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Gene: Lamtor2 (late endosomal/lysosomal adaptor, MAPK and MTOR activator 2) Rattus norvegicus

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Symbol:

Lamtor2

Name:

late endosomal/lysosomal adaptor, MAPK and MTOR activator 2

RGD ID:

1562501

Description:

Predicted to contribute to guanyl-nucleotide exchange factor activity and molecular adaptor activity. Predicted to be involved in several processes, including cellular response to amino acid stimulus; positive regulation of TORC1 signaling; and regulation of cell growth. Predicted to act upstream of or within several processes, including fibroblast migration; positive regulation of MAPK cascade; and regulation of cell-substrate junction organization. Predicted to be located in late endosome. Predicted to be part of FNIP-folliculin RagC/D GAP and Ragulator complex. Predicted to be active in lysosomal membrane. Orthologous to human LAMTOR2 (late endosomal/lysosomal adaptor, MAPK and MTOR activator 2); PARTICIPATES IN mTOR signaling pathway; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; acetamide.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC295234; Mapbpip; mitogen activated protein binding protein interacting protein; mitogen-activated protein binding protein interacting protein; mitogen-activated protein-binding protein-interacting protein; ragulator complex protein LAMTOR2; RGD1562501; roadblock domain containing 3; Robld3; similar to Late endosomal/lysosomal Mp1 interacting protein (p14)

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Related Pseudogenes:

Robld3-ps1

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	176,306,353 - 176,310,617 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	2	176,306,280 - 176,310,730 (-)	Ensembl				GRCr8
mRatBN7.2	2	174,008,556 - 174,011,950 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	174,008,548 - 174,013,013 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	2	181,152,706 - 181,156,089 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	179,175,071 - 179,178,454 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	173,775,155 - 173,778,545 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	187,911,530 - 187,914,930 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	187,911,533 - 187,915,596 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	2	207,313,930 - 207,317,305 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	2	180,665,354 - 180,668,729 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	2	167,952,942 - 167,956,317 (-)	NCBI		Celera
Cytogenetic Map	2	q34	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Immunodeficiency due to Defect in MAPBP-Interacting Protein (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

(-)-epigallocatechin 3-gallate (ISO)

(1->4)-beta-D-glucan (ISO)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (EXP,ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4,6-tribromophenol (ISO)

3,3',5,5'-tetrabromobisphenol A (ISO)

5-aza-2'-deoxycytidine (ISO)

7,12-dimethyltetraphene (ISO)

acetamide (EXP)

all-trans-retinoic acid (ISO)

aristolochic acid A (ISO)

arsenite(3-) (ISO)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

Bisphenol B (ISO)

buspirone (EXP)

cadmium dichloride (EXP)

carbon nanotube (ISO)

chloropicrin (ISO)

cisplatin (ISO)

cobalt dichloride (ISO)

copper(II) sulfate (ISO)

crocidolite asbestos (ISO)

cumene (ISO)

cyclosporin A (ISO)

decabromodiphenyl ether (ISO)

dextran sulfate (ISO)

Dibutyl phosphate (ISO)

dibutyl phthalate (EXP,ISO)

diuron (EXP)

doxorubicin (ISO)

ethanol (ISO)

Evodiamine (ISO)

folic acid (ISO)

inulin (ISO)

ivermectin (ISO)

menadione (ISO)

methyl methanesulfonate (ISO)

Monobutylphthalate (ISO)

nimesulide (EXP)

nitrates (ISO)

perfluorooctane-1-sulfonic acid (ISO)

potassium chromate (ISO)

sarin (ISO)

SB 431542 (ISO)

sodium arsenite (ISO)

sodium fluoride (ISO)

testosterone (ISO)

tetrachloroethene (ISO)

tetrachloromethane (EXP,ISO)

thioacetamide (EXP)

thiram (ISO)

trichloroethene (ISO)

triphenyl phosphate (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to amino acid stimulus (IBA,ISO)

fibroblast migration (ISO)

intracellular protein localization (ISO)

positive regulation of MAPK cascade (ISO)

positive regulation of TOR signaling (IBA,IEA,ISO)

positive regulation of TORC1 signaling (ISO)

protein localization to cell junction (ISO)

regulation of cell growth (ISO)

regulation of cell-substrate junction organization (ISO)

