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Gene: Ldlrap1 (low density lipoprotein receptor adaptor protein 1) Rattus norvegicus

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Symbol:

Ldlrap1

Name:

low density lipoprotein receptor adaptor protein 1

RGD ID:

1563417

Description:

Predicted to enable several functions, including AP-1 adaptor complex binding activity; AP-2 adaptor complex binding activity; and amyloid-beta binding activity. Predicted to be involved in several processes, including low-density lipoprotein particle clearance; positive regulation of low-density lipoprotein particle clearance; and receptor-mediated endocytosis. Predicted to act upstream of or within cholesterol homeostasis. Located in axon. Human ortholog(s) of this gene implicated in autosomal recessive hypercholesterolemia. Orthologous to human LDLRAP1 (low density lipoprotein receptor adaptor protein 1); PARTICIPATES IN endocytosis pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; amphetamine.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

autosomal recessive hypercholesterolemia protein homolog; LOC500564; low density lipoprotein receptor adapter protein 1; RGD1563417; similar to LDL receptor adaptor protein

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	152,239,296 - 152,262,290 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	5	152,229,505 - 152,262,290 (-)	Ensembl				GRCr8
mRatBN7.2	5	146,955,607 - 146,978,601 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	146,955,607 - 146,978,601 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	5	149,656,442 - 149,679,565 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	151,427,752 - 151,450,746 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	151,412,689 - 151,435,812 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	152,964,294 - 152,987,286 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	152,966,591 - 152,987,211 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	5	156,742,863 - 156,765,855 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	5	153,504,535 - 153,527,523 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	5	145,368,945 - 145,391,939 (-)	NCBI		Celera
Cytogenetic Map	5	q36	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autosomal recessive hypercholesterolemia (ISO,ISS)

familial hypercholesterolemia (ISO)

Hypercholesterolemia (ISO)

Hyperlipoproteinemia Type II (ISO)

hyperlipoproteinemia type III (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-demecolcine (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

2-hydroxypropanoic acid (ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

6-propyl-2-thiouracil (EXP)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

amphetamine (EXP)

arsane (ISO)

arsenic atom (ISO)

arsenite(3-) (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

calcitriol (ISO)

chlorpyrifos (ISO)

cisplatin (ISO)

Cuprizon (EXP)

daidzein (ISO)

daidzein 7-O-beta-D-glucoside (ISO)

dexamethasone (ISO)

Dibutyl phosphate (ISO)

dibutyl phthalate (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

elemental selenium (ISO)

entinostat (ISO)

epoxiconazole (ISO)

ethyl methanesulfonate (ISO)

fenthion (ISO)

formaldehyde (ISO)

FR900359 (ISO)

genistein (ISO)

genistein 7-O-beta-D-glucoside (ISO)

gentamycin (EXP)

glycitein (ISO)

glycitin (ISO)

glyphosate (EXP)

indometacin (ISO)

isoflurane (ISO)

lipopolysaccharide (ISO)

manganese atom (ISO)

manganese(0) (ISO)

manganese(II) chloride (ISO)

methoxychlor (EXP)

methyl methanesulfonate (ISO)

mifepristone (EXP)

ozone (ISO)

paracetamol (EXP,ISO)

potassium dichromate (ISO)

rac-lactic acid (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

SB 431542 (ISO)

selenium atom (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

titanium dioxide (ISO)

trichostatin A (ISO)

triphenyl phosphate (ISO)

trovafloxacin (ISO)

valproic acid (ISO)

vincristine (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

amyloid precursor protein metabolic process (ISO)

biological_process (ND)

cellular response to cytokine stimulus (ISO)

cholesterol homeostasis (ISO)

cholesterol metabolic process (IEA)

endocytosis (IEA)

lipid metabolic process (IEA)

low-density lipoprotein particle clearance (ISO)

positive regulation of low-density lipoprotein particle clearance (ISO)

positive regulation of receptor-mediated endocytosis (ISO)

positive regulation of receptor-mediated endocytosis involved in cholesterol transport (ISO)

positive regulation of vascular associated smooth muscle cell proliferation (ISO)

receptor internalization (ISO)

receptor-mediated endocytosis (ISO)

receptor-mediated endocytosis involved in cholesterol transport (ISO)

regulation of protein localization to plasma membrane (ISO)

steroid metabolic process (IEA)

