Tmed11 (transmembrane emp24 protein transport domain containing 11) - Rat Genome Database

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Gene: Tmed11 (transmembrane emp24 protein transport domain containing 11) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Tmed11
Name: transmembrane emp24 protein transport domain containing 11
RGD ID: 1588776
Description: Predicted to be involved in Golgi organization; endoplasmic reticulum to Golgi vesicle-mediated transport; and intracellular protein transport. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in several cellular components, including COPII-coated ER to Golgi transport vesicle; Golgi apparatus; and endoplasmic reticulum-Golgi intermediate compartment; INTERACTS WITH bisphenol A; sodium dichromate.
Type: protein-coding
RefSeq Status: INFERRED
Previously known as: LOC689712; similar to Glycoprotein 25L precursor (GP25L); transmembrane emp24 domain-containing protein 11; transmembrane emp24 protein transport domain containing; transmembrane emp24 protein transport domain containing 4-like
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8141,071,410 - 1,091,793 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl141,071,410 - 1,092,026 (+)EnsemblGRCr8
mRatBN7.214926,983 - 947,574 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl14927,001 - 947,321 (+)EnsemblmRatBN7.2
Dahl_SR_JrHsd14816,191 - 836,591 (+)NCBIDahl_SR_JrHsd
Lyon_Normotensive14815,097 - 835,499 (+)NCBILyon_Normotensive
Lyon_Hypertensive14814,062 - 834,452 (+)NCBILyon_Hypertensive
F344_StmMcwi141,095,840 - 1,116,274 (+)NCBIF344_StmMcwi
Rnor_6.0141,936,972 - 1,959,089 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl141,937,041 - 1,957,579 (+)Ensemblrn6Rnor6.0
Rnor_5.0141,932,659 - 1,953,450 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4141,466,847 - 1,487,827 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera14965,819 - 987,611 (+)NCBICelera
Cytogenetic Map14p22NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Variants

.
Variants in Tmed11
80 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:13
Count of miRNA genes:13
Interacting mature miRNAs:13
Transcripts:ENSRNOT00000000040
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411573Bw139Body weight QTL 1394.70.001body mass (VT:0001259)body weight gain (CMO:0000420)14140068101Rat
9589814Gluco67Glucose level QTL 674.540.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)14140068101Rat
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14141415516Rat
71115Niddm15Non-insulin dependent diabetes mellitus QTL 154.8blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)14111334906Rat
71117Niddm17Non-insulin dependent diabetes mellitus QTL 172.35blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)14117877928Rat
70204Niddm20Non-insulin dependent diabetes mellitus QTL 205.10.000008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)14131893212Rat

Markers in Region
D14Got1  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8141,083,398 - 1,083,596 (+)Marker Load Pipeline
mRatBN7.214938,989 - 939,366 (+)MAPPERmRatBN7.2
mRatBN7.214938,989 - 939,187 (+)MAPPERmRatBN7.2
Rnor_6.0141,949,012 - 1,949,438NCBIRnor6.0
Rnor_6.0141,949,012 - 1,949,209NCBIRnor6.0
Rnor_5.0141,944,738 - 1,945,164UniSTSRnor5.0
Rnor_5.0141,944,738 - 1,944,935UniSTSRnor5.0
RGSC_v3.4141,479,488 - 1,479,686RGDRGSC3.4
RGSC_v3.4141,479,489 - 1,479,686UniSTSRGSC3.4
Celera14977,833 - 978,025UniSTS
RGSC_v3.1141,479,488 - 1,479,686RGD
RH 2.0 Map149.8RGD
Cytogenetic Map14p22UniSTS
AI178079  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.214946,752 - 946,879 (+)MAPPERmRatBN7.2
Rnor_6.0141,957,011 - 1,957,137NCBIRnor6.0
Rnor_5.0141,952,737 - 1,952,863UniSTSRnor5.0
RGSC_v3.4141,487,259 - 1,487,385UniSTSRGSC3.4
Celera14985,533 - 985,659UniSTS
Cytogenetic Map14p22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
7 2 10 31 37 35 15 20 15 5 74 44 17 6 39 20