Cellular Component

FNIP-folliculin RagC/D GAP (ISO)

late endosome (ISO)

late endosome membrane (IEA)

lysosomal membrane (IEA,ISO)

Ragulator complex (IBA,ISO)

Molecular Function

guanyl-nucleotide exchange factor activity (IEA,ISO)

molecular adaptor activity (IEA,ISO)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

mTOR signaling pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Regulation of mTORC1 by amino acids.	Bar-Peled L and Sabatini DM, Trends Cell Biol. 2014 Jul;24(7):400-6. doi: 10.1016/j.tcb.2014.03.003. Epub 2014 Mar 31.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
4.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:15263099	PMID:17897319	PMID:19177150	PMID:20381137	PMID:22980980	PMID:23376485	PMID:24841562

Genomics

Comparative Map Data

Lamtor2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	176,306,353 - 176,310,617 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	2	176,306,280 - 176,310,730 (-)	Ensembl				GRCr8
mRatBN7.2	2	174,008,556 - 174,011,950 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	174,008,548 - 174,013,013 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	2	181,152,706 - 181,156,089 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	179,175,071 - 179,178,454 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	173,775,155 - 173,778,545 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	187,911,530 - 187,914,930 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	187,911,533 - 187,915,596 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	2	207,313,930 - 207,317,305 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	2	180,665,354 - 180,668,729 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	2	167,952,942 - 167,956,317 (-)	NCBI		Celera
Cytogenetic Map	2	q34	NCBI

LAMTOR2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	156,054,782 - 156,058,506 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	156,054,738 - 156,058,510 (+)	Ensembl			hg38	GRCh38
GRCh37	1	156,024,573 - 156,028,297 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	154,291,229 - 154,294,923 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Celera	1	129,097,578 - 129,101,362 (+)	NCBI		Celera
Cytogenetic Map	1	q22	NCBI
HuRef	1	127,387,097 - 127,390,882 (+)	NCBI		HuRef
CHM1_1	1	157,420,604 - 157,424,391 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	1	155,193,248 - 155,196,972 (+)	NCBI		T2T-CHM13v2.0

Lamtor2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	3	88,457,126 - 88,460,258 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	3	88,457,126 - 88,460,381 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	3	88,549,819 - 88,552,951 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	3	88,549,819 - 88,553,074 (-)	Ensembl			mm10	GRCm38
MGSCv37	3	88,353,741 - 88,356,849 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	3	88,635,746 - 88,638,854 (-)	NCBI		MGSCv36	mm8
Celera	3	88,589,626 - 88,592,744 (-)	NCBI		Celera
Cytogenetic Map	3	F1	NCBI
cM Map	3	38.87	NCBI

Lamtor2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955545	2,236,868 - 2,242,137 (+)	Ensembl
ChiLan1.0	NW_004955545	2,237,506 - 2,242,070 (+)	NCBI	ChiLan1.0	ChiLan1.0

LAMTOR2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	93,787,756 - 93,791,536 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	93,519,704 - 93,523,481 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	131,396,937 - 131,400,695 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	135,226,400 - 135,230,167 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	135,226,400 - 135,230,167 (+)	Ensembl			panPan2	panpan1.1

LAMTOR2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	7	41,760,632 - 41,764,926 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	7	41,760,638 - 41,763,299 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	7	41,250,160 - 41,252,889 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	7	41,627,377 - 41,630,107 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	7	41,627,383 - 41,630,065 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	7	41,408,225 - 41,410,954 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	7	41,461,577 - 41,464,307 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	7	41,746,005 - 41,748,735 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Lamtor2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	26,286,374 - 26,289,979 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936580	5,316,616 - 5,322,158 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936580	5,316,748 - 5,320,364 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

LAMTOR2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	4	93,971,871 - 93,976,304 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	4	93,972,112 - 93,975,561 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	4	102,714,889 - 102,718,338 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