Cellular Component

axon (IDA)

basal plasma membrane (ISO)

cytoplasm (IEA,ISO)

cytoplasmic side of plasma membrane (ISO)

cytosol (ISO)

early endosome (IBA,ISO)

neurofilament (ISO)

recycling endosome (ISO)

Molecular Function

amyloid-beta binding (ISO)

AP-1 adaptor complex binding (ISO)

AP-2 adaptor complex binding (ISO)

clathrin adaptor activity (ISO)

clathrin binding (ISO)

low-density lipoprotein particle receptor binding (ISO)

phosphatidylinositol-4,5-bisphosphate binding (ISO)

phosphotyrosine residue binding (ISO)

protein binding (IPI,ISO)

signaling adaptor activity (ISO)

signaling receptor complex adaptor activity (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

endocytosis pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	A novel ARH splice site mutation in a Mexican kindred with autosomal recessive hypercholesterolemia.	Canizales-Quinteros S, etal., Hum Genet. 2005 Jan;116(1-2):114-20. Epub 2004 Nov 17.
2.	Atomic structure of the autosomal recessive hypercholesterolemia phosphotyrosine-binding domain in complex with the LDL-receptor tail.	Dvir H, etal., Proc Natl Acad Sci U S A. 2012 May 1;109(18):6916-21. doi: 10.1073/pnas.1114128109. Epub 2012 Apr 16.
3.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4.	Characterization of the adaptor protein ARH expression in the brain and ARH molecular interactions.	Mameza MG, etal., J Neurochem. 2007 Nov;103(3):927-41. Epub 2007 Aug 28.
5.	The adaptor protein ARH escorts megalin to and through endosomes.	Nagai M, etal., Mol Biol Cell. 2003 Dec;14(12):4984-96. Epub 2003 Oct 3.
6.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
7.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
8.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
10.	Comprehensive gene review and curation	RGD comprehensive gene curation
11.	Mechanisms of disease: genetic causes of familial hypercholesterolemia.	Soutar AK and Naoumova RP, Nat Clin Pract Cardiovasc Med. 2007 Apr;4(4):214-25.

Additional References at PubMed

PMID:12221107	PMID:12417523	PMID:12451172	PMID:12464675	PMID:12746448	PMID:12805363	PMID:15166224	PMID:15728179	PMID:18417616	PMID:23836931	PMID:28257760

Genomics

Comparative Map Data

Ldlrap1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	152,239,296 - 152,262,290 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	5	152,229,505 - 152,262,290 (-)	Ensembl				GRCr8
mRatBN7.2	5	146,955,607 - 146,978,601 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	146,955,607 - 146,978,601 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	5	149,656,442 - 149,679,565 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	151,427,752 - 151,450,746 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	151,412,689 - 151,435,812 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	152,964,294 - 152,987,286 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	152,966,591 - 152,987,211 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	5	156,742,863 - 156,765,855 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	5	153,504,535 - 153,527,523 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	5	145,368,945 - 145,391,939 (-)	NCBI		Celera
Cytogenetic Map	5	q36	NCBI

LDLRAP1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	25,543,606 - 25,590,400 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	25,543,573 - 25,591,200 (+)	Ensembl			hg38	GRCh38
GRCh37	1	25,870,097 - 25,895,377 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	25,742,663 - 25,767,964 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Celera	1	24,265,963 - 24,291,423 (+)	NCBI		Celera
Cytogenetic Map	1	p36.11	NCBI
HuRef	1	24,124,497 - 24,149,801 (+)	NCBI		HuRef
CHM1_1	1	25,983,497 - 26,008,795 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	1	25,380,944 - 25,427,735 (+)	NCBI		T2T-CHM13v2.0

Ldlrap1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	134,468,865 - 134,495,342 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	134,468,865 - 134,495,335 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	4	134,741,554 - 134,768,032 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	134,741,554 - 134,768,024 (-)	Ensembl			mm10	GRCm38
MGSCv37	4	134,301,327 - 134,323,919 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	4	134,017,498 - 134,040,023 (-)	NCBI		MGSCv36	mm8
Celera	4	132,929,656 - 132,952,236 (-)	NCBI		Celera
Cytogenetic Map	4	D3	NCBI
cM Map	4	67.09	NCBI

