Pnpla6 (patatin like domain 6, lysophospholipase) - Rat Genome Database

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Pathways
Gene: Pnpla6 (patatin like domain 6, lysophospholipase) Rattus norvegicus
Analyze
Symbol: Pnpla6
Name: patatin like domain 6, lysophospholipase (Ensembl:patatin-like phospholipase domain containing 6)
RGD ID: 1564611
Description: Predicted to enable phosphatidylcholine lysophospholipase activity and phospholipase B activity. Predicted to be involved in lipid catabolic process and phosphatidylcholine metabolic process. Predicted to act upstream of or within angiogenesis and animal organ morphogenesis. Predicted to be located in cytosol and membrane. Predicted to be active in endoplasmic reticulum. Human ortholog(s) of this gene implicated in Boucher-Neuhauser syndrome; Laurence-Moon syndrome; Oliver-McFarlane syndrome; and hereditary spastic paraplegia 39. Orthologous to human PNPLA6 (patatin like domain 6, lysophospholipase); PARTICIPATES IN glycerophospholipid metabolic pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol; atrazine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC360753; neuropathy target esterase; patatin-like phospholipase domain containing 6; patatin-like phospholipase domain-containing protein 6; RGD1564611; similar to neuropathy target esterase homolog
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8126,372,284 - 6,401,632 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl126,372,293 - 6,401,631 (+)EnsemblGRCr8
mRatBN7.2121,574,387 - 1,603,735 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl121,560,363 - 1,603,734 (+)EnsemblmRatBN7.2
Dahl_SR_JrHsd127,170,854 - 7,200,167 (+)NCBIDahl_SR_JrHsd
Lyon_Normotensive127,572,329 - 7,601,611 (+)NCBILyon_Normotensive
Lyon_Hypertensive127,093,661 - 7,122,972 (-)NCBILyon_Hypertensive
F344_StmMcwi1217,039,753 - 17,069,064 (+)NCBIF344_StmMcwi
Rnor_6.0122,068,749 - 2,098,139 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl122,069,959 - 2,097,904 (+)Ensemblrn6Rnor6.0
Rnor_5.0124,232,111 - 4,260,327 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4122,610,552 - 2,638,753 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera123,430,758 - 3,460,163 (+)NCBICelera
Cytogenetic Map12p12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,5,6-trichloro-2-pyridinol  (ISO)
3,5,6-trichloropyridine-2-one  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (EXP)
5-fluorouracil  (ISO)
9-(tetrahydrofuryl)adenine  (ISO)
all-trans-retinoic acid  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
benzylpenicillin  (ISO)
beta-lapachone  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bucladesine  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbaryl  (EXP)
carbon nanotube  (ISO)
chloroacetaldehyde  (ISO)
chlorpyrifos  (ISO)
cidofovir anhydrous  (ISO)
clodronic acid  (ISO)
colforsin daropate hydrochloride  (ISO)
copper(II) chloride  (ISO)
coumarin  (ISO)
cycloheximide  (ISO)
cyclosporin A  (EXP)
DDE  (ISO)
diarsenic trioxide  (ISO)
dichlorvos  (EXP,ISO)
dieldrin  (ISO)
diethylstilbestrol  (EXP)
diisopropyl fluorophosphate  (EXP,ISO)
dioxygen  (ISO)
diuron  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
ethanol  (ISO)
fulvestrant  (ISO)
gentamycin  (EXP)
glycerylphosphorylcholine  (ISO)
ketoconazole  (EXP)
lysophosphatidylcholine  (ISO)
malaoxon  (ISO)
metformin  (EXP)
methamidophos  (EXP,ISO)
Mipafox  (EXP,ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
nickel atom  (ISO)
paracetamol  (ISO)
paraoxon  (ISO)
phenobarbital  (ISO)
phenol  (ISO)
phenylmethanesulfonyl fluoride  (ISO)
phosphatidylcholine  (ISO)
pirinixic acid  (ISO)
saccharin  (ISO)
sarin  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dodecyl sulfate  (ISO)
succimer  (ISO)
sunitinib  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichlorfon  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. GOA pipeline RGD automated data pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12514188   PMID:14749382   PMID:15044461   PMID:18086666   PMID:19946888   PMID:28206686  


Genomics

Comparative Map Data
Pnpla6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8126,372,284 - 6,401,632 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl126,372,293 - 6,401,631 (+)EnsemblGRCr8
mRatBN7.2121,574,387 - 1,603,735 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl121,560,363 - 1,603,734 (+)EnsemblmRatBN7.2
Dahl_SR_JrHsd127,170,854 - 7,200,167 (+)NCBIDahl_SR_JrHsd
Lyon_Normotensive127,572,329 - 7,601,611 (+)NCBILyon_Normotensive
Lyon_Hypertensive127,093,661 - 7,122,972 (-)NCBILyon_Hypertensive
F344_StmMcwi1217,039,753 - 17,069,064 (+)NCBIF344_StmMcwi
Rnor_6.0122,068,749 - 2,098,139 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl122,069,959 - 2,097,904 (+)Ensemblrn6Rnor6.0
Rnor_5.0124,232,111 - 4,260,327 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4122,610,552 - 2,638,753 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera123,430,758 - 3,460,163 (+)NCBICelera
Cytogenetic Map12p12NCBI
PNPLA6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38197,534,164 - 7,561,767 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl197,534,004 - 7,561,764 (+)Ensemblhg38GRCh38
GRCh37197,599,050 - 7,626,653 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36197,505,043 - 7,532,652 (+)NCBIBuild 36Build 36hg18NCBI36
Celera197,471,561 - 7,499,172 (+)NCBICelera
Cytogenetic Map19p13.2NCBI
HuRef197,270,194 - 7,297,789 (+)NCBIHuRef
CHM1_1197,598,956 - 7,626,567 (+)NCBICHM1_1
T2T-CHM13v2.0197,534,898 - 7,562,499 (+)NCBIT2T-CHM13v2.0
Pnpla6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3983,565,341 - 3,594,267 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl83,565,384 - 3,594,267 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm3883,515,235 - 3,544,267 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl83,515,384 - 3,544,267 (+)Ensemblmm10GRCm38
MGSCv3783,515,384 - 3,544,267 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3683,515,384 - 3,544,267 (+)NCBIMGSCv36mm8
Celera83,741,358 - 3,770,284 (+)NCBICelera
Cytogenetic Map8A1.1NCBI
cM Map81.92NCBI
Pnpla6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555631,680,818 - 1,703,287 (-)Ensembl
ChiLan1.0NW_0049555631,681,112 - 1,703,287 (-)NCBIChiLan1.0ChiLan1.0
PNPLA6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22012,205,996 - 12,233,596 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11911,324,029 - 11,351,648 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0196,825,299 - 6,852,900 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1197,683,241 - 7,710,444 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl197,683,789 - 7,710,241 (+)EnsemblpanPan2panpan1.1
PNPLA6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12052,327,547 - 52,349,006 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2052,318,408 - 52,348,963 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2052,115,682 - 52,153,150 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02052,840,755 - 52,878,224 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2052,856,097 - 52,878,224 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12052,060,536 - 52,081,963 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02052,488,224 - 52,525,671 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02052,719,117 - 52,756,573 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Pnpla6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118213,202,585 - 213,225,879 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365884,608,963 - 4,632,183 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365884,608,856 - 4,632,198 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PNPLA6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl271,577,168 - 71,602,777 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1271,577,165 - 71,602,756 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2272,031,152 - 72,056,544 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PNPLA6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.167,030,802 - 7,056,664 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl67,032,445 - 7,056,661 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666081809,119 - 837,403 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pnpla6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624828643,471 - 664,665 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624828643,552 - 664,665 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Pnpla6
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1161,444,652 - 1,473,500 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Pnpla6
321 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:140
Count of miRNA genes:60
Interacting mature miRNAs:70
Transcripts:ENSRNOT00000001298, ENSRNOT00000072952
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2312418Kidm41Kidney mass QTL 413.70.0001kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)12592191825247790Rat
724526Uae3Urinary albumin excretion QTL 34.90.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)12115486827Rat
2306789Ean6Experimental allergic neuritis QTL 64.9nervous system integrity trait (VT:0010566)experimental autoimmune neuritis severity score (CMO:0001528)12129775522Rat
7204484Bp358Blood pressure QTL 3580.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)12124849755Rat
7387292Kidm42Kidney mass QTL 423.030.0004kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)12141361854Rat
1357337Gluco3Glucose level QTL 30.0004adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)12116966671Rat
5684888Pia42Pristane induced arthritis QTL 42joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12348941648489416Rat
1331739Hrtrt14Heart rate QTL 143.56232heart pumping trait (VT:2000009)heart rate (CMO:0000002)12138687564Rat
1298081Cia25Collagen induced arthritis QTL 254.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12274769447747694Rat
2303568Bw88Body weight QTL 883body mass (VT:0001259)body weight (CMO:0000012)12128606299Rat
61331Eau2Experimental allergic uveoretinitis QTL 20.0005uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)12133700600Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12308718048087180Rat
61334Gluco17Glucose level QTL 176.3adipocyte glucose uptake trait (VT:0004185)adipocyte maximal glucose uptake to basal glucose uptake ratio (CMO:0000874)12116966671Rat
2293684Bmd26Bone mineral density QTL 264.40.0002femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)12138635130Rat
6893681Bw109Body weight QTL 1092.30.004body mass (VT:0001259)body weight (CMO:0000012)12128133365Rat
7243862Mcs30Mammary carcinoma susceptibility QTL 308.62mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)12563330650633306Rat
1300174Bw15Body weight QTL 152.93body mass (VT:0001259)body weight loss (CMO:0001399)12128606299Rat
1600391Edcs2Endometrial carcinoma susceptibility QTL23.50.01uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)12111869600Rat
1331787Rf41Renal function QTL 412.998kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)12133700556Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 161 91 90 59 92 59 6 356 192 11 140 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001427127 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001427128 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008758450 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008758453 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008758457 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008758460 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008758463 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008758465 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008758466 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008769005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008769007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008769008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008769009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008769010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008769012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598469 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017604415 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039089893 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039089895 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039089897 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063271425 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063271426 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063271427 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063271428 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063271429 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063271430 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063271431 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063271433 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063271434 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063271435 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063271436 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063271437 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide CH474084 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000001298   ⟹   ENSRNOP00000001298
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl126,373,559 - 6,401,631 (+)Ensembl
mRatBN7.2 Ensembl121,560,363 - 1,603,734 (+)Ensembl
Rnor_6.0 Ensembl122,069,959 - 2,097,904 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000072952   ⟹   ENSRNOP00000065231
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl126,373,635 - 6,401,631 (+)Ensembl
mRatBN7.2 Ensembl121,574,426 - 1,603,734 (+)Ensembl
Rnor_6.0 Ensembl122,070,365 - 2,097,904 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000143082   ⟹   ENSRNOP00000105327
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl126,372,293 - 6,401,631 (+)Ensembl
RefSeq Acc Id: NM_001427127   ⟹   NP_001414056
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8126,372,311 - 6,401,632 (+)NCBI
Dahl_SR_JrHsd127,170,854 - 7,200,167 (+)NCBI
Lyon_Normotensive127,572,329 - 7,601,611 (+)NCBI
Lyon_Hypertensive127,093,661 - 7,122,972 (-)NCBI
F344_StmMcwi1217,039,753 - 17,069,064 (+)NCBI
RefSeq Acc Id: NM_001427128   ⟹   NP_001414057
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8126,372,311 - 6,401,632 (+)NCBI
Dahl_SR_JrHsd127,170,854 - 7,200,167 (+)NCBI
Lyon_Normotensive127,572,329 - 7,601,611 (+)NCBI
Lyon_Hypertensive127,093,661 - 7,122,972 (-)NCBI
F344_StmMcwi1217,039,753 - 17,069,064 (+)NCBI
RefSeq Acc Id: XM_008769005   ⟹   XP_008767227
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8126,373,834 - 6,401,629 (+)NCBI
mRatBN7.2121,575,747 - 1,603,735 (+)NCBI
Rnor_6.0122,070,165 - 2,098,139 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008769007   ⟹   XP_008767229
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8126,373,834 - 6,401,629 (+)NCBI
mRatBN7.2121,575,747 - 1,603,735 (+)NCBI
Rnor_6.0122,070,165 - 2,098,139 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008769008   ⟹   XP_008767230
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8126,373,834 - 6,401,629 (+)NCBI
mRatBN7.2121,575,748 - 1,603,735 (+)NCBI
Rnor_6.0122,070,165 - 2,098,139 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008769009   ⟹   XP_008767231
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8126,372,285 - 6,401,629 (+)NCBI
mRatBN7.2121,574,387 - 1,603,735 (+)NCBI
Rnor_6.0122,068,749 - 2,098,139 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008769010   ⟹   XP_008767232
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8126,372,284 - 6,401,629 (+)NCBI
mRatBN7.2121,574,387 - 1,603,735 (+)NCBI
Rnor_6.0122,068,749 - 2,098,139 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008769012   ⟹   XP_008767234
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8126,372,285 - 6,401,629 (+)NCBI
mRatBN7.2121,574,387 - 1,603,735 (+)NCBI
Rnor_6.0122,069,073 - 2,098,139 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039089893   ⟹   XP_038945821
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8126,373,834 - 6,401,629 (+)NCBI
mRatBN7.2121,575,935 - 1,603,735 (+)NCBI
RefSeq Acc Id: XM_039089895   ⟹   XP_038945823
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8126,373,834 - 6,401,629 (+)NCBI
mRatBN7.2121,575,935 - 1,603,735 (+)NCBI
RefSeq Acc Id: XM_039089897   ⟹   XP_038945825
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8126,372,285 - 6,401,629 (+)NCBI
mRatBN7.2121,574,387 - 1,603,735 (+)NCBI
RefSeq Acc Id: XM_063271425   ⟹   XP_063127495
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8126,373,834 - 6,401,629 (+)NCBI
RefSeq Acc Id: XM_063271426   ⟹   XP_063127496
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8126,373,834 - 6,401,629 (+)NCBI
RefSeq Acc Id: XM_063271427   ⟹   XP_063127497
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8126,373,834 - 6,401,629 (+)NCBI
RefSeq Acc Id: XM_063271428   ⟹   XP_063127498
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8126,373,834 - 6,401,629 (+)NCBI
RefSeq Acc Id: XM_063271429   ⟹   XP_063127499
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8126,373,834 - 6,401,629 (+)NCBI
RefSeq Acc Id: XM_063271430   ⟹   XP_063127500
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8126,372,285 - 6,401,629 (+)NCBI
RefSeq Acc Id: XM_063271431   ⟹   XP_063127501
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8126,372,285 - 6,401,629 (+)NCBI
RefSeq Acc Id: XM_063271433   ⟹   XP_063127503
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8126,372,477 - 6,401,629 (+)NCBI
RefSeq Acc Id: XM_063271434   ⟹   XP_063127504
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8126,372,285 - 6,401,629 (+)NCBI
RefSeq Acc Id: XM_063271435   ⟹   XP_063127505
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8126,372,477 - 6,401,629 (+)NCBI
RefSeq Acc Id: XM_063271436   ⟹   XP_063127506
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8126,372,285 - 6,401,629 (+)NCBI
RefSeq Acc Id: XM_063271437   ⟹   XP_063127507
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8126,372,285 - 6,401,629 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001414056 (Get FASTA)   NCBI Sequence Viewer  
  NP_001414057 (Get FASTA)   NCBI Sequence Viewer  
  XP_008767227 (Get FASTA)   NCBI Sequence Viewer  
  XP_008767229 (Get FASTA)   NCBI Sequence Viewer  
  XP_008767230 (Get FASTA)   NCBI Sequence Viewer  
  XP_008767231 (Get FASTA)   NCBI Sequence Viewer  
  XP_008767232 (Get FASTA)   NCBI Sequence Viewer  
  XP_008767234 (Get FASTA)   NCBI Sequence Viewer  
  XP_038945821 (Get FASTA)   NCBI Sequence Viewer  
  XP_038945823 (Get FASTA)   NCBI Sequence Viewer  
  XP_038945825 (Get FASTA)   NCBI Sequence Viewer  
  XP_063127495 (Get FASTA)   NCBI Sequence Viewer  
  XP_063127496 (Get FASTA)   NCBI Sequence Viewer  
  XP_063127497 (Get FASTA)   NCBI Sequence Viewer  
  XP_063127498 (Get FASTA)   NCBI Sequence Viewer  
  XP_063127499 (Get FASTA)   NCBI Sequence Viewer  
  XP_063127500 (Get FASTA)   NCBI Sequence Viewer  
  XP_063127501 (Get FASTA)   NCBI Sequence Viewer  
  XP_063127503 (Get FASTA)   NCBI Sequence Viewer  
  XP_063127504 (Get FASTA)   NCBI Sequence Viewer  
  XP_063127505 (Get FASTA)   NCBI Sequence Viewer  
  XP_063127506 (Get FASTA)   NCBI Sequence Viewer  
  XP_063127507 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL74933 (Get FASTA)   NCBI Sequence Viewer  
  EDL74934 (Get FASTA)   NCBI Sequence Viewer  
  EDL74935 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000001298
  ENSRNOP00000001298.7
  ENSRNOP00000065231
  ENSRNOP00000065231.3
  ENSRNOP00000105327
  ENSRNOP00000105327.1
RefSeq Acc Id: XP_008767231   ⟸   XM_008769009
- Peptide Label: isoform X12
- UniProtKB: D3ZRF6 (UniProtKB/TrEMBL),   A6KQ10 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008767232   ⟸   XM_008769010
- Peptide Label: isoform X12
- UniProtKB: D3ZRF6 (UniProtKB/TrEMBL),   A6KQ10 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008767234   ⟸   XM_008769012
- Peptide Label: isoform X13
- UniProtKB: A6KQ09 (UniProtKB/TrEMBL),   A6KQ10 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008767229   ⟸   XM_008769007
- Peptide Label: isoform X6
- UniProtKB: A6KQ10 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008767230   ⟸   XM_008769008
- Peptide Label: isoform X8
- UniProtKB: M0R715 (UniProtKB/TrEMBL),   A6KQ10 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008767227   ⟸   XM_008769005
- Peptide Label: isoform X7
- UniProtKB: A6KQ10 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000065231   ⟸   ENSRNOT00000072952
Ensembl Acc Id: ENSRNOP00000001298   ⟸   ENSRNOT00000001298
RefSeq Acc Id: XP_038945825   ⟸   XM_039089897
- Peptide Label: isoform X15
- UniProtKB: A6KQ10 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038945821   ⟸   XM_039089893
- Peptide Label: isoform X9
- UniProtKB: A6KQ10 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038945823   ⟸   XM_039089895
- Peptide Label: isoform X11
- UniProtKB: A6KQ10 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063127501   ⟸   XM_063271431
- Peptide Label: isoform X10
- UniProtKB: A6KQ10 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063127506   ⟸   XM_063271436
- Peptide Label: isoform X14
- UniProtKB: A6KQ10 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063127504   ⟸   XM_063271434
- Peptide Label: isoform X13
- UniProtKB: A6KQ09 (UniProtKB/TrEMBL),   A6KQ10 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063127500   ⟸   XM_063271430
- Peptide Label: isoform X10
- UniProtKB: A6KQ10 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063127507   ⟸   XM_063271437
- Peptide Label: isoform X16
- UniProtKB: A6KQ10 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001414056   ⟸   NM_001427127
- Peptide Label: isoform 1
- UniProtKB: A6KQ10 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001414057   ⟸   NM_001427128
- Peptide Label: isoform 2
- UniProtKB: A6KQ10 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063127503   ⟸   XM_063271433
- Peptide Label: isoform X12
- UniProtKB: D3ZRF6 (UniProtKB/TrEMBL),   A6KQ10 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063127505   ⟸   XM_063271435
- Peptide Label: isoform X13
- UniProtKB: A6KQ09 (UniProtKB/TrEMBL),   A6KQ10 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063127495   ⟸   XM_063271425
- Peptide Label: isoform X1
- UniProtKB: A6KQ10 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063127496   ⟸   XM_063271426
- Peptide Label: isoform X2
- UniProtKB: A6KQ10 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063127497   ⟸   XM_063271427
- Peptide Label: isoform X3
- UniProtKB: A6KQ10 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063127498   ⟸   XM_063271428
- Peptide Label: isoform X4
- UniProtKB: A6KQ10 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063127499   ⟸   XM_063271429
- Peptide Label: isoform X5
- UniProtKB: A6KQ10 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000105327   ⟸   ENSRNOT00000143082
Protein Domains
Cyclic nucleotide-binding   PNPLA

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0R715-F1-model_v2 AlphaFold M0R715 1-1354 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1564611 AgrOrtholog
BioCyc Gene G2FUF-20395 BioCyc
Ensembl Genes ENSRNOG00000000977 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000001298 ENTREZGENE
  ENSRNOT00000001298.9 UniProtKB/TrEMBL
  ENSRNOT00000072952 ENTREZGENE
  ENSRNOT00000072952.3 UniProtKB/TrEMBL
  ENSRNOT00000143082 ENTREZGENE
  ENSRNOT00000143082.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.10 UniProtKB/TrEMBL
  Cytosolic phospholipase A2 catalytic domain UniProtKB/TrEMBL
InterPro Acyl_Trfase/lysoPLipase UniProtKB/TrEMBL
  cNMP-bd-like UniProtKB/TrEMBL
  cNMP-bd_dom UniProtKB/TrEMBL
  LysoPLipase_patatin_CS UniProtKB/TrEMBL
  NTE UniProtKB/TrEMBL
  NTE1_P-loop_dom UniProtKB/TrEMBL
  Patatin/PLipase_A2-rel UniProtKB/TrEMBL
  RmlC-like_jellyroll UniProtKB/TrEMBL
NCBI Gene 360753 ENTREZGENE
PANTHER NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER UniProtKB/TrEMBL
  PATATIN-LIKE PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN 6 UniProtKB/TrEMBL
Pfam cNMP_binding UniProtKB/TrEMBL
  NTE_Ploop UniProtKB/TrEMBL
  Patatin UniProtKB/TrEMBL
PhenoGen Pnpla6 PhenoGen
PROSITE CNMP_BINDING_3 UniProtKB/TrEMBL
  PNPLA UniProtKB/TrEMBL
  UPF0028 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000000977 RatGTEx
SMART cNMP UniProtKB/TrEMBL
Superfamily-SCOP Acyl_Trfase/lysoPlipase UniProtKB/TrEMBL
  cNMP_binding UniProtKB/TrEMBL
UniProt A0ABK0LK64_RAT UniProtKB/TrEMBL
  A6KQ09 ENTREZGENE, UniProtKB/TrEMBL
  A6KQ10 ENTREZGENE, UniProtKB/TrEMBL
  D3ZRF6 ENTREZGENE, UniProtKB/TrEMBL
  M0R715 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2025-11-13 Pnpla6  patatin like domain 6, lysophospholipase  Pnpla6  patatin-like phospholipase domain containing 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-06 Pnpla6  patatin-like phospholipase domain containing 6  RGD1564611_predicted  similar to neuropathy target esterase homolog (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1564611_predicted  similar to neuropathy target esterase homolog (predicted)  LOC360753  similar to neuropathy target esterase homolog  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC360753  similar to neuropathy target esterase homolog      Symbol and Name status set to provisional 70820 PROVISIONAL