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Gene: Tmed11 (transmembrane emp24 protein transport domain containing 11) Rattus norvegicus

Analyze

No known orthologs.

Symbol:

Tmed11

Name:

transmembrane emp24 protein transport domain containing 11

RGD ID:

1588776

Description:

Predicted to be involved in Golgi organization; endoplasmic reticulum to Golgi vesicle-mediated transport; and intracellular protein transport. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in several cellular components, including COPII-coated ER to Golgi transport vesicle; Golgi apparatus; and endoplasmic reticulum-Golgi intermediate compartment; INTERACTS WITH bisphenol A; sodium dichromate.

Type:

protein-coding

RefSeq Status:

INFERRED

Previously known as:

LOC689712; similar to Glycoprotein 25L precursor (GP25L); transmembrane emp24 domain-containing protein 11; transmembrane emp24 protein transport domain containing; transmembrane emp24 protein transport domain containing 4-like

RGD Orthologs

Alliance Orthologs

More Info

homologs ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Other homologs ²				less info ...
Homo sapiens (human):	RGS7 (regulator of G protein signaling 7)	HGNC	OMA
Alliance orthologs ³
Mus musculus (house mouse):	Tmed11 (transmembrane p24 trafficking protein 11)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	si:ch211-255i20.3	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)
Saccharomyces cerevisiae (baker's yeast):	ERP1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	T08D2.1	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PhylomeDB)
Saccharomyces cerevisiae (baker's yeast):	ERP5	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	ERP6	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	gp25l	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	14	1,071,410 - 1,091,793 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	14	1,071,410 - 1,092,026 (+)	Ensembl				GRCr8
mRatBN7.2	14	926,983 - 947,574 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	927,001 - 947,321 (+)	Ensembl				mRatBN7.2
Rnor_6.0	14	1,936,972 - 1,959,089 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	1,937,041 - 1,957,579 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	14	1,932,659 - 1,953,450 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	14	1,466,847 - 1,487,827 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	14	965,819 - 987,611 (+)	NCBI		Celera
Cytogenetic Map	14	p22	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

bisphenol A (EXP)

sodium dichromate (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

endoplasmic reticulum to Golgi vesicle-mediated transport (IBA)

Golgi organization (IBA)

intracellular protein transport (IBA)

Cellular Component

COPII-coated ER to Golgi transport vesicle (IBA)

endoplasmic reticulum (IBA)

endoplasmic reticulum membrane (IEA)

endoplasmic reticulum-Golgi intermediate compartment (IBA)

Golgi apparatus (IBA)

membrane (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Genomics

Variants

Variants in Tmed11
80 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	13
Count of miRNA genes:	13
Interacting mature miRNAs:	13
Transcripts:	ENSRNOT00000000040
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
7411573	Bw139	Body weight QTL 139	4.7	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	14	1	40068101	Rat
9589814	Gluco67	Glucose level QTL 67	4.54	0.001	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	14	1	40068101	Rat
634352	Apr6	Acute phase response QTL 6	3.7		blood interleukin-6 amount (VT:0008595)	plasma interleukin-6 level (CMO:0001927)	14	1	41415516	Rat
71115	Niddm15	Non-insulin dependent diabetes mellitus QTL 15	4.8		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	14	1	11334906	Rat
71117	Niddm17	Non-insulin dependent diabetes mellitus QTL 17	2.35		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	14	1	17877928	Rat
70204	Niddm20	Non-insulin dependent diabetes mellitus QTL 20	5.1	0.000008	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	14	1	31893212	Rat

Markers in Region

D14Got1

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	14	1,083,398 - 1,083,596 (+)	Marker Load Pipeline
mRatBN7.2	14	938,989 - 939,366 (+)	MAPPER	mRatBN7.2
mRatBN7.2	14	938,989 - 939,187 (+)	MAPPER	mRatBN7.2
Rnor_6.0	14	1,949,012 - 1,949,438	NCBI	Rnor6.0
Rnor_6.0	14	1,949,012 - 1,949,209	NCBI	Rnor6.0
Rnor_5.0	14	1,944,738 - 1,945,164	UniSTS	Rnor5.0
Rnor_5.0	14	1,944,738 - 1,944,935	UniSTS	Rnor5.0
RGSC_v3.4	14	1,479,488 - 1,479,686	RGD	RGSC3.4
RGSC_v3.4	14	1,479,489 - 1,479,686	UniSTS	RGSC3.4
Celera	14	977,833 - 978,025	UniSTS
RGSC_v3.1	14	1,479,488 - 1,479,686	RGD
RH 2.0 Map	14	9.8	RGD
Cytogenetic Map	14	p22	UniSTS

