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Gene: Pwp2 (PWP2, small subunit processome component) Rattus norvegicus

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Symbol:

Pwp2

Name:

PWP2, small subunit processome component

RGD ID:

1582817

Description:

Predicted to be involved in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) and ribosomal small subunit assembly. Predicted to be located in nucleolus. Predicted to be part of Pwp2p-containing subcomplex of 90S preribosome and small-subunit processome. Orthologous to human PWP2 (PWP2 small subunit processome component); PARTICIPATES IN ribosome biogenesis pathway; INTERACTS WITH amphetamine; bisphenol A; cadmium dichloride.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC690297; periodic tryptophan protein 2 homolog; PWP2 periodic tryptophan protein homolog; PWP2 periodic tryptophan protein homolog (yeast); PWP2, UTPB SSU processome subunit; similar to PWP2 periodic tryptophan protein homolog

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	PWP2 (PWP2 small subunit processome component)	HGNC	EggNOG, Ensembl, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Pwp2 (PWP2 periodic tryptophan protein homolog (yeast))	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Pwp2 (PWP2 small subunit processome component)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	PWP2 (PWP2 small subunit processome component)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	PWP2 (PWP2 small subunit processome component)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Pwp2 (PWP2 small subunit processome component)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	PWP2 (PWP2 small subunit processome component)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	PWP2 (PWP2 small subunit processome component)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Pwp2 (PWP2 small subunit processome component)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Pwp2 (PWP2 small subunit processome component)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	FP565260.1 (periodic tryptophan protein 2 homolog)	HGNC	EggNOG, Panther
Alliance orthologs ³
Homo sapiens (human):	PWP2 (PWP2 small subunit processome component)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Pwp2 (PWP2 periodic tryptophan protein homolog (yeast))	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	pwp2h (PWP2 small subunit processome component)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG12325	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	F55F8.3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	PWP2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	pwp2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	pwp2	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	20	10,498,998 - 10,512,631 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	20	10,499,013 - 10,513,309 (+)	Ensembl				GRCr8
mRatBN7.2	20	10,499,332 - 10,512,965 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	20	10,499,363 - 10,513,640 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	20	11,198,339 - 11,211,993 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	20	10,559,232 - 10,572,886 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	20	11,031,598 - 11,045,231 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	20	11,228,892 - 11,243,204 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	20	11,228,844 - 11,243,205 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	20	13,398,455 - 13,412,898 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	20	10,836,094 - 10,849,727 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	20	12,005,711 - 12,019,344 (+)	NCBI		Celera
Cytogenetic Map	20	p12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2-palmitoylglycerol (ISO)

4,4'-diaminodiphenylmethane (ISO)

4,4'-sulfonyldiphenol (ISO)

5-fluorouracil (ISO)

all-trans-retinoic acid (ISO)

amphetamine (EXP)

antirheumatic drug (ISO)

arsane (ISO)

arsenic atom (ISO)

benzatropine (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP)

cadmium dichloride (EXP)

caffeine (EXP,ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

chlorpyrifos (ISO)

chromium(6+) (ISO)

cisplatin (ISO)

clozapine (ISO)

cobalt dichloride (ISO)

copper atom (ISO)

copper(0) (ISO)

coumarin (ISO)

dioxygen (ISO)

ethanol (ISO)

ethyl methanesulfonate (ISO)

formaldehyde (ISO)

FR900359 (ISO)

fulvestrant (ISO)

genistein (ISO)

manganese atom (ISO)

manganese(0) (ISO)

manganese(II) chloride (ISO)

methoxyacetic acid (EXP)

methyl methanesulfonate (ISO)

methylmercury chloride (EXP)

Monobutylphthalate (EXP)

nickel atom (ISO)

paracetamol (EXP,ISO)

paraquat (EXP)

perfluorooctane-1-sulfonic acid (ISO)

pirinixic acid (ISO)

potassium chromate (ISO)

pregnenolone 16alpha-carbonitrile (ISO)

quercetin (ISO)

resveratrol (ISO)

SB 431542 (ISO)

sodium arsenite (ISO)

sunitinib (ISO)

tetrachloromethane (EXP)

thioacetamide (EXP)

thiram (ISO)

Triptolide (ISO)

valproic acid (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) (IBA)

ribosomal small subunit assembly (IBA)

ribosomal small subunit biogenesis (IEA,ISO)

Cellular Component

nucleolus (IEA,ISO)

Pwp2p-containing subcomplex of 90S preribosome (IBA)

small-subunit processome (IBA,IEA,ISO)

Molecular Function

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

ribosome biogenesis pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
3.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:22658674	PMID:22681889

Genomics

Comparative Map Data

Pwp2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	20	10,498,998 - 10,512,631 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	20	10,499,013 - 10,513,309 (+)	Ensembl				GRCr8
mRatBN7.2	20	10,499,332 - 10,512,965 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	20	10,499,363 - 10,513,640 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	20	11,198,339 - 11,211,993 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	20	10,559,232 - 10,572,886 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	20	11,031,598 - 11,045,231 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	20	11,228,892 - 11,243,204 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	20	11,228,844 - 11,243,205 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	20	13,398,455 - 13,412,898 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	20	10,836,094 - 10,849,727 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	20	12,005,711 - 12,019,344 (+)	NCBI		Celera
Cytogenetic Map	20	p12	NCBI

PWP2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	21	44,107,399 - 44,131,181 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	21	44,107,358 - 44,131,181 (+)	Ensembl			hg38	GRCh38
GRCh37	21	45,527,280 - 45,551,063 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	21	44,351,636 - 44,375,491 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	21	44,351,635 - 44,375,490	NCBI
Celera	21	30,632,847 - 30,656,721 (+)	NCBI		Celera
Cytogenetic Map	21	q22.3	NCBI
HuRef	21	30,897,487 - 30,921,342 (+)	NCBI		HuRef
CHM1_1	21	45,088,074 - 45,111,933 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	21	42,463,009 - 42,486,796 (+)	NCBI		T2T-CHM13v2.0

Pwp2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	10	78,006,743 - 78,021,005 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	10	78,006,743 - 78,020,983 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	10	78,170,909 - 78,185,171 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	10	78,170,909 - 78,185,149 (-)	Ensembl			mm10	GRCm38
MGSCv37	10	77,633,655 - 77,647,894 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	10	77,574,039 - 77,588,278 (-)	NCBI		MGSCv36	mm8
MGSCv36	10	78,620,541 - 78,634,804 (-)	NCBI		MGSCv36	mm8
Celera	10	79,210,325 - 79,216,560 (-)	NCBI		Celera
Cytogenetic Map	10	C1	NCBI
cM Map	10	39.72	NCBI

Pwp2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955407	41,256,855 - 41,269,582 (-)	Ensembl
ChiLan1.0	NW_004955407	41,256,603 - 41,269,648 (-)	NCBI	ChiLan1.0	ChiLan1.0

PWP2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	22	40,114,435 - 40,139,438 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	21	34,964,918 - 34,989,877 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	21	30,364,398 - 30,389,202 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	21	43,660,425 - 43,685,044 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	21	43,660,425 - 43,685,044 (+)	Ensembl			panPan2	panpan1.1

PWP2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	31	38,000,181 - 38,012,882 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	31	37,157,745 - 37,170,451 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	31	37,547,946 - 37,560,665 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	31	37,547,969 - 37,560,665 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	31	37,415,061 - 37,427,758 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	31	37,399,004 - 37,411,676 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	31	37,893,793 - 37,906,472 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Pwp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404971	37,203,253 - 37,221,145 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936500	244,144 - 264,577 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936500	248,102 - 264,534 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PWP2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	207,015,125 - 207,031,879 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	13	207,015,047 - 207,031,752 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	13	216,898,394 - 216,908,121 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PWP2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	2	87,858,003 - 87,881,072 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	2	87,858,029 - 87,881,102 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666054	15,948,133 - 15,972,690 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Pwp2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624745	29,942,528 - 29,958,854 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624745	29,944,211 - 29,958,861 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Pwp2
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	18	1,452,542 - 1,466,156 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Pwp2
75 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	256
Count of miRNA genes:	178
Interacting mature miRNAs:	197
Transcripts:	ENSRNOT00000001605
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
4889610	Pancm3	Pancreatic morphology QTL 3	3.75	0.001	pancreas mass (VT:0010144)	pancreas wet weight (CMO:0000626)	20	4189476	49189476	Rat
2317057	Aia27	Adjuvant induced arthritis QTL 27	2.83		joint integrity trait (VT:0010548)	right rear ankle joint diameter (CMO:0002150)	20	1	26925056	Rat
1641915	Colcr9	Colorectal carcinoma resistance QTL 9	2.97	0.0024	intestine integrity trait (VT:0010554)	benign colorectal tumor number (CMO:0001795)	20	1	33724594	Rat
7387283	Uae44	Urinary albumin excretion QTL 44		0.1712	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	20	1	26128279	Rat
4889870	Pur30	Proteinuria QTL 30	19	0.005	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	20	8043920	29865039	Rat
7411668	Foco32	Food consumption QTL 32	8	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	20	1	36600300	Rat
2305926	Iddm37	Insulin dependent diabetes mellitus QTL 37	6		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	20	1533083	46533083	Rat
1354642	Despr15	Despair related QTL 15		0.0027	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	20	1	24164241	Rat
1558640	Prcs2	Prostate cancer susceptibility QTL 2	3.3		prostate integrity trait (VT:0010571)	percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)	20	1	34066551	Rat
631265	Iresp1	Immunoglobin response QTL1	8.3		blood anti-double stranded DNA antibody amount (VT:0004762)	serum anti-DNA antibody level (CMO:0001533)	20	9041099	11115921	Rat
8694189	Bw153	Body weight QTL 153	3.13	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	20	1	29193376	Rat
4889857	Pur27	Proteinuria QTL 27	12.2	0.001	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	20	1	27341128	Rat
1598870	Bp289	Blood pressure QTL 289	2.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	20	8216359	53216359	Rat
9590109	Sffal8	Serum free fatty acids level QTL 8	5.32	0.01	blood free fatty acid amount (VT:0001553)	plasma free fatty acids level (CMO:0000546)	20	1	29193376	Rat
9589155	Insul32	Insulin level QTL 32	6.38	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	20	1	29193376	Rat
9590275	Scort15	Serum corticosterone level QTL 15	3.48	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	20	1	29193376	Rat
1581577	Pur15	Proteinuria QTL 15	4.38	0.0002	urine total protein amount (VT:0000032)	urine protein excretion rate (CMO:0000759)	20	8043920	15089182	Rat
1598858	Cm61	Cardiac mass QTL 61	3.6		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	20	8216359	53216359	Rat
7411650	Foco23	Food consumption QTL 23	20.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	20	1	29193376	Rat
61432	Cia1	Collagen induced arthritis QTL 1			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	20	1	14100378	Rat
2317851	Alcrsp22	Alcohol response QTL 22	3.2	0.05	response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	20	1	27341128	Rat
1641893	Alcrsp7	Alcohol response QTL 7			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	20	1	27341128	Rat
6893685	Bw111	Body weight QTL 111	2.7	0.004	body mass (VT:0001259)	body weight (CMO:0000012)	20	1	32578510	Rat
9590252	Scort12	Serum corticosterone level QTL 12	20.46	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	20	1	36600300	Rat

Markers in Region

Gabrb1

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	20	10,502,820 - 10,503,258 (+)	MAPPER	mRatBN7.2
Rnor_6.0	20	11,232,381 - 11,232,818	NCBI	Rnor6.0
Rnor_5.0	20	13,401,944 - 13,402,381	UniSTS	Rnor5.0
RGSC_v3.4	20	10,839,583 - 10,840,020	UniSTS	RGSC3.4
Celera	20	12,009,200 - 12,009,637	UniSTS
Cytogenetic Map	20	p12	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	161	91	90	59	92	59	6	356	192	11	140	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001168653	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006256257	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC135582	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000020	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000001605 ⟹ ENSRNOP00000001605

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	20	10,499,013 - 10,513,309 (+)	Ensembl
mRatBN7.2 Ensembl	20	10,499,363 - 10,513,640 (+)	Ensembl
Rnor_6.0 Ensembl	20	11,228,844 - 11,243,205 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000108782 ⟹ ENSRNOP00000090526

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	20	10,499,479 - 10,513,309 (+)	Ensembl
mRatBN7.2 Ensembl	20	10,499,953 - 10,513,640 (+)	Ensembl

RefSeq Acc Id:

NM_001168653 ⟹ NP_001162124

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	20	10,498,998 - 10,512,631 (+)	NCBI
mRatBN7.2	20	10,499,332 - 10,512,965 (+)	NCBI
Rnor_6.0	20	11,228,892 - 11,242,525 (+)	NCBI
Rnor_5.0	20	13,398,455 - 13,412,898 (+)	NCBI
RGSC_v3.4	20	10,836,094 - 10,849,727 (+)	RGD
Celera	20	12,005,711 - 12,019,344 (+)	RGD

Sequence:

show sequence

GCCGGAGATAGTTCGTATTCCGGAAGTGGCTGGAGCAGGGTTCCGCACGTGTGGCTCCGGGATG
AAATTCGCTTATCGGTTCTCCAATTTGCTGGGTACAGTTTATCGGTGTGGAAACCTAAATTTCT
CACGTGATGGAAATTCTGTTATCAGCCCTGTGGGAAACAGAGTCACTGTGTTTGACCTTAAGAA
CAACAGATCAGACACATTGCCTCTGGCCACCAAGTACAACATCAAGTGCGTGGGGCTGTCCCCA
GATGGTCGCCTGGCAATCATCGTCGACGAAGGAGGCGCCGCTCTGCTAGTTAGCTTGGTGTGCA
GGTCCGTGCTCCACCACTTCCACTTCAAGGGTTCCGTGCACAGTGTCTCCTTCTCCCCCGATGG
CAGAAAATTTGTCATCACGAAGGGCAACATTGCCCAGATGTACCATGCCCCCGGAAAGAAGCGA
GAATTCAATGCCTTTGTTCTGGACAAAACCTATTTTGGGCCCTACGATGAGACCACGTGCATTG
ACTGGACAGATGACTCCAAGTGCTTTGTGGTCGGAAGCAAAGACATGTCCACCTGGGTGTTTGG
AGCTGAGCGCTGGGACAACCTTATCTACTATGCACTGAGTGGACACAAAGACGCCATTGTGGCC
TGCTTCTTTGAGTCCAACAGCCTAGATCTGTACTCGCTCAGCCAAGATGGAGCCCTGTGTGTGT
GGCAGTGTGACACACCCCCTGAGGGCCTGCGGCTTAAGGCGCCTAGGGGCTGGAAGGCAGACAT
ACTTCAGAGGGAGAAGGAAGAAGAGGAGGAGGAGGATGAAGAAGGGGAAGGGAATCGAGAAACC
ACCATCCGAGGGAAGGCCGTGCCAGCCGAGCAGGAGAGGGTCGGGAAAGTGAAATACTCACGGC
TGGCCAAGTACTTCTTGAACAAAGAAGGAGACTTTAACAACCTGACAGCCGCCGCTTATCATAA
GAAGACCCATCTCTTGGTCACGGGTTTTGCTTCTGGAATCTTCCATCTGCATGAGCTCCCAGAG
TTCAACCTCATCCACTCCCTGAGCATCTCTGATCAGAGGGTCGCTTCGGTTGCGATCAACAGCT
CTGGGGACTGGATCGCCTTTGGCTGCTCAGGCTTGGGCCAGCTGCTGGTGTGGGAGTGGCAGAG
TGAATCCTACGTGCTCAAACAACAAGGCCACTTCAACAGCATGGTGGCCCTGGCCTACTCCCCT
GACGGGCAGTACATTGTCACCGGTGGGGACGATGGCAAGGTCAAGGTGTGGAACACCCTCAGTG
GCTTCTGCTTTGTCACTCTCACGGAACACTCCAGTGGGGTCACTGGAGTGACATTCACTGCCAC
AGGCCATGTCATTGTCACCTCCTCCTTGGATGGCACCGTGAGAGCCTACGATCTTCACAGGTAC
CGGAATTTCCGCACCTTCACGTCTCCACGGCCCACACAGTTCTCTTGTGTGGCCGTCGACTCAA
GCGGGGAAATCGTCTCTGCAGGGGCGCAGGACTCCTTTGAGATCTTTGTGTGGTCCATGCAGAC
AGGCAGGCTCCTTGATGTTCTCTCTGGCCATGAGGGGCCCATCAGTGGTCTTTGCTTTAACCCC
ATGAAGTCCATCCTGGCTAGTGCCTCTTGGGACAAGACAGTGCGTCTGTGGGACATGTTCGACA
GTTGGAGAACCAAGGAGACCTTGAGTCTGACCTCTGACGTCCTAGCTGTGACTTACCGGCCTGA
TGGTGCAGAGCTGGCTGTGGCTACTCTGAATTCACAGATCACTTTCTGGGATCCGGAGAATGCT
GTACAGGTGGGCTCCATCGAGGGCAGGCATGACCTGAAGACGGGCAGGAAAGAGCTGGACAAGA
TCACAGCTAAACACTCGGCCAAGGGCAAGGCCTTCACCACCGTGTGTTACTCTGCGGACGGCCA
GAACATCCTGGCGGGAGGCATGTCCAAGTTCGTCTGCCTTTACCACGTCCGGGAACAAATCCTG
GTGAAGAGGTTTGAGCTCTCCTGCAACTTCTCTCTGGATGCCATGGAAGAATTCCTGAACCGGA
GAAAGATGACGGAGTTTGGCAACCTGGCACTCATCGACCAAGATGCCGGGGAAGAGAACGGGGT
AGCGATTCCGTTGCCGGGTGTAAGGAAGGGTGACATGAGCTCCAGACACTTCAAACCTGAAATC
AGGGTGACTTCTCTACGCTTCTCTCCCACTGGGCGCTGCTGGGCAGCCACCAGCACAGAGGGGC
TCCTCATCTTCTCCCTGGACGCCCAGATGCTCTTTGACCCATTCGAGCTGGACACCAGTGTGAC
CCCTGGACGGATCCGGGAAGCCCTCCGACAGAGGGAGTTTACCCGGGCCATCCTTATGGCCTTC
CGCCTCAATGAGAAAAAACTGGCCCAGGAGGCCCTGGAGGCTGTACCACAGAATGAGATTGAGG
TGGTCAGCGCTTCTCTGCCTGAGCTGTATGTGGTGAAAGTGCTAGAGTTCTTAGCCGCCTCCTT
TGAAGAGTCTCGGCACCTGGAATTCTACCTTATATGGACACAGAAGTTACTGATGTCACATGGA
CAGCGCCTGAAGTCCAGGGCGGGACAGTTGCTGCCTGTGGTCCAGTTCCTTCAGAAGGGCCTCC
AGCGGCATCTAGATGACATTTCCAAGCTCTGTGACTGGAACCGCTATAACATCCAGTACGCGCT
GGCGGTTTCCAAGCAGAGGGGTATGAAACGCACCCTCGAACCTGTAGACACAGAGGAGGACACA
GATGCATCTGATGAGGACAGTCTGCACCTACTCAGAGCTGCAGAGGAGGAGGAAGAGGGGATGC
TGGTGTAGAACCGCGTACGTCATAGCCTCATTGGCTGATTGGAGATGGAACCACGGTGCTCCTG
GGCCCAGGAAGTGGGAGATGCCAGAGGTCCGAAGACCCTCCAGCCAGGCCTCTTCCTGTGAGAC
TGCTCATGCTGCCATGAGCAGGACACAATGGGCACACACGCTGTGGGCCCAGAACGCTGGCGTC
ATGGATGACGACCCTGCACAGACTTCCTGAGGAGTGGACAGGTTTAGAAGTGTGGGCTTGCAAA
ATTCCTGTCAGAGTTATTTATATTTTTATATGACATTCTACGATGAACTTAGGGTTGGAAAGTG
GGCTTCTTAAAAAATATGAGGGCTTCGCTTTTCAACTTTG

