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Gene: Usp4 (ubiquitin specific peptidase 4) Rattus norvegicus

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Symbol:

Usp4

Name:

ubiquitin specific peptidase 4

RGD ID:

1587387

Description:

Predicted to enable adenosine receptor binding activity; cysteine-type deubiquitinase activity; and identical protein binding activity. Predicted to be involved in several processes, including positive regulation of TORC1 signaling; protein localization to cell surface; and spliceosomal tri-snRNP complex assembly. Predicted to act upstream of or within several processes, including TORC1 signaling; negative regulation of TORC1 signaling; and regulation of translational initiation. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Orthologous to human USP4 (ubiquitin specific peptidase 4); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 3,4-methylenedioxymethamphetamine; aconitine.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

deubiquitinating enzyme 4; LOC290864; similar to Ubiquitin carboxyl-terminal hydrolase 4 (Ubiquitin thiolesterase 4) (Ubiquitin-specific processing protease 4) (Deubiquitinating enzyme 4) (Ubiquitous nuclear protein); ubiquitin carboxyl-terminal hydrolase 4; ubiquitin specific peptidase 4 (proto-oncogene); ubiquitin specific protease 4; ubiquitin specific protease 4 (proto-oncogene); ubiquitin thioesterase 4; ubiquitin-specific-processing protease 4

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	USP4 (ubiquitin specific peptidase 4)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, Panther, PhylomeDB
Mus musculus (house mouse):	Usp4 (ubiquitin specific peptidase 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Usp4 (ubiquitin specific peptidase 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	LOC100967331 (ubiquitin carboxyl-terminal hydrolase 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	USP4 (ubiquitin specific peptidase 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Usp4 (ubiquitin specific peptidase 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	USP4 (ubiquitin specific peptidase 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	USP4 (ubiquitin specific peptidase 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Usp4 (ubiquitin specific peptidase 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Usp4 (ubiquitin specific peptidase 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	USP4 (ubiquitin specific peptidase 4)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Usp4 (ubiquitin specific peptidase 4)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	usp4 (ubiquitin specific peptidase 4 (proto-oncogene))	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	UBP12	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	UBP12	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	H34C03.2	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	H34C03.2	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	usp4	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	usp4	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	117,912,576 - 117,957,934 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	8	117,914,614 - 117,957,949 (+)	Ensembl				GRCr8
mRatBN7.2	8	109,035,402 - 109,079,382 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	109,036,099 - 109,080,427 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	8	114,663,178 - 114,706,678 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	112,862,508 - 112,906,009 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	110,705,153 - 110,748,655 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	117,126,692 - 117,171,012 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	117,126,692 - 117,171,012 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	8	116,474,812 - 116,519,375 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
Celera	8	108,338,833 - 108,383,118 (+)	NCBI		Celera
Cytogenetic Map	8	q32	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

hepatocellular carcinoma (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (EXP)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

3,3',4,4'-tetrachlorobiphenyl (ISO)

3,4-methylenedioxymethamphetamine (EXP,ISO)

4,4'-diaminodiphenylmethane (ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

aconitine (EXP)

allethrin (EXP)

antirheumatic drug (ISO)

arsenite(3-) (ISO)

benzo[a]pyrene (EXP,ISO)

beta-lapachone (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

Brodifacoum (EXP)

Butylbenzyl phthalate (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

caffeine (ISO)

clofibrate (EXP)

coumestrol (ISO)

cyclosporin A (ISO)

cyhalothrin (EXP)

cylindrospermopsin (ISO)

cypermethrin (EXP)

decabromodiphenyl ether (EXP)

Dibutyl phosphate (ISO)

elemental selenium (ISO)

ellagic acid (ISO)

fenofibrate (EXP)

fenthion (ISO)

fenvalerate (EXP)

finasteride (EXP)

folic acid (ISO)

