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Gene: Spib (Spi-B transcription factor) Rattus norvegicus
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Symbol:
Spib
Name:
Spi-B transcription factor
RGD ID:
1565899
Description:
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in immature B cell differentiation and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within macrophage differentiation and regulation of DNA-templated transcription. Predicted to be active in nucleus. Orthologous to human SPIB (Spi-B transcription factor); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Previously known as:
MGC109046; similar to Transcription factor Spi-B; Spi-B transcription factor (Spi-1/PU.1 related); transcription factor Spi-B
RGD Orthologs
Alliance Orthologs
More Info
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More Info
Latest Assembly:
GRCr8 - GRCr8 Assembly
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCr8 1 104,155,456 - 104,161,311 (-) NCBI GRCr8 GRCr8 GRCr8 GRCr8 Ensembl 1 104,155,464 - 104,161,517 (-) Ensembl GRCr8 mRatBN7.2 1 95,018,939 - 95,024,804 (-) NCBI mRatBN7.2 mRatBN7.2 mRatBN7.2 Ensembl 1 95,018,947 - 95,024,780 (-) Ensembl mRatBN7.2 UTH_Rnor_SHR_Utx 1 100,404,347 - 100,410,182 (-) NCBI UTH_Rnor_SHR_Utx UTH_Rnor_SHR_Utx UTH_Rnor_SHRSP_BbbUtx_1.0 1 108,876,991 - 108,882,826 (-) NCBI UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_WKY_Bbb_1.0 1 102,167,412 - 102,173,247 (-) NCBI UTH_Rnor_WKY_Bbb_1.0 UTH_Rnor_WKY_Bbb_1.0 Rnor_6.0 1 100,531,538 - 100,537,397 (-) NCBI Rnor_6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 1 100,531,457 - 100,537,377 (-) Ensembl rn6 Rnor6.0 Rnor_5.0 1 101,596,925 - 101,602,767 (-) NCBI Rnor_5.0 Rnor_5.0 rn5 RGSC_v3.4 1 95,004,163 - 95,009,998 (-) NCBI RGSC_v3.4 RGSC_v3.4 rn4 Celera 1 89,281,409 - 89,287,244 (-) NCBI Celera Cytogenetic Map 1 q22 NCBI
JBrowse:
Imported Disease Annotations - CTD
Only show annotations with direct experimental evidence (0 objects hidden)
Spib Rat 1,2-dimethylhydrazine increases expression ISO Spib (Mus musculus) 6480464 1,2-Dimethylhydrazine results in increased expression of SPIB mRNA CTD PMID:22206623 Spib Rat 17beta-estradiol multiple interactions EXP 6480464 [estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of SPIB mRNA CTD PMID:32741896 Spib Rat 17beta-estradiol 3-benzoate multiple interactions EXP 6480464 [estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of SPIB mRNA CTD PMID:32741896 Spib Rat 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO Spib (Mus musculus) 6480464 Tetrachlorodibenzodioxin affects the expression of SPIB mRNA CTD PMID:21570461|PMID:24058054 Spib Rat 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of SPIB mRNA CTD PMID:33387578 Spib Rat 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of SPIB mRNA CTD PMID:32109520 Spib Rat 2,4-dibromophenyl 2,4,5-tribromophenyl ether affects expression ISO Spib (Mus musculus) 6480464 2,2',4,4',5-brominated diphenyl ether affects the expression of SPIB mRNA CTD PMID:38648751 Spib Rat 2,6-di-tert-butyl-4-methylphenol decreases expression ISO Spib (Mus musculus) 6480464 Butylated Hydroxytoluene results in decreased expression of SPIB mRNA CTD PMID:19925653 Spib Rat 2-butoxyethanol decreases expression ISO Spib (Mus musculus) 6480464 n-butoxyethanol results in decreased expression of SPIB mRNA CTD PMID:19812364 Spib Rat 2-palmitoylglycerol increases expression ISO SPIB (Homo sapiens) 6480464 2-palmitoylglycerol results in increased expression of SPIB mRNA CTD PMID:37199045 Spib Rat 3-methylcholanthrene increases expression ISO Spib (Mus musculus) 6480464 Methylcholanthrene results in increased expression of SPIB mRNA