Treml1 (triggering receptor expressed on myeloid cells-like 1) - Rat Genome Database

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Gene: Treml1 (triggering receptor expressed on myeloid cells-like 1) Rattus norvegicus
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Symbol: Treml1
Name: triggering receptor expressed on myeloid cells-like 1
RGD ID: 1565175
Description: Predicted to be involved in calcium-mediated signaling and platelet activation. Predicted to be located in cell surface and platelet alpha granule. Orthologous to human TREML1 (triggering receptor expressed on myeloid cells like 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; acrylamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC501096; RGD1565175; similar to triggering receptor expressed on myeloid cells-like 1; trem-like transcript 1 protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8920,133,193 - 20,139,933 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl920,133,199 - 20,139,956 (-)EnsemblGRCr8
mRatBN7.2912,635,584 - 12,642,324 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl912,635,590 - 12,642,347 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx921,148,706 - 21,155,418 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0926,214,930 - 26,221,642 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0924,604,229 - 24,610,926 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0914,597,172 - 14,603,622 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl914,597,172 - 14,599,594 (-)Ensemblrn6Rnor6.0
Rnor_5.0913,521,172 - 13,523,578 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.498,018,145 - 8,052,719 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera910,409,481 - 10,411,887 (-)NCBICelera
Cytogenetic Map9q12NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cell surface  (IEA,ISO)
cytosol  (IEA,ISO)
plasma membrane  (IEA,ISO)
platelet alpha granule  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:15100151   PMID:15128762  


Genomics

Comparative Map Data
Treml1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8920,133,193 - 20,139,933 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl920,133,199 - 20,139,956 (-)EnsemblGRCr8
mRatBN7.2912,635,584 - 12,642,324 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl912,635,590 - 12,642,347 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx921,148,706 - 21,155,418 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0926,214,930 - 26,221,642 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0924,604,229 - 24,610,926 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0914,597,172 - 14,603,622 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl914,597,172 - 14,599,594 (-)Ensemblrn6Rnor6.0
Rnor_5.0913,521,172 - 13,523,578 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.498,018,145 - 8,052,719 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera910,409,481 - 10,411,887 (-)NCBICelera
Cytogenetic Map9q12NCBI
TREML1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38641,149,260 - 41,155,403 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl641,149,167 - 41,155,553 (-)Ensemblhg38GRCh38
GRCh37641,116,998 - 41,122,087 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36641,225,320 - 41,230,048 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34641,225,319 - 41,230,048NCBI
Celera642,670,032 - 42,674,760 (-)NCBICelera
Cytogenetic Map6p21.1NCBI
HuRef640,834,784 - 40,839,873 (-)NCBIHuRef
CHM1_1641,119,893 - 41,124,982 (-)NCBICHM1_1
T2T-CHM13v2.0640,977,812 - 40,983,997 (-)NCBIT2T-CHM13v2.0
Treml1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391748,666,944 - 48,674,204 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1748,666,944 - 48,674,204 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381748,359,916 - 48,367,176 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1748,359,916 - 48,367,176 (+)Ensemblmm10GRCm38
MGSCv371748,499,241 - 48,506,471 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361747,825,483 - 47,832,713 (+)NCBIMGSCv36mm8
Celera1751,790,069 - 51,797,287 (+)NCBICelera
Cytogenetic Map17CNCBI
cM Map1723.99NCBI
Treml1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554377,773,612 - 7,777,575 (-)Ensembl
ChiLan1.0NW_0049554377,773,279 - 7,778,197 (-)NCBIChiLan1.0ChiLan1.0
TREML1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2555,634,009 - 55,643,116 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1651,503,953 - 51,513,065 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0640,726,243 - 40,731,358 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1642,034,644 - 42,039,750 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl642,034,988 - 42,039,695 (-)EnsemblpanPan2panpan1.1
Treml1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494645,286,753 - 45,291,405 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647618,668,816 - 18,673,222 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647618,668,809 - 18,673,183 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TREML1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl736,455,634 - 36,460,715 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1736,455,628 - 36,460,711 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2741,752,082 - 41,757,313 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TREML1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11731,002,893 - 31,008,366 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1731,003,331 - 31,008,036 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604441,149,307 - 41,154,429 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Treml1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475417,650,247 - 17,654,256 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462475417,649,650 - 17,654,992 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Treml1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1481,564,676 - 81,570,933 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Treml1
71 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:51
Count of miRNA genes:46
Interacting mature miRNAs:48
Transcripts:ENSRNOT00000018138
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)9671488884474983Rat
631211Bw4Body weight QTL45.31retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)9534647950346479Rat
10054141Gmadr4Adrenal mass QTL 42.450.0074adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)9121707400Rat
2303559Gluco54Glucose level QTL 542blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)9875049253750492Rat
7207814Bmd91Bone mineral density QTL 913.5femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)9131250552Rat
1578675Bss17Bone structure and strength QTL 173.8femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)9360535521031556Rat
9589055Scfw5Subcutaneous fat weight QTL 55.550.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)949664545496645Rat
1641911Alcrsp13Alcohol response QTL 13response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)9621499551214995Rat
1354650Despr5Despair related QTL 54.010.0017locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)9875049253750492Rat
1300124Cm4Cardiac mass QTL 43.55heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)9141763315Rat
61425Cia15Collagen induced arthritis QTL 154.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)9534647950416711Rat
631643Bp120Blood pressure QTL 12030.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)9671488829567695Rat
9589158Gluco65Glucose level QTL 656.820.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)949664545496645Rat
7411592Foco8Food consumption QTL 87.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)949664545496645Rat
1298088Edpm11Estrogen-dependent pituitary mass QTL 112.5pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)9621499551214995Rat

Markers in Region
RH134936  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2912,635,611 - 12,635,796 (+)MAPPERmRatBN7.2
Rnor_6.0914,597,200 - 14,597,384NCBIRnor6.0
Rnor_5.0913,521,200 - 13,521,384UniSTSRnor5.0
RGSC_v3.498,018,173 - 8,018,357UniSTSRGSC3.4
Celera910,409,509 - 10,409,693UniSTS
RH 3.4 Map90.0UniSTS
Cytogenetic Map9q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
6 7 67 149 90 89 59 91 59 5 330 188 11 121 72 86 30 9 9

Sequence


Ensembl Acc Id: ENSRNOT00000018138   ⟹   ENSRNOP00000018138
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl920,133,199 - 20,139,956 (-)Ensembl
mRatBN7.2 Ensembl912,635,590 - 12,642,347 (-)Ensembl
Rnor_6.0 Ensembl914,597,172 - 14,599,594 (-)Ensembl
RefSeq Acc Id: NM_001192001   ⟹   NP_001178930
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8920,133,193 - 20,139,933 (-)NCBI
mRatBN7.2912,635,584 - 12,642,324 (-)NCBI
Rnor_6.0914,597,172 - 14,603,622 (-)NCBI
Rnor_5.0913,521,172 - 13,523,578 (-)NCBI
Celera910,409,481 - 10,411,887 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001419518   ⟹   NP_001406447
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8920,133,193 - 20,139,933 (-)NCBI
mRatBN7.2912,635,584 - 12,642,324 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001178930 (Get FASTA)   NCBI Sequence Viewer  
  NP_001406447 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM18929 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000018138
  ENSRNOP00000018138.7
RefSeq Acc Id: NP_001178930   ⟸   NM_001192001
- Peptide Label: isoform 1 precursor
- UniProtKB: D3ZYT6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000018138   ⟸   ENSRNOT00000018138
RefSeq Acc Id: NP_001406447   ⟸   NM_001419518
- Peptide Label: isoform 2 precursor

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZYT6-F1-model_v2 AlphaFold D3ZYT6 1-202 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1565175 AgrOrtholog
BioCyc Gene G2FUF-28308 BioCyc
Ensembl Genes ENSRNOG00000040109 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000018138 ENTREZGENE
  ENSRNOT00000018138.8 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
InterPro Ig-like_dom UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig_sub UniProtKB/TrEMBL
  Immune_rcpt_domain UniProtKB/TrEMBL
KEGG Report rno:501096 UniProtKB/TrEMBL
NCBI Gene 501096 ENTREZGENE
PANTHER TREM-LIKE TRANSCRIPT PROTEIN UniProtKB/TrEMBL
  TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS 2-RELATED UniProtKB/TrEMBL
PhenoGen Treml1 PhenoGen
PROSITE IG_LIKE UniProtKB/TrEMBL
RatGTEx ENSRNOG00000040109 RatGTEx
SMART SM00409 UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/TrEMBL
UniProt D3ZYT6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-06 Treml1  triggering receptor expressed on myeloid cells-like 1  RGD1565175_predicted  similar to triggering receptor expressed on myeloid cells-like 1 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1565175_predicted  similar to triggering receptor expressed on myeloid cells-like 1 (predicted)  LOC501096  similar to triggering receptor expressed on myeloid cells-like 1  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC501096  similar to triggering receptor expressed on myeloid cells-like 1      Symbol and Name status set to provisional 70820 PROVISIONAL