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Gene: Tmem270 (transmembrane protein 270) Rattus norvegicus

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Symbol:

Tmem270

Name:

transmembrane protein 270

RGD ID:

1561903

Description:

Predicted to be located in membrane. Orthologous to human TMEM270 (transmembrane protein 270); INTERACTS WITH 6-propyl-2-thiouracil; bisphenol A; cefaloridine.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC288604; RGD1561903; similar to Williams-Beuren syndrome critical region protein 28 isoform A; Wbscr28; Williams-Beuren syndrome chromosome region 28; Williams-Beuren syndrome chromosome region 28 (human)

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	TMEM270 (transmembrane protein 270)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther
Mus musculus (house mouse):	Tmem270 (transmembrane protein 270)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Tmem270 (transmembrane protein 270)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	TMEM270 (transmembrane protein 270)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	TMEM270 (transmembrane protein 270)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Tmem270 (transmembrane protein 270)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	TMEM270 (transmembrane protein 270)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	TMEM270 (transmembrane protein 270)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Tmem270 (transmembrane protein 270)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Tmem270 (transmembrane protein 270)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	COX6A1 (cytochrome c oxidase subunit 6A1)	HGNC	OMA
Alliance orthologs ³
Mus musculus (house mouse):	Tmem270 (transmembrane protein 270)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	TMEM270 (transmembrane protein 270)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	12	27,430,092 - 27,435,243 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	12	27,429,985 - 27,435,242 (+)	Ensembl				GRCr8
mRatBN7.2	12	21,793,631 - 21,798,723 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	21,794,130 - 21,798,731 (+)	Ensembl				mRatBN7.2
Rnor_6.0	12	24,803,204 - 24,808,287 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	24,803,686 - 24,808,288 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	12	26,803,487 - 26,808,557 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	12	22,858,647 - 22,863,206 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	12	23,554,551 - 23,559,628 (+)	NCBI		Celera
Cytogenetic Map	12	q12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

17beta-hydroxy-5alpha-androstan-3-one (ISO)

3,4-methylenedioxymethamphetamine (ISO)

6-propyl-2-thiouracil (EXP)

aflatoxin B1 (ISO)

arsane (ISO)

arsenic atom (ISO)

benzo[a]pyrene (ISO)

benzo[e]pyrene (ISO)

bisphenol A (EXP)

butanal (ISO)

cadmium dichloride (ISO)

cefaloridine (EXP)

CGP 52608 (ISO)

methapyrilene (ISO)

methoxychlor (EXP)

paracetamol (EXP,ISO)

pentanal (ISO)

permethrin (ISO)

propanal (ISO)

silicon dioxide (ISO)

silver atom (ISO)

silver(0) (ISO)

sotorasib (ISO)

trametinib (ISO)

vinclozolin (EXP)

References

References - curated

#	Reference Title	Reference Citation
1.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data

Tmem270
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	12	27,430,092 - 27,435,243 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	12	27,429,985 - 27,435,242 (+)	Ensembl				GRCr8
mRatBN7.2	12	21,793,631 - 21,798,723 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	21,794,130 - 21,798,731 (+)	Ensembl				mRatBN7.2
Rnor_6.0	12	24,803,204 - 24,808,287 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	24,803,686 - 24,808,288 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	12	26,803,487 - 26,808,557 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	12	22,858,647 - 22,863,206 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	12	23,554,551 - 23,559,628 (+)	NCBI		Celera
Cytogenetic Map	12	q12	NCBI

TMEM270
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	7	73,860,848 - 73,865,890 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	7	73,861,159 - 73,865,890 (+)	Ensembl			hg38	GRCh38
GRCh37	7	73,275,489 - 73,280,220 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	7	72,913,425 - 72,918,159 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Celera	7	68,754,191 - 68,758,926 (+)	NCBI		Celera
Cytogenetic Map	7	q11.23	NCBI
HuRef	7	69,158,848 - 69,163,564 (+)	NCBI		HuRef
CHM1_1	7	73,420,949 - 73,425,683 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	7	75,061,792 - 75,066,837 (+)	NCBI		T2T-CHM13v2.0
CRA_TCAGchr7v2	7	72,608,561 - 72,613,295 (+)	NCBI

