Bex2 (brain expressed X-linked 2) - Rat Genome Database

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Gene: Bex2 (brain expressed X-linked 2) Rattus norvegicus
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Symbol: Bex2
Name: brain expressed X-linked 2
RGD ID: 1564466
Description: Predicted to enable several functions, including molecular function inhibitor activity; signaling adaptor activity; and transcription coactivator binding activity. Predicted to be involved in negative regulation of protein ubiquitination; positive regulation of transcription by RNA polymerase II; and signal transduction. Located in cytoplasm and nucleus. Orthologous to human BEX1 (brain expressed X-linked 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; aflatoxin B1; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Bex1; Bex22; brain expressed X-linked 1; brain-expressed X-linked protein 1 homolog; brain-expressed X-linked protein 2 homolog; EG2RVC; expression gene 2 in rat visual cortex; LOC363498; similar to brain expressed X-linked protein 2
RGD Orthologs
Human
Mouse
Bonobo
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
NCBI Annotation Information: Note: The Bex1 and Bex2 genes appear to have undergone gene conversion, exchanging bits of coding sequence with each other. This complicates determination of orthologs in other species. For this reason, gene name assignments may not be consistent between species. [06 Dec 2023]
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X103,811,458 - 103,812,986 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX103,808,935 - 103,812,092 (-)EnsemblGRCr8
mRatBN7.2X99,019,847 - 99,021,375 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX99,019,000 - 99,021,503 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_UtxX101,154,459 - 101,155,987 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X104,665,072 - 104,666,600 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X102,216,920 - 102,218,448 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X106,556,838 - 106,558,366 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX106,556,838 - 106,558,366 (-)Ensemblrn6Rnor6.0
Rnor_5.0X106,563,910 - 106,565,438 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4X123,322,594 - 123,324,122 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
CeleraX100,125,684 - 100,126,322 (+)NCBICelera
Cytogenetic MapXq32NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-hydroxypropanoic acid  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acrylamide  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butan-1-ol  (ISO)
butanal  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP)
carbamazepine  (ISO)
carbon nanotube  (ISO)
cefaloridine  (EXP)
chlorophyllin  (ISO)
chlorpyrifos  (EXP)
choline  (ISO)
cisplatin  (EXP)
copper(II) sulfate  (ISO)
corticosterone  (EXP)
cyclosporin A  (ISO)
dexamethasone  (ISO)
dicrotophos  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
ethanol  (ISO)
fenvalerate  (EXP)
folic acid  (ISO)
genistein  (ISO)
gentamycin  (EXP)
hydrogen peroxide  (ISO)
indometacin  (ISO)
isobutanol  (ISO)
L-methionine  (ISO)
maneb  (ISO)
microcystin-LR  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
nickel sulfate  (ISO)
nitrofen  (EXP)
ozone  (ISO)
paracetamol  (EXP)
paraquat  (ISO)
phenformin  (EXP)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
triptonide  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA,IDA,IEA)
nucleus  (IBA,IDA,IEA)
transcription regulator complex  (ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Characterization of the Bex gene family in humans, mice, and rats. Alvarez E, etal., Gene. 2005 Aug 29;357(1):18-28.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Bex1, a novel interactor of the p75 neurotrophin receptor, links neurotrophin signaling to the cell cycle. Vilar M, etal., EMBO J. 2006 Mar 22;25(6):1219-30. Epub 2006 Feb 23.
Additional References at PubMed
PMID:15033532   PMID:19711341  


Genomics

Comparative Map Data
Bex2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X103,811,458 - 103,812,986 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX103,808,935 - 103,812,092 (-)EnsemblGRCr8
mRatBN7.2X99,019,847 - 99,021,375 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX99,019,000 - 99,021,503 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_UtxX101,154,459 - 101,155,987 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X104,665,072 - 104,666,600 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X102,216,920 - 102,218,448 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X106,556,838 - 106,558,366 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX106,556,838 - 106,558,366 (-)Ensemblrn6Rnor6.0
Rnor_5.0X106,563,910 - 106,565,438 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4X123,322,594 - 123,324,122 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
CeleraX100,125,684 - 100,126,322 (+)NCBICelera
Cytogenetic MapXq32NCBI
BEX1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X103,062,651 - 103,064,171 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX103,062,645 - 103,064,342 (-)Ensemblhg38GRCh38
GRCh37X102,317,579 - 102,319,099 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X102,204,237 - 102,205,824 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34X102,123,732 - 102,125,244NCBI
CeleraX102,756,620 - 102,758,207 (-)NCBICelera
Cytogenetic MapXq22.1NCBI
HuRefX91,981,857 - 91,983,443 (-)NCBIHuRef
CHM1_1X102,210,282 - 102,211,859 (-)NCBICHM1_1
T2T-CHM13v2.0X101,507,581 - 101,509,098 (-)NCBIT2T-CHM13v2.0
Bex2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X134,967,314 - 134,968,985 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX134,967,313 - 134,968,985 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38X136,066,565 - 136,068,236 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX136,066,564 - 136,068,236 (-)Ensemblmm10GRCm38
MGSCv37X132,601,104 - 132,602,775 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36X131,412,930 - 131,414,474 (-)NCBIMGSCv36mm8
CeleraX119,382,324 - 119,382,968 (-)NCBICelera
Cytogenetic MapXF1NCBI
cM MapX57.37NCBI
BEX2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X102,921,539 - 102,923,194 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X102,925,144 - 102,926,795 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X92,538,901 - 92,540,550 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X102,917,692 - 102,919,392 (-)NCBIPanPan1.1PanPan1.1panPan2
LOC103232401
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X91,212,951 - 91,214,607 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX91,213,194 - 91,213,580 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366606516,070,407 - 16,072,081 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Bex2
1 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:198
Count of miRNA genes:138
Interacting mature miRNAs:156
Transcripts:ENSRNOT00000042126
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1598872Memor14Memory QTL 144.5exploratory behavior trait (VT:0010471)difference between duration of physical contact or close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X97528096142528096Rat
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X80434318125434318Rat
738029Stresp2Stress response QTL 23.40.0004stress-related behavior trait (VT:0010451)defensive burying - approachX92979612117740458Rat
738035Stresp1Stress response QTL 14.960.000011stress-related behavior trait (VT:0010451)defensive burying - copingX45182909117740458Rat
2302047Pia34Pristane induced arthritis QTL 345.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1996916163141916163Rat