AI178079

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	14	946,752 - 946,879 (+)	MAPPER	mRatBN7.2
Rnor_6.0	14	1,957,011 - 1,957,137	NCBI	Rnor6.0
Rnor_5.0	14	1,952,737 - 1,952,863	UniSTS	Rnor5.0
RGSC_v3.4	14	1,487,259 - 1,487,385	UniSTS	RGSC3.4
Celera	14	985,533 - 985,659	UniSTS
Cytogenetic Map	14	p22	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
7	2	10	31	37	35	15	19	15	5	73	43	17	6	39	20

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001432994	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_001071744	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_003752699	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAXUCZ010000014	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000000040 ⟹ ENSRNOP00000000040

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	14	1,071,410 - 1,092,026 (+)	Ensembl
mRatBN7.2 Ensembl	14	927,001 - 947,321 (+)	Ensembl
Rnor_6.0 Ensembl	14	1,937,041 - 1,957,579 (+)	Ensembl

RefSeq Acc Id:

XM_001071744 ⟹ XP_001071744

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	14	1,071,410 - 1,091,793 (+)	NCBI
mRatBN7.2	14	926,983 - 947,574 (+)	NCBI
Rnor_6.0	14	1,936,972 - 1,959,089 (+)	NCBI
Rnor_5.0	14	1,932,659 - 1,953,450 (+)	NCBI
RGSC_v3.4	14	1,466,847 - 1,487,827 (+)	RGD

Sequence:

show sequence

CCCTATAAACAGTCACTTGTAACTGCTTCATTTCAAAGAAAGGACCTTGGGCTGGCTAATGCTG
TAGAGATGCAAACTCAGACAATTCTCTTATGTTTCAGTTTTTCCTTTTCAGCTGCTTTTTATTT
CCATGCTGGGGAGCGAGAGGAGAAATGTATAATCGAAGACATTCCAAGTGACACGTTGATAACA
GGGACATTCAAGATACAGCAGTGGGACATTGGTAGACATGACTTTCTTGAATCTGCTCCTGGCT
TAGGAATGTTTGTGACTGTTACAAACAATGATGAGGTATTATTATCCAAGTTATATGGTGCACA
AGGGACATTCTATTTTACTTCACACTCATCTGGTGAACACATCATTTGCTTAGAATCTAATTCT
ACACAATTTGTGTCATTTGGAGGGAGTAAGCTGCGCATCCACTTAGATATTCGAGTTGGAGAGC
ATGACCTTGATGCAGTTATTGTTCAAGCAAAGGACAAAGTTAATGAAGTAGCCTTCACGCTTCG
ACATCTAATTGAACAAATTGAACAAATACTCAAAGAACAAGACTATCAAAGGGACCGTGAGGAA
AATTTCCGTATCACCAGTGAAGATACCAATAGAAATGTTTTATGGTGGGCTTTCGCACAAATAT
TAATCTTTATCTCAGTTGGAATTTTTCAAATGAAGCACCTTAAAGATTTCTTCATAGCTAAGAA
GCTTGTTTAAAACACAAGTTAAAGTAAATAATTTGTACAATGTTTGAGTTAATAAACCAAAATA
CATGCATAAGTCTGCTATTTTCTGATTTAAAAGATATTAGATATTGAAGTTAATATTATAGATG
GCATTCCTGGTTTTTAAAAAGTGTCACTTTAATAATGTAGCTTCTGAATGTGGTAAAAAAAAAA
TAAGCACGTCGTTTTAATTTAAACTTGATATAAATCAGCAATACCAAATGAGCTACAGATGCAA
TTTTAAGTTATTTGGTCACACATTAAAAAAAAAAAGATTTTATGTTCTATCTATCTATCCATCT
CCCCTTCTCTCTCTGCAAGCGGATCCTTTCTCTTTTTTTCTTCCCCTCTTACTCCCTTATCCCC
ATGACAATTTCCCTGGCCTCAGTCCTTGGGGCCAGTAAACAGCTTCCCCAAAAACCTGCCTTTA
ATATTAAAAGAAAGAGGATTTTACAAAAGGGTACATTTTAATAATTGTGGAACCAGGTGGTGGT
AGTGCTAGCAACACCTTTAATAACATCGCTTGGGAGGCAGAGACAGGTGGTTCTCTGAATTCGA
GGCCAGCTGAGTCTACAGAGTAAGTTTCAGACTACACAGAGAAGCTCTTTATCAAGAAGGGGAG
AGGGGGACAGGGACCTTTGTGGCATATATTTATCATAGCATACCAAACAAAGTACTATCAGTCA
GAGCATGTCACATTGGCTTCTACTGCTGCTCTTAAGGAGACTGAAGCAGGAAGATCCCCAGAGC
CCCCAAGTAGAGACCAGACTGACAGCAGACTTAGTCACTGTTCTACTGATGTGAAGAGACACCA
TGACTAAGGCAACTCTTATTAAAGAACACATTTAATTGGGAGTCTGCGTACAGTTGCACAGGTT
TAATCTATTACCATCATGTTGGGGAGCATGGTGGCATGTAGGCAGGTGCTGGAGCAGTAGTTGA
GAGCTATATCCTGATCCACACAAGGTGGTGGGGAGGGAGGACTATGTCTGACATGGGCTTTTCA
AAGCCTTTTCTAGTGTCAAACTTCCACCAACAAGGTCATACCTGCTAATCGTTATAACTCTAAT
ATTGCCACTCTCCATTAACTAAGCATTCAAATCCCTAGTGGATAAGCATTCAAATATATAGGGG
CTACATTCTTACCCAAACCAACACAGAGACCTTCTCTCATAAACATGGGAGTGCAACACAAAGA
AACAAAGCTACTTTAATTTTAATGTATACTCAATACAAAGTAGATAAGATATTTTATATCTTTT
TAATCATACTACATTTGTAAACAAGTATATTTTTAGGACTTGATGAAACTCACAACTGCAGTAC
TGCACAAATACATTCTTTCCCCAAATTACTTCACTAAGAAACACAGTCACCTGAATCTTTACTT
TTTCCTAATTCCTTGAAAAACACTAAACTTTGCTCCATAGAAGTAAATAGCTCAGGAATTTTCT
CACACAGACTCTATGGATCCAAGCACACTTAGGAAGTGGGGAGGAAAG