FR900359 (ISO)

ivermectin (ISO)

methidathion (ISO)

methyl methanesulfonate (ISO)

ozone (EXP)

paracetamol (ISO)

perfluorooctane-1-sulfonic acid (ISO)

phlorizin (ISO)

pirinixic acid (EXP,ISO)

pyrethrins (EXP)

quercetin (ISO)

resveratrol (ISO)

selenium atom (ISO)

sodium arsenite (ISO)

sodium fluoride (ISO)

tetrachloromethane (ISO)

thiram (ISO)

titanium dioxide (ISO)

torcetrapib (ISO)

triphenyl phosphate (ISO)

valproic acid (ISO)

vinclozolin (EXP)

vitamin E (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

negative regulation of protein ubiquitination (IEA,ISO,ISS)

positive regulation of TORC1 signaling (IEA,ISO,ISS)

protein deubiquitination (IEA,ISO,ISS)

protein localization to cell surface (IEA,ISO,ISS)

proteolysis (IEA)

regulation of protein stability (IEA,ISO,ISS)

spliceosomal tri-snRNP complex assembly (IEA,ISO,ISS)

Cellular Component

cytoplasm (IEA,ISO,ISS)

cytosol (IEA,ISO)

nucleoplasm (IEA,ISO)

nucleus (IBA,IEA,ISO,ISS)

Molecular Function

adenosine receptor binding (IEA,ISO)

cysteine-type deubiquitinase activity (IEA,ISO,ISS)

cysteine-type peptidase activity (IEA)

hydrolase activity (IEA)

identical protein binding (IEA,ISO)

metal ion binding (IEA)

peptidase activity (IEA)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	GOA pipeline	RGD automated data pipeline
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12477932	PMID:16316627	PMID:16339847	PMID:16472766	PMID:20595234	PMID:22001210	PMID:22871113	PMID:27114249	PMID:28755289

Genomics

Comparative Map Data

Usp4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	117,912,576 - 117,957,934 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	8	117,914,614 - 117,957,949 (+)	Ensembl				GRCr8
mRatBN7.2	8	109,035,402 - 109,079,382 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	109,036,099 - 109,080,427 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	8	114,663,178 - 114,706,678 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	112,862,508 - 112,906,009 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	110,705,153 - 110,748,655 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	117,126,692 - 117,171,012 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	117,126,692 - 117,171,012 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	8	116,474,812 - 116,519,375 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
Celera	8	108,338,833 - 108,383,118 (+)	NCBI		Celera
Cytogenetic Map	8	q32	NCBI

USP4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	3	49,277,144 - 49,340,053 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	3	49,277,144 - 49,340,712 (-)	Ensembl			hg38	GRCh38
GRCh37	3	49,314,577 - 49,377,486 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	49,289,997 - 49,352,519 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	3	49,289,997 - 49,352,519	NCBI
Celera	3	49,278,021 - 49,342,350 (-)	NCBI		Celera
Cytogenetic Map	3	p21.31	NCBI
HuRef	3	49,371,896 - 49,436,532 (-)	NCBI		HuRef
CHM1_1	3	49,267,379 - 49,330,367 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	3	49,305,224 - 49,369,431 (-)	NCBI		T2T-CHM13v2.0

Usp4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	108,223,763 - 108,269,744 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	9	108,225,052 - 108,269,744 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	9	108,346,564 - 108,392,545 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	108,347,853 - 108,392,545 (+)	Ensembl			mm10	GRCm38
MGSCv37	9	108,250,162 - 108,294,860 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	9	108,205,963 - 108,250,621 (+)	NCBI		MGSCv36	mm8
Celera	9	107,957,048 - 108,001,736 (+)	NCBI		Celera
Cytogenetic Map	9	F2	NCBI
cM Map	9	59.25	NCBI

Usp4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955532	1,247,110 - 1,285,121 (-)	Ensembl
ChiLan1.0	NW_004955532	1,247,110 - 1,284,564 (-)	NCBI	ChiLan1.0	ChiLan1.0