LAMTOR2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	7,806,509 - 7,810,296 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	7,806,510 - 7,810,456 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666038	7,102,867 - 7,106,653 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Lamtor2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624885	1,398,505 - 1,403,789 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624885	1,399,235 - 1,403,669 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Lamtor2
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	3	65,010,035 - 65,013,332 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Lamtor2
7 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	49
Count of miRNA genes:	46
Interacting mature miRNAs:	49
Transcripts:	ENSRNOT00000026974
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1358356	Srcrt1	Stress Responsive Cort QTL1	3.66		blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	2	163997722	225110681	Rat
1578648	Bss11	Bone structure and strength QTL 11	4.7		femur morphology trait (VT:0000559)	femoral neck cortical cross-sectional area (CMO:0001702)	2	169358774	214358774	Rat
1331734	Bp204	Blood pressure QTL 204	3.61192		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	170656145	239614549	Rat
631566	Bp90	Blood pressure QTL 90		0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	149957381	221199885	Rat
1298074	Bp164	Blood pressure QTL 164		0.003	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	44537979	205135428	Rat
1354648	Bp239	Blood pressure QTL 239		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	67845370	229470703	Rat
1354649	Kidm17	Kidney mass QTL 17	2.9		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	2	83465462	229820014	Rat
10755499	Bp389	Blood pressure QTL 389	2.61		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	20695736	231474293	Rat
1298076	Bp166	Blood pressure QTL 166		0.0009	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	138595962	205135428	Rat
1581576	Pur7	Proteinuria QTL 7		0.0001	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	2	80396178	220931218	Rat
152025245	Scl81	Serum cholesterol level QTL 81	3.49		blood cholesterol amount (VT:0000180)		2	124537199	209621565	Rat
1581578	Cm49	Cardiac mass QTL 49	4.9	0.01	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	2	145807215	220931416	Rat
631198	Cm22	Cardiac mass QTL 22	4.3	0.0008	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	2	78269809	208420281	Rat
1554319	Bmd2	Bone mineral density QTL 2	13.4	0.0001	lumbar vertebra area (VT:0010570)	lumbar vertebra cross-sectional area (CMO:0001689)	2	122597372	215234002	Rat
12879836	Kidm61	Kidney mass QTL 61		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	154723085	199723085	Rat
1581569	Uae32	Urinary albumin excretion QTL 32		0.0001	urine protein amount (VT:0005160)	urine albumin excretion rate (CMO:0000757)	2	80396178	220931218	Rat
10043136	Iddm54	Insulin dependent diabetes mellitus QTL 54	3.4	0.0001	blood glucose amount (VT:0000188)	age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)	2	145807215	190807215	Rat
12879837	Am2	Aortic mass QTL 2		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	2	154723085	199723085	Rat
10043139	Iddm55	Insulin dependent diabetes mellitus QTL 55	3.1	0.0001	blood glucose amount (VT:0000188)	age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)	2	150313808	195313808	Rat
12879838	Cm86	Cardiac mass QTL 86		0.002	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	2	154723085	199723085	Rat
1302793	Bw16	Body weight QTL 16	5	0.0001	body mass (VT:0001259)	body weight (CMO:0000012)	2	159440891	205135267	Rat
12879839	Cm85	Cardiac mass QTL 85		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	2	154723085	199723085	Rat
1549833	Bp257	Blood pressure QTL 257		0.003	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	170652929	215652929	Rat
1358900	Bw48	Body weight QTL 48	4.88		body mass (VT:0001259)	body weight (CMO:0000012)	2	159440891	220931218	Rat
4889834	Pur24	Proteinuria QTL 24	5.8	0.014	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	2	171994826	205135428	Rat
12879845	Cm89	Cardiac mass QTL 89		0.008	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	2	154723085	178247591	Rat
61473	Bp19	Blood pressure QTL 19	6.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	175008837	178247591	Rat
1359030	Bp277	Blood pressure QTL 277			arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	143565208	188565208	Rat
12879846	Cm90	Cardiac mass QTL 90		0.011	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	2	154723085	178247591	Rat
12879847	Am4	Aortic mass QTL 4		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	2	154723085	178247591	Rat
1331760	Bp206	Blood pressure QTL 206	3.62454		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	4265106	205135428	Rat
12879840	Bw179	Body weight QTL 179		0.005	body mass (VT:0001259)	body weight (CMO:0000012)	2	154723085	199723085	Rat
1581502	Esta3	Estrogen-induced thymic atrophy QTL 3			thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	2	139067258	192287892	Rat
