C15h8orf74 (similar to human chromosome 8 open reading frame 74) - Rat Genome Database

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Gene: C15h8orf74 (similar to human chromosome 8 open reading frame 74) Rattus norvegicus
Analyze
Symbol: C15h8orf74
Name: similar to human chromosome 8 open reading frame 74
RGD ID: 1565212
Description: Orthologous to human C8orf74 (chromosome 8 open reading frame 74); INTERACTS WITH bisphenol A; antirheumatic drug (ortholog); benzo[a]pyrene (ortholog).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: hypothetical protein LOC498534; LOC498534; RGD1565212; similar to 4930578I06Rik protein; uncharacterized protein C8orf74 homolog; uncharacterized protein LOC498534
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81542,384,768 - 42,401,641 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1542,384,768 - 42,401,641 (-)EnsemblGRCr8
mRatBN7.21538,208,864 - 38,225,737 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1538,208,864 - 38,225,737 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1540,066,177 - 40,083,084 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01541,216,862 - 41,233,771 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01539,669,457 - 39,686,341 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01547,322,058 - 47,338,931 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1547,322,076 - 47,338,976 (-)Ensemblrn6Rnor6.0
Rnor_5.01551,081,452 - 51,098,325 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41543,236,341 - 43,253,214 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1537,890,446 - 37,907,319 (-)NCBICelera
Cytogenetic Map15p12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
C15h8orf74
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81542,384,768 - 42,401,641 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1542,384,768 - 42,401,641 (-)EnsemblGRCr8
mRatBN7.21538,208,864 - 38,225,737 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1538,208,864 - 38,225,737 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1540,066,177 - 40,083,084 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01541,216,862 - 41,233,771 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01539,669,457 - 39,686,341 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01547,322,058 - 47,338,931 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1547,322,076 - 47,338,976 (-)Ensemblrn6Rnor6.0
Rnor_5.01551,081,452 - 51,098,325 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41543,236,341 - 43,253,214 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1537,890,446 - 37,907,319 (-)NCBICelera
Cytogenetic Map15p12NCBI
C8orf74
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38810,672,628 - 10,700,590 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl810,672,628 - 10,700,590 (+)Ensemblhg38GRCh38
GRCh37810,530,138 - 10,558,100 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36810,567,557 - 10,595,513 (+)NCBIBuild 36Build 36hg18NCBI36
Celera89,658,009 - 9,685,862 (+)NCBICelera
Cytogenetic Map8p23.1NCBI
HuRef89,460,643 - 9,488,406 (+)NCBIHuRef
CHM1_1810,595,741 - 10,623,612 (+)NCBICHM1_1
T2T-CHM13v2.089,038,498 - 9,066,367 (-)NCBIT2T-CHM13v2.0
4930578I06Rik
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391464,208,570 - 64,225,229 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1464,206,788 - 64,225,239 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381463,971,121 - 63,987,780 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1463,969,339 - 63,987,790 (-)Ensemblmm10GRCm38
MGSCv371464,589,959 - 64,606,617 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361462,923,449 - 62,941,900 (-)NCBIMGSCv36mm8
Celera1461,748,124 - 61,764,780 (-)NCBICelera
Cytogenetic Map14D1NCBI
cM Map1433.34NCBI
CUNH8orf74
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540352,224,523 - 52,240,567 (+)Ensembl
ChiLan1.0NW_00495540352,224,529 - 52,240,276 (+)NCBIChiLan1.0ChiLan1.0
C7H8orf74
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2727,129,497 - 27,161,157 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan183,161,934 - 3,193,621 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v088,506,220 - 8,534,431 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
C25H8orf74
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12527,244,758 - 27,269,731 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2527,244,756 - 27,269,638 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2527,901,610 - 27,927,184 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02527,400,103 - 27,425,077 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2527,400,101 - 27,425,463 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12527,354,216 - 27,379,792 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02527,248,398 - 27,273,382 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02527,402,282 - 27,427,276 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
CUNH8orf74
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049435,989,360 - 6,007,721 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366752,578,490 - 2,596,685 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366752,578,470 - 2,596,685 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
C14H8orf74
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1413,890,107 - 13,915,841 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11413,890,346 - 13,916,783 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21415,237,141 - 15,263,567 (+)NCBISscrofa10.2Sscrofa10.2susScr3
C8H8orf74
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.188,398,245 - 8,426,890 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl88,398,377 - 8,426,744 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605233,997,843 - 34,030,072 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
CUNH8orf74
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475824,525,826 - 24,542,168 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462475824,525,826 - 24,546,108 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
C12H8orf74
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11260,417,957 - 60,434,815 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in C15h8orf74
96 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:28
Count of miRNA genes:26
Interacting mature miRNAs:28
Transcripts:ENSRNOT00000016562
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1641913Colcr2Colorectal carcinoma resistance QTL 26.570.0197intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)15231575947315759Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15144836456Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15231575953331089Rat
152025253Hrtrt24Heart rate QTL 243.82heart pumping trait (VT:2000009)153185580392671517Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152852773273527732Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1525285835104695021Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)152233635152597086Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)1525285835104695021Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151915576287086765Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)15278592347785923Rat
1598828Glom14Glomerulus QTL 142.5kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)154046315285463152Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151492659471614418Rat
631550Bw7Body weight QTL 73.6body mass (VT:0001259)body weight (CMO:0000012)152233635167336351Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)1525285835104695021Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
11 3 1 37 24 17 7 4 7 5 42 17 21 5 74 10