LOC100967331
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	2	49,253,962 - 49,320,547 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	3	49,258,730 - 49,325,329 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	3	49,199,328 - 49,263,861 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	3	50,279,642 - 50,343,901 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	3	50,279,642 - 50,343,903 (-)	Ensembl			panPan2	panpan1.1

USP4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	39,899,880 - 39,952,959 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	20	39,899,897 - 39,952,420 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	20	39,818,226 - 39,871,287 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	20	40,256,219 - 40,309,777 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	20	40,256,236 - 40,309,829 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	20	39,623,674 - 39,676,723 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	20	40,027,139 - 40,080,595 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	20	40,306,950 - 40,360,016 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Usp4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	64,180,540 - 64,229,266 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936529	938,501 - 989,884 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936529	941,042 - 989,781 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

USP4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	31,848,851 - 31,904,243 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	13	31,844,780 - 31,904,418 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	13	35,075,799 - 35,135,425 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

USP4
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	22	10,672,920 - 10,735,374 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	22	10,672,388 - 10,732,104 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666041	156,278,755 - 156,354,831 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Usp4
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624730	3,253,407 - 3,306,341 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624730	3,252,980 - 3,306,439 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Usp4
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	8	99,678,118 - 99,720,728 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Usp4
402 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	166
Count of miRNA genes:	99
Interacting mature miRNAs:	102
Transcripts:	ENSRNOT00000071561, ENSRNOT00000073725
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2303171	Bp331	Blood pressure QTL 331	5.57	0.005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	105462581	132782436	Rat
1549909	Stresp11	Stress response QTL 11	6.83	0.0019	stress-related behavior trait (VT:0010451)	number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)	8	82352698	127352698	Rat
631210	Bw3	Body weight QTL3	5.9		mesenteric fat pad mass (VT:0010427)	mesenteric fat pad weight to body weight ratio (CMO:0000654)	8	61019838	121662124	Rat
1554321	Bmd3	Bone mineral density QTL 3	7.9	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	8	49849908	118871671	Rat
9590292	Uminl3	Urine mineral level QTL 3	3.62	0.001	urine mineral amount (VT:0015086)	urine electrolyte level (CMO:0000593)	8	80768445	125768445	Rat
8694446	Bw170	Body weight QTL 170	12.07	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	8	80768445	125768445	Rat
631650	Stl6	Serum triglyceride level QTL 6	4	0.0019	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	8	70041301	121080908	Rat
1581557	Eae16	Experimental allergic encephalomyelitis QTL 16	3.8		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	8	68690349	119799881	Rat
10450865	Bw175	Body weight QTL 175	4.1		total fat pad mass (VT:0015008)	adipose tissue molecular composition measurement (CMO:0000484)	8	84192326	129192326	Rat
738011	Anxrr9	Anxiety related response QTL 9	6.1		exploratory behavior trait (VT:0010471)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	8	102413464	132782436	Rat
724539	Cm19	Cardiac mass QTL 19	2.6		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	8	103375781	129871912	Rat
70197	BpQTLcluster8	Blood pressure QTL cluster 8	3.482		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	55428333	127966348	Rat
634332	Pia18	Pristane induced arthritis QTL 18	4		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	8	84192326	132782436	Rat
2300181	Bmd55	Bone mineral density QTL 55	5.7	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	8	85348065	130348065	Rat
1300171	Bp184	Blood pressure QTL 184	3.66		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	8	79394435	132782436	Rat
2313400	Anxrr25	Anxiety related response QTL 25			aggression-related behavior trait (VT:0015014)	tameness/aggressiveness composite score (CMO:0002136)	8	98145073	122898010	Rat
8694200	Abfw4	Abdominal fat weight QTL 4	9.07	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	8	80768445	125768445	Rat
8694392	Bw161	Body weight QTL 161	8.06	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	8	80768445	125768445	Rat
61437	Cia6	Collagen induced arthritis QTL 6			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	8	91340911	131690273	Rat