hide sequence

Protein Sequences


Protein RefSeqs	NP_001419923	(Get FASTA)	NCBI Sequence Viewer
	XP_001071744	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000000040
	ENSRNOP00000000040.1

RefSeq Acc Id:

XP_001071744 ⟸ XM_001071744

- Sequence:

show sequence

MQTQTILLCFSFSFSAAFYFHAGEREEKCIIEDIPSDTLITGTFKIQQWDIGRHDFLESAPGLG
MFVTVTNNDEVLLSKLYGAQGTFYFTSHSSGEHIICLESNSTQFVSFGGSKLRIHLDIRVGEHD
LDAVIVQAKDKVNEVAFTLRHLIEQIEQILKEQDYQRDREENFRITSEDTNRNVLWWAFAQILI
FISVGIFQMKHLKDFFIAKKLV

hide sequence

Ensembl Acc Id:

ENSRNOP00000000040 ⟸ ENSRNOT00000000040

Protein Domains

GOLD

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZE21-F1-model_v2	AlphaFold	D3ZE21	1-214	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13699158

Promoter ID:

EPDNEW_R9666

Type:

single initiation site

Name:

Tmed11_1

Description:

transmembrane emp24 protein transport domain containing 11

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	14	1,936,986 - 1,937,046	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1588776	AgrOrtholog
BioCyc Gene	G2FUF-16688	BioCyc
Ensembl Genes	ENSRNOG00000000035	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000000040	ENTREZGENE
	ENSRNOT00000000040.4	UniProtKB/TrEMBL
InterPro	GOLD	UniProtKB/TrEMBL
	TMP21-related	UniProtKB/TrEMBL
KEGG Report	rno:689712	UniProtKB/TrEMBL
NCBI Gene	689712	ENTREZGENE
PANTHER	PTHR22811	UniProtKB/TrEMBL
Pfam	EMP24_GP25L	UniProtKB/TrEMBL
PhenoGen	Tmed11	PhenoGen
PROSITE	GOLD	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000000035	RatGTEx
SMART	EMP24_GP25L	UniProtKB/TrEMBL
UniProt	D3ZE21	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2013-05-24	Tmed11	transmembrane emp24 protein transport domain containing 11	LOC100363761	transmembrane emp24 protein transport domain containing 4-like	Data merged from RGD:2322390	1643240	APPROVED
2012-02-03	Tmed11	transmembrane emp24 protein transport domain containing 11	Tmed11	transmembrane emp24 protein transport domain containing	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2010-05-06	LOC100363761	transmembrane emp24 protein transport domain containing 4-like			Symbol and Name status set to provisional	70820	PROVISIONAL
2010-02-12	Tmed11	transmembrane emp24 protein transport domain containing	LOC689712	similar to Glycoprotein 25L precursor (GP25L)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-01-09	LOC689712	similar to Glycoprotein 25L precursor (GP25L)	LOC682110	similar to Glycoprotein 25L precursor (GP25L)	Data merged from RGD:1586975	1643240	APPROVED
2006-11-19	LOC689712	similar to Glycoprotein 25L precursor (GP25L)			Symbol and Name status set to provisional	70820	PROVISIONAL
2006-11-19	LOC682110	similar to Glycoprotein 25L precursor (GP25L)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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