Ldlrap1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955452	5,081,556 - 5,095,182 (+)	Ensembl
ChiLan1.0	NW_004955452	5,081,919 - 5,102,349 (+)	NCBI	ChiLan1.0	ChiLan1.0

LDLRAP1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	201,263,219 - 201,336,642 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	200,376,406 - 200,434,513 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	24,809,535 - 24,852,394 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	25,871,874 - 25,920,550 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	25,878,358 - 25,903,336 (+)	Ensembl			panPan2	panpan1.1

LDLRAP1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	2	74,340,272 - 74,363,929 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	2	74,341,036 - 74,364,162 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	2	70,914,328 - 70,937,998 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	2	74,901,453 - 74,925,396 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	2	74,901,458 - 74,925,371 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	2	71,724,767 - 71,748,432 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	2	72,731,525 - 72,755,221 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	2	73,735,844 - 73,759,564 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Ldlrap1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	44,371,440 - 44,395,584 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936474	10,196,211 - 10,221,777 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936474	10,196,228 - 10,219,137 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

LDLRAP1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	83,030,702 - 83,054,377 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	6	83,030,629 - 83,054,387 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	76,601,373 - 76,625,132 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

LDLRAP1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	107,207,363 - 107,232,237 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	107,207,334 - 107,229,210 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666033	9,131,295 - 9,155,884 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ldlrap1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624764	9,675,845 - 9,699,597 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624764	9,675,917 - 9,699,597 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Ldlrap1
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	1	23,487,123 - 23,508,185 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Ldlrap1
333 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	285
Count of miRNA genes:	179
Interacting mature miRNAs:	211
Transcripts:	ENSRNOT00000000163
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1331796	Thshl2	Thyroid stimulating hormone level QTL 2	2.3		blood thyroid-stimulating hormone amount (VT:0005119)	serum thyroid stimulating hormone level (CMO:0001248)	5	102105698	152749382	Rat
10053720	Scort26	Serum corticosterone level QTL 26	2.06	0.0147	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	5	130249266	172190305	Rat
1549845	Scl44	Serum cholesterol level QTL 44	6		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	5	44924861	153890773	Rat
8552960	Pigfal15	Plasma insulin-like growth factor 1 level QTL 15			blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	5	116702075	161702075	Rat
1354583	Despr3	Despair related QTL3	4.98	0.0002	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	5	132930505	172190305	Rat
61444	Strs2	Sensitivity to stroke QTL 2	4.7		cerebrum integrity trait (VT:0010549)	post-insult time to onset of cerebrovascular lesion (CMO:0002343)	5	141212838	172190305	Rat
1300119	Bp180	Blood pressure QTL 180	3.82		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	5	149642129	171146538	Rat
61452	Ciaa5	CIA Autoantibody QTL 5	3.5		blood autoantibody amount (VT:0003725)	calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)	5	99905133	172190305	Rat
70156	Niddm30	Non-insulin dependent diabetes mellitus QTL 30	3.98		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	5	134369218	156289444	Rat
8552908	Pigfal4	Plasma insulin-like growth factor 1 level QTL 4	6.6		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	5	133789363	172190305	Rat
1331803	Rf32	Renal function QTL 32	2.798		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal vascular resistance (CMO:0001900)	5	134369199	172190305	Rat
61393	Bp7	Blood pressure QTL 7	4.5	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	65089051	166764498	Rat
7794791	Mcs33	Mammary carcinoma susceptibility QTL 33	1.93		mammary gland integrity trait (VT:0010552)	mammary tumor incidence/prevalence measurement (CMO:0000946)	5	136631198	172190305	Rat
7207486	Bss109	Bone structure and strength QTL 109			femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	5	112142946	157142946	Rat
7207481	Bss106	Bone structure and strength QTL 106	7.9		femur strength trait (VT:0010010)	femur ultimate force (CMO:0001675)	5	112142946	157142946	Rat
1302790	Scl20	Serum cholesterol level QTL 20	6.4	0.0001	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	110770739	155770739	Rat
1598861	Cm64	Cardiac mass QTL 64	2.9		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	5	133081618	172190305	Rat
1578766	Tcas11	Tongue tumor susceptibility QTL 11	4.12		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	5	51657967	166600247	Rat
631263	Cm24	Cardiac mass QTL 24	3.5		heart mass (VT:0007028)	heart left ventricle weight to body weight ratio (CMO:0000530)	5	149805999	162987697	Rat
631505	Bp103	Blood pressure QTL 103	3.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	138002522	170842766	Rat
1549838	Bss4	Bone structure and strength QTL 4	9.2		femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	5	112142946	157142946	Rat
1581505	Rf54	Renal function QTL 54			kidney physiology trait (VT:0002136)	kidney 20-HETE level (CMO:0001854)	5	133270647	172190305	Rat
2317753	Glom24	Glomerulus QTL 24	3.1		kidney glomerulus integrity trait (VT:0010546)	kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)	5	141764300	172190305	Rat
8694169	Bw148	Body weight QTL 148	5	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	5	133789363	172190305	Rat
1331721	Bp210	Blood pressure QTL 210	3.413		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	5	148093485	172129029	Rat
1581510	Cm54	Cardiac mass QTL 54	3.4	0.05	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	5	125969677	172190305	Rat
1576312	Emca8	Estrogen-induced mammary cancer QTL 8	4.1		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	55124766	172190305	Rat
2317056	Wbc3	White blood cell count QTL 3	2.51	0.01	leukocyte quantity (VT:0000217)	white blood cell count (CMO:0000027)	5	111236572	156236572	Rat
724525	Bp147	Blood pressure QTL 147	4.3	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	131708216	172190305	Rat
1598847	Cm62	Cardiac mass QTL 62	3.4		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	5	114131300	159131300	Rat
2293642	Bss37	Bone structure and strength QTL 37	4.64	0.0001	femur strength trait (VT:0010010)	femur ultimate force (CMO:0001675)	5	125969677	156302135	Rat
2313096	Bmd78	Bone mineral density QTL 78	3.1	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	5	149661912	166600247	Rat
7207488	Bss110	Bone structure and strength QTL 1	8.4		femur strength trait (VT:0010010)	femur stiffness (CMO:0001674)	5	112142946	157142946	Rat
8694441	Bw169	Body weight QTL 169	17.61	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	5	116702075	161702075	Rat
7207491	Bss112	Bone structure and strength QTL 112	7		femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	5	112142946	157142946	Rat
8694389	Bw160	Body weight QTL 160	6.17	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	5	116702075	161702075	Rat
1354598	Srn6	Serum renin concentration QTL 6	3.8		blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	5	74335621	156302135	Rat
8694198	Abfw3	Abdominal fat weight QTL 3	16.13	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	5	116702075	161702075	Rat
1298089	Scl14	Serum cholesterol level QTL 14	5.8	0.0004	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	114131300	159131300	Rat
1598819	Bp292	Blood pressure QTL 292	4.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	133081618	172190305	Rat
1358187	Emca1	Estrogen-induced mammary cancer QTL 1	4.4		mammary gland integrity trait (VT:0010552)	post-insult time to mammary tumor formation (CMO:0000345)	5	104262817	153890625	Rat