Sequence


Ensembl Acc Id: ENSRNOT00000000040   ⟹   ENSRNOP00000000040
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl141,071,410 - 1,092,026 (+)Ensembl
mRatBN7.2 Ensembl14927,001 - 947,321 (+)Ensembl
Rnor_6.0 Ensembl141,937,041 - 1,957,579 (+)Ensembl
RefSeq Acc Id: NM_001432994   ⟹   NP_001419923
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Dahl_SR_JrHsd14816,191 - 836,591 (+)NCBI
Lyon_Normotensive14815,097 - 835,499 (+)NCBI
Lyon_Hypertensive14814,062 - 834,452 (+)NCBI
F344_StmMcwi141,095,840 - 1,116,274 (+)NCBI
RefSeq Acc Id: XM_001071744   ⟹   XP_001071744
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8141,071,410 - 1,091,793 (+)NCBI
mRatBN7.214926,983 - 947,574 (+)NCBI
Rnor_6.0141,936,972 - 1,959,089 (+)NCBI
Rnor_5.0141,932,659 - 1,953,450 (+)NCBI
RGSC_v3.4141,466,847 - 1,487,827 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001419923 (Get FASTA)   NCBI Sequence Viewer  
  XP_001071744 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000000040
  ENSRNOP00000000040.1
RefSeq Acc Id: XP_001071744   ⟸   XM_001071744
- Sequence:
Ensembl Acc Id: ENSRNOP00000000040   ⟸   ENSRNOT00000000040
RefSeq Acc Id: NP_001419923   ⟸   NM_001432994
Protein Domains
GOLD

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZE21-F1-model_v2 AlphaFold D3ZE21 1-214 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699158
Promoter ID:EPDNEW_R9666
Type:single initiation site
Name:Tmed11_1
Description:transmembrane emp24 protein transport domain containing 11
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0141,936,986 - 1,937,046EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1588776 AgrOrtholog
BioCyc Gene G2FUF-16688 BioCyc
Ensembl Genes ENSRNOG00000000035 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000000040 ENTREZGENE
  ENSRNOT00000000040.4 UniProtKB/TrEMBL
InterPro GOLD UniProtKB/TrEMBL
  TMP21-related UniProtKB/TrEMBL
KEGG Report rno:689712 UniProtKB/TrEMBL
NCBI Gene 689712 ENTREZGENE
PANTHER PTHR22811 UniProtKB/TrEMBL
Pfam EMP24_GP25L UniProtKB/TrEMBL
PhenoGen Tmed11 PhenoGen
PROSITE GOLD UniProtKB/TrEMBL
RatGTEx ENSRNOG00000000035 RatGTEx
SMART EMP24_GP25L UniProtKB/TrEMBL
UniProt D3ZE21 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-05-24 Tmed11  transmembrane emp24 protein transport domain containing 11  LOC100363761  transmembrane emp24 protein transport domain containing 4-like  Data merged from RGD:2322390 1643240 APPROVED
2012-02-03 Tmed11  transmembrane emp24 protein transport domain containing 11  Tmed11  transmembrane emp24 protein transport domain containing  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-05-06 LOC100363761  transmembrane emp24 protein transport domain containing 4-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2010-02-12 Tmed11  transmembrane emp24 protein transport domain containing  LOC689712  similar to Glycoprotein 25L precursor (GP25L)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-01-09 LOC689712  similar to Glycoprotein 25L precursor (GP25L)  LOC682110  similar to Glycoprotein 25L precursor (GP25L)  Data merged from RGD:1586975 1643240 APPROVED
2006-11-19 LOC689712  similar to Glycoprotein 25L precursor (GP25L)      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC682110  similar to Glycoprotein 25L precursor (GP25L)      Symbol and Name status set to provisional 70820 PROVISIONAL