Oc90 (otoconin 90) - Rat Genome Database

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Gene: Oc90 (otoconin 90) Rattus norvegicus
Analyze
Symbol: Oc90
Name: otoconin 90
RGD ID: 1593441
Description: Predicted to enable several functions, including calcium ion binding activity; calcium-dependent phospholipase A2 activity; and phospholipid binding activity. Predicted to be involved in otolith mineralization; phosphatidylcholine metabolic process; and phosphatidylglycerol metabolic process. Predicted to be located in extracellular region and membrane. Predicted to be active in extracellular matrix. Orthologous to human OC90 (otoconin 90); INTERACTS WITH 2,2',5,5'-tetrachlorobiphenyl; 6-propyl-2-thiouracil; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC690625; otoconin-90; otoconin-90-like; similar to Otoconin 90 precursor (Oc90) (Otoconin-95) (Oc95)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8799,524,975 - 99,558,386 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl799,524,975 - 99,558,386 (-)EnsemblGRCr8
mRatBN7.2797,635,890 - 97,669,303 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl797,635,890 - 97,669,416 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx799,389,432 - 99,422,935 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07101,591,090 - 101,624,593 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07101,510,430 - 101,543,933 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.07106,615,859 - 106,697,089 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7106,619,326 - 106,653,567 (-)Ensemblrn6Rnor6.0
Rnor_5.07106,389,398 - 106,417,375 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47103,230,625 - 103,264,151 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera794,190,792 - 94,224,290 (-)NCBICelera
Cytogenetic Map7q33NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9892667   PMID:12651873   PMID:15632090   PMID:21655225   PMID:24748133   PMID:34403090  


Genomics

Comparative Map Data
Oc90
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8799,524,975 - 99,558,386 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl799,524,975 - 99,558,386 (-)EnsemblGRCr8
mRatBN7.2797,635,890 - 97,669,303 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl797,635,890 - 97,669,416 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx799,389,432 - 99,422,935 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07101,591,090 - 101,624,593 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07101,510,430 - 101,543,933 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.07106,615,859 - 106,697,089 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7106,619,326 - 106,653,567 (-)Ensemblrn6Rnor6.0
Rnor_5.07106,389,398 - 106,417,375 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47103,230,625 - 103,264,151 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera794,190,792 - 94,224,290 (-)NCBICelera
Cytogenetic Map7q33NCBI
OC90
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh388132,024,216 - 132,059,382 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl8132,024,216 - 132,059,382 (-)Ensemblhg38GRCh38
GRCh378133,036,463 - 133,071,629 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 368133,105,910 - 133,131,298 (-)NCBIBuild 36Build 36hg18NCBI36
Celera8129,212,212 - 129,247,331 (-)NCBICelera
Cytogenetic Map8q24.22NCBI
HuRef8128,354,049 - 128,389,180 (-)NCBIHuRef
CHM1_18133,076,804 - 133,112,437 (-)NCBICHM1_1
T2T-CHM13v2.08133,147,149 - 133,182,286 (-)NCBIT2T-CHM13v2.0
Oc90
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391565,747,899 - 65,784,260 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1565,747,902 - 65,784,246 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381565,876,050 - 65,912,411 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1565,876,053 - 65,912,397 (-)Ensemblmm10GRCm38
MGSCv371565,707,619 - 65,740,615 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361565,705,730 - 65,738,726 (-)NCBIMGSCv36mm8
Celera1567,383,723 - 67,416,687 (-)NCBICelera
Cytogenetic Map15D1NCBI
cM Map1529.16NCBI
Oc90
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554616,697,936 - 6,723,172 (-)Ensembl
ChiLan1.0NW_0049554616,697,930 - 6,729,764 (-)NCBIChiLan1.0ChiLan1.0
OC90
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v27149,406,762 - 149,442,651 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan18124,921,364 - 124,957,250 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v08128,672,427 - 128,708,307 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.18131,650,395 - 131,685,172 (-)NCBIPanPan1.1PanPan1.1panPan2
OC90
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11328,680,910 - 28,700,816 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1328,653,732 - 28,681,822 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01329,035,487 - 29,060,155 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
UMICH_Zoey_3.11328,762,634 - 28,790,706 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01328,862,287 - 28,886,939 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01329,174,271 - 29,198,930 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Oc90
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244053039,642,906 - 9,673,254 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647017,072,435 - 17,099,118 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647017,072,435 - 17,099,520 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
OC90
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl49,018,994 - 9,053,372 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.149,028,483 - 9,054,503 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.249,060,872 - 9,089,157 (+)NCBISscrofa10.2Sscrofa10.2susScr3
OC90
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.18126,468,666 - 126,500,293 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl8126,469,272 - 126,499,919 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603913,604,150 - 13,639,411 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Oc90
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473523,825,939 - 23,855,799 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473523,829,050 - 23,856,026 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Oc90
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11240,038,289 - 240,072,154 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Oc90
272 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:174
Count of miRNA genes:131
Interacting mature miRNAs:144
Transcripts:ENSRNOT00000042522
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)792388565119280177Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)782111245123048330Rat
2317035Aia16Adjuvant induced arthritis QTL 162.71joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)771103011106126789Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)731770293110435881Rat
70159Bp61Blood pressure QTL 610.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)773618702118618702Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)793302009131686183Rat
1298525Cm1Cardiac mass QTL 12.7heart mass (VT:0007028)heart wet weight (CMO:0000069)756625161101625161Rat
1357338Stl17Serum triglyceride level QTL 173.23blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)771621154114982716Rat
61397Bw17Body weight QTL 176.3body mass (VT:0001259)body weight (CMO:0000012)795485047137014596Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)746307490127866166Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)785043242130043242Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)785497398130497398Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)792362341137014596Rat
1331723Bw25Body weight QTL 253.348body mass (VT:0001259)body weight (CMO:0000012)796700404111672180Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)783626689128626689Rat
631529Tls2T-lymphoma susceptibility QTL 200.001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)782111382132099989Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)798549867137014596Rat
1559283Emca4Estrogen-induced mammary cancer QTL 43.7mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)763889858108889858Rat
1300151Bp181Blood pressure QTL 1813.36arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)755498584105834451Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)71011291699900612Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)71104117804Rat
7411607Foco15Food consumption QTL 150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)777807807122807807Rat
631201Panci1Pancreas inflammation QTL 100.001pancreas integrity trait (VT:0010560)percentage of study population displaying chronic pancreatitis at a point in time (CMO:0001214)773557047118557047Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)71509236116977875Rat
1331768Kidm10Kidney mass QTL 104.62096kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)782111245123048330Rat
2313102Bmd79Bone mineral density QTL 792.30.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)796700404118618702Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)740540077123682549Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)749682832115766396Rat
10450862Kidm55Kidney mass QTL 554.9kidney mass (VT:0002707)kidney weight (CMO:0000081)772725037117725037Rat
1298528Bp169Blood pressure QTL 1690.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)762963207107963207Rat
1331746Kidm9Kidney mass QTL 93.934kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)782111245134948181Rat
1576303Ept7Estrogen-induced pituitary tumorigenesis QTL 73.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)763889858108889858Rat
7411654Foco25Food consumption QTL 259.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)777807807122807807Rat
10450856Livw4Liver weight QTL 43.8liver mass (VT:0003402)liver weight (CMO:0000092)772725037117725037Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)749682832115766396Rat
10402855Bp379Blood pressure QTL 3790.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)778682549123682549Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)749682832115766396Rat
631540Bw9Body weight QTL 94.5body mass (VT:0001259)body weight (CMO:0000012)771621154119349044Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)771827901136544683Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
3 7 17 46 26 26 3 35 3 1 95 68 37 15 25 23 1 1

