Fbll1 (fibrillarin like rRNA 2'-O-methyltransferase 1) - Rat Genome Database

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Gene: Fbll1 (fibrillarin like rRNA 2'-O-methyltransferase 1) Rattus norvegicus
Analyze
Symbol: Fbll1
Name: fibrillarin like rRNA 2'-O-methyltransferase 1 (Ensembl:fibrillarin-like 1)
RGD ID: 1562841
Description: Predicted to enable RNA binding activity and methyltransferase activity. Predicted to be involved in box C/D sno(s)RNA 3'-end processing; mRNA stabilization; and rRNA methylation. Predicted to act upstream of or within blastocyst hatching. Predicted to be located in fibrillar center and nucleoplasm. Predicted to be part of box C/D methylation guide snoRNP complex and small-subunit processome. Predicted to be active in Cajal body and nucleolus. Orthologous to human FBLL1 (fibrillarin like 1); PARTICIPATES IN ribosome biogenesis pathway; INTERACTS WITH bisphenol A; C60 fullerene; furan.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: fibrillarin rRNA 2'-O-methyltransferase like 1; fibrillarin-like 1; LOC363563; RGD1562841; rRNA/tRNA 2'-O-methyltransferase fibrillarin-like protein 1; similar to fibrillarin
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81020,762,716 - 20,764,359 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1020,761,581 - 20,764,670 (-)EnsemblGRCr8
mRatBN7.21020,258,656 - 20,260,299 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1020,258,656 - 20,260,299 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1025,009,770 - 25,011,413 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01024,498,295 - 24,499,938 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01019,982,445 - 19,984,088 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01020,620,957 - 20,622,600 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1020,620,957 - 20,622,600 (-)Ensemblrn6Rnor6.0
Rnor_5.01020,494,593 - 20,496,236 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41020,709,269 - 20,710,912 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1019,877,688 - 19,879,331 (-)NCBICelera
Cytogenetic Map10q12NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:27869233   PMID:33450132  


Genomics

Comparative Map Data
Fbll1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81020,762,716 - 20,764,359 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1020,761,581 - 20,764,670 (-)EnsemblGRCr8
mRatBN7.21020,258,656 - 20,260,299 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1020,258,656 - 20,260,299 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1025,009,770 - 25,011,413 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01024,498,295 - 24,499,938 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01019,982,445 - 19,984,088 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01020,620,957 - 20,622,600 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1020,620,957 - 20,622,600 (-)Ensemblrn6Rnor6.0
Rnor_5.01020,494,593 - 20,496,236 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41020,709,269 - 20,710,912 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1019,877,688 - 19,879,331 (-)NCBICelera
Cytogenetic Map10q12NCBI
FBLL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385168,529,305 - 168,530,634 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5168,529,305 - 168,530,634 (+)Ensemblhg38GRCh38
GRCh375167,956,310 - 167,957,639 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365167,889,088 - 167,890,217 (+)NCBIBuild 36Build 36hg18NCBI36
Celera5163,991,936 - 163,992,990 (+)NCBICelera
Cytogenetic Map5q34NCBI
HuRef5163,055,105 - 163,056,011 (+)NCBIHuRef
CHM1_15167,389,597 - 167,390,566 (+)NCBICHM1_1
T2T-CHM13v2.05169,064,086 - 169,065,415 (+)NCBIT2T-CHM13v2.0
Fbll1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391135,688,207 - 35,689,711 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1135,688,209 - 35,689,711 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381135,797,380 - 35,798,884 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1135,797,382 - 35,798,884 (-)Ensemblmm10GRCm38
MGSCv371135,610,882 - 35,612,386 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361135,640,807 - 35,641,997 (-)NCBIMGSCv36mm8
Celera1139,580,423 - 39,581,927 (-)NCBICelera
Cytogenetic Map11A4NCBI
cM Map1121.96NCBI
FBLL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24163,690,335 - 163,693,526 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15161,831,647 - 161,833,071 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05163,892,890 - 163,896,064 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15170,658,674 - 170,660,746 (+)NCBIPanPan1.1PanPan1.1panPan2
FBLL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1443,214,112 - 43,216,772 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha443,170,650 - 43,173,588 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0443,635,950 - 43,638,372 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
UMICH_Zoey_3.1443,405,709 - 43,408,625 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0443,600,117 - 43,602,557 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0444,106,037 - 44,108,471 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Fbll1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721397,229,143 - 97,231,063 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936622846,044 - 847,081 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936622844,128 - 846,673 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOC100512568
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1655,351,727 - 55,352,725 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11655,351,616 - 55,354,642 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21659,934,769 - 59,936,157 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FBLL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12370,757,760 - 70,758,891 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660347,921,376 - 7,923,933 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fbll1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1918,980,617 - 18,982,086 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Fbll1
3 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:37
Count of miRNA genes:36
Interacting mature miRNAs:36
Transcripts:ENSRNOT00000020554
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101577675460776754Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10666092373950353Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10589381150893811Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10125055464349221Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10589381150893811Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)101465354159653541Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101553301273695498Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10687714251877142Rat
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135730538Rat
7387235Uae41Urinary albumin excretion QTL 415.260.1874urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)10130004247Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)101993920764939207Rat
737823Alc12Alcohol consumption QTL 124.5consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)101774978420796344Rat
61332Eau3Experimental allergic uveoretinitis QTL 30.004uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)101803578263035782Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1092219745922197Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)10210370847103708Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10589381150893811Rat
2298495Eae23Experimental allergic encephalomyelitis QTL 2316.93nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis duration (CMO:0001424)101617552561175525Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101866841963668419Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)102011061465110614Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138832698Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
631660Hcar1Hepatocarcinoma resistance QTL 13.40.0001liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)10666111835509383Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101803578263035782Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101499153586964295Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)102011061465110614Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
13 1 12 138 41 32 13 75 13 6 139 101 118 11 43 19 16 16

