TREML1 (triggering receptor expressed on myeloid cells like 1) - Rat Genome Database

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Gene: TREML1 (triggering receptor expressed on myeloid cells like 1) Homo sapiens
Analyze
Symbol: TREML1
Name: triggering receptor expressed on myeloid cells like 1
RGD ID: 1344660
HGNC Page HGNC:20434
Description: Predicted to enable transmembrane signaling receptor activity. Involved in calcium-mediated signaling and platelet activation. Located in several cellular components, including Golgi apparatus; nuclear speck; and platelet alpha granule.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: dJ238O23.3; GLTL1825; MGC119173; PRO3438; TLT-1; TLT1; trem-like transcript 1 protein; triggering receptor expressed on myeloid cells-like 1; triggering receptor expressed on myeloid cells-like protein 1
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38641,149,260 - 41,155,403 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl641,149,337 - 41,154,347 (-)EnsemblGRCh38hg38GRCh38
GRCh37641,116,998 - 41,122,087 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36641,225,320 - 41,230,048 (-)NCBINCBI36Build 36hg18NCBI36
Build 34641,225,319 - 41,230,048NCBI
Celera642,670,032 - 42,674,760 (-)NCBICelera
Cytogenetic Map6p21.1NCBI
HuRef640,834,784 - 40,839,873 (-)NCBIHuRef
CHM1_1641,119,893 - 41,124,982 (-)NCBICHM1_1
T2T-CHM13v2.0640,977,812 - 40,983,997 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cell surface  (IDA,IEA)
cytoplasm  (IEA)
cytosol  (IDA)
Golgi apparatus  (IDA)
membrane  (NAS)
nuclear speck  (IDA)
plasma membrane  (IBA,IDA,IEA,TAS)
platelet alpha granule  (IDA,IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12393607   PMID:12466851   PMID:12477932   PMID:12645956   PMID:12665801   PMID:12975309   PMID:14574404   PMID:15100151   PMID:15128762   PMID:15489334   PMID:16505478   PMID:17549298  
PMID:18612537   PMID:19230638   PMID:19436112   PMID:20093931   PMID:21873635   PMID:22283904   PMID:22551551   PMID:23867815   PMID:25147325   PMID:27939925   PMID:30120105   PMID:30545930  
PMID:31713591   PMID:31923473   PMID:32296183   PMID:32513696   PMID:32831023   PMID:33958244   PMID:33961781   PMID:35277419   PMID:35348422   PMID:37766406  


Genomics

Comparative Map Data
TREML1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38641,149,260 - 41,155,403 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl641,149,337 - 41,154,347 (-)EnsemblGRCh38hg38GRCh38
GRCh37641,116,998 - 41,122,087 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36641,225,320 - 41,230,048 (-)NCBINCBI36Build 36hg18NCBI36
Build 34641,225,319 - 41,230,048NCBI
Celera642,670,032 - 42,674,760 (-)NCBICelera
Cytogenetic Map6p21.1NCBI
HuRef640,834,784 - 40,839,873 (-)NCBIHuRef
CHM1_1641,119,893 - 41,124,982 (-)NCBICHM1_1
T2T-CHM13v2.0640,977,812 - 40,983,997 (-)NCBIT2T-CHM13v2.0
Treml1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391748,666,944 - 48,674,204 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1748,666,944 - 48,674,204 (+)EnsemblGRCm39 Ensembl
GRCm381748,359,916 - 48,367,176 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1748,359,916 - 48,367,176 (+)EnsemblGRCm38mm10GRCm38
MGSCv371748,499,241 - 48,506,471 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361747,825,483 - 47,832,713 (+)NCBIMGSCv36mm8
Celera1751,790,069 - 51,797,287 (+)NCBICelera
Cytogenetic Map17CNCBI
cM Map1723.99NCBI
Treml1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8920,133,193 - 20,139,933 (-)NCBIGRCr8
mRatBN7.2912,635,584 - 12,642,324 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl912,635,590 - 12,642,347 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx921,148,706 - 21,155,418 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0926,214,930 - 26,221,642 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0924,604,229 - 24,610,926 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0914,597,172 - 14,603,622 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl914,597,172 - 14,599,594 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0913,521,172 - 13,523,578 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.498,018,145 - 8,052,719 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera910,409,481 - 10,411,887 (-)NCBICelera
Cytogenetic Map9q12NCBI
Treml1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554377,773,612 - 7,777,575 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554377,773,279 - 7,778,197 (-)NCBIChiLan1.0ChiLan1.0
TREML1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2555,634,009 - 55,643,116 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1651,503,953 - 51,513,065 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0640,726,243 - 40,731,358 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1642,034,644 - 42,039,750 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl642,034,988 - 42,039,695 (-)Ensemblpanpan1.1panPan2
Treml1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494645,286,753 - 45,291,405 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647618,668,816 - 18,673,222 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647618,668,809 - 18,673,183 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TREML1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl736,455,634 - 36,460,715 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1736,455,628 - 36,460,711 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2741,752,082 - 41,757,313 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TREML1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11731,002,893 - 31,008,366 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1731,003,331 - 31,008,036 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604441,149,307 - 41,154,429 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Treml1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475417,650,247 - 17,654,256 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475417,649,650 - 17,654,992 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in TREML1
10 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 6p21.2-21.1(chr6:37777369-45653843)x1 copy number loss See cases [RCV000052181] Chr6:37777369..45653843 [GRCh38]
Chr6:37745145..45621580 [GRCh37]
Chr6:37853123..45729558 [NCBI36]
Chr6:6p21.2-21.1		 pathogenic
NM_018965.3(TREM2):c.496G>A (p.Gly166Arg) single nucleotide variant Malignant melanoma [RCV000067362] Chr6:41159053 [GRCh38]
Chr6:41126791 [GRCh37]
Chr6:41234769 [NCBI36]
Chr6:6p21.1		 not provided
GRCh38/hg38 6p25.3-12.3(chr6:156974-46789291)x3 copy number gain See cases [RCV000143497] Chr6:156974..46789291 [GRCh38]
Chr6:156974..46757028 [GRCh37]
Chr6:101974..46864987 [NCBI36]
Chr6:6p25.3-12.3		 pathogenic
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482)x3 copy number gain See cases [RCV000512067] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482) copy number gain See cases [RCV000510595] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
NM_178174.4(TREML1):c.854T>A (p.Ile285Asn) single nucleotide variant not specified [RCV004313628] Chr6:41149686 [GRCh38]
Chr6:41117424 [GRCh37]
Chr6:6p21.1		 uncertain significance
NM_178174.4(TREML1):c.730A>T (p.Thr244Ser) single nucleotide variant not specified [RCV004302555] Chr6:41149810 [GRCh38]
Chr6:41117548 [GRCh37]
Chr6:6p21.1		 uncertain significance
GRCh37/hg19 6p25.3-q27(chr6:60107-171054786)x3 copy number gain not provided [RCV000745400] Chr6:60107..171054786 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
GRCh37/hg19 6p25.3-q27(chr6:108666-170980171)x3 copy number gain not provided [RCV000745403] Chr6:108666..170980171 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
GRCh37/hg19 6p25.3-q27(chr6:165632-170919470)x3 copy number gain not provided [RCV000745404] Chr6:165632..170919470 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
GRCh37/hg19 6p22.1-q14.1(chr6:29455465-81447367) copy number gain not provided [RCV000767714] Chr6:29455465..81447367 [GRCh37]
Chr6:6p22.1-q14.1		 pathogenic
NM_178174.4(TREML1):c.452C>T (p.Pro151Leu) single nucleotide variant not specified [RCV004311435] Chr6:41151309 [GRCh38]
Chr6:41119047 [GRCh37]
Chr6:6p21.1		 uncertain significance
NM_178174.4(TREML1):c.921G>C (p.Gln307His) single nucleotide variant not specified [RCV004117444] Chr6:41149619 [GRCh38]
Chr6:41117357 [GRCh37]
Chr6:6p21.1		 uncertain significance
NM_178174.4(TREML1):c.832C>T (p.Pro278Ser) single nucleotide variant not specified [RCV004135890] Chr6:41149708 [GRCh38]
Chr6:41117446 [GRCh37]
Chr6:6p21.1		 uncertain significance
NM_178174.4(TREML1):c.314T>C (p.Met105Thr) single nucleotide variant not specified [RCV004201603] Chr6:41153820 [GRCh38]
Chr6:41121558 [GRCh37]
Chr6:6p21.1		 uncertain significance
NM_178174.4(TREML1):c.439G>A (p.Gly147Ser) single nucleotide variant not specified [RCV004114807] Chr6:41151322 [GRCh38]
Chr6:41119060 [GRCh37]
Chr6:6p21.1		 uncertain significance
NM_178174.4(TREML1):c.500C>T (p.Ala167Val) single nucleotide variant not specified [RCV004140071] Chr6:41150887 [GRCh38]
Chr6:41118625 [GRCh37]
Chr6:6p21.1		 uncertain significance
NM_178174.4(TREML1):c.576G>T (p.Arg192Ser) single nucleotide variant not specified [RCV004076728] Chr6:41150306 [GRCh38]
Chr6:41118044 [GRCh37]
Chr6:6p21.1		 uncertain significance
NM_178174.4(TREML1):c.158G>A (p.Arg53Gln) single nucleotide variant not specified [RCV004260650] Chr6:41153976 [GRCh38]
Chr6:41121714 [GRCh37]
Chr6:6p21.1		 uncertain significance
GRCh37/hg19 6p21.31-21.1(chr6:35562152-42003452)x1 copy number loss not provided [RCV003485510] Chr6:35562152..42003452 [GRCh37]
Chr6:6p21.31-21.1		 pathogenic
NM_178174.4(TREML1):c.167C>T (p.Pro56Leu) single nucleotide variant not specified [RCV004473508] Chr6:41153967 [GRCh38]
Chr6:41121705 [GRCh37]
Chr6:6p21.1		 uncertain significance
NM_178174.4(TREML1):c.205C>T (p.Arg69Cys) single nucleotide variant not specified [RCV004473509] Chr6:41153929 [GRCh38]
Chr6:41121667 [GRCh37]
Chr6:6p21.1		 uncertain significance
NM_178174.4(TREML1):c.67C>T (p.Pro23Ser) single nucleotide variant not specified [RCV004473512] Chr6:41154067 [GRCh38]
Chr6:41121805 [GRCh37]
Chr6:6p21.1		 uncertain significance
NM_178174.4(TREML1):c.286G>A (p.Glu96Lys) single nucleotide variant not specified [RCV004473510] Chr6:41153848 [GRCh38]
Chr6:41121586 [GRCh37]
Chr6:6p21.1		 uncertain significance
NM_178174.4(TREML1):c.848C>T (p.Thr283Ile) single nucleotide variant not specified [RCV004473514] Chr6:41149692 [GRCh38]
Chr6:41117430 [GRCh37]
Chr6:6p21.1		 uncertain significance
NM_178174.4(TREML1):c.523G>A (p.Val175Met) single nucleotide variant not specified [RCV004473511] Chr6:41150864 [GRCh38]
Chr6:41118602 [GRCh37]
Chr6:6p21.1		 uncertain significance
NM_178174.4(TREML1):c.875G>A (p.Gly292Asp) single nucleotide variant not specified [RCV004473515] Chr6:41149665 [GRCh38]
Chr6:41117403 [GRCh37]
Chr6:6p21.1		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1021
Count of miRNA genes:446
Interacting mature miRNAs:471
Transcripts:ENST00000373127, ENST00000426005, ENST00000437044, ENST00000590581
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
STS-R02728  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37641,117,175 - 41,117,303UniSTSGRCh37
Build 36641,225,153 - 41,225,281RGDNCBI36
Celera642,669,865 - 42,669,993RGD
Cytogenetic Map6p21.1UniSTS
HuRef640,834,961 - 40,835,089UniSTS
GeneMap99-GB4 RH Map6156.31UniSTS
NCBI RH Map6633.7UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component
High
Medium 635 7 5 739 5 14 16 6 27 14 1
Low 252 787 804 175 500 97 1319 72 2211 145 471 999 79 640 835 1
Below cutoff 1822 1389 829 389 278 308 2346 1576 1379 195 812 406 84 1 525 1494 3

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001271807 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001271808 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_178174 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017010822 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017010823 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017010824 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017010825 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054355320 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054355321 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054355322 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF508193 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF534822 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF534823 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL133404 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY358357 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC100944 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC100945 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC100946 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ023322 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471081 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068272 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DW009745 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000373127   ⟹   ENSP00000362219
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl641,149,342 - 41,154,337 (-)Ensembl
RefSeq Acc Id: ENST00000426005   ⟹   ENSP00000402855
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl641,149,337 - 41,154,347 (-)Ensembl
RefSeq Acc Id: ENST00000437044   ⟹   ENSP00000400405
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl641,149,604 - 41,154,332 (-)Ensembl
RefSeq Acc Id: ENST00000590581
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl641,149,804 - 41,151,620 (-)Ensembl
RefSeq Acc Id: NM_001271807   ⟹   NP_001258736
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38641,149,260 - 41,154,349 (-)NCBI
GRCh37641,116,998 - 41,122,087 (-)NCBI
HuRef640,834,784 - 40,839,873 (-)NCBI
CHM1_1641,119,893 - 41,124,982 (-)NCBI
T2T-CHM13v2.0640,977,812 - 40,982,901 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001271808   ⟹   NP_001258737
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38641,149,260 - 41,154,349 (-)NCBI
GRCh37641,116,998 - 41,122,087 (-)NCBI
HuRef640,834,784 - 40,839,873 (-)NCBI
CHM1_1641,119,893 - 41,124,982 (-)NCBI
T2T-CHM13v2.0640,977,812 - 40,982,901 (-)NCBI
Sequence:
RefSeq Acc Id: NM_178174   ⟹   NP_835468
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38641,149,337 - 41,154,347 (-)NCBI
GRCh37641,116,998 - 41,122,087 (-)NCBI
Build 36641,225,320 - 41,230,048 (-)NCBI Archive
HuRef640,834,784 - 40,839,873 (-)NCBI
CHM1_1641,119,893 - 41,124,982 (-)NCBI
T2T-CHM13v2.0640,977,889 - 40,982,899 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017010822   ⟹   XP_016866311
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38641,149,260 - 41,155,403 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017010823   ⟹   XP_016866312
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38641,149,260 - 41,155,380 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017010825   ⟹   XP_016866314
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38641,149,260 - 41,155,403 (-)NCBI
Sequence:
RefSeq Acc Id: XM_054355320   ⟹   XP_054211295
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0640,977,812 - 40,983,997 (-)NCBI
RefSeq Acc Id: XM_054355321   ⟹   XP_054211296
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0640,977,812 - 40,983,956 (-)NCBI
RefSeq Acc Id: XM_054355322   ⟹   XP_054211297
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0640,977,812 - 40,983,997 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_835468   ⟸   NM_178174
- Peptide Label: isoform a precursor
- UniProtKB: Q8IWY1 (UniProtKB/Swiss-Prot),   Q496B3 (UniProtKB/Swiss-Prot),   Q8IWY2 (UniProtKB/Swiss-Prot),   Q86YW5 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001258737   ⟸   NM_001271808
- Peptide Label: isoform c precursor
- UniProtKB: Q86YW5 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001258736   ⟸   NM_001271807
- Peptide Label: isoform b precursor
- UniProtKB: Q86YW5 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_016866314   ⟸   XM_017010825
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_016866311   ⟸   XM_017010822
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_016866312   ⟸   XM_017010823
- Peptide Label: isoform X2
- UniProtKB: Q8IWY1 (UniProtKB/Swiss-Prot),   Q496B3 (UniProtKB/Swiss-Prot),   Q8IWY2 (UniProtKB/Swiss-Prot),   Q86YW5 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000402855   ⟸   ENST00000426005
RefSeq Acc Id: ENSP00000362219   ⟸   ENST00000373127
RefSeq Acc Id: ENSP00000400405   ⟸   ENST00000437044
RefSeq Acc Id: XP_054211297   ⟸   XM_054355322
- Peptide Label: isoform X3
RefSeq Acc Id: XP_054211295   ⟸   XM_054355320
- Peptide Label: isoform X1
RefSeq Acc Id: XP_054211296   ⟸   XM_054355321
- Peptide Label: isoform X2
- UniProtKB: Q8IWY1 (UniProtKB/Swiss-Prot),   Q86YW5 (UniProtKB/Swiss-Prot),   Q496B3 (UniProtKB/Swiss-Prot),   Q8IWY2 (UniProtKB/Swiss-Prot)
Protein Domains
Ig-like V-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q86YW5-F1-model_v2 AlphaFold Q86YW5 1-311 view protein structure

Promoters
RGD ID:7207979
Promoter ID:EPDNEW_H9735
Type:initiation region
Name:TREML1_1
Description:triggering receptor expressed on myeloid cells like 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38641,154,334 - 41,154,394EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:20434 AgrOrtholog
COSMIC TREML1 COSMIC
Ensembl Genes ENSG00000161911 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000373127 ENTREZGENE
  ENST00000373127.8 UniProtKB/Swiss-Prot
  ENST00000426005 ENTREZGENE
  ENST00000426005.7 UniProtKB/Swiss-Prot
  ENST00000437044 ENTREZGENE
  ENST00000437044.2 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot
GTEx ENSG00000161911 GTEx
HGNC ID HGNC:20434 ENTREZGENE
Human Proteome Map TREML1 Human Proteome Map
InterPro Ig-like_dom_sf UniProtKB/Swiss-Prot
  Ig-like_fold UniProtKB/Swiss-Prot
KEGG Report hsa:340205 UniProtKB/Swiss-Prot
NCBI Gene 340205 ENTREZGENE
OMIM 609714 OMIM
PANTHER POLYMERIC-IMMUNOGLOBULIN RECEPTOR UniProtKB/Swiss-Prot
  TREM-LIKE TRANSCRIPT 1 PROTEIN UniProtKB/Swiss-Prot
PharmGKB PA134878709 PharmGKB
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot
UniProt Q496B3 ENTREZGENE
  Q86YW5 ENTREZGENE
  Q8IWY1 ENTREZGENE
  Q8IWY2 ENTREZGENE
  TRML1_HUMAN UniProtKB/Swiss-Prot
UniProt Secondary Q496B3 UniProtKB/Swiss-Prot
  Q8IWY1 UniProtKB/Swiss-Prot
  Q8IWY2 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-01 TREML1  triggering receptor expressed on myeloid cells like 1  TREML1  triggering receptor expressed on myeloid cells-like 1  Symbol and/or name change 5135510 APPROVED