Markers in Region

RH132731

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	109,080,249 - 109,080,399 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	117,170,835 - 117,170,984	NCBI	Rnor6.0
Rnor_5.0	8	116,519,198 - 116,519,347	UniSTS	Rnor5.0
Celera	8	108,382,941 - 108,383,090	UniSTS
Cytogenetic Map	16	q12.5	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	165	91	90	59	92	59	6	356	192	11	144	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001135012	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039080938	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063264999	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063265000	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063265001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063265002	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010053934	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC128721	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC166460	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000008	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000083046 ⟹ ENSRNOP00000071463

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	8	117,914,650 - 117,957,949 (+)	Ensembl
mRatBN7.2 Ensembl	8	109,036,099 - 109,080,427 (+)	Ensembl
Rnor_6.0 Ensembl	8	117,126,692 - 117,171,012 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000085609 ⟹ ENSRNOP00000069514

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	8	117,914,614 - 117,957,626 (+)	Ensembl
mRatBN7.2 Ensembl	8	109,036,099 - 109,080,427 (+)	Ensembl
Rnor_6.0 Ensembl	8	117,126,692 - 117,171,012 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000112882 ⟹ ENSRNOP00000082514

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	8	117,914,650 - 117,957,626 (+)	Ensembl

RefSeq Acc Id:

NM_001135012 ⟹ NP_001128484

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	117,914,655 - 117,957,934 (+)	NCBI
mRatBN7.2	8	109,036,099 - 109,079,382 (+)	NCBI
Rnor_6.0	8	117,126,692 - 117,171,012 (+)	NCBI
Rnor_5.0	8	116,474,812 - 116,519,375 (+)	NCBI
Celera	8	108,338,833 - 108,383,118 (+)	NCBI

Sequence:

