Birc7 (baculoviral IAP repeat-containing 7) - Rat Genome Database

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Gene: Birc7 (baculoviral IAP repeat-containing 7) Rattus norvegicus
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Symbol: Birc7
Name: baculoviral IAP repeat-containing 7
RGD ID: 1562883
Description: Predicted to enable cysteine-type endopeptidase inhibitor activity involved in apoptotic process and ubiquitin protein ligase activity. Predicted to be involved in several processes, including positive regulation of protein ubiquitination; regulation of apoptotic process; and regulation of signal transduction. Predicted to act upstream of with a negative effect on regulation of apoptotic process. Predicted to act upstream of or within lens development in camera-type eye. Predicted to be located in Golgi apparatus. Predicted to be active in cytoplasm and nucleus. Orthologous to human BIRC7 (baculoviral IAP repeat containing 7); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acrylamide; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: baculoviral IAP repeat-containing 7 (livin); baculoviral IAP repeat-containing protein 7; LOC296468; RGD1562883; similar to livin inhibitor of apoptosis isoform beta
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83188,425,392 - 188,430,174 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3188,425,392 - 188,430,174 (+)EnsemblGRCr8
mRatBN7.23168,047,824 - 168,052,606 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3168,047,824 - 168,052,606 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3172,428,000 - 172,432,781 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03181,387,091 - 181,391,872 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03178,048,785 - 178,053,567 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03176,438,335 - 176,443,864 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3176,439,199 - 176,443,195 (+)Ensemblrn6Rnor6.0
Rnor_5.03180,150,723 - 180,153,671 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43170,037,778 - 170,043,277 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3164,532,360 - 164,537,207 (-)NCBICelera
Cytogenetic Map3q43NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
centrosome  (IEA,ISO)
cytoplasm  (IBA,IEA,ISO)
cytosol  (IEA,ISO)
Golgi apparatus  (IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IBA,IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Expression patterns of inhibitor of apoptosis proteins in malignant pleural mesothelioma. Gordon GJ, etal., J Pathol. 2007 Mar;211(4):447-54. doi: 10.1002/path.2121.
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. [Expression and significance of JNK1, Raf-1 and Livin in the carcinogenesis of sporadic colorectal tubular adenoma]. Wu WX, etal., Zhonghua Zhong Liu Za Zhi. 2010 Sep;32(9):671-5.
Additional References at PubMed
PMID:16729033   PMID:17294084   PMID:18034418   PMID:21617971   PMID:26218911  


Genomics

Comparative Map Data
Birc7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83188,425,392 - 188,430,174 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3188,425,392 - 188,430,174 (+)EnsemblGRCr8
mRatBN7.23168,047,824 - 168,052,606 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3168,047,824 - 168,052,606 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3172,428,000 - 172,432,781 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03181,387,091 - 181,391,872 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03178,048,785 - 178,053,567 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03176,438,335 - 176,443,864 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3176,439,199 - 176,443,195 (+)Ensemblrn6Rnor6.0
Rnor_5.03180,150,723 - 180,153,671 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43170,037,778 - 170,043,277 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3164,532,360 - 164,537,207 (-)NCBICelera
Cytogenetic Map3q43NCBI
BIRC7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382063,235,905 - 63,240,495 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2063,235,883 - 63,240,495 (+)Ensemblhg38GRCh38
GRCh372061,867,257 - 61,871,847 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362061,337,721 - 61,342,299 (+)NCBIBuild 36Build 36hg18NCBI36
Build 342061,337,720 - 61,342,299NCBI
Celera2058,544,759 - 58,549,338 (+)NCBICelera
Cytogenetic Map20q13.33NCBI
HuRef2058,592,772 - 58,597,397 (+)NCBIHuRef
CHM1_12061,768,290 - 61,772,915 (+)NCBICHM1_1
T2T-CHM13v2.02065,041,538 - 65,046,510 (+)NCBIT2T-CHM13v2.0
Birc7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392180,570,402 - 180,575,803 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2180,570,816 - 180,575,803 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm382180,928,609 - 180,934,010 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2180,929,023 - 180,934,010 (+)Ensemblmm10GRCm38
MGSCv372180,663,728 - 180,668,715 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv362180,850,322 - 180,862,738 (+)NCBIMGSCv36mm8
Celera2185,015,239 - 185,020,226 (+)NCBICelera
Cytogenetic Map2H4NCBI
cM Map2103.53NCBI
Birc7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955528919,246 - 922,619 (-)Ensembl
ChiLan1.0NW_004955528919,246 - 922,581 (-)NCBIChiLan1.0ChiLan1.0
BIRC7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22169,022,107 - 69,027,217 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12069,014,113 - 69,019,185 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02059,618,530 - 59,623,612 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12061,156,871 - 61,161,932 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2061,157,302 - 61,161,932 (+)EnsemblpanPan2panpan1.1
BIRC7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12446,950,700 - 46,956,375 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2446,952,474 - 46,955,495 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2446,136,510 - 46,140,424 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02447,906,319 - 47,910,219 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2447,906,319 - 47,909,340 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12446,921,701 - 46,925,622 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02447,045,709 - 47,049,636 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02447,802,069 - 47,805,983 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Birc7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640195,164,678 - 195,169,263 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493651410,618,289 - 10,622,931 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493651410,618,347 - 10,622,906 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BIRC7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11762,351,663 - 62,356,220 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
BIRC7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12965,811 - 970,983 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605048,703,511 - 48,708,637 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Birc7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474128,937,836 - 28,944,000 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Birc7
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v15158,037,768 - 158,041,918 (+)NCBIRrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:71
Count of miRNA genes:61
Interacting mature miRNAs:64
Transcripts:ENSRNOT00000068252
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3152055202189428310Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)3145335553189428310Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3151075912189428310Rat
1298068Bp167Blood pressure QTL 1670.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3161492708189428310Rat
1582256Insul9Insulin level QTL 94.40.0016blood insulin amount (VT:0001560)absolute change in serum insulin level (CMO:0002038)3155759447189428310Rat
1582248Insul7Insulin level QTL 73.90.0041blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)3155759447189428310Rat
1578666Vnigr1Vascular neointimal growth QTL 14.6artery morphology trait (VT:0002191)artery lumen area (CMO:0001409)3151075912189428310Rat
1300161Rf10Renal function QTL 103.57renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)3181611379189428310Rat
8552791Vie2Viral induced encephalitis QTL 24.1brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)3166376089189428310Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3151075912189428310Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3144575244189428310Rat
1582213Insul6Insulin level QTL 63.70.0009blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)3155759447189428310Rat
1598854Memor10Memory QTL 102exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)3166376089189428310Rat

