Astl (astacin like metalloendopeptidase) - Rat Genome Database

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Gene: Astl (astacin like metalloendopeptidase) Rattus norvegicus
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Symbol: Astl
Name: astacin like metalloendopeptidase
RGD ID: 1562279
Description: Predicted to enable aspartic-type peptidase activity; glutamic-type peptidase activity; and metalloendopeptidase activity. Predicted to be involved in several processes, including negative regulation of binding activity of sperm to zona pellucida; positive regulation of protein processing; and prevention of polyspermy. Predicted to be located in cortical granule and plasma membrane. Predicted to be active in extracellular space. Orthologous to human ASTL (astacin like metalloendopeptidase); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; glycidol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: astacin-like metalloendopeptidase; astacin-like metalloendopeptidase (M12 family); LOC296129; RGD1562279; similar to oocyte astacin
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83135,016,444 - 135,032,177 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3135,016,444 - 135,032,177 (+)EnsemblGRCr8
mRatBN7.23114,563,135 - 114,580,295 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3114,563,135 - 114,578,868 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3118,452,397 - 118,468,141 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03127,047,958 - 127,063,702 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03124,708,329 - 124,724,073 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03119,783,717 - 119,799,450 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3119,783,717 - 119,799,450 (+)Ensemblrn6Rnor6.0
Rnor_5.03126,310,094 - 126,325,827 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43114,845,320 - 114,861,053 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3113,402,096 - 113,417,834 (+)NCBICelera
Cytogenetic Map3q36NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:22206759   PMID:22472438  


Genomics

Comparative Map Data
Astl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83135,016,444 - 135,032,177 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3135,016,444 - 135,032,177 (+)EnsemblGRCr8
mRatBN7.23114,563,135 - 114,580,295 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3114,563,135 - 114,578,868 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3118,452,397 - 118,468,141 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03127,047,958 - 127,063,702 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03124,708,329 - 124,724,073 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03119,783,717 - 119,799,450 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3119,783,717 - 119,799,450 (+)Ensemblrn6Rnor6.0
Rnor_5.03126,310,094 - 126,325,827 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43114,845,320 - 114,861,053 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3113,402,096 - 113,417,834 (+)NCBICelera
Cytogenetic Map3q36NCBI
ASTL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38296,122,818 - 96,138,564 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl296,122,818 - 96,138,564 (-)Ensemblhg38GRCh38
GRCh37296,788,557 - 96,804,241 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36296,153,316 - 96,167,902 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34296,211,462 - 96,226,049NCBI
Celera291,230,396 - 91,244,982 (-)NCBICelera
Cytogenetic Map2q11.2NCBI
HuRef290,750,866 - 90,765,452 (-)NCBIHuRef
CHM1_1296,793,916 - 96,808,503 (-)NCBICHM1_1
T2T-CHM13v2.0296,629,422 - 96,645,168 (-)NCBIT2T-CHM13v2.0
Astl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392127,180,559 - 127,199,575 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2127,180,559 - 127,199,571 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm382127,338,639 - 127,357,655 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2127,338,639 - 127,357,651 (+)Ensemblmm10GRCm38
MGSCv372127,164,375 - 127,183,387 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv362127,030,080 - 127,049,092 (+)NCBIMGSCv36mm8
Celera2128,584,628 - 128,599,928 (+)NCBICelera
Cytogenetic Map2F1NCBI
cM Map261.93NCBI
Astl
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554703,719,254 - 3,732,607 (-)Ensembl
ChiLan1.0NW_0049554703,719,254 - 3,732,598 (-)NCBIChiLan1.0ChiLan1.0
ASTL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21232,169,814 - 32,185,721 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A32,172,596 - 32,188,480 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A103,176,662 - 103,192,542 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A97,048,871 - 97,063,747 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A97,049,184 - 97,063,747 (-)EnsemblpanPan2panpan1.1
ASTL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11734,594,701 - 34,608,708 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1734,594,026 - 34,607,961 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1734,363,562 - 34,378,272 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01735,365,149 - 35,379,752 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1735,365,007 - 35,379,047 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11734,494,438 - 34,509,160 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01734,562,766 - 34,577,482 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01734,769,924 - 34,784,663 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Astl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629283,005,750 - 83,015,976 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936744259,188 - 268,928 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936744259,188 - 268,919 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ASTL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl347,059,040 - 47,070,664 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1347,058,104 - 47,071,681 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2349,198,467 - 49,211,812 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ASTL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.114568,071 - 577,182 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666041167,978,725 - 167,994,724 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Astl
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247492,241,511 - 2,254,640 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Astl
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v15106,126,472 - 106,142,524 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Astl
103 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:87
Count of miRNA genes:73
Interacting mature miRNAs:81
Transcripts:ENSRNOT00000039043
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582233Insul10Insulin level QTL 105.40.0015blood insulin amount (VT:0001560)serum insulin level times blood glucose level (CMO:0002040)3133259579178259579Rat
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)396509147141509147Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)3129154923182114333Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)373592512136118980Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)367641776167835660Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)358601291153936591Rat
1582216Bw65Body weight QTL 656.3body mass (VT:0001259)body weight (CMO:0000012)3122654702136118980Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)349872657138829559Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
1582219Bw63Body weight QTL 633.80.001body mass (VT:0001259)body weight (CMO:0000012)3116582412136118980Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)385062224136118980Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)385062224136118980Rat
7387306Bw124Body weight QTL 1243.20.0003body mass (VT:0001259)body weight (CMO:0000012)3104545086149545086Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3133134628178134628Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)381425008141509147Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)370845569136091483Rat
1600376Arunc5Aerobic running capacity QTL 50.21exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)393829559138829559Rat
8694437Bw167Body weight QTL 16722.460.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)3112250810157250810Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)379649560177741895Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)396509147141509147Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)3117537367162537367Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3125116475170116475Rat
631649Bp123Blood pressure QTL 1233.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3110225882155225882Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)390755164141509147Rat
5686842Rf59Renal function QTL 59urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)3122395989167395989Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)3131036586176036586Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)3131036586176036586Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)398651826167012663Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)3125814931139636791Rat
1331758Bp207Blood pressure QTL 2072.848arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3110634702155634702Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)3116188400161188400Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
7 18 28 33 37 18 70 18 5 176 89 22 62 51 19 3 3