show sequence

GGCTGGGCCCGGGCGGCGGACGAGATGGCGGAAGGCCGGGGCACCCATGAGCGACCGGATGTGG
AGACCCAGAAGACGGAGCTCGGAGCCTTGATGGGGACCACGCTCCAGCGTGGGGCTCAGTGGTA
TCTGATCGACAGCCGGTGGTTCAAGCAGTGGAAGAAGTACGTCGGCTTTGACAGCTGGGACATG
TACAACGTGGGGGAGCACAATCTCTTTCCTGGACCGATTGACAACTCTGGGCTCTTCTCAGATC
CTGAGAGTCAGACCTTGAAGGAACACTTAATCGATGAGCTGGACTATGTGTTGGTTCCAACTGA
AGCCTGGAATAAATTGCTAAATTGGTATGGCTGTGTGGAAGGCCAGCAGCCTATTGTCAGAAAA
GTTGTGGAGCATGGCCTGTTTGTCAAGCACTGCAAAGTGGAAGTGTATTTGCTGGAGTTGAAGC
TCTGTGAGAACAGTGACCCCACCAATGTGCTAAGTTGCCATTTTAGCAAAGCAGATACCATTGC
AACTATTGAGAAGGAGATGAGGAAGCTCTTCAACATCCCTGCAGAGCGTGAAACACGACTTTGG
AACAAATACATGAGCAACACCTATGAGCAGTTGAGCAAGCTAGACAACACTATCCAGGATGCTG
GGCTGTACCAGGGTCAGGTGCTAGTAATTGAGCCCCAAAATGAAGACGGCACATGGCCCAGGCA
GACCCTGCAATCAAAATCAAGCACTGCACCTAGCAGAAATTTTACTACCTCTTCAAAACCATCC
GCAAGTCCCTATTCCTCAATGTCTGCCTCTCTCATTGCAAATGGTGATAGCACTAACAGCTCTG
GGATGCACAACTCCGGTGTCAGCAGGGGTGGAGCTGGCTTCTCTGCCTCGTATAATTGCCAGGA
GCCCCCATCACCTCATATCCAGCCTGGCCTCTGTGGACTCGGAAACCTGGGAAACACCTGTTTT
ATGAATTCTGCTTTGCAGTGCCTGAGCAACACTGGTCCACTGACTGAGTACTTTCTCAAAGATG
AGTATGAGGCCGAGATCAACAGAGACAACCCTCTGGGGATGAAAGGGGAGATTGCAGAGGCCTA
TGCAGAGCTCATCAAGCAGATGTGGTCTGGAAGGGACACCCACGTAGCACCACGGATGTTCAAA
ACGCAAGTGGGACGTTTCGCCCCTCAGTTTTCTGGCTACCAACAACAAGACTCTCAAGAGCTGT
TAGCCTTTATTCTAGATGGATTGCATGAAGACCTGAACCGAGTAAAGAAGAAGCCTTACCTGGA
GCCAAAGGATGCCAATGGGCGACCAGATGCGGTGGTAGCAAAGGAAGCCTGGGAAAATCACAGG
CTGAGGAATGACTCTGTGATTGTGGATACTTTCCATGGCCTTTTCAAATCTACTTTGGTTTGCC
CAGAATGTGCTAAAGTTTCTGTGACCTTTGACCCATTTTGCTATCTAACTCTCCCACTGCCTTT
GAAGAAAGATCGAATTATGGAGGTCTTCCTGGTTCCTGCTGACCCTCATTGCAGACCTATCCAG
TACCGTGTGACTGTGCCATTGATGGGGGCCATTTCTGACCTGTGTGAAGCACTCTCCAAGCTGT
CTGGCATTGCTGCAGAAAATATGGTGGTCACTGATGTGTATAATCACCGCTTCCACAAAATTTT
CCAAATGGATGAAGGTTTAAGCCACATCACGCCTCGAGATGACATTTTTGTGTATGAGATCTGC
ACCACTCCCATGGATGGCTCAGAATATATCACTCTCCCAGTCTACTTCAGAGAAAAGAAGTCCA
GGCCATCGAGTACTTCCTCTGGGGCCGTGCTCTATGGACAGCCACTTCTTGTTTCTGTCCCTAA
GCACAGACTAACCCTCGAGTCCTTATACCAGGCTGTTTGTGAACGTATCAGCCGCTATATAAAG
CAGCCTTTGCCTGAGGAGTTTCTCAGCTCTCCCTTAGAGCCTGGGGCCTGCAATGGCTCTAGGG
GTAGCTATGAAGGAGATGAAGAAGAAATGGATCATCAAGAGGAAGGGAAAGAACAGCTTTCTGA
