protein MBD2)  Data merged from RGD:1593905 737654 APPROVED
2008-03-05 Mbd2  methyl-CpG binding domain protein 2  LOC680172  similar to Methyl-CpG-binding domain protein 2 (Methyl-CpG-binding protein MBD2)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC680172  similar to Methyl-CpG-binding domain protein 2 (Methyl-CpG-binding protein MBD2)      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-20 LOC684150  similar to Methyl-CpG-binding domain protein 2 (Methyl-CpG-binding protein MBD2)      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-01-12 Mbd2_predicted  methyl-CpG binding domain protein 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED