Srgap1 (SLIT-ROBO Rho GTPase activating protein 1) - Rat Genome Database

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Gene: Srgap1 (SLIT-ROBO Rho GTPase activating protein 1) Rattus norvegicus
Analyze
Symbol: Srgap1
Name: SLIT-ROBO Rho GTPase activating protein 1
RGD ID: 1566260
Description: Predicted to enable GTPase activator activity and small GTPase binding activity. Predicted to be involved in negative regulation of cell migration; nervous system development; and regulation of synapse assembly. Predicted to act upstream of or within Rho protein signal transduction and cell migration. Human ortholog(s) of this gene implicated in papillary thyroid carcinoma. Orthologous to human SRGAP1 (SLIT-ROBO Rho GTPase activating protein 1); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC314903; RGD1566260; similar to SLIT-ROBO Rho GTPase-activating protein 1; SLIT-ROBO Rho GTPase-activating protein 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8759,215,007 - 59,479,600 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl759,215,007 - 59,656,213 (-)EnsemblGRCr8
mRatBN7.2757,329,532 - 57,594,681 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl757,329,532 - 57,596,196 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx759,234,813 - 59,501,455 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0761,437,683 - 61,704,315 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0761,215,405 - 61,482,043 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0763,968,915 - 64,251,449 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl763,973,279 - 64,251,110 (-)Ensemblrn6Rnor6.0
Rnor_5.0764,192,305 - 64,472,925 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4761,372,294 - 61,633,209 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera754,326,023 - 54,585,733 (+)NCBICelera
Cytogenetic Map7q22NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Recombinant Slit2 attenuates neuronal apoptosis via the Robo1-srGAP1 pathway in a rat model of neonatal HIE. Kaur H, etal., Neuropharmacology. 2019 Nov 1;158:107727. doi: 10.1016/j.neuropharm.2019.107727. Epub 2019 Jul 26.
3. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:11672528   PMID:17710530   PMID:26026792  


Genomics

Comparative Map Data
Srgap1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8759,215,007 - 59,479,600 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl759,215,007 - 59,656,213 (-)EnsemblGRCr8
mRatBN7.2757,329,532 - 57,594,681 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl757,329,532 - 57,596,196 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx759,234,813 - 59,501,455 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0761,437,683 - 61,704,315 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0761,215,405 - 61,482,043 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0763,968,915 - 64,251,449 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl763,973,279 - 64,251,110 (-)Ensemblrn6Rnor6.0
Rnor_5.0764,192,305 - 64,472,925 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4761,372,294 - 61,633,209 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera754,326,023 - 54,585,733 (+)NCBICelera
Cytogenetic Map7q22NCBI
SRGAP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381263,844,700 - 64,162,217 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1263,843,761 - 64,162,217 (+)Ensemblhg38GRCh38
GRCh371264,238,480 - 64,555,997 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361262,524,808 - 62,823,841 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341262,524,807 - 62,823,827NCBI
Celera1263,903,548 - 64,206,828 (+)NCBICelera
Cytogenetic Map12q14.2NCBI
HuRef1261,290,158 - 61,593,347 (+)NCBIHuRef
CHM1_11264,206,267 - 64,509,435 (+)NCBICHM1_1
T2T-CHM13v2.01263,823,410 - 64,141,021 (+)NCBIT2T-CHM13v2.0
Srgap1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910121,616,896 - 121,883,740 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10121,616,896 - 121,883,220 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm3810121,780,991 - 122,047,911 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10121,780,991 - 122,047,315 (-)Ensemblmm10GRCm38
MGSCv3710121,222,298 - 121,484,249 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3610121,188,302 - 121,450,375 (-)NCBIMGSCv36mm8