AGTGGAAGAAAGTGGTGAGGACAGTCAGGGAGGGGACCCTACTGAGACCACCCAAAAGGCGAAA
GGCCCGCCCCGCCACAAGAGGCTTTTCACCTTCAGCCTCGTGAACTCCTGTGGAACTGCTGATA
TCAACTCGCTGGCCACTGACGGAAAACTCCTCAAGCTCAACTCTCGATCCACACTGGCCATTGA
CTGGGACAGTGAGACCCGAAGCCTTTACTTTGATGAGCAAGAATCTGAGGCCTGTGAGAAGCAC
ACGAGCATGTCCCAGCCTCAGAAGAAGAAGAAGGCTGCAATAGCCCTGCGGGAGTGCATCGAGC
TCTTTACTACCATGGAGACCCTTGGGGAGCATGACCCCTGGTACTGTCCCACCTGTAAGAAGCA
CCAACAGGCAACAAAAAAGTTTGATTTGTGGTCTTTGCCCAAGATCCTGGTGGTTCATCTCAAA
CGTTTCTCCTATAACAGATACTGGCGGGATAAACTGGACACAGTTGTGGAATTCCCAGTAAGAG
CTCTGAACATGTCCGAGTTTGTGTGTGACCGGGCAGCAAGGCCTTATGTCTATGACCTGATTGC
TGTGTCCAATCACTATGGCGCTATGGGGGTCGGTCACTATACTGCATATGCGAAGAACAGACTG
AATGGGAAATGGTATTACTTTGATGATAGCAGCGTGTCCCTGGCCTCTGAGGATCAGATAGTGA
CGAAGGCCGCCTACGTGTTGTTTTACCAGCGTCGGGATGATGAGTGTCCCAGCACCTCCTCACC
TGTCAGCTTCCCGGGTTCTGATGGAGGGGCGAAGCTCAGCAGCTCACAGCAGGACTTGGGGGAA
GAGGAGGCTTACACCATGGACACCAACTGACTCTGTGACCTGCCACCCCACAGCACCAGTGTCC
TCCCCAGAATACCTTTGGCACTCTGAAGACCACTCGTATCAATCTAAACCAGATGAAGAAATTA
CCTTCTTTTATGAGAAGAGGAAGGAAAAACAAACAAACAAACAAAAAAAAAAAAACAACCCTGC
TTTCTCTGAAGGGTTCAGAGGCTGAATTATTTTTTTCTTTTAAACGGGTGGTGAGATAAAAACC
TGTGGAGCTGAAATGTGGGGTGGATTTGGTGCACAGTGGCGCATGTCTCGCAGACTACAAAGAC
TGGAGAGGAACATCCTGTGAGGAGTAGTGCAGCCATGAAGACCCACCTGCAGGGCTGCTCTGAA
CTCCTGGGTTTGGGATTCTGGTGCCCACACTGCTCACCCCAGTAGTCTGGCCACAGTAAACCAA
GCCTCCAGTAAATTCGATGTTGTCCTCAAGTTCTTTACTGTTCATTGAGATGGGCTTACAGGTT
TTTTTTTGTTTGTTCCCCCCCCCCGCCCCCCCCCCGGAGCTGGGGACCGAACCCAGGGCCTTGT
GCTTGCTAGGCAAGCGCTCTACCACTGAGCTAAATCCCCAACCCCAGGGCTTAAAGTTTTTTAA
ACAGTCACTGAAACCGTTTCTATTCTCTTGTTCTCAGAATTTCCAGCCTTCTTCCCGGTTATGA
ATTGAAGTTACTATTGGGGTATTGTTTTCAGTTTCTCACAGAACCCTAGAAGTTCTGTCCCCCA
CTGCCCGTGATAAAGTGATTCTATGTAGAACTTTCATTAGCTCTCCCTTCAAAGTTTATTCATA
AAACTGGGTGCAGTGTGTGGATTGTTTCTCCATGTTAGCTTCAGAACAACACGATGGATGTTTT
TCAGATTTCCAGACATTTTAGTTAATGAGGTTTAAGAAAATATTTAGACCCCCTCAAGACCGGA
TTCTCTTCCGCCTTACTCGCTGGCCTACTAACAGGCCAGCCCTGGAGCCCCCCCCCCCCCCCCC
GTGACCTAGGGTCCCCTGAGAATGGCGGGTGATACTCCCCTCTCAGAGGAAAAAAACGAAGGAT
GATGTTGTATAACTGTAGCTGAAACTCGAAATCGGGGTTGGATCTCAGCCTCTTGTATAGAAGC
ATCATTCTCACGTTGCTCCGTGCATGTGAAATTATTACTTAATAAAAAAAGGCATGGTCACTTT