hide sequence

Protein Sequences


Protein RefSeqs	NP_001162124	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000001605
	ENSRNOP00000001605.4
	ENSRNOP00000090526.1

RefSeq Acc Id:

NP_001162124 ⟸ NM_001168653

- UniProtKB:

D3ZV54 (UniProtKB/TrEMBL), A0A8I6A9Q2 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MKFAYRFSNLLGTVYRCGNLNFSRDGNSVISPVGNRVTVFDLKNNRSDTLPLATKYNIKCVGLS
PDGRLAIIVDEGGAALLVSLVCRSVLHHFHFKGSVHSVSFSPDGRKFVITKGNIAQMYHAPGKK
REFNAFVLDKTYFGPYDETTCIDWTDDSKCFVVGSKDMSTWVFGAERWDNLIYYALSGHKDAIV
ACFFESNSLDLYSLSQDGALCVWQCDTPPEGLRLKAPRGWKADILQREKEEEEEEDEEGEGNRE
TTIRGKAVPAEQERVGKVKYSRLAKYFLNKEGDFNNLTAAAYHKKTHLLVTGFASGIFHLHELP
EFNLIHSLSISDQRVASVAINSSGDWIAFGCSGLGQLLVWEWQSESYVLKQQGHFNSMVALAYS
PDGQYIVTGGDDGKVKVWNTLSGFCFVTLTEHSSGVTGVTFTATGHVIVTSSLDGTVRAYDLHR
YRNFRTFTSPRPTQFSCVAVDSSGEIVSAGAQDSFEIFVWSMQTGRLLDVLSGHEGPISGLCFN
PMKSILASASWDKTVRLWDMFDSWRTKETLSLTSDVLAVTYRPDGAELAVATLNSQITFWDPEN
AVQVGSIEGRHDLKTGRKELDKITAKHSAKGKAFTTVCYSADGQNILAGGMSKFVCLYHVREQI
LVKRFELSCNFSLDAMEEFLNRRKMTEFGNLALIDQDAGEENGVAIPLPGVRKGDMSSRHFKPE
IRVTSLRFSPTGRCWAATSTEGLLIFSLDAQMLFDPFELDTSVTPGRIREALRQREFTRAILMA
FRLNEKKLAQEALEAVPQNEIEVVSASLPELYVVKVLEFLAASFEESRHLEFYLIWTQKLLMSH
GQRLKSRAGQLLPVVQFLQKGLQRHLDDISKLCDWNRYNIQYALAVSKQRGMKRTLEPVDTEED
TDASDEDSLHLLRAAEEEEEGMLV

hide sequence

Ensembl Acc Id:

ENSRNOP00000001605 ⟸ ENSRNOT00000001605

Ensembl Acc Id:

ENSRNOP00000090526 ⟸ ENSRNOT00000108782

Protein Domains

Small-subunit processome Utp12

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZV54-F1-model_v2	AlphaFold	D3ZV54	1-920	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13701487

Promoter ID:

EPDNEW_R12011

Type:

multiple initiation site

Name:

Pwp2_1

Description:

PWP2, small subunit processome component

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	20	11,228,908 - 11,228,968	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1582817	AgrOrtholog
BioCyc Gene	G2FUF-4278	BioCyc
Ensembl Genes	ENSRNOG00000001210	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000001605	ENTREZGENE
	ENSRNOT00000001605.9	UniProtKB/TrEMBL
	ENSRNOT00000108782.2	UniProtKB/TrEMBL
Gene3D-CATH	2.130.10.10	UniProtKB/TrEMBL
InterPro	G-protein_beta_WD-40_rep_reg	UniProtKB/TrEMBL
	PWP2	UniProtKB/TrEMBL
	Quino_AlcDH-like	UniProtKB/TrEMBL
	SSU_processome_Utp12	UniProtKB/TrEMBL
	WD40/YVTN_repeat-like_dom	UniProtKB/TrEMBL
	WD40_repeat	UniProtKB/TrEMBL
	WD40_repeat_CS	UniProtKB/TrEMBL
KEGG Report	rno:690297	UniProtKB/TrEMBL
NCBI Gene	690297	ENTREZGENE
PANTHER	PERIODIC TRYPTOPHAN PROTEIN 2 HOMOLOG	UniProtKB/TrEMBL
	PTHR19858	UniProtKB/TrEMBL
Pfam	Utp12	UniProtKB/TrEMBL
	WD40	UniProtKB/TrEMBL
PhenoGen	Pwp2	PhenoGen
PRINTS	GPROTEINBRPT	UniProtKB/TrEMBL
PROSITE	WD_REPEATS_1	UniProtKB/TrEMBL
	WD_REPEATS_2	UniProtKB/TrEMBL
	WD_REPEATS_REGION	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000001210	RatGTEx
SMART	WD40	UniProtKB/TrEMBL
Superfamily-SCOP	Calcium-dependent phosphotriesterase	UniProtKB/TrEMBL
	Quin_alc_DH_like	UniProtKB/TrEMBL
UniProt	A0A8I6A9Q2	ENTREZGENE, UniProtKB/TrEMBL
	D3ZV54	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2017-06-20	Pwp2	PWP2, small subunit processome component	Pwp2	PWP2, UTPB SSU processome subunit	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2017-05-24	Pwp2	PWP2, UTPB SSU processome subunit	Pwp2	PWP2 periodic tryptophan protein homolog (yeast)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-03-06	Pwp2	PWP2 periodic tryptophan protein homolog (yeast)	LOC690297	similar to PWP2 periodic tryptophan protein homolog	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-11-19	LOC690297	similar to PWP2 periodic tryptophan protein homolog			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Annotations - KEGG (archival)