Celera10124,170,327 - 124,436,483 (-)NCBICelera
Cytogenetic Map10D2NCBI
cM Map1069.96NCBI
Srgap1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545810,841,896 - 10,991,500 (+)Ensembl
ChiLan1.0NW_00495545810,842,745 - 10,991,500 (+)NCBIChiLan1.0ChiLan1.0
SRGAP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21030,191,993 - 30,514,237 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11230,203,110 - 30,511,008 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01224,760,093 - 25,066,794 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11225,257,695 - 25,565,053 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1225,262,893 - 25,564,180 (-)EnsemblpanPan2panpan1.1
SRGAP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1106,677,409 - 6,947,495 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl106,677,403 - 6,944,677 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha106,606,734 - 6,883,229 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0106,780,375 - 7,057,381 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl106,780,141 - 7,056,166 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1106,646,578 - 6,923,413 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0106,904,465 - 7,175,147 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0107,035,897 - 7,306,554 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Srgap1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494551,552,795 - 51,831,889 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365452,278,290 - 2,552,552 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365452,277,449 - 2,557,330 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SRGAP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl528,300,950 - 28,605,120 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1528,300,955 - 28,605,122 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2531,727,143 - 31,847,065 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SRGAP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11159,548,703 - 59,856,493 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1159,549,225 - 59,851,302 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666037185,950,136 - 186,257,801 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Srgap1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248024,165,054 - 4,472,293 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248024,164,969 - 4,472,491 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Srgap1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11200,215,485 - 200,480,973 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Srgap1
1911 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:39
Count of miRNA genes:37
Interacting mature miRNAs:39
Transcripts:ENSRNOT00000006180
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411569Bw137Body weight QTL 1370.001body mass (VT:0001259)body weight gain (CMO:0000420)72380760668807606Rat
10053722Scort27Serum corticosterone level QTL 272.410.0083blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)74511390390113903Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)71051708662346019Rat
1549840Bss5Bone structure and strength QTL 59.8femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)72663805771638057Rat
1357336Gluco6Glucose level QTL 63.4blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)75170064396700643Rat
1300127Srn1Serum renin concentration QTL 13.87blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)72417947886817926Rat
10059605Kidm47Kidney mass QTL 472.910.05kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)74913799967614020Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)731770293110435881Rat
1298525Cm1Cardiac mass QTL 12.7heart mass (VT:0007028)heart wet weight (CMO:0000069)756625161101625161Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)71011291660150541Rat
631513Scl7Serum cholesterol level QTL 74.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)73984590284845902Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)746307490127866166Rat
10755453Coatc12Coat color QTL 120coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)73299870277998702Rat
2317059Aia15Adjuvant induced arthritis QTL 152.46joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)74968283263890004Rat