Sequence


Ensembl Acc Id: ENSRNOT00000039043   ⟹   ENSRNOP00000037567
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3135,016,444 - 135,032,177 (+)Ensembl
mRatBN7.2 Ensembl3114,563,135 - 114,578,868 (+)Ensembl
Rnor_6.0 Ensembl3119,783,717 - 119,799,450 (+)Ensembl
RefSeq Acc Id: NM_001106504   ⟹   NP_001099974
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83135,016,444 - 135,032,177 (+)NCBI
mRatBN7.23114,563,135 - 114,578,868 (+)NCBI
Rnor_6.03119,783,717 - 119,799,450 (+)NCBI
Rnor_5.03126,310,094 - 126,325,827 (+)NCBI
RGSC_v3.43114,845,320 - 114,861,053 (+)RGD
Celera3113,402,096 - 113,417,834 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001099974 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL80114 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000037567
  ENSRNOP00000037567.4
RefSeq Acc Id: NP_001099974   ⟸   NM_001106504
- Peptide Label: precursor
- UniProtKB: D3ZX09 (UniProtKB/TrEMBL),   A6HQ13 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000037567   ⟸   ENSRNOT00000039043
Protein Domains
Peptidase M12A

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZX09-F1-model_v2 AlphaFold D3ZX09 1-439 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1562279 AgrOrtholog
BioCyc Gene G2FUF-47994 BioCyc
Ensembl Genes ENSRNOG00000022603 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000039043 ENTREZGENE
  ENSRNOT00000039043.6 UniProtKB/TrEMBL
Gene3D-CATH 3.40.390.10 UniProtKB/TrEMBL
InterPro MetalloPept_cat_dom UniProtKB/TrEMBL
  Peptidase_M12A UniProtKB/TrEMBL
  Peptidase_Metallo UniProtKB/TrEMBL
KEGG Report rno:296129 UniProtKB/TrEMBL
NCBI Gene 296129 ENTREZGENE
PANTHER ASTACIN-LIKE METALLOENDOPEPTIDASE UniProtKB/TrEMBL
  DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING UniProtKB/TrEMBL
Pfam Astacin UniProtKB/TrEMBL
PhenoGen Astl PhenoGen
PRINTS ASTACIN UniProtKB/TrEMBL
PROSITE ASTACIN UniProtKB/TrEMBL
RatGTEx ENSRNOG00000022603 RatGTEx
SMART ZnMc UniProtKB/TrEMBL
Superfamily-SCOP Metalloproteases ('zincins'), catalytic domain UniProtKB/TrEMBL
UniProt A6HQ13 ENTREZGENE, UniProtKB/TrEMBL
  D3ZX09 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-18 Astl  astacin like metalloendopeptidase  Astl  astacin-like metalloendopeptidase (M12 family)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-29 Astl  astacin-like metalloendopeptidase (M12 family)  RGD1562279_predicted  similar to oocyte astacin (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1562279_predicted  similar to oocyte astacin (predicted)  LOC296129  similar to oocyte astacin  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC296129  similar to oocyte astacin      Symbol and Name status set to provisional 70820 PROVISIONAL