Markers in Region
RH126864  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X99,219,015 - 99,219,251 (+)MAPPERmRatBN7.2
Rnor_6.01116,565,791 - 116,566,026NCBIRnor6.0
Rnor_5.01117,724,203 - 117,724,438UniSTSRnor5.0
Rnor_5.0X106,565,167 - 106,565,438UniSTSRnor5.0
Cytogenetic MapXq35UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 11 61 153 90 89 58 86 58 6 341 178 11 131 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000042126   ⟹   ENSRNOP00000041688
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX103,809,120 - 103,812,092 (-)Ensembl
mRatBN7.2 EnsemblX99,019,000 - 99,021,503 (-)Ensembl
Rnor_6.0 EnsemblX106,556,838 - 106,558,366 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000172221   ⟹   ENSRNOP00000105717
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX103,808,935 - 103,812,092 (-)Ensembl
RefSeq Acc Id: NM_001077435   ⟹   NP_001070903
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X103,811,458 - 103,812,986 (-)NCBI
mRatBN7.2X99,019,847 - 99,021,375 (-)NCBI
Rnor_6.0X106,556,838 - 106,558,366 (-)NCBI
Rnor_5.0X106,563,910 - 106,565,438 (+)NCBI
RGSC_v3.4X123,322,594 - 123,324,122 (-)RGD
CeleraX100,125,684 - 100,126,322 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001070903 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAX40673 (Get FASTA)   NCBI Sequence Viewer  
  EDL85816 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000041688
  ENSRNOP00000041688.3
RefSeq Acc Id: NP_001070903   ⟸   NM_001077435
- UniProtKB: Q3MKQ1 (UniProtKB/Swiss-Prot),   A6KT30 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000041688   ⟸   ENSRNOT00000042126
Ensembl Acc Id: ENSRNOP00000105717   ⟸   ENSRNOT00000172221

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q3MKQ2-F1-model_v2 AlphaFold Q3MKQ2 1-128 view protein structure
AF-Q3MKQ1-F1-model_v2 AlphaFold Q3MKQ1 1-129 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701939
Promoter ID:EPDNEW_R12463
Type:initiation region
Name:Bex2_1
Description:brain expressed X-linked 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X106,558,406 - 106,558,466EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1564466 AgrOrtholog
BioCyc Gene G2FUF-1638 BioCyc
Ensembl Genes ENSRNOG00000032729 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000042126 ENTREZGENE
  ENSRNOT00000042126.4 UniProtKB/Swiss-Prot
InterPro BEX UniProtKB/Swiss-Prot
  TF_A-like/BEX UniProtKB/Swiss-Prot
KEGG Report rno:363498 UniProtKB/Swiss-Prot
NCBI Gene 363498 ENTREZGENE
PANTHER PROTEIN BEX1 UniProtKB/Swiss-Prot
  PTHR19430 UniProtKB/Swiss-Prot
Pfam BEX UniProtKB/Swiss-Prot
PhenoGen Bex2 PhenoGen
PIRSF BEX UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000032729 RatGTEx
UniProt A6KT30 ENTREZGENE, UniProtKB/TrEMBL
  BEX2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-12-07 Bex2  brain expressed X-linked 2  Bex1  brain expressed X-linked 1  Name and Symbol changed 629549 APPROVED
2022-03-21 Bex1  brain expressed X-linked 1  Bex2  brain expressed X-linked 2  Name and Symbol changed 629549 APPROVED
2008-03-05 Bex2  brain expressed X-linked 2  LOC363498  similar to brain expressed X-linked protein 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-02-09 LOC363498  similar to brain expressed X-linked protein 2      Symbol and Name status set to provisional 70820 PROVISIONAL