Sequence


Ensembl Acc Id: ENSRNOT00000042522   ⟹   ENSRNOP00000046821
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl799,524,975 - 99,558,386 (-)Ensembl
mRatBN7.2 Ensembl797,635,890 - 97,669,416 (-)Ensembl
Rnor_6.0 Ensembl7106,619,326 - 106,653,567 (-)Ensembl
RefSeq Acc Id: NM_001134765   ⟹   NP_001128237
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8799,524,975 - 99,558,386 (-)NCBI
mRatBN7.2797,635,890 - 97,669,303 (-)NCBI
Rnor_6.07106,619,326 - 106,653,567 (-)NCBI
Rnor_5.07106,389,398 - 106,417,375 (-)NCBI
RGSC_v3.47103,230,625 - 103,264,151 (-)RGD
Celera794,190,792 - 94,224,290 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001128237 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM16165 (Get FASTA)   NCBI Sequence Viewer  
  EDM16166 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000046821
  ENSRNOP00000046821.4
RefSeq Acc Id: NP_001128237   ⟸   NM_001134765
- Peptide Label: precursor
- UniProtKB: A6HRQ7 (UniProtKB/TrEMBL),   D3Z9Z1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000046821   ⟸   ENSRNOT00000042522
Protein Domains
Phospholipase A2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3Z9Z1-F1-model_v2 AlphaFold D3Z9Z1 1-539 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1593441 AgrOrtholog
BioCyc Gene G2FUF-33130 BioCyc
Ensembl Genes ENSRNOG00000025516 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000042522 ENTREZGENE
  ENSRNOT00000042522.5 UniProtKB/TrEMBL
Gene3D-CATH 1.20.90.10 UniProtKB/TrEMBL
InterPro Otoconin-90 UniProtKB/TrEMBL
  PLipase_A2 UniProtKB/TrEMBL
  PLipase_A2_Asp_AS UniProtKB/TrEMBL
  PLipase_A2_dom UniProtKB/TrEMBL
  PLipase_A2_dom_sf UniProtKB/TrEMBL
  PLipase_A2_His_AS UniProtKB/TrEMBL
KEGG Report rno:690625 UniProtKB/TrEMBL
NCBI Gene 690625 ENTREZGENE
PANTHER OTOCONIN-90 UniProtKB/TrEMBL
  PTHR11716 UniProtKB/TrEMBL
Pfam Phospholip_A2_1 UniProtKB/TrEMBL
PhenoGen Oc90 PhenoGen
PRINTS PHPHLIPASEA2 UniProtKB/TrEMBL
PROSITE PA2_ASP UniProtKB/TrEMBL
  PA2_HIS UniProtKB/TrEMBL
RatGTEx ENSRNOG00000025516 RatGTEx
SMART PA2c UniProtKB/TrEMBL
Superfamily-SCOP SSF48619 UniProtKB/TrEMBL
UniProt A6HRQ7 ENTREZGENE, UniProtKB/TrEMBL
  D3Z9Z1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-17 Oc90  otoconin 90  LOC684671  similar to Otoconin 90 precursor (Oc90) (Otoconin-95) (Oc95)  Data merged from RGD:1587903 1643240 APPROVED
2008-03-06 Oc90  otoconin 90  LOC690625  similar to Otoconin 90 precursor (Oc90) (Otoconin-95) (Oc95)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC690625  similar to Otoconin 90 precursor (Oc90) (Otoconin-95) (Oc95)      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC684671  similar to Otoconin 90 precursor (Oc90) (Otoconin-95) (Oc95)      Symbol and Name status set to provisional 70820 PROVISIONAL