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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1595452
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mbd2
Name: methyl-CpG binding domain protein 2
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mbd2affects expressionEXP 6480464CTDTetrachlorodibenzodioxin affects the expression of MBD2 mRNAPMID:34747641
Mbd2multiple interactionsISOMBD2 (Homo sapiens)6480464CTD[Estradiol co-treated with Tetrachlorodibenzodioxin] promotes the reaction [MBD2 protein binds to BRCA1 promoter]; Resveratrol inhibits the reaction [[Estradiol co-treated with Tetrachlorodibenzodioxin] promotes the reaction [MBD2 protein binds to BRCA1 promoter]]; Resveratrol inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [MBD2 protein binds to BRCA1 promoter]]; Tetrachlorodibenzodioxin inhibits the reaction [MBD2 protein binds to BRCA1 promoter]; Tetrachlorodibenzodioxin promotes the reaction [MBD2 protein binds to BRCA1 promoter]PMID:20631324 PMID:22197621
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