Markers in Region
RH134165  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr83188,429,465 - 188,430,117 (+)Marker Load Pipeline
mRatBN7.23168,051,897 - 168,052,549 (+)MAPPERmRatBN7.2
Rnor_6.03176,443,149 - 176,443,800NCBIRnor6.0
Rnor_5.03180,152,963 - 180,153,614UniSTSRnor5.0
RGSC_v3.43170,042,569 - 170,043,220UniSTSRGSC3.4
Celera3164,532,417 - 164,533,068UniSTS
RH 3.4 Map31532.2UniSTS
Cytogenetic Map3q43UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
1 2 30 119 26 31 9 7 9 6 86 51 6 99 23 43 22 5 5

Sequence


Ensembl Acc Id: ENSRNOT00000068252   ⟹   ENSRNOP00000059533
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3188,425,392 - 188,430,174 (+)Ensembl
mRatBN7.2 Ensembl3168,047,824 - 168,052,606 (+)Ensembl
Rnor_6.0 Ensembl3176,439,199 - 176,443,195 (+)Ensembl
RefSeq Acc Id: NM_001305210   ⟹   NP_001292139
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83188,425,392 - 188,430,174 (+)NCBI
mRatBN7.23168,047,824 - 168,052,606 (+)NCBI
Rnor_6.03176,439,075 - 176,443,857 (+)NCBI
Celera3164,532,360 - 164,537,207 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001292139 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL88780 (Get FASTA)   NCBI Sequence Viewer  
  EDL88781 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000059533
  ENSRNOP00000059533.3
RefSeq Acc Id: NP_001292139   ⟸   NM_001305210
- UniProtKB: D4A690 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000059533   ⟸   ENSRNOT00000068252
Protein Domains
RING-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A690-F1-model_v2 AlphaFold D4A690 1-285 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1562883 AgrOrtholog
BioCyc Gene G2FUF-46312 BioCyc
Ensembl Genes ENSRNOG00000043311 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000068252 ENTREZGENE
  ENSRNOT00000068252.5 UniProtKB/TrEMBL
Gene3D-CATH 3.30.40.10 UniProtKB/TrEMBL
  Inhibitor Of Apoptosis Protein (2mihbC-IAP-1), Chain A UniProtKB/TrEMBL
InterPro BIR UniProtKB/TrEMBL
  IAP UniProtKB/TrEMBL
  Znf_RING UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/TrEMBL
  Znf_RING_CS UniProtKB/TrEMBL
KEGG Report rno:296468 UniProtKB/TrEMBL
NCBI Gene 296468 ENTREZGENE
PANTHER BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 7 UniProtKB/TrEMBL
  INHIBITOR OF APOPTOSIS UniProtKB/TrEMBL
Pfam BIR UniProtKB/TrEMBL
  zf-C3HC4_3 UniProtKB/TrEMBL
PhenoGen Birc7 PhenoGen
PROSITE BIR_REPEAT_1 UniProtKB/TrEMBL
  BIR_REPEAT_2 UniProtKB/TrEMBL
  ZF_RING_1 UniProtKB/TrEMBL
  ZF_RING_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000043311 RatGTEx
SMART BIR UniProtKB/TrEMBL
  RING UniProtKB/TrEMBL
Superfamily-SCOP Inhibitor of apoptosis (IAP) repeat UniProtKB/TrEMBL
UniProt D4A690 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-26 Birc7  baculoviral IAP repeat-containing 7  Birc7  baculoviral IAP repeat-containing 7 (livin)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-06 Birc7  baculoviral IAP repeat-containing 7 (livin)  RGD1562883_predicted  similar to livin inhibitor of apoptosis isoform beta (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1562883_predicted  similar to livin inhibitor of apoptosis isoform beta (predicted)  LOC296468  similar to livin inhibitor of apoptosis isoform beta  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC296468  similar to livin inhibitor of apoptosis isoform beta      Symbol and Name status set to provisional 70820 PROVISIONAL