CTD PMID:25926378 Spib Rat aflatoxin B1 increases methylation ISO SPIB (Homo sapiens) 6480464 Aflatoxin B1 results in increased methylation of SPIB intron CTD PMID:30157460 Spib Rat aldehydo-D-glucose multiple interactions ISO Spib (Mus musculus) 6480464 [lard co-treated with Cholesterol, Dietary co-treated with Dietary Sucrose co-treated with Fructose co-treated with Glucose] more ... CTD PMID:37567420 Spib Rat alpha-Zearalanol increases expression EXP 6480464 Zeranol results in increased expression of SPIB mRNA CTD PMID:35163327 Spib Rat amphetamine decreases expression EXP 6480464 Amphetamine results in decreased expression of SPIB mRNA CTD PMID:30779732 Spib Rat aristolochic acid A increases expression ISO SPIB (Homo sapiens) 6480464 aristolochic acid I results in increased expression of SPIB mRNA CTD PMID:33212167 Spib Rat arsane decreases response to substance ISO SPIB (Homo sapiens) 6480464 SPIB mRNA results in decreased susceptibility to Arsenic CTD PMID:17976673 Spib Rat arsenic atom decreases response to substance ISO SPIB (Homo sapiens) 6480464 SPIB mRNA results in decreased susceptibility to Arsenic CTD PMID:17976673 Spib Rat arsenous acid decreases expression ISO SPIB (Homo sapiens) 6480464 Arsenic Trioxide results in decreased expression of SPIB mRNA CTD PMID:20458559 Spib Rat benzo[a]pyrene affects expression ISO Spib (Mus musculus) 6480464 Benzo(a)pyrene affects the expression of SPIB mRNA CTD PMID:21569818 Spib Rat benzo[a]pyrene increases methylation ISO SPIB (Homo sapiens) 6480464 Benzo(a)pyrene results in increased methylation of SPIB 5' UTR CTD PMID:27901495 Spib Rat benzo[a]pyrene decreases methylation ISO SPIB (Homo sapiens) 6480464 Benzo(a)pyrene results in decreased methylation of SPIB 3' UTR CTD PMID:27901495 Spib Rat benzo[a]pyrene affects methylation ISO SPIB (Homo sapiens) 6480464 Benzo(a)pyrene affects the methylation of SPIB promoter CTD PMID:27901495 Spib Rat benzo[a]pyrene increases expression ISO SPIB (Homo sapiens) 6480464 Benzo(a)pyrene results in increased expression of SPIB mRNA CTD PMID:22316170 Spib Rat bisphenol A multiple interactions EXP 6480464 [bisphenol A co-treated with Testosterone] results in decreased expression of SPIB mRNA CTD PMID:26496021 Spib Rat bisphenol A increases expression ISO Spib (Mus musculus) 6480464 bisphenol A results in increased expression of SPIB mRNA CTD PMID:32156529|PMID:38701888 Spib Rat bisphenol A increases methylation EXP 6480464 bisphenol A results in increased methylation of SPIB gene CTD PMID:28505145 Spib Rat bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of SPIB mRNA CTD PMID:30816183|PMID:32528016 Spib Rat bisphenol A affects expression EXP 6480464 bisphenol A affects the expression of SPIB mRNA CTD PMID:25181051 Spib Rat bisphenol AF increases expression EXP 6480464 bisphenol AF results in increased expression of SPIB mRNA CTD PMID:27567155 Spib Rat bromobenzene decreases expression EXP 6480464 bromobenzene results in decreased expression of SPIB mRNA CTD PMID:32479839 Spib Rat buta-1,3-diene decreases expression ISO Spib (Mus musculus) 6480464 1,3-butadiene results in decreased expression of SPIB mRNA CTD PMID:29038090 Spib Rat cadmium dichloride increases expression EXP 6480464 Cadmium Chloride results in increased expression of SPIB mRNA CTD PMID:33453195 Spib Rat carbon nanotube decreases expression ISO Spib (Mus musculus) 6480464 Nanotubes, Carbon analog results in decreased expression of SPIB mRNA; Nanotubes, Carbon results in decreased more ... CTD PMID:25554681 Spib Rat chloroprene decreases expression ISO Spib (Mus musculus) 6480464 Chloroprene results in decreased expression of SPIB mRNA CTD PMID:23125180 Spib Rat