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Gene: Tsc22d4 (TSC22 domain family, member 4) Rattus norvegicus

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Symbol:

Tsc22d4

Name:

TSC22 domain family, member 4

RGD ID:

1584380

Description:

Predicted to be involved in several processes, including glucose homeostasis; negative regulation of transcription by RNA polymerase II; and neuron projection extension. Predicted to be located in several cellular components, including dendrite; nucleus; and synapse. Orthologous to human TSC22D4 (TSC22 domain family member 4); INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC102550456; MGC125073; similar to TSC22 domain family protein 4 (TSC22-related-inducible leucine zipper protein 2); Spacdr; sperm acrosome developmental regulator; thg-1pit; Tilz2; TSC22 domain family protein 4; TSC22 domain family protein 4-like; TSC22-related-inducible leucine zipper protein 2; uncharacterized protein C7orf61 homolog

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	TSC22D4 (TSC22 domain family member 4)	RGD	RGD
Mus musculus (house mouse):	Tsc22d4 (Tsc22 domain family, member 4)	RGD	RGD
Chinchilla lanigera (long-tailed chinchilla):	Tsc22d4 (TSC22 domain family member 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	TSC22D4 (TSC22 domain family member 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	TSC22D4 (TSC22 domain family member 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Tsc22d4 (TSC22 domain family member 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	LOC100514038 (TSC22 domain family protein 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	LOC103246737 (TSC22 domain family protein 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Tsc22d4 (TSC22 domain family member 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Tsc22d4 (TSC22 domain family member 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Tsc22d4 (Tsc22 domain family, member 4)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	TSC22D4 (TSC22 domain family member 4)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	T18D3.7	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector)
Caenorhabditis elegans (roundworm):	T18D3.7	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PhylomeDB)
Drosophila melanogaster (fruit fly):	bun	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector)
Xenopus tropicalis (tropical clawed frog):	tsc22d4	Alliance	DIOPT (InParanoid\|OMA\|OrthoFinder\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	12	24,575,948 - 24,588,806 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	12	24,567,176 - 24,587,894 (-)	Ensembl				GRCr8
mRatBN7.2	12	18,939,150 - 18,952,008 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	18,914,398 - 18,952,008 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	12	20,094,279 - 20,107,085 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	12	20,707,155 - 20,719,962 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	12	19,771,483 - 19,784,290 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	12	22,008,956 - 22,021,814 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	22,009,011 - 22,021,851 (-)	Ensembl			rn6	Rnor6.0
Rnor_6.0 Ensembl	12	21,722,075 - 21,761,487 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	12	24,017,638 - 24,039,147 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	12	19,814,586 - 19,826,254 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	12	20,744,972 - 20,757,750 (-)	NCBI		Celera
Cytogenetic Map	12	q12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

1-naphthyl isothiocyanate (EXP)

17beta-estradiol (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3',4,4',5-Pentachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4,6-tribromophenol (ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

6-propyl-2-thiouracil (EXP)

acrolein (ISO)

all-trans-retinoic acid (ISO)

alpha-pinene (ISO)

amitrole (EXP)

aristolochic acid A (ISO)

Aroclor 1254 (ISO)

arsane (ISO)

arsenic atom (ISO)

benzo[a]pyrene (ISO)

Benzo[ghi]perylene (ISO)

beta-lapachone (ISO)

bisphenol A (EXP,ISO)

bisphenol AF (ISO)

caffeine (ISO)

carbon nanotube (ISO)

clobetasol (ISO)

clofibrate (ISO)

coumarin (ISO)

DDE (ISO)

doxorubicin (ISO)

fipronil (EXP)

flutamide (EXP)

folic acid (ISO)

FR900359 (ISO)

genistein (EXP)

hydrogen peroxide (ISO)

isoprenaline (ISO)

N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal (ISO)

ozone (ISO)

paracetamol (ISO)

perfluorononanoic acid (ISO)

resveratrol (ISO)

rotenone (EXP)

selenomethionine (ISO)

sodium arsenite (ISO)

thioacetamide (EXP)

thiram (ISO)

titanium dioxide (ISO)

trichloroethene (EXP)

triphenyl phosphate (ISO)

triptonide (ISO)

urethane (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

DNA-templated transcription (IEA)

glucose homeostasis (ISO,ISS)

negative regulation of transcription by RNA polymerase II (ISO,ISS)

neuron cellular homeostasis (ISO,ISS)

neuron projection extension (ISO,ISS)

regulation of transcription by RNA polymerase II (IEA)

response to osmotic stress (IBA,ISO)

Cellular Component

cytoplasm (IEA,ISO,ISS)

dendrite (IEA,ISO,ISS)

nucleus (IEA,ISO,ISS)

synapse (IEA,ISO,ISS)

Molecular Function

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	GOA pipeline	RGD automated data pipeline
3.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12477932	PMID:15057822	PMID:17147695	PMID:19084601

Genomics

Comparative Map Data

Tsc22d4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	12	24,575,948 - 24,588,806 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	12	24,567,176 - 24,587,894 (-)	Ensembl				GRCr8
mRatBN7.2	12	18,939,150 - 18,952,008 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	18,914,398 - 18,952,008 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	12	20,094,279 - 20,107,085 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	12	20,707,155 - 20,719,962 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	12	19,771,483 - 19,784,290 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	12	22,008,956 - 22,021,814 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	22,009,011 - 22,021,851 (-)	Ensembl			rn6	Rnor6.0
Rnor_6.0 Ensembl	12	21,722,075 - 21,761,487 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	12	24,017,638 - 24,039,147 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	12	19,814,586 - 19,826,254 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	12	20,744,972 - 20,757,750 (-)	NCBI		Celera
Cytogenetic Map	12	q12	NCBI

TSC22D4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	7	100,466,519 - 100,479,214 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	7	100,466,519 - 100,479,232 (-)	Ensembl			hg38	GRCh38
GRCh37	7	100,064,142 - 100,076,837 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	7	99,902,078 - 99,914,838 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Celera	7	94,793,941 - 94,806,701 (-)	NCBI		Celera
Cytogenetic Map	7	q22.1	NCBI
HuRef	7	94,697,543 - 94,710,215 (-)	NCBI		HuRef
CHM1_1	7	99,994,757 - 100,007,518 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	7	101,706,601 - 101,719,289 (-)	NCBI		T2T-CHM13v2.0
CRA_TCAGchr7v2	7	99,424,226 - 99,436,987 (-)	NCBI

Tsc22d4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	137,744,274 - 137,758,011 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	137,744,221 - 137,759,670 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	5	137,745,969 - 137,768,453 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	137,745,730 - 137,768,450 (+)	Ensembl			mm10	GRCm38
MGSCv37	5	138,187,224 - 138,200,975 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	5	137,975,784 - 137,989,539 (+)	NCBI		MGSCv36	mm8
Celera	5	134,732,531 - 134,746,249 (+)	NCBI		Celera
Cytogenetic Map	5	G2	NCBI
cM Map	5	76.64	NCBI

Tsc22d4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955573	415,826 - 429,105 (+)	Ensembl
ChiLan1.0	NW_004955573	414,984 - 425,480 (+)	NCBI	ChiLan1.0	ChiLan1.0

TSC22D4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	6	118,379,740 - 118,392,879 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	7	166,644,372 - 166,657,180 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	7	92,495,407 - 92,508,204 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	7	105,887,295 - 105,909,981 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	7	105,896,307 - 105,909,967 (-)	Ensembl			panPan2	panpan1.1

TSC22D4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	6	9,196,199 - 9,206,929 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	6	9,197,197 - 9,211,885 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	6	10,900,933 - 10,911,479 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	6	9,130,449 - 9,140,993 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	6	9,126,041 - 9,145,943 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	6	8,982,924 - 8,993,466 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	6	8,960,443 - 8,971,023 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	6	9,142,821 - 9,153,385 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Tsc22d4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	133,486,985 - 133,497,302 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936543	537,969 - 548,617 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936543	539,222 - 549,542 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

LOC100514038
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	8,395,229 - 8,406,218 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	3	8,390,945 - 8,406,240 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	7,734,046 - 7,750,006 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

LOC103246737
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	28	12,729,798 - 12,744,222 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	28	12,749,795 - 12,751,957 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
ChlSab1.1 Ensembl	28	12,730,714 - 12,745,483 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666070	3,552,822 - 3,565,856 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Tsc22d4
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624740	16,589,309 - 16,600,155 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624740	16,582,726 - 16,598,477 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Tsc22d4
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	16	16,255,521 - 16,277,126 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Tsc22d4
189 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	84
Count of miRNA genes:	63
Interacting mature miRNAs:	74
Transcripts:	ENSRNOT00000059592
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2312418	Kidm41	Kidney mass QTL 41	3.7	0.0001	kidney mass (VT:0002707)	single kidney wet weight to body weight ratio (CMO:0000622)	12	5921918	25247790	Rat
61443	Btemp2	Thermal response to stress QTL 2	3.3	0.000094	body temperature trait (VT:0005535)	core body temperature (CMO:0001036)	12	20139028	26430640	Rat
70213	Niddm27	Non-insulin dependent diabetes mellitus QTL 27	3.72		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	12	11200494	52308831	Rat
2306789	Ean6	Experimental allergic neuritis QTL 6	4.9		nervous system integrity trait (VT:0010566)	experimental autoimmune neuritis severity score (CMO:0001528)	12	1	29775522	Rat
8552964	Pigfal17	Plasma insulin-like growth factor 1 level QTL 17	3.5		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	11200494	52308831	Rat
7411641	Foco19	Food consumption QTL 19	27.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	11200494	52308831	Rat
5684888	Pia42	Pristane induced arthritis QTL 42			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	3489416	48489416	Rat
1331739	Hrtrt14	Heart rate QTL 14	3.56232		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	12	1	38687564	Rat
1641928	Alcrsp5	Alcohol response QTL 5			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	12	18473041	52308831	Rat
8552912	Pigfal6	Plasma insulin-like growth factor 1 level QTL 6	5		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	11200497	52308831	Rat
1549829	Scl48	Serum cholesterol level QTL 48	5		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	12	15264248	52308831	Rat
61331	Eau2	Experimental allergic uveoretinitis QTL 2		0.0005	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	12	1	33700600	Rat
10059594	Kidm46	Kidney mass QTL 46	3.79	0.025	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	12	11743528	52308831	Rat
8552918	Pigfal7	Plasma insulin-like growth factor 1 level QTL 7			blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	11200494	52308831	Rat
2293684	Bmd26	Bone mineral density QTL 26	4.4	0.0002	femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	12	1	38635130	Rat
6893681	Bw109	Body weight QTL 109	2.3	0.004	body mass (VT:0001259)	body weight (CMO:0000012)	12	1	28133365	Rat
1302792	Scl21	Serum cholesterol level QTL 21	3.8	0.0011	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	12	12233000	30490641	Rat
61404	Bw120	Body weight QTL 120	5.1		body mass (VT:0001259)	body mass index (BMI) (CMO:0000105)	12	17464979	46784661	Rat
1300174	Bw15	Body weight QTL 15	2.93		body mass (VT:0001259)	body weight loss (CMO:0001399)	12	1	28606299	Rat
1331786	Kidm11	Kidney mass QTL 11	3.571		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	12	16187438	52308831	Rat
1331787	Rf41	Renal function QTL 41	2.998		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	12	1	33700556	Rat
2293699	Bss49	Bone structure and strength QTL 49	5.61	0.0001	lumbar vertebra size trait (VT:0010518)	lumbar vertebra trabecular cross-sectional area (CMO:0001692)	12	16135029	52308831	Rat
1331761	Bp218	Blood pressure QTL 218	2.973		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	12	16187438	51213550	Rat
1331763	Wbc2	White blood cell count QTL 2	3.162		leukocyte quantity (VT:0000217)	total white blood cell count (CMO:0000365)	12	11200494	52308831	Rat
61416	Pia4	Pristane induced arthritis QTL 4	8.4		joint integrity trait (VT:0010548)	arthritic paw count (CMO:0001460)	12	18749469	36488809	Rat
7204484	Bp358	Blood pressure QTL 358		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	12	1	24849755	Rat
7411547	Bw129	Body weight QTL 129		0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	6	11200494	52308831	Rat
7387292	Kidm42	Kidney mass QTL 42	3.03	0.0004	kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	12	1	41361854	Rat
61421	Cia12	Collagen induced arthritis QTL 12	4.6		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	18749469	34312613	Rat
1298081	Cia25	Collagen induced arthritis QTL 25	4.7		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	2747694	47747694	Rat
2303569	Gluco44	Glucose level QTL 44	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	12	18473041	52308831	Rat
2303568	Bw88	Body weight QTL 88	3		body mass (VT:0001259)	body weight (CMO:0000012)	12	1	28606299	Rat
2303575	Insul14	Insulin level QTL 14	4		blood insulin amount (VT:0001560)	blood insulin level (CMO:0000349)	12	3087180	48087180	Rat
7411588	Foco6	Food consumption QTL 6		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	11200494	52308831	Rat
7243862	Mcs30	Mammary carcinoma susceptibility QTL 30	8.62		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	12	5633306	50633306	Rat
2300186	Bmd59	Bone mineral density QTL 59	7.1	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	12	16135029	52308831	Rat
2293086	Iddm30	Insulin dependent diabetes mellitus QTL 30	3.82		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	12	7901625	33938215	Rat
7411597	Foco10	Food consumption QTL 10		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	11200494	52308831	Rat
1331755	Bp219	Blood pressure QTL 219	3.041		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	12	16187438	33700556	Rat

Markers in Region

RH133351

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	12	18,939,355 - 18,939,557 (+)	MAPPER	mRatBN7.2
Rnor_6.0	12	22,009,162 - 22,009,363	NCBI	Rnor6.0
Rnor_6.0	12	21,748,808 - 21,749,009	NCBI	Rnor6.0
Rnor_5.0	12	23,769,676 - 23,769,877	UniSTS	Rnor5.0
Rnor_5.0	12	24,026,448 - 24,026,649	UniSTS	Rnor5.0
RGSC_v3.4	12	19,825,869 - 19,826,070	UniSTS	RGSC3.4
Celera	12	20,745,178 - 20,745,379	UniSTS
Cytogenetic Map	12	q12	UniSTS

RH142348

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	12	18,939,316 - 18,939,503 (+)	MAPPER	mRatBN7.2
Rnor_6.0	12	21,748,769 - 21,748,955	NCBI	Rnor6.0
Rnor_6.0	12	22,009,123 - 22,009,309	NCBI	Rnor6.0
Rnor_5.0	12	24,026,409 - 24,026,595	UniSTS	Rnor5.0
Rnor_5.0	12	23,769,637 - 23,769,823	UniSTS	Rnor5.0
RGSC_v3.4	12	19,825,923 - 19,826,109	UniSTS	RGSC3.4
Celera	12	20,745,139 - 20,745,325	UniSTS
RH 3.4 Map	12	263.8	UniSTS
Cytogenetic Map	12	q12	UniSTS

RH143037

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	12	18,946,519 - 18,946,777 (+)	MAPPER	mRatBN7.2
Rnor_6.0	12	21,755,971 - 21,756,228	NCBI	Rnor6.0
Rnor_6.0	12	22,016,325 - 22,016,582	NCBI	Rnor6.0
Rnor_5.0	12	24,033,611 - 24,033,868	UniSTS	Rnor5.0
Rnor_5.0	12	23,776,839 - 23,777,096	UniSTS	Rnor5.0
RGSC_v3.4	12	19,818,650 - 19,818,907	UniSTS	RGSC3.4
Celera	12	20,752,342 - 20,752,599	UniSTS
RH 3.4 Map	12	264.3	UniSTS
Cytogenetic Map	12	q12	UniSTS

RH136799

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	12	18,930,954 - 18,931,076 (+)	MAPPER	mRatBN7.2
Rnor_6.0	12	22,000,913 - 22,001,034	NCBI	Rnor6.0
Rnor_6.0	12	21,740,404 - 21,740,525	NCBI	Rnor6.0
Rnor_5.0	12	24,017,961 - 24,018,082	UniSTS	Rnor5.0
Rnor_5.0	12	23,761,272 - 23,761,393	UniSTS	Rnor5.0
RGSC_v3.4	12	19,834,353 - 19,834,474	UniSTS	RGSC3.4
Celera	12	20,736,866 - 20,736,987	UniSTS
RH 3.4 Map	12	268.1	UniSTS
Cytogenetic Map	12	q12	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
13	1	24	82	34	30	18	73	18	6	196	119	11	69	46	51	12	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001044284	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC107410	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC105911	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473973	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FM034641	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FM049873	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ214513	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ230841	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000012	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000001869 ⟹ ENSRNOP00000001869