Markers in Region

BE106628

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	5	152,240,029 - 152,240,191 (+)	Marker Load Pipeline
mRatBN7.2	5	146,956,339 - 146,956,502 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	152,965,027 - 152,965,189	NCBI	Rnor6.0
Rnor_5.0	5	156,743,596 - 156,743,758	UniSTS	Rnor5.0
RGSC_v3.4	5	153,505,268 - 153,505,430	UniSTS	RGSC3.4
Celera	5	145,369,678 - 145,369,840	UniSTS
RH 3.4 Map	5	990.6	UniSTS
Cytogenetic Map	5	q36	UniSTS

BE097787

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	146,957,228 - 146,957,396 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	152,965,916 - 152,966,083	NCBI	Rnor6.0
Rnor_5.0	5	156,744,485 - 156,744,652	UniSTS	Rnor5.0
RGSC_v3.4	5	153,506,157 - 153,506,324	UniSTS	RGSC3.4
Celera	5	145,370,567 - 145,370,734	UniSTS
RH 3.4 Map	5	990.6	UniSTS
Cytogenetic Map	5	q36	UniSTS

BI275057

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	146,956,487 - 146,956,667 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	152,965,175 - 152,965,354	NCBI	Rnor6.0
Rnor_5.0	5	156,743,744 - 156,743,923	UniSTS	Rnor5.0
RGSC_v3.4	5	153,505,416 - 153,505,595	UniSTS	RGSC3.4
Celera	5	145,369,826 - 145,370,005	UniSTS
RH 3.4 Map	5	990.5	UniSTS
Cytogenetic Map	5	q36	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	158	91	90	59	92	59	6	356	192	11	137	81	92	31	13	13