chlorpyrifos decreases expression ISO Spib (Mus musculus) 6480464 Chlorpyrifos results in decreased expression of SPIB mRNA CTD PMID:37019170 Spib Rat chrysene increases expression ISO Spib (Mus musculus) 6480464 chrysene results in increased expression of SPIB mRNA CTD PMID:26377693 Spib Rat cisplatin multiple interactions ISO Spib (Mus musculus) 6480464 [Cisplatin co-treated with RELB mutant form co-treated with TNF protein] results in decreased expression of more ... CTD PMID:23625948 Spib Rat clofibrate multiple interactions ISO Spib (Mus musculus) 6480464 [Clofibrate co-treated with Acetaminophen] affects the expression of SPIB mRNA; PPARA affects the reaction [[Clofibrate more ... CTD PMID:17585979 Spib Rat clofibrate decreases expression ISO Spib (Mus musculus) 6480464 Clofibrate results in decreased expression of SPIB mRNA CTD PMID:17585979 Spib Rat copper(II) sulfate increases expression ISO SPIB (Homo sapiens) 6480464 Copper Sulfate results in increased expression of SPIB mRNA CTD PMID:19549813 Spib Rat curcumin increases expression ISO SPIB (Homo sapiens) 6480464 Curcumin results in increased expression of SPIB mRNA CTD PMID:17198877 Spib Rat D-glucose multiple interactions ISO Spib (Mus musculus) 6480464 [lard co-treated with Cholesterol, Dietary co-treated with Dietary Sucrose co-treated with Fructose co-treated with Glucose] more ... CTD PMID:37567420 Spib Rat diarsenic trioxide decreases expression ISO SPIB (Homo sapiens) 6480464 Arsenic Trioxide results in decreased expression of SPIB mRNA CTD PMID:20458559 Spib Rat dioxygen multiple interactions ISO Spib (Mus musculus) 6480464 [NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of SPIB mRNA CTD PMID:30529165 Spib Rat doxorubicin decreases expression ISO Spib (Mus musculus) 6480464 Doxorubicin results in decreased expression of SPIB mRNA CTD PMID:39631538 Spib Rat fructose multiple interactions ISO Spib (Mus musculus) 6480464 [lard co-treated with Cholesterol, Dietary co-treated with Dietary Sucrose co-treated with Fructose co-treated with Glucose] more ... CTD PMID:37567420 Spib Rat furan increases expression EXP 6480464 furan results in increased expression of SPIB mRNA CTD PMID:27387713 Spib Rat glucose multiple interactions ISO Spib (Mus musculus) 6480464 [lard co-treated with Cholesterol, Dietary co-treated with Dietary Sucrose co-treated with Fructose co-treated with Glucose] more ... CTD PMID:37567420 Spib Rat irinotecan increases expression ISO SPIB (Homo sapiens) 6480464 Irinotecan metabolite results in increased expression of SPIB mRNA; Irinotecan results in increased expression of more ... CTD PMID:15956246 Spib Rat manganese(II) chloride increases expression EXP 6480464 manganese chloride results in increased expression of SPIB mRNA CTD PMID:28801915 Spib Rat N-ethyl-N-nitrosourea increases mutagenesis ISO Spib (Mus musculus) 6480464 Ethylnitrosourea results in increased mutagenesis of SPIB gene CTD PMID:27776689 Spib Rat N-methyl-4-phenylpyridinium decreases expression EXP 6480464 1-Methyl-4-phenylpyridinium results in decreased expression of SPIB mRNA CTD PMID:28801915 Spib Rat nickel atom increases expression ISO SPIB (Homo sapiens) 6480464 Nickel results in increased expression of SPIB mRNA CTD PMID:25583101 Spib Rat nitrates multiple interactions ISO Spib (Mus musculus) 6480464 [Particulate Matter results in increased abundance of Nitrates] which results in increased expression of SPIB more ... CTD PMID:35964746 Spib Rat okadaic acid increases expression ISO SPIB (Homo sapiens) 6480464 Okadaic Acid results in increased expression of SPIB mRNA CTD PMID:38832940 Spib Rat ozone multiple interactions ISO Spib (Mus musculus) 6480464 [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in decreased more ... CTD PMID:34911549 Spib Rat paracetamol multiple interactions ISO Spib (Mus musculus) 6480464 [Clofibrate co-treated with Acetaminophen] affects the expression of SPIB mRNA; PPARA affects the reaction [[Clofibrate more ... CTD PMID:17585979 Spib Rat paracetamol increases expression EXP 6480464 Acetaminophen results in increased expression of SPIB mRNA CTD PMID:33387578 Spib Rat phosphorus atom increases expression ISO SPIB (Homo sapiens) 6480464 Phosphorus results in increased expression of SPIB mRNA CTD PMID:17715259 Spib Rat phosphorus(.) increases expression ISO SPIB (Homo sapiens) 6480464 Phosphorus results in increased expression of SPIB mRNA CTD PMID:17715259 Spib Rat pirinixic acid decreases expression ISO Spib (Mus musculus) 6480464 pirinixic acid results in decreased expression of SPIB mRNA CTD PMID:17426115 Spib Rat silicon dioxide increases expression ISO SPIB (Homo sapiens) 6480464 Silicon Dioxide analog results in increased expression of SPIB mRNA CTD PMID:25895662 Spib Rat silicon dioxide increases expression ISO Spib (Mus musculus) 6480464 Silicon Dioxide results in increased expression of SPIB mRNA CTD PMID:36403901|PMID:38811393 Spib Rat testosterone multiple interactions EXP 6480464 [bisphenol A co-treated with Testosterone] results in decreased expression of SPIB mRNA; [estradiol 3-benzoate co-treated more ... CTD PMID:26496021|PMID:32741896 Spib Rat tetraphene increases expression ISO Spib (Mus musculus) 6480464 benz(a)anthracene results in increased expression of SPIB mRNA CTD PMID:26377693 Spib Rat thioacetamide increases expression EXP 6480464 Thioacetamide results in increased expression of SPIB mRNA CTD PMID:34492290 Spib Rat titanium dioxide increases expression ISO Spib (Mus musculus) 6480464 titanium dioxide results in increased expression of SPIB mRNA CTD PMID:23557971 Spib Rat titanium dioxide decreases expression ISO Spib (Mus musculus) 6480464 titanium dioxide results in decreased expression of SPIB mRNA CTD PMID:27760801 Spib Rat trichloroethene increases expression EXP 6480464 Trichloroethylene results in increased expression of SPIB mRNA CTD PMID:33387578 Spib Rat triphenyl phosphate affects expression ISO SPIB (Homo sapiens) 6480464 triphenyl phosphate affects the expression of SPIB mRNA CTD PMID:37042841 Spib Rat valproic acid increases methylation ISO SPIB (Homo sapiens) 6480464 Valproic Acid results in increased methylation of SPIB gene CTD PMID:29154799
QTLs in Region (GRCr8)
1582234 Gluco18 Glucose level QTL 18 3.4 0.0003 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) 1 87889942 132889942 Rat 1358359 Sradr1 Stress Responsive Adrenal Weight QTL 1 4.74 adrenal gland mass (VT:0010420) both adrenal glands wet weight (CMO:0000164) 1 39728272 132889942 Rat 634314 Niddm44 Non-insulin dependent diabetes mellitus QTL 44 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) 1 51941022 208479811 Rat 1331793 Bp200 Blood pressure QTL 200 3.71601 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 1 102780511 182384005 Rat 1578654 Bss10 Bone structure and strength QTL 10 4 femur morphology trait (VT:0000559) femoral neck cortical cross-sectional area (CMO:0001702) 1 51940904 168768703 Rat 2300324 Fetw1 Fetal weight QTL 1 12.1 0.005 fetal growth trait (VT:0004201) fetal body weight (CMO:0002080) 1 92963855 109494029 Rat 1554320 Bmd1 Bone mineral density QTL 1 12.2 0.0001 femur mineral mass (VT:0010011) volumetric bone mineral density (CMO:0001553) 1 101228864 146228864 Rat 1331800 Scl25 Serum cholesterol level QTL 25 3.013 blood cholesterol amount (VT:0000180) serum total cholesterol level (CMO:0000363) 1 87785026 142582336 