1359032	Hrtrt18	Heart rate QTL 18			heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	2	159440760	195313808	Rat
2301966	Bp322	Blood pressure QTL 322	3.58		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	144882354	205135428	Rat
1298080	Bp163	Blood pressure QTL 163		0.02	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	67845182	205135428	Rat
1357991	Ael2	Aortic elastin QTL 2	4.2	0.000071	aorta elastin amount (VT:0003905)	aortic elastin	2	169227906	214227906	Rat
8662832	Vetf7	Vascular elastic tissue fragility QTL 7	3.5		aorta elastin amount (VT:0003905)	aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)	2	83400752	223709938	Rat
1298085	Bp165	Blood pressure QTL 165		0.0006	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	44537979	205135428	Rat
1578671	Bmd10	Bone mineral density QTL 10	5.4		femur mineral mass (VT:0010011)	compact volumetric bone mineral density (CMO:0001730)	2	175931416	220931416	Rat
1359022	Ppulsi1	Prepulse inhibition QTL 1	3.63		prepulse inhibition trait (VT:0003088)	acoustic startle response measurement (CMO:0001519)	2	139067258	184067258	Rat
1641891	Alcrsp17	Alcohol response QTL 17			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	2	151869660	251712708	Rat
724534	Uae6	Urinary albumin excretion QTL 6	10		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	2	80396034	220931416	Rat
61374	Edpm2	Estrogen-dependent pituitary mass QTL 2	4.42	0.86	pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	2	78269809	205135428	Rat
8662843	Vetf9	Vascular elastic tissue fragility QTL 9	2.05		thoracic aorta molecular composition trait (VT:0010568)	aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)	2	159440760	228950743	Rat
2301415	Cm67	Cardiac mass QTL 67		0.003	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	2	154723085	178247591	Rat
1331794	Bp202	Blood pressure QTL 202	3.66819		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	143344967	251712708	Rat
71113	Cari2	Carrageenan-induced inflammation QTL 2	2.7	0.009	hypodermis integrity trait (VT:0010550)	inflammatory exudate volume (CMO:0001429)	2	143746578	205135428	Rat
1331805	Cm29	Cardiac mass QTL 29	3.50746		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	2	143344967	251712708	Rat
11565180	Kidm56	Kidney mass QTL 56		0.003	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	154723085	178247591	Rat
634308	Sach6	Saccharin preference QTL 6	4.9		taste sensitivity trait (VT:0001986)	saccharin intake volume to total fluid intake volume ratio (CMO:0001601)	2	114384617	215381366	Rat
1598805	Memor8	Memory QTL 8	3		exploratory behavior trait (VT:0010471)	average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)	2	150096616	195096616	Rat
11565181	Bw176	Body weight QTL 176		0.002	body mass (VT:0001259)	body weight (CMO:0000012)	2	154723085	178247591	Rat
1358917	Cm42	Cardiac mass QTL 42	2.82		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	27148328	206613235	Rat
724568	Uae13	Urinary albumin excretion QTL 13	4.4		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	2	145306936	212705578	Rat
1358913	Cm41	Cardiac mass QTL 41	2.73		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	27148328	206613235	Rat
1300165	Rf9	Renal function QTL 9	3.28		kidney glomerulus integrity trait (VT:0010546)	index of glomerular damage (CMO:0001135)	2	113746222	205135428	Rat
61401	Niddm2	Non-insulin dependent diabetes mellitus QTL 2	4.54		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	2	147287892	192287892	Rat
631507	Bp105	Blood pressure QTL 105		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	114384617	215381366	Rat
1641925	Alcrsp2	Alcohol response QTL 2			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	2	151869660	223841096	Rat
1354609	Niddm62	Non-insulin dependent diabetes mellitus QTL 62	4.72	0.000006	insulin secretion trait (VT:0003564)	plasma insulin level (CMO:0000342)	2	117415288	205135428	Rat
1598833	Bp295	Blood pressure QTL 295	3.5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	150096616	195096616	Rat
1354622	Kidm16	Kidney mass QTL 16	3		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	2	83465462	225110681	Rat
631266	Bp132	Blood pressure QTL 132		0.0005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	47856345	205135428	Rat
631522	Bp74	Blood pressure QTL 74		0.05	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	175008837	220008837	Rat
7488927	Bp365	Blood pressure QTL 365		0.008	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	165453811	210453811	Rat
7488925	Bp364	Blood pressure QTL 364		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	163253030	208253030	Rat
2293843	Kiddil6	Kidney dilation QTL 6	3.1		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	2	44537979	184731399	Rat
2306901	Bp337	Blood pressure QTL 337		0.01	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	166372086	229820014	Rat
1354605	Rf48	Renal function QTL 48	2.9		blood creatinine amount (VT:0005328)	plasma creatinine level (CMO:0000537)	2	76328396	209350714	Rat
7488904	Bp363	Blood pressure QTL 363		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	175279960	178247591	Rat

Markers in Region

RH125318

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_5.0	11	90,555,404 - 90,555,590	NCBI	Rnor5.0
RGSC_v3.4	11	85,397,389 - 85,397,574	UniSTS	RGSC3.4
Celera	11	82,176,907 - 82,177,092	UniSTS
Cytogenetic Map	2	q34	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	165	91	90	59	92	59	6	356	192	11	144	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001106441	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001439859	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001439860	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008761134	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063281607	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063281608	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC117919	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473976	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000002	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000026974 ⟹ ENSRNOP00000026974

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	2	187,911,533 - 187,914,905 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000092924

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	2	187,911,534 - 187,912,872 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000093008 ⟹ ENSRNOP00000076016

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	2	176,306,353 - 176,310,730 (-)	Ensembl
mRatBN7.2 Ensembl	2	174,008,556 - 174,013,013 (-)	Ensembl
Rnor_6.0 Ensembl	2	187,911,536 - 187,915,596 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000093086

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	2	187,912,435 - 187,914,749 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000093121

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	2	176,306,280 - 176,309,728 (-)	Ensembl
mRatBN7.2 Ensembl	2	174,008,548 - 174,011,946 (-)	Ensembl
Rnor_6.0 Ensembl	2	187,911,534 - 187,912,264 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000140736 ⟹ ENSRNOP00000109860

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	2	176,306,353 - 176,309,862 (-)	Ensembl

RefSeq Acc Id:

NM_001106441 ⟹ NP_001099911

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	176,306,353 - 176,309,728 (-)	NCBI
mRatBN7.2	2	174,008,556 - 174,011,932 (-)	NCBI
Rnor_6.0	2	187,911,530 - 187,914,905 (-)	NCBI
Rnor_5.0	2	207,313,930 - 207,317,305 (-)	NCBI
RGSC_v3.4	2	180,665,354 - 180,668,729 (-)	RGD
Celera	2	167,952,942 - 167,956,317 (-)	RGD

Sequence:

show sequence

CCGGAAGCGATGAGGGAGGGCAAGAGGCTGCGACTGTAGTGTTTGTGGGAGCAGGTCAGGGTTA
AGAGACGCAGGCATGCTGCGTCCTAAGGCTTTGACGCAGGTGCTAAGCCAAGCCAACACTGGAG
GAGTCCAAAGTACCCTGCTGCTGAATAATGAGGGATCGTTGCTGGCCTACTCCGGTTATGGGGA
CACAGATGCCCGGGTCACCGCGGCCATCGCCAGTAACATCTGGGCCGCATACGATAGGAACGGG
AACCAAGCGTTTAATGAAGACAGTCTCAAATTTATCCTCATGGACTGCATGGAGGGCCGTGTAG
CCATTACCAGGGTGGCCAACCTTCTGCTATGTATGTATGCCAAGGAGACTGTAGGCTTCGGGAT
GCTCAAGGCCAAGGCCCAGGCCTTGGTGCAGTACCTGGAGGAACCCCTCACCCAAGTAGCAGCC
TCATAATAGTGTGATGGAAGCTGGAGTGGAAAAGGGATCGTGATTGGGAAGAGCAGGGCCCCGG
AAATGCCTCACTGGGCTGGGTGAGGGGTTGCTTTTTTCTAAATAAATTTTCAACTCTTGCCT

hide sequence

RefSeq Acc Id:

XM_008761134 ⟹ XP_008759356

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	176,306,357 - 176,309,744 (-)	NCBI
mRatBN7.2	2	174,008,559 - 174,011,950 (-)	NCBI
Rnor_6.0	2	187,911,533 - 187,914,930 (-)	NCBI

Sequence:

show sequence

GCCTCGTAGCTGGGCTTCCGGGCCACCGGAAGCGATGAGGGAGGGCAAGAGGCTGCGACTGTAG
TGTTTGTGGGAGCAGGTCAGGGTTAAGAGACGCAGGCATGCTGCGTCCTAAGGCTTTGACGCAG
GTGCTAAGCCAAGCCAACACTGGAGGAGTCCAAAGTACCCTGCTGCTGAATAATGAGGGATCGT
TGCTGGCCTACTCCGGTTATGGGGACACAGATGCCCGGGTCACCGCGGCCATCGCCAGTAACAT
CTGGGCCGCATACGATAGGAACGGGAACCAAGCGTTTAATGAAGACAGTCTCAAATTTATCCTC
ATGGACTGCATGGACCAGAGGAACCCTGGGGAAGGCAGGAACCAAGGATGTCAAGCAGAGTGCC
CCAGTGTATTATGTCATTCCCACCAGGAGGGCCGTGTAGCCATTACCAGGGTGGCCAACCTTCT
GCTATGTATGTATGCCAAGGAGACTGTAGGCTTCGGGATGCTCAAGGCCAAGGCCCAGGCCTTG
GTGCAGTACCTGGAGGAACCCCTCACCCAAGTAGCAGCCTCATAATAGTGTGATGGAAGCTGGA
GTGGAAAAGGGATCGTGATTGGGAAGAGCAGGGCCCCGGAAATGCCTCACTGGGCTGGGTGAGG
GGTTGCTTTTTTCTAAATAAATTTTCAACTCTTG

hide sequence

RefSeq Acc Id:

XM_063281607 ⟹ XP_063137677

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	176,306,357 - 176,309,748 (-)	NCBI

RefSeq Acc Id:

XM_063281608 ⟹ XP_063137678

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	176,307,898 - 176,310,617 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001099911	(Get FASTA)	NCBI Sequence Viewer
	NP_001426788	(Get FASTA)	NCBI Sequence Viewer
	NP_001426789	(Get FASTA)	NCBI Sequence Viewer
	XP_008759356	(Get FASTA)	NCBI Sequence Viewer
	XP_063137677	(Get FASTA)	NCBI Sequence Viewer
	XP_063137678	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDM00701	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000076016.3
	ENSRNOP00000094702.2
	ENSRNOP00000109860
	ENSRNOP00000109860.1

RefSeq Acc Id:	NP_001099911 ⟸ NM_001106441
- UniProtKB:	A6J687 (UniProtKB/TrEMBL), A6KSI4 (UniProtKB/TrEMBL)
- Sequence:	show sequence MLRPKALTQVLSQANTGGVQSTLLLNNEGSLLAYSGYGDTDARVTAAIASNIWAAYDRNGNQAF NEDSLKFILMDCMEGRVAITRVANLLLCMYAKETVGFGMLKAKAQALVQYLEEPLTQVAAS hide sequence