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001109271	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473968	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000000163 ⟹ ENSRNOP00000000163

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	5	152,239,296 - 152,262,290 (-)	Ensembl
mRatBN7.2 Ensembl	5	146,955,607 - 146,978,601 (-)	Ensembl
Rnor_6.0 Ensembl	5	152,966,591 - 152,987,211 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000167620 ⟹ ENSRNOP00000104770

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	5	152,229,505 - 152,262,290 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000172668 ⟹ ENSRNOP00000106724

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	5	152,235,243 - 152,262,290 (-)	Ensembl

RefSeq Acc Id:

NM_001109271 ⟹ NP_001102741

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	152,239,296 - 152,262,290 (-)	NCBI
mRatBN7.2	5	146,955,607 - 146,978,601 (-)	NCBI
Rnor_6.0	5	152,964,294 - 152,987,286 (-)	NCBI
Rnor_5.0	5	156,742,863 - 156,765,855 (-)	NCBI
RGSC_v3.4	5	153,504,535 - 153,527,523 (-)	RGD
Celera	5	145,368,945 - 145,391,939 (-)	RGD

Sequence:

show sequence

AAAGTTTTCCTGGAGGACTTTTGGCGGCGGCAGCGGCGGCAGAGGCAGCAGCGGCGGCGGCAAC
CGGAGCGGGCCATGGACGCGCTCAAGTCGGCGGGGCGCGCGCTAATCCGGAGCCCCAGTCTGGC
CAAGCAGAGCTGGGCGGGCGGCCGGCACCGCAAGTTGCCAGAGAACTGGACGGACACTCGGGAG
ACACTGCTGGAGGGCATGGTTTTTAGCCTCAAGTACCTTGGTATGACATTGGTGGAGAGGCCCA
AGGGTGAGGAGCTGTCTGCAGCTGCTGTCAAAAGAATCGTGGCTACGGCCAAGGCGAGCGGGAA
GAAGCTGCAGAAGGTGACACTGAAGGTGTCACCCCGGGGGATCATCCTGACTGACAGCCTCACT
AGCCAACTCATTGAGAACGTGTCCATTTACAGGATCTCCTACTGCACCGCAGACAAGATGCATG
ACAAGGTGTTCGCGTACATCGCCCAGAGCCAGCAGAACGAGAGCCTGGAGTGTCATGCGTTCCT
CTGCACCAAGCGGAAAGTGGCACAAGCTGTCACCCTCACTGTAGCCCAAGCCTTCAAAGTTGCC
TTTGAGTTTTGGCAGGTGTCCAAGGAAGAGAAAGAGAAGAGAGAGAAAGCCAACCAGGAGGGAG
GAGACGTCCCAGGGACCCGACGTGACAGCACCCCCTCGTTGAAAACCTCGGTCGCTACTGGGAA
CCTGCTGGATCTGGAAGAGCTGGCTAAGGCCCCGTTGTCCACAGTCAGCGCTAATACTAAGAAC
ATGGACGACGCACTGCGGCCTCAAGTCTTGGGCAACAACAGCGTCGTCTGGGAGCTGGATGACG
GTCTGGATGAAGCGTTTTCAAGGCTGGCGCAGTCACGGACAAACCCTCAAGTCCTGGACACTGG
ACTGACAGCACAGGATATCCATTACGCACAGTGCTTATCGCCCACTGACTGGGACAAGCCTGAC
AGCAGTGGCTTTGATCAAGACGACGTCTTCAGCTTCTGAGGGCCTGAGGCTGGCAGTACACGGC
TGGCCTAGCCATGTGGTGGACCACCAGCCACCTGCAGCAGGACAACCAGCCCCAGGAGCCATCA
GCTGCCTTTGGCCAGTGGCGTCAGAGCCTGCAGATTTGAGTTGCACAGTCACGCAGGGAGAGGG
GTTAGAAAGATGCCTGGGGTATCTGGTTGATGACTCCTGGTTTATGCTCGGAAACCAGGTTCAA
TTCAGGTGCTCATGGTGTGTGCAGGGCAGGGCTGGCCTCCTGGCCTCTCTCCTGGAGCCAGTAT
CCCCGCTGTGGGTGTCCAGACAATGACCAAAGTGTTGCTTGTTCCTCTTCTCTGGGGCATCCTT
ACTCCTGAAGCAGTAGGAGCCTGTCGTTCTTTGTGTGCTGGATGGGACATGGCTTTCAGGAAAG
TCGGGGTCCTCAAGCTCGGCTTCCTCAGGGCTGAGAAGCTGAGGCTTTCAAAGAGGCAGCCCCT
GACCAAAGACATTTAATCTGCACTTTAACTCTCACGTAATGGACGTAATGGACGTGGTTCGAGG
TCCGTGATGGTGCTCTAGGAGTAGAGTTTGCTTCCTGCCCTCCCTCCACAAGAGGGCCCCAGTC
CCTGACATGGTCCACATAGTGCTAGGACCTAGTGTACCAGCTGACTACGACTCCAGAGTCACTG
CAACCATAGGGATCTCCTTTGTGGCTCCTGGGAGCCCCCAAAACAGACAAAGCTGGGCCTGCTC
TTCTGTCTTGTCTGTATGTCCCTGTGCGTGCTCCGTTTTCTGCCTCCCCATAACTCCTGGGACG
ATACCGAAGCCTGGTACTAGGTTGTGGCAGGATATTTTGCATCCATTTTACAGATAAAGAAACT
GAGGCAACACGTTGGGGTGGGGGGCGGTGGAGTTGAGAATAGAACCCAGATCTGATACCAAAGC
TGCCGTCTGTGCTGCCGCCTTGCAGCCCACGCCTCTTTCTCTCCGGCTTTGTTGTCCTCCCAGG
AACCAGAACGCCCCAGCTATTTTCTGACCAAAATGTGTTTCATAACAAACCGTCTGGTGCCTTT
CCACACAGCGCTGGCGCAGGCCGCCATGCCCTGCTAGCTGCTACGTGGCTGACTTCTGTGCAGA
TGTGTTTGGAAGTCTGTTAATTCCCTGGGTGAAACAGAATCCTGCTCTAGAAACACCTCGCTGT
CCTTTCCTGACCTGCAGCCTTAGAGGTCCCTCAGCCCTAGCTGGTGGTGGTTGGGAGGTCCAGT
GGTGAGCTTCCCTTAGTCTCTCTTTTCTCCCTTCGCTGTTACGCAGGCTCTGGCATCCTGAACC
ACAGCCAAATCACAACCATCTTTCCATCCCAAGGAGCCCCCAGTGGCCGGCCGGGCTTGTGAAA
GCAGGTCTCAGTATCCCCGGGAAAAACACACTCTTCCTGAGTGGCTGAGTCAAACCCGTGCCTT
GGGGAGGGCACTTGGAGAATTCCGGCTAGAATAAAGGTTGCTAGCTCCCTTTCCGGCCAGCTCC
GGGGCCTGCTCCCAGCCCAGGCGGCGGGGGTCCGGGCGCAAGGGGGGCTACTGTGCTTGCTGCC
GGTGCTGCTGTGTGAGGCTGGGGCTTCTGAGTAGGAAACAATAAATGTTCTCTTTCTAAGTGTG
AGCACCGCCTGGGGTGCTGCGGGTGACAAAGGGCAGGGTCGTCATGGCTTCTGCCCTCCGTGAT
GGGGGCAGCAGTTATGTCAAGAGACTGGGGTAGGCTGCTGCACCAGAATGGAGGGTGATGGCAG
GTCCCCAGTTGGTGGGCCAGCAGGGTACCTTTCTTTCTCTGTAGACTGCCATTGTGACAAGGTC
GCTGTTGGGTGATGTGAGACCCCGCCAGTGGGCCAGCACATAAGCGCTCACTGTTTCTAACTGT
GTGTTCTAGTCAGGCCTGAACCCCTGAGACACGAGTGTGAGAGTGAGTGTGCCCATGTGTACCC
CTTCCCAGGGCTGGTGGTATCCCCATGCCTCTCCAGTGACTCAGACTTTTAGGTTTACTCTGCT
ACTCAAGTTTGGACCAGGGCTCCGTGCTAGGAATTTGAATTCAAGTTGTGTGGCTTTGTGTTGA
AGGGGGACAGAGGCAAAGGAATGGGTGGGTGGAGTCCTGTGACTTAAGACATCCAAAGTCCAGC
TACTGCTATGGGTCAGTTACCTATTTCCTTGAGCCTCAGTTTTCCTGTCTGTAAACAGGGTACA
GCAGTCTCCTGTGCCTATGTTCCTGGGGTTTTATGAGACCATTGCCCTTTAACACATGATTGGC
AGTACCTATCCAGTGGCTCAAAGGTTTTCTCA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001102741	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	D3ZAR1	(Get FASTA)	NCBI Sequence Viewer
	EDL80736	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000000163