Tmem270
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	134,930,447 - 134,935,587 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	134,930,447 - 134,935,587 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	5	134,901,593 - 134,906,733 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	134,901,593 - 134,906,733 (-)	Ensembl			mm10	GRCm38
MGSCv37	5	135,377,464 - 135,382,603 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	5	135,186,221 - 135,191,360 (-)	NCBI		MGSCv36	mm8
Celera	5	131,912,152 - 131,917,291 (-)	NCBI		Celera
Cytogenetic Map	5	G2	NCBI
cM Map	5	74.88	NCBI

Tmem270
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955456	13,947,798 - 13,949,603 (-)	Ensembl
ChiLan1.0	NW_004955456	13,947,773 - 13,953,965 (-)	NCBI	ChiLan1.0	ChiLan1.0

TMEM270
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	6	91,037,439 - 91,048,490 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	7	139,302,070 - 139,313,122 (-)	NCBI		NHGRI_mPanPan1
PanPan1.1	7	81,011,217 - 81,016,100 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	7	81,011,217 - 81,016,100 (+)	Ensembl			panPan2	panpan1.1

TMEM270
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	6	6,472,495 - 6,475,051 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	6	6,472,520 - 6,474,976 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	6	8,170,118 - 8,172,674 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	6	6,287,508 - 6,290,064 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	6	6,286,533 - 6,289,989 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	6	6,277,242 - 6,279,798 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	6	6,225,118 - 6,227,687 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	6	6,388,863 - 6,391,438 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Tmem270
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	131,029,940 - 131,032,296 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936543	3,004,326 - 3,006,608 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936543	3,004,326 - 3,006,608 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TMEM270
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	11,075,901 - 11,078,442 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	3	11,059,177 - 11,079,858 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	10,752,341 - 10,768,852 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TMEM270
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	28	9,212,358 - 9,217,628 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	28	9,212,377 - 9,217,517 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666070	7,273,087 - 7,296,893 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Tmem270
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624740	14,017,188 - 14,021,587 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Tmem270
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	16	19,139,919 - 19,145,167 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Tmem270
29 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	37
Count of miRNA genes:	36
Interacting mature miRNAs:	37
Transcripts:	ENSRNOT00000033499
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
631560	Apr1	Acute phase response QTL 1	6.1		orosomucoid 1 amount (VT:0010541)	plasma orosomucoid 1 level (CMO:0001467)	12	24805022	52308831	Rat
70213	Niddm27	Non-insulin dependent diabetes mellitus QTL 27	3.72		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	12	11200494	52308831	Rat
2306789	Ean6	Experimental allergic neuritis QTL 6	4.9		nervous system integrity trait (VT:0010566)	experimental autoimmune neuritis severity score (CMO:0001528)	12	1	29775522	Rat
8552964	Pigfal17	Plasma insulin-like growth factor 1 level QTL 17	3.5		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	11200494	52308831	Rat
7411641	Foco19	Food consumption QTL 19	27.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	11200494	52308831	Rat
7411643	Foco20	Food consumption QTL 20		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	25989355	52308831	Rat
5684888	Pia42	Pristane induced arthritis QTL 42			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	3489416	48489416	Rat
1331739	Hrtrt14	Heart rate QTL 14	3.56232		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	12	1	38687564	Rat
1641928	Alcrsp5	Alcohol response QTL 5			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	12	18473041	52308831	Rat
8552912	Pigfal6	Plasma insulin-like growth factor 1 level QTL 6	5		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	11200497	52308831	Rat
1549829	Scl48	Serum cholesterol level QTL 48	5		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	12	15264248	52308831	Rat