RefSeq Acc Id:	XP_008759356 ⟸ XM_008761134
- Peptide Label:	isoform X1
- Sequence:	show sequence MLRPKALTQVLSQANTGGVQSTLLLNNEGSLLAYSGYGDTDARVTAAIASNIWAAYDRNGNQAF NEDSLKFILMDCMDQRNPGEGRNQGCQAECPSVLCHSHQEGRVAITRVANLLLCMYAKETVGFG MLKAKAQALVQYLEEPLTQVAAS hide sequence

Ensembl Acc Id:

ENSRNOP00000026974 ⟸ ENSRNOT00000026974

Ensembl Acc Id:

ENSRNOP00000076016 ⟸ ENSRNOT00000093008

RefSeq Acc Id:	XP_063137677 ⟸ XM_063281607
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_063137678 ⟸ XM_063281608
- Peptide Label:	isoform X3

Ensembl Acc Id:

ENSRNOP00000109860 ⟸ ENSRNOT00000140736

Protein Domains

Roadblock/LAMTOR2

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D4A465-F1-model_v2	AlphaFold	D4A465	1-125	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13691445

Promoter ID:

EPDNEW_R1969

Type:

initiation region

Name:

Lamtor2_1

Description:

late endosomal/lysosomal adaptor, MAPK and MTOR activator 2

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_R1970

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	2	187,914,868 - 187,914,928	EPDNEW

RGD ID:

13691449

Promoter ID:

EPDNEW_R1970

Type:

multiple initiation site

Name:

Lamtor2_2

Description:

late endosomal/lysosomal adaptor, MAPK and MTOR activator 2

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_R1969

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	2	187,915,563 - 187,915,623	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1562501	AgrOrtholog
BioCyc Gene	G2FUF-52476	BioCyc
Ensembl Genes	ENSRNOG00000019908	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000093008.3	UniProtKB/TrEMBL
	ENSRNOT00000093121.3	UniProtKB/TrEMBL
	ENSRNOT00000140736	ENTREZGENE
	ENSRNOT00000140736.1	UniProtKB/TrEMBL
Gene3D-CATH	Dynein light chain 2a, cytoplasmic	UniProtKB/TrEMBL
InterPro	LAMTOR2-like	UniProtKB/TrEMBL
	Roadblock/LAMTOR2_dom	UniProtKB/TrEMBL
KEGG Report	rno:295234	UniProtKB/TrEMBL
NCBI Gene	295234	ENTREZGENE
PANTHER	PTHR13323	UniProtKB/TrEMBL
Pfam	Robl_LC7	UniProtKB/TrEMBL
PhenoGen	Lamtor2	PhenoGen
RatGTEx	ENSRNOG00000019908	RatGTEx
SMART	Robl_LC7	UniProtKB/TrEMBL
Superfamily-SCOP	Roadblock/LC7 domain	UniProtKB/TrEMBL
UniProt	A0A1B0GWT7_RAT	UniProtKB/TrEMBL
	A0A8I6ALB3_RAT	UniProtKB/TrEMBL
	A0ABK0LZB2_RAT	UniProtKB/TrEMBL
	A6J687	ENTREZGENE, UniProtKB/TrEMBL
	A6KSI4	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2011-08-01	Lamtor2	late endosomal/lysosomal adaptor, MAPK and MTOR activator 2	Robld3	roadblock domain containing 3	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-10-24	Robld3	roadblock domain containing 3	Mapbpip	mitogen-activated protein binding protein interacting protein	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-02-29	Mapbpip	mitogen-activated protein binding protein interacting protein	RGD1562501_predicted	similar to Late endosomal/lysosomal Mp1 interacting protein (p14) (predicted)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-07	RGD1562501_predicted	similar to Late endosomal/lysosomal Mp1 interacting protein (p14) (predicted)	LOC295234	similar to Late endosomal/lysosomal Mp1 interacting protein (p14)	Symbol and Name status set to approved	1299863	APPROVED
2006-02-09	LOC295234	similar to Late endosomal/lysosomal Mp1 interacting protein (p14)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

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Imported Disease Annotations - ClinVar

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