1300151Bp181Blood pressure QTL 1813.36arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)755498584105834451Rat
7411605Foco14Food consumption QTL 1424.10.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)73617876481178764Rat
738030Anxrr8Anxiety related response QTL 84.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)74847504993475049Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)71011291699900612Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)71104117804Rat
631534Lnnr1Liver neoplastic nodule remodeling QTL 13.850.001liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)73617876481178764Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)71509236116977875Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)740540077123682549Rat
70190Mcs6Mammary carcinoma susceptibility QTL 62.29mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)72862457565788017Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)749682832115766396Rat
1300132Bp182Blood pressure QTL 1823.49arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)72154197786817926Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)749682832115766396Rat
738033Anxrr6Anxiety related response QTL 64.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)71746044762460447Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)749682832115766396Rat
2303582Gluco53Glucose level QTL 533blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)74860308793603087Rat
70207Niddm31Non-insulin dependent diabetes mellitus QTL 313.9blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)72005723265057232Rat
61439Cia8Collagen induced arthritis QTL 85.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)72718291472182914Rat

Markers in Region
AW530622  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2757,348,133 - 57,348,332 (+)MAPPERmRatBN7.2
Rnor_6.0763,987,513 - 63,987,711NCBIRnor6.0
Rnor_5.0764,210,903 - 64,211,101UniSTSRnor5.0
RGSC_v3.4761,386,536 - 61,386,734UniSTSRGSC3.4
Celera754,571,219 - 54,571,417UniSTS
RH 3.4 Map7499.6UniSTS
Cytogenetic Map7q22UniSTS
RH133174  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2757,359,115 - 57,359,295 (+)MAPPERmRatBN7.2
Rnor_6.0763,998,495 - 63,998,674NCBIRnor6.0
Rnor_5.0764,221,885 - 64,222,064UniSTSRnor5.0
RGSC_v3.4761,397,518 - 61,397,697UniSTSRGSC3.4
Celera754,560,257 - 54,560,436UniSTS
RH 3.4 Map7504.0UniSTS
Cytogenetic Map7q22UniSTS
RH142664  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2757,533,696 - 57,533,816 (+)MAPPERmRatBN7.2
Rnor_6.0764,190,918 - 64,191,037NCBIRnor6.0
Rnor_5.0764,412,807 - 64,412,926UniSTSRnor5.0
RGSC_v3.4761,572,629 - 61,572,748UniSTSRGSC3.4
Celera754,386,665 - 54,386,784UniSTS
RH 3.4 Map7501.1UniSTS
Cytogenetic Map7q22UniSTS
BE120932  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2757,344,163 - 57,344,338 (+)MAPPERmRatBN7.2
Rnor_6.0763,983,543 - 63,983,717NCBIRnor6.0
Rnor_5.0764,206,933 - 64,207,107UniSTSRnor5.0
RGSC_v3.4761,382,566 - 61,382,740UniSTSRGSC3.4
Celera754,575,212 - 54,575,386UniSTS
RH 3.4 Map7499.3UniSTS
Cytogenetic Map7q22UniSTS
BE119433  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2757,535,879 - 57,536,033 (+)MAPPERmRatBN7.2
Rnor_6.0764,193,101 - 64,193,254NCBIRnor6.0
Rnor_5.0764,414,990 - 64,415,143UniSTSRnor5.0
RGSC_v3.4761,574,812 - 61,574,965UniSTSRGSC3.4
Celera754,384,448 - 54,384,601UniSTS
RH 3.4 Map7500.1UniSTS
Cytogenetic Map7q22UniSTS
AU049549  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2757,575,261 - 57,575,476 (+)MAPPERmRatBN7.2
Rnor_6.0764,232,477 - 64,232,691NCBIRnor6.0
Rnor_5.0764,454,366 - 64,454,580UniSTSRnor5.0
RGSC_v3.4761,614,189 - 61,614,403UniSTSRGSC3.4
Celera754,344,535 - 54,344,749UniSTS
Cytogenetic Map7q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 66 164 91 90 59 56 59 6 318 155 11 143 80 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000006180   ⟹   ENSRNOP00000006180
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl759,215,007 - 59,479,724 (-)Ensembl
mRatBN7.2 Ensembl757,329,532 - 57,596,196 (-)Ensembl
Rnor_6.0 Ensembl763,973,279 - 64,251,110 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000103838   ⟹   ENSRNOP00000094388
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl759,215,007 - 59,479,724 (-)Ensembl
mRatBN7.2 Ensembl757,329,532 - 57,596,196 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000107733   ⟹   ENSRNOP00000076872
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl759,215,007 - 59,656,213 (-)Ensembl
mRatBN7.2 Ensembl757,329,532 - 57,596,196 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000170106   ⟹   ENSRNOP00000110834
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl759,215,007 - 59,479,166 (-)Ensembl
RefSeq Acc Id: NM_001191784   ⟹   NP_001178713
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8759,215,007 - 59,479,525 (-)NCBI
mRatBN7.2757,329,532 - 57,594,072 (-)NCBI
Rnor_6.0763,973,279 - 64,251,110 (-)NCBI
Rnor_5.0764,192,305 - 64,472,925 (-)NCBI
Celera754,326,023 - 54,585,733 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008765403   ⟹   XP_008763625
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8759,215,007 - 59,479,600 (-)NCBI
mRatBN7.2757,329,532 - 57,594,681 (-)NCBI
Rnor_6.0763,968,915 - 64,251,449 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001178713 (Get FASTA)   NCBI Sequence Viewer  
  XP_008763625 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL84471 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000006180
  ENSRNOP00000006180.6
  ENSRNOP00000076872
  ENSRNOP00000076872.2
  ENSRNOP00000094388.2
  ENSRNOP00000110834.1
RefSeq Acc Id: NP_001178713   ⟸   NM_001191784
- UniProtKB: F1M287 (UniProtKB/TrEMBL),   A6KU40 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008763625   ⟸   XM_008765403
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZJB2 (UniProtKB/TrEMBL),   A6KU40 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000006180   ⟸   ENSRNOT00000006180
Ensembl Acc Id: ENSRNOP00000076872   ⟸   ENSRNOT00000107733
Ensembl Acc Id: ENSRNOP00000094388   ⟸   ENSRNOT00000103838
Ensembl Acc Id: ENSRNOP00000110834   ⟸   ENSRNOT00000170106
Protein Domains
F-BAR   Rho-GAP   SH3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1M287-F1-model_v2 AlphaFold F1M287 1-1085 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695230
Promoter ID:EPDNEW_R5754
Type:single initiation site
Name:Srgap1_1
Description:SLIT-ROBO Rho GTPase activating protein 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0764,251,174 - 64,251,234EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1566260 AgrOrtholog
BioCyc Gene G2FUF-33866 BioCyc
Ensembl Genes ENSRNOG00000004603 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000006180 ENTREZGENE
  ENSRNOT00000006180.8 UniProtKB/TrEMBL
  ENSRNOT00000103838.2 UniProtKB/TrEMBL
  ENSRNOT00000107733 ENTREZGENE
  ENSRNOT00000107733.2 UniProtKB/TrEMBL
  ENSRNOT00000170106.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.555.10 UniProtKB/TrEMBL
  1.20.1270.60 UniProtKB/TrEMBL
  SH3 Domains UniProtKB/TrEMBL
InterPro AH/BAR-dom UniProtKB/TrEMBL
  F_BAR UniProtKB/TrEMBL
  FCH UniProtKB/TrEMBL
  Rho_GTPase_activation_prot UniProtKB/TrEMBL
  RhoGAP_dom UniProtKB/TrEMBL
  SH3-like_dom UniProtKB/TrEMBL
  SH3_domain UniProtKB/TrEMBL
  SLIT-ROBO_RhoGAP UniProtKB/TrEMBL
  srGAP1/2/3_SH3 UniProtKB/TrEMBL
  srGAP1_F-BAR UniProtKB/TrEMBL
KEGG Report rno:314903 UniProtKB/TrEMBL
NCBI Gene 314903 ENTREZGENE
PANTHER SLIT-ROBO RHO GTPASE ACTIVATING PROTEIN UniProtKB/TrEMBL
Pfam FCH UniProtKB/TrEMBL
  RhoGAP UniProtKB/TrEMBL
  SH3_1 UniProtKB/TrEMBL
PhenoGen Srgap1 PhenoGen
PROSITE F_BAR UniProtKB/TrEMBL
  RHOGAP UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000004603 RatGTEx
SMART FCH UniProtKB/TrEMBL
  RhoGAP UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
Superfamily-SCOP Rho_GAP UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
  SSF103657 UniProtKB/TrEMBL
UniProt A0A8I5ZJB2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AKP5_RAT UniProtKB/TrEMBL
  A0ABK0LZ56_RAT UniProtKB/TrEMBL
  A6KU40 ENTREZGENE, UniProtKB/TrEMBL
  F1M287 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-07 Srgap1  SLIT-ROBO Rho GTPase activating protein 1  RGD1566260_predicted  similar to SLIT-ROBO Rho GTPase-activating protein 1 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1566260_predicted  similar to SLIT-ROBO Rho GTPase-activating protein 1 (predicted)  LOC314903  similar to SLIT-ROBO Rho GTPase-activating protein 1  Symbol and Name status set to approved 1299863 APPROVED