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	12	18,930,608 - 18,936,787 (-)	Ensembl
Rnor_6.0 Ensembl	12	21,740,057 - 21,746,236 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000039280 ⟹ ENSRNOP00000033658

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	12	18,939,150 - 18,952,008 (-)	Ensembl
Rnor_6.0 Ensembl	12	22,009,011 - 22,021,851 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000059592 ⟹ ENSRNOP00000056350

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	12	18,939,158 - 18,940,736 (-)	Ensembl
Rnor_6.0 Ensembl	12	21,748,633 - 21,760,292 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000082910 ⟹ ENSRNOP00000071995

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	12	18,930,608 - 18,952,008 (-)	Ensembl
Rnor_6.0 Ensembl	12	21,722,075 - 21,761,487 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000105126 ⟹ ENSRNOP00000079951

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	12	18,914,398 - 18,952,008 (-)	Ensembl

RefSeq Acc Id:

NM_001044284 ⟹ NP_001037749

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	24,575,948 - 24,588,806 (-)	NCBI
mRatBN7.2	12	18,939,150 - 18,952,008 (-)	NCBI
Rnor_6.0	12	22,008,956 - 22,021,814 (-)	NCBI
Rnor_5.0	12	24,017,638 - 24,039,147 (-)	NCBI
RGSC_v3.4	12	19,814,586 - 19,826,254 (+)	RGD
Celera	12	20,744,972 - 20,757,750 (-)	NCBI

Sequence:

show sequence

GAGCAGGCCCGAGAAGGCAGGACTTCCTGGTGTGGGGGTTGTCAACAGCCCAGAAAGAGAGAGC
CCGAGACCCAGACTGAGACGGAGCGGAGCGGAGCTGAGGAGCCGAGAGATACATCCAGTGGGGC
CACGTGGGAGGAGCCTTGAGAGAGAGCGAGCCACTCAAGGGACTGGAGTCAGCGGGGGGCTGAG
CCGCCCCCTCCCACAGCAACAGAGAAGACCCGTGGAGTGTTAACGGAGGCTGCGCCTGGGCTCC
ACCGTGGAAGCGCTGGTTTCTTCTCGTCTCAACTGCAAACTTTCCACCGAGATGCCTCGCAGAG
TGAGATGCGGACGCCAGAGAACACTGGGCAGCCCTTGACTGCTGCCTGCCGTGGCCTGCGCTAG
GCCGCCTTAGGATTAAAAAAAAAAAAAAAAAAAAAGGCATCTTTAGTCCCCAGGTCCTCTCTCC
AGCTCAGCTCGGTGGCCGAGGCCCGAGAGTTTGCAAGCTCAGCTCTGGGGTTTCAGCAGCGACA
GCAGCAGGAAAAACCTGCCTCTGCTCCCCCCCCCCCCCCTCCTGCCACCTCCCCTCTCCAGTCA
CTAACCAGGCACCCCCAAGTTCCCACAAGGCCCTCCTGCCATGACGGACCCAGACGTCCCCAGG
GGCCCTGATGTCCCTGCCATGTGGCCCCCTTGTTCCAGAGGTGCCTGAGCCCCTCTTCAGGAGC
CCAGCCCCTCCCCCACCCCAGCCCAGTCCGGAGCCCTAGGGACCATGAGTGGTGGTAAGAAGAA
AAGTAGTTTTCAGATCACCAGCGTCACCACGGACTATGAGGGCCCAGGAAGCCCAGGGGCTTCG
GACCCCCCTGCCCCTCCGGCTCCCGCTGGGCCCCCGCCCCGCCTCCCCAACGGGGAACCCAACC
CTGATCCAGGGGGCAGGGGCACCCCCCGGAATGGCTCTCCGCCACCTGGAGCCCCTGCCTCCCG
TTTCCGGGTGGTGAAGCTGCCCCAAGGTTTAGGAGAGCCTTATCGACGAGGTCGGTGGACGTGT
GTGGATGTTTACGAGAGAGACCTGGAGCCCCCGAGCTTCGGTCGGCTTCTGGAGGGAATTCGAG
GGGCCTCAGGAGGCACCGGAGGCAGATCATTGGATTCTAGGTTGGAGCTGGCTAGCTTGGGCAT
AAGCACCCCTATCCCTCAGCCAGGCCTGTCTCAGGGCCCCACCTCTTGGCTCCGCCCGCCCCCT
ACTTCTCCTGGACCACAGGCTCGATCCTTCACAGGGGGGCTGGGCCAGCTGGCAGGACCTGGCA
AGGCTAAGGTGGAGACGCCCCCGCTGTCAGCCTCTCCACCCCAGCAGCGCCCCCCAGGGCCTGG
GACTGGAGATAGTGCTCAAACCCTGCCCTCCCTGAGGGTAGAAGTGGAGTCTGGGGGTTTAGCA
GCCGGAACCCCTCCTCTGTCACGGAGAAGAGATGGAGCAGTTCGGCTGAGGATGGAGTTAGTTG
CTCCAGAGGAGACAGGGAAGGTACCTCCCATCGACTCTCGCCCCAACTCCCCAGCCCTCTACTT
CGATGCCAGCCTGGTTCACAAGTCTCCAGACCCATTCGGAGCTGCAGCAGCCCAGAGCCTCAGC
CTGGCTCGGTCCATGTTGGCCATCAGCGGTCACCTGGACAGTGATGACGACAGTGGTTCCGGAA
GCCTGGTTGGCATTGACAACAAGATTGAACAAGCCATGGACTTGGTGAAGTCCCACCTCATGTT
TGCCGTGCGAGAGGAGGTGGAGGTGCTGAAGGAGCAGATCCGGGACCTGGCAGAGCGGAATGCT
GCACTGGAGCAGGAAAATGGATTGCTGCGTGCCCTGGCCAGCCCGGAGCAGCTGGCCCAGCTGC
CATCCTCGGGGCTCCCAAGGCTCGGGCCCTCTGCACCCAATGGGCCTTCCATCTGAGCCTTCTT
TCCCTCACAATGTGCCTTTGGGGGCTGCCACTGGCCGCCGGGCCTTGTGCCAGCAGCCTGCCCC
CTCTTCCTATGTAGCTTTAATGCCCACGCCCGACCCCAATGCCCAGGGATGGGAGTTGAGGCTA
AATATTGGCCTGTCCCTTCCCACCTGGTCTCCCCAGAAGCCTCAGGCCTTGCCGGAAGAGAAAG
AACCCAGGAGGGGATGTTTATCTGAAGCCCCTCATCCATGAAAGAACCCAGCCCCACCTCCTTC
CCTGGGAATCAGTGTTCTGGGGAGCCCCTCAGCAGCAGATGGCTCAGAAAGATTTGGAGGTTCC
CTGGCAGGCCCCCTCACCATCCCACCTTGTTCTCTTCAAGTGCCCCCTCTCCTCTGCCCAGGGA
GGGGGTATGGACAGTATCTTCAACTTCTTGGATTCAGGTTGTTATTAAAATAATAATTATAATT
AAAAAAAAATCTGAAGAAACTTGAATATGGA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001037749	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI05912	(Get FASTA)	NCBI Sequence Viewer
	EDM13242	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000033658
	ENSRNOP00000033658.4
GenBank Protein	Q3B8N7	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001037749 ⟸ NM_001044284

- UniProtKB:

Q3B8N7 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MSGGKKKSSFQITSVTTDYEGPGSPGASDPPAPPAPAGPPPRLPNGEPNPDPGGRGTPRNGSPP
PGAPASRFRVVKLPQGLGEPYRRGRWTCVDVYERDLEPPSFGRLLEGIRGASGGTGGRSLDSRL
ELASLGISTPIPQPGLSQGPTSWLRPPPTSPGPQARSFTGGLGQLAGPGKAKVETPPLSASPPQ
QRPPGPGTGDSAQTLPSLRVEVESGGLAAGTPPLSRRRDGAVRLRMELVAPEETGKVPPIDSRP
NSPALYFDASLVHKSPDPFGAAAAQSLSLARSMLAISGHLDSDDDSGSGSLVGIDNKIEQAMDL
VKSHLMFAVREEVEVLKEQIRDLAERNAALEQENGLLRALASPEQLAQLPSSGLPRLGPSAPNG
PSI

hide sequence

Ensembl Acc Id:

ENSRNOP00000033658 ⟸ ENSRNOT00000039280

Ensembl Acc Id:

ENSRNOP00000056350 ⟸ ENSRNOT00000059592

Ensembl Acc Id:

ENSRNOP00000071995 ⟸ ENSRNOT00000082910

Ensembl Acc Id:

ENSRNOP00000001869 ⟸ ENSRNOT00000001869

Ensembl Acc Id:

ENSRNOP00000079951 ⟸ ENSRNOT00000105126

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q3B8N7-F1-model_v2	AlphaFold	Q3B8N7	1-387	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13698508

Promoter ID:

EPDNEW_R9033

Type:

multiple initiation site

Name:

Tsc22d4_2

Description:

TSC22 domain family, member 4

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_R9034

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	12	22,021,602 - 22,021,662	EPDNEW

RGD ID:

13698509

Promoter ID:

EPDNEW_R9034

Type:

initiation region

Name:

Tsc22d4_1

Description:

TSC22 domain family, member 4

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_R9033

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	12	22,021,763 - 22,021,823	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1584380	AgrOrtholog
BioCyc Gene	G2FUF-19719	BioCyc
Ensembl Genes	ENSRNOG00000024616	Ensembl
	ENSRNOG00000050805	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000039280	ENTREZGENE
	ENSRNOT00000039280.6	UniProtKB/Swiss-Prot
Gene3D-CATH	Single helix bin	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7387593	IMAGE-MGC_LOAD
InterPro	TSC-22_Dip_Bun	UniProtKB/Swiss-Prot
	TSC22/BUN_CS	UniProtKB/Swiss-Prot
	TSC22D4	UniProtKB/Swiss-Prot
KEGG Report	rno:684980	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:125073	IMAGE-MGC_LOAD
NCBI Gene	684980	ENTREZGENE
PANTHER	PTHR47610	UniProtKB/Swiss-Prot
	TSC22 DOMAIN FAMILY PROTEIN 4	UniProtKB/Swiss-Prot
Pfam	TSC22	UniProtKB/Swiss-Prot
PhenoGen	Tsc22d4	PhenoGen
PROSITE	TSC22	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000024616	RatGTEx
	ENSRNOG00000050805	RatGTEx
Superfamily-SCOP	Delta-sleep-inducing peptide immunoreactive peptide	UniProtKB/Swiss-Prot
UniProt	A0A0G2K1V1_RAT	UniProtKB/TrEMBL
	A0A8L2QRK4_RAT	UniProtKB/TrEMBL
	Q3B8N7	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2021-03-09	Tsc22d4	TSC22 domain family, member 4	LOC102550456	TSC22 domain family protein 4-like	Data merged from RGD:7605479	737654	PROVISIONAL
2013-12-18	LOC102550456	TSC22 domain family protein 4-like			Symbol and Name status set to provisional	70820	PROVISIONAL
2008-07-08	Tsc22d4	TSC22 domain family, member 4	LOC686226	similar to TSC22 domain family protein 4 (TSC22-related-inducible leucine zipper protein 2)	Data merged from RGD:1584337	1643240	APPROVED
2008-03-06	Tsc22d4	TSC22 domain family, member 4	MGC125073	similar to TSC22 domain family protein 4 (TSC22-related-inducible leucine zipper protein 2)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-11-19	MGC125073	similar to TSC22 domain family protein 4 (TSC22-related-inducible leucine zipper protein 2)			Symbol and Name status set to provisional	70820	PROVISIONAL
2006-11-19	LOC686226	similar to TSC22 domain family protein 4 (TSC22-related-inducible leucine zipper protein 2)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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