hide sequence

RefSeq Acc Id:

XM_039080938 ⟹ XP_038936866

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	117,933,065 - 117,957,934 (+)	NCBI
mRatBN7.2	8	109,054,293 - 109,079,099 (+)	NCBI

RefSeq Acc Id:

XM_063264999 ⟹ XP_063121069

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	117,912,576 - 117,957,934 (+)	NCBI

RefSeq Acc Id:

XM_063265000 ⟹ XP_063121070

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	117,912,576 - 117,947,143 (+)	NCBI

RefSeq Acc Id:

XM_063265001 ⟹ XP_063121071

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	117,912,576 - 117,933,058 (+)	NCBI

RefSeq Acc Id:

XM_063265002 ⟹ XP_063121072

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	117,912,576 - 117,933,058 (+)	NCBI

RefSeq Acc Id:

XR_010053934

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	117,912,576 - 117,937,968 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001128484	(Get FASTA)	NCBI Sequence Viewer
	XP_038936866	(Get FASTA)	NCBI Sequence Viewer
	XP_063121069	(Get FASTA)	NCBI Sequence Viewer
	XP_063121070	(Get FASTA)	NCBI Sequence Viewer
	XP_063121071	(Get FASTA)	NCBI Sequence Viewer
	XP_063121072	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI66460	(Get FASTA)	NCBI Sequence Viewer
	B2GUZ1	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000069514
	ENSRNOP00000071463
	ENSRNOP00000071463.1

RefSeq Acc Id:

NP_001128484 ⟸ NM_001135012

- UniProtKB:

B2GUZ1 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MAEGRGTHERPDVETQKTELGALMGTTLQRGAQWYLIDSRWFKQWKKYVGFDSWDMYNVGEHNL
FPGPIDNSGLFSDPESQTLKEHLIDELDYVLVPTEAWNKLLNWYGCVEGQQPIVRKVVEHGLFV
KHCKVEVYLLELKLCENSDPTNVLSCHFSKADTIATIEKEMRKLFNIPAERETRLWNKYMSNTY
EQLSKLDNTIQDAGLYQGQVLVIEPQNEDGTWPRQTLQSKSSTAPSRNFTTSSKPSASPYSSMS
ASLIANGDSTNSSGMHNSGVSRGGAGFSASYNCQEPPSPHIQPGLCGLGNLGNTCFMNSALQCL
SNTGPLTEYFLKDEYEAEINRDNPLGMKGEIAEAYAELIKQMWSGRDTHVAPRMFKTQVGRFAP
QFSGYQQQDSQELLAFILDGLHEDLNRVKKKPYLEPKDANGRPDAVVAKEAWENHRLRNDSVIV
DTFHGLFKSTLVCPECAKVSVTFDPFCYLTLPLPLKKDRIMEVFLVPADPHCRPIQYRVTVPLM
GAISDLCEALSKLSGIAAENMVVTDVYNHRFHKIFQMDEGLSHITPRDDIFVYEICTTPMDGSE
YITLPVYFREKKSRPSSTSSGAVLYGQPLLVSVPKHRLTLESLYQAVCERISRYIKQPLPEEFL
SSPLEPGACNGSRGSYEGDEEEMDHQEEGKEQLSEVEESGEDSQGGDPTETTQKAKGPPRHKRL
FTFSLVNSCGTADINSLATDGKLLKLNSRSTLAIDWDSETRSLYFDEQESEACEKHTSMSQPQK
KKKAAIALRECIELFTTMETLGEHDPWYCPTCKKHQQATKKFDLWSLPKILVVHLKRFSYNRYW
RDKLDTVVEFPVRALNMSEFVCDRAARPYVYDLIAVSNHYGAMGVGHYTAYAKNRLNGKWYYFD
DSSVSLASEDQIVTKAAYVLFYQRRDDECPSTSSPVSFPGSDGGAKLSSSQQDLGEEEAYTMDT
N

hide sequence

Ensembl Acc Id:

ENSRNOP00000071463 ⟸ ENSRNOT00000083046

Ensembl Acc Id:

ENSRNOP00000069514 ⟸ ENSRNOT00000085609

RefSeq Acc Id:	XP_038936866 ⟸ XM_039080938
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_063121069 ⟸ XM_063264999
- Peptide Label:	isoform X1
- UniProtKB:	A6I350 (UniProtKB/TrEMBL), M0R851 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063121070 ⟸ XM_063265000
- Peptide Label:	isoform X3

RefSeq Acc Id:	XP_063121071 ⟸ XM_063265001
- Peptide Label:	isoform X4

RefSeq Acc Id:	XP_063121072 ⟸ XM_063265002
- Peptide Label:	isoform X5

Ensembl Acc Id:

ENSRNOP00000082514 ⟸ ENSRNOT00000112882

Protein Domains

DUSP Ubiquitin-like USP

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-B2GUZ1-F1-model_v2	AlphaFold	B2GUZ1	1-961	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13696298

Promoter ID:

EPDNEW_R6822

Type:

initiation region

Name:

Usp4_1

Description:

ubiquitin specific peptidase 4

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	8	117,126,696 - 117,126,756	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1587387	AgrOrtholog
BioCyc Gene	G2FUF-29146	BioCyc
Ensembl Genes	ENSRNOG00000054863	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000083046	ENTREZGENE
	ENSRNOT00000083046.2	UniProtKB/Swiss-Prot
	ENSRNOT00000085609	ENTREZGENE
Gene3D-CATH	3.30.2230.10	UniProtKB/Swiss-Prot
	Cysteine proteinases	UniProtKB/Swiss-Prot
	Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:9027936	IMAGE-MGC_LOAD
InterPro	DUSP-like_sf	UniProtKB/Swiss-Prot
	Papain-like_cys_pep_sf	UniProtKB/Swiss-Prot
	Pept_C19_DUSP	UniProtKB/Swiss-Prot
	Peptidase_C19_UCH	UniProtKB/Swiss-Prot
	Ub_carboxyl-term_hydrolase	UniProtKB/Swiss-Prot
	Ub_USP-typ	UniProtKB/Swiss-Prot
	USP_CS	UniProtKB/Swiss-Prot
	USP_dom	UniProtKB/Swiss-Prot
KEGG Report	rno:290864	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:187765	IMAGE-MGC_LOAD
NCBI Gene	290864	ENTREZGENE
PANTHER	UBIQUITIN CARBOXYL-TERMINAL HYDROLASE	UniProtKB/Swiss-Prot
	UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 4	UniProtKB/Swiss-Prot
Pfam	DUSP	UniProtKB/Swiss-Prot
	Ubiquitin_3	UniProtKB/Swiss-Prot
	UCH	UniProtKB/Swiss-Prot
PhenoGen	Usp4	PhenoGen
PROSITE	DUSP	UniProtKB/Swiss-Prot
	USP_1	UniProtKB/Swiss-Prot
	USP_2	UniProtKB/Swiss-Prot
	USP_3	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000054863	RatGTEx
SMART	DUSP	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF143791	UniProtKB/Swiss-Prot
	SSF54001	UniProtKB/Swiss-Prot
UniProt	A6I350	ENTREZGENE, UniProtKB/TrEMBL
	B2GUZ1	ENTREZGENE
	M0R851	ENTREZGENE, UniProtKB/TrEMBL
	UBP4_RAT	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-04-13	Usp4	ubiquitin specific peptidase 4	Usp4	ubiquitin specific peptidase 4 (proto-oncogene)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-03-04	Usp4	ubiquitin specific peptidase 4 (proto-oncogene)	LOC290864	similar to Ubiquitin carboxyl-terminal hydrolase 4 (Ubiquitin thiolesterase 4) (Ubiquitin-specific processing protease 4) (Deubiquitinating enzyme 4) (Ubiquitous nuclear protein)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-11-19	LOC290864	similar to Ubiquitin carboxyl-terminal hydrolase 4 (Ubiquitin thiolesterase 4) (Ubiquitin-specific processing protease 4) (Deubiquitinating enzyme 4) (Ubiquitous nuclear protein)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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