61331	Eau2	Experimental allergic uveoretinitis QTL 2		0.0005	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	12	1	33700600	Rat
10059594	Kidm46	Kidney mass QTL 46	3.79	0.025	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	12	11743528	52308831	Rat
8552918	Pigfal7	Plasma insulin-like growth factor 1 level QTL 7			blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	11200494	52308831	Rat
2293684	Bmd26	Bone mineral density QTL 26	4.4	0.0002	femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	12	1	38635130	Rat
6893681	Bw109	Body weight QTL 109	2.3	0.004	body mass (VT:0001259)	body weight (CMO:0000012)	12	1	28133365	Rat
1302792	Scl21	Serum cholesterol level QTL 21	3.8	0.0011	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	12	12233000	30490641	Rat
61404	Bw120	Body weight QTL 120	5.1		body mass (VT:0001259)	body mass index (BMI) (CMO:0000105)	12	17464979	46784661	Rat
1300174	Bw15	Body weight QTL 15	2.93		body mass (VT:0001259)	body weight loss (CMO:0001399)	12	1	28606299	Rat
1331786	Kidm11	Kidney mass QTL 11	3.571		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	12	16187438	52308831	Rat
1331787	Rf41	Renal function QTL 41	2.998		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	12	1	33700556	Rat
2293699	Bss49	Bone structure and strength QTL 49	5.61	0.0001	lumbar vertebra size trait (VT:0010518)	lumbar vertebra trabecular cross-sectional area (CMO:0001692)	12	16135029	52308831	Rat
1331761	Bp218	Blood pressure QTL 218	2.973		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	12	16187438	51213550	Rat
1331763	Wbc2	White blood cell count QTL 2	3.162		leukocyte quantity (VT:0000217)	total white blood cell count (CMO:0000365)	12	11200494	52308831	Rat
61416	Pia4	Pristane induced arthritis QTL 4	8.4		joint integrity trait (VT:0010548)	arthritic paw count (CMO:0001460)	12	18749469	36488809	Rat
7411547	Bw129	Body weight QTL 129		0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	6	11200494	52308831	Rat
7387292	Kidm42	Kidney mass QTL 42	3.03	0.0004	kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	12	1	41361854	Rat
61421	Cia12	Collagen induced arthritis QTL 12	4.6		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	18749469	34312613	Rat
1298081	Cia25	Collagen induced arthritis QTL 25	4.7		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	2747694	47747694	Rat
2303569	Gluco44	Glucose level QTL 44	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	12	18473041	52308831	Rat
2303568	Bw88	Body weight QTL 88	3		body mass (VT:0001259)	body weight (CMO:0000012)	12	1	28606299	Rat
2303575	Insul14	Insulin level QTL 14	4		blood insulin amount (VT:0001560)	blood insulin level (CMO:0000349)	12	3087180	48087180	Rat
7411588	Foco6	Food consumption QTL 6		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	11200494	52308831	Rat
7243862	Mcs30	Mammary carcinoma susceptibility QTL 30	8.62		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	12	5633306	50633306	Rat
2300186	Bmd59	Bone mineral density QTL 59	7.1	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	12	16135029	52308831	Rat
2293086	Iddm30	Insulin dependent diabetes mellitus QTL 30	3.82		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	12	7901625	33938215	Rat
7411597	Foco10	Food consumption QTL 10		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	11200494	52308831	Rat
1331755	Bp219	Blood pressure QTL 219	3.041		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	12	16187438	33700556	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
15	6	48	120	35	40	13	17	13	6	162	83	2	105	48	84	27	10	10

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001431982	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001431983	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001431984	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001431985	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_001077705	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006221338	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006249213	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017598506	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017598507	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017604475	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017604476	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_213758	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAXUCZ010000012	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000033499 ⟹ ENSRNOP00000034323

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	12	27,430,654 - 27,435,242 (+)	Ensembl
mRatBN7.2 Ensembl	12	21,794,130 - 21,798,731 (+)	Ensembl
Rnor_6.0 Ensembl	12	24,803,686 - 24,808,288 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000114794 ⟹