Sequence


Ensembl Acc Id: ENSRNOT00000016562   ⟹   ENSRNOP00000016562
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1542,384,768 - 42,401,641 (-)Ensembl
mRatBN7.2 Ensembl1538,208,864 - 38,225,737 (-)Ensembl
Rnor_6.0 Ensembl1547,322,076 - 47,338,976 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000105668   ⟹   ENSRNOP00000080931
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1538,209,936 - 38,225,737 (-)Ensembl
RefSeq Acc Id: NM_001109103   ⟹   NP_001102573
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81542,384,768 - 42,401,641 (-)NCBI
mRatBN7.21538,208,864 - 38,225,737 (-)NCBI
Rnor_6.01547,322,058 - 47,338,931 (-)NCBI
Rnor_5.01551,081,452 - 51,098,325 (-)NCBI
RGSC_v3.41543,236,341 - 43,253,214 (-)RGD
Celera1537,890,446 - 37,907,319 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001102573 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL85329 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000016562
  ENSRNOP00000016562.4
RefSeq Acc Id: NP_001102573   ⟸   NM_001109103
- UniProtKB: D3ZT70 (UniProtKB/TrEMBL),   A6K6G9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000016562   ⟸   ENSRNOT00000016562
Ensembl Acc Id: ENSRNOP00000080931   ⟸   ENSRNOT00000105668

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZT70-F1-model_v2 AlphaFold D3ZT70 1-298 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699783
Promoter ID:EPDNEW_R10305
Type:multiple initiation site
Name:RGD1565212_1
Description:similar to 4930578I06Rik protein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01547,338,898 - 47,338,958EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1565212 AgrOrtholog
BioCyc Gene G2FUF-13393 BioCyc
Ensembl Genes ENSRNOG00000012402 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000016562 ENTREZGENE
  ENSRNOT00000016562.7 UniProtKB/TrEMBL
InterPro CLAMP UniProtKB/TrEMBL
KEGG Report rno:498534 UniProtKB/TrEMBL
NCBI Gene 498534 ENTREZGENE
PANTHER PTHR28457 UniProtKB/TrEMBL
  SIMILAR TO 4930578I06RIK PROTEIN UniProtKB/TrEMBL
Pfam CLAMP UniProtKB/TrEMBL
PhenoGen C15h8orf74 PhenoGen
RatGTEx ENSRNOG00000012402 RatGTEx
UniProt A6K6G9 ENTREZGENE, UniProtKB/TrEMBL
  D3ZT70 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-07-21 C15h8orf74  similar to human chromosome 8 open reading frame 74  RGD1565212  similar to 4930578I06Rik protein  Name and Symbol changed 629549 APPROVED
2008-04-30 RGD1565212  similar to 4930578I06Rik protein   RGD1565212_predicted  similar to 4930578I06Rik protein (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1565212_predicted  similar to 4930578I06Rik protein (predicted)  LOC498534  similar to 4930578I06Rik protein  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC498534  similar to 4930578I06Rik protein      Symbol and Name status set to provisional 70820 PROVISIONAL