Sequence


Ensembl Acc Id: ENSRNOT00000020554   ⟹   ENSRNOP00000020554
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1020,761,581 - 20,764,670 (-)Ensembl
mRatBN7.2 Ensembl1020,258,656 - 20,260,299 (-)Ensembl
Rnor_6.0 Ensembl1020,620,957 - 20,622,600 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000130242   ⟹   ENSRNOP00000102660
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1020,761,945 - 20,764,119 (-)Ensembl
RefSeq Acc Id: NM_001108824   ⟹   NP_001102294
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81020,762,716 - 20,764,359 (-)NCBI
mRatBN7.21020,258,656 - 20,260,299 (-)NCBI
Rnor_6.01020,620,957 - 20,622,600 (-)NCBI
Rnor_5.01020,494,593 - 20,496,236 (-)NCBI
RGSC_v3.41020,709,269 - 20,710,912 (-)RGD
Celera1019,877,688 - 19,879,331 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001102294 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM04094 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000020554
  ENSRNOP00000020554.6
  ENSRNOP00000102660.1
RefSeq Acc Id: NP_001102294   ⟸   NM_001108824
- UniProtKB: D3ZVA5 (UniProtKB/TrEMBL),   A6HDI9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000020554   ⟸   ENSRNOT00000020554
Ensembl Acc Id: ENSRNOP00000102660   ⟸   ENSRNOT00000130242

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZVA5-F1-model_v2 AlphaFold D3ZVA5 1-324 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1562841 AgrOrtholog
BioCyc Gene G2FUF-25538 BioCyc
Ensembl Genes ENSRNOG00000015303 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000020554 ENTREZGENE
  ENSRNOT00000020554.9 UniProtKB/TrEMBL
  ENSRNOT00000130242.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.150 UniProtKB/TrEMBL
  Phosphorylase Kinase, domain 1 UniProtKB/TrEMBL
InterPro Fibrillarin UniProtKB/TrEMBL
  Fibrillarin_CS UniProtKB/TrEMBL
  SAM-dependent_MTases-like UniProtKB/TrEMBL
KEGG Report rno:363563 UniProtKB/TrEMBL
NCBI Gene 363563 ENTREZGENE
PANTHER RRNA 2-O-METHYLTRANSFERASE FIBRILLARIN UniProtKB/TrEMBL
  RRNA/TRNA 2'-O-METHYLTRANSFERASE FIBRILLARIN-LIKE PROTEIN 1 UniProtKB/TrEMBL
Pfam Fibrillarin UniProtKB/TrEMBL
PhenoGen Fbll1 PhenoGen
PRINTS FIBRILLARIN UniProtKB/TrEMBL
PROSITE FIBRILLARIN UniProtKB/TrEMBL
RatGTEx ENSRNOG00000015303 RatGTEx
SMART Fibrillarin UniProtKB/TrEMBL
Superfamily-SCOP SSF53335 UniProtKB/TrEMBL
UniProt A0ABK0LLX6_RAT UniProtKB/TrEMBL
  A6HDI9 ENTREZGENE, UniProtKB/TrEMBL
  D3ZVA5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2025-11-17 Fbll1  fibrillarin like rRNA 2'-O-methyltransferase 1  Fbll1  fibrillarin rRNA 2'-O-methyltransferase like 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2025-11-13 Fbll1  fibrillarin rRNA 2'-O-methyltransferase like 1  Fbll1  fibrillarin-like 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-06-12 Fbll1  fibrillarin-like 1  RGD1562841  similar to fibrillarin   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1562841  similar to fibrillarin   RGD1562841_predicted  similar to fibrillarin (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1562841_predicted  similar to fibrillarin (predicted)  LOC363563  similar to fibrillarin  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC363563  similar to fibrillarin      Symbol and Name status set to provisional 70820 PROVISIONAL