RefSeq Acc Id:

NP_001102741 ⟸ NM_001109271

- UniProtKB:

D3ZAR1 (UniProtKB/Swiss-Prot), A0A8L2PZA1 (UniProtKB/TrEMBL), A6IT35 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MDALKSAGRALIRSPSLAKQSWAGGRHRKLPENWTDTRETLLEGMVFSLKYLGMTLVERPKGEE
LSAAAVKRIVATAKASGKKLQKVTLKVSPRGIILTDSLTSQLIENVSIYRISYCTADKMHDKVF
AYIAQSQQNESLECHAFLCTKRKVAQAVTLTVAQAFKVAFEFWQVSKEEKEKREKANQEGGDVP
GTRRDSTPSLKTSVATGNLLDLEELAKAPLSTVSANTKNMDDALRPQVLGNNSVVWELDDGLDE
AFSRLAQSRTNPQVLDTGLTAQDIHYAQCLSPTDWDKPDSSGFDQDDVFSF

hide sequence

Ensembl Acc Id:

ENSRNOP00000000163 ⟸ ENSRNOT00000000163

Ensembl Acc Id:

ENSRNOP00000106724 ⟸ ENSRNOT00000172668

Ensembl Acc Id:

ENSRNOP00000104770 ⟸ ENSRNOT00000167620

Protein Domains

PID

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZAR1-F1-model_v2	AlphaFold	D3ZAR1	1-306	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13694143

Promoter ID:

EPDNEW_R4668

Type:

multiple initiation site

Name:

Ldlrap1_1

Description:

low density lipoprotein receptor adaptor protein 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	5	152,987,264 - 152,987,324	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1563417	AgrOrtholog
BioCyc Gene	G2FUF-39559	BioCyc
Ensembl Genes	ENSRNOG00000000151	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000000163	ENTREZGENE
Gene3D-CATH	2.30.29.30	UniProtKB/Swiss-Prot
InterPro	Adapter_Engulfment-Domain	UniProtKB/Swiss-Prot
	PH-like_dom_sf	UniProtKB/Swiss-Prot
	PTB/PI_dom	UniProtKB/Swiss-Prot
NCBI Gene	500564	ENTREZGENE
PANTHER	LOW DENSITY LIPOPROTEIN RECEPTOR ADAPTER PROTEIN 1	UniProtKB/Swiss-Prot
	PHOSPHOTYROSINE INTERACTION DOMAIN-CONTAINING FAMILY MEMBER	UniProtKB/Swiss-Prot
Pfam	PID	UniProtKB/Swiss-Prot
PhenoGen	Ldlrap1	PhenoGen
PROSITE	PID	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000000151	RatGTEx
SMART	PTB	UniProtKB/Swiss-Prot
Superfamily-SCOP	PH domain-like	UniProtKB/Swiss-Prot
UniProt	A0A8L2PZA1	ENTREZGENE, UniProtKB/TrEMBL
	A0ABK0LGJ2_RAT	UniProtKB/TrEMBL
	A0ABK0LRX9_RAT	UniProtKB/TrEMBL
	A6IT35	ENTREZGENE, UniProtKB/TrEMBL
	ARH_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-03-06	Ldlrap1	low density lipoprotein receptor adaptor protein 1	RGD1563417_predicted	similar to LDL receptor adaptor protein (predicted)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-07	RGD1563417_predicted	similar to LDL receptor adaptor protein (predicted)	LOC500564	similar to LDL receptor adaptor protein	Symbol and Name status set to approved	1299863	APPROVED
2006-02-09	LOC500564	similar to LDL receptor adaptor protein			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)