Rat 7421628 Bp361 Blood pressure QTL 361 0.001 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 1 83019780 128019780 Rat 631495 Bp96 Blood pressure QTL 96 4.52 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 1 66404680 111404680 Rat 70225 Bp58 Blood pressure QTL 58 3.3 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 1 34184556 172281316 Rat 2298545 Neuinf8 Neuroinflammation QTL 8 4.6 nervous system integrity trait (VT:0010566) spinal cord beta-2 microglobulin mRNA level (CMO:0002125) 1 66009857 160501508 Rat 10059597 Bp377 Blood pressure QTL 377 3.42 0.025 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 1 34565911 208798288 Rat 631519 Pia11 Pristane induced arthritis QTL 11 5.3 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) 1 93903998 191260518 Rat 1302788 Scl19 Serum cholesterol QTL 19 4.6 0.001 blood cholesterol amount (VT:0000180) plasma total cholesterol level (CMO:0000585) 1 66400974 132889942 Rat 1549903 Bp267 Blood pressure QTL 267 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 1 84107164 115183752 Rat 2313083 Bmd74 Bone mineral density QTL 74 4 0.0001 tibia mineral mass (VT:1000283) total volumetric bone mineral density (CMO:0001728) 1 91302413 136302413 Rat 2313402 Anxrr24 Anxiety related response QTL 24 aggression-related behavior trait (VT:0015014) tameness/aggressiveness composite score (CMO:0002136) 1 51511344 153680016 Rat 724567 Tcas6 Tongue tumor susceptibility QTL 6 6.85 tongue integrity trait (VT:0010553) number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950) 1 102359314 153680016 Rat 724521 Uae1 Urinary albumin excretion QTL 1 3.8 0.0001 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) 1 99645382 182701046 Rat 1358902 Bw47 Body weight QTL 47 1.67 body mass (VT:0001259) body weight (CMO:0000012) 1 99645382 221502378 Rat 1358192 Ept13 Estrogen-induced pituitary tumorigenesis QTL 13 3.4 pituitary gland mass (VT:0010496) pituitary gland wet weight (CMO:0000853) 1 86622262 131622262 Rat 2300164 Bmd44 Bone mineral density QTL 44 5.4 0.0001 lumbar vertebra mineral mass (VT:0010511) volumetric bone mineral density (CMO:0001553) 1 66077886 111077886 Rat 731168 Bp154 Blood pressure QTL 154 3.4 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 1 103779152 223964440 Rat 631205 Bp196 Blood pressure QTL 196 4 0.0001 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 1 98879955 208479939 Rat 738022 Anxrr13 Anxiety related response QTL 13 4.6 0.00039 locomotor behavior trait (VT:0001392) measurement of voluntary locomotion into, out of, or within a discrete space in an open field apparatus (CMO:0001514) 1 92683681 137683681 Rat 152025249 Scl82 Serum cholesterol level QTL 82 4.77 blood cholesterol amount (VT:0000180) 1 52891222 109116986 Rat 10054135 Gmadr2 Adrenal mass QTL 2 1.97 0.0129 adrenal gland mass (VT:0010420) both adrenal glands wet weight (CMO:0000164) 1 86993904 131993904 Rat 7411712 Strs4 Sensitivity to stroke QTL 4 8.7 cerebrum integrity trait (VT:0010549) percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932) 1 87558587 132558587 Rat 1331749 Hrtrt11 Heart rate QTL 11 2.973 heart pumping trait (VT:2000009) heart rate (CMO:0000002) 1 92683681 137683681 Rat 737977 Bp160 Blood pressure QTL 160 0.001 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 1 97582336 142582336 Rat 2293142 Bp314 Blood pressure QTL 314 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 1 101594089 146594089 Rat 61433 Cia2 Collagen induced arthritis QTL 2 5 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) 1 100345976 145345976 Rat 724529 Cm16 Cardiac mass QTL 16 2.7 heart mass (VT:0007028) calculated heart weight (CMO:0000073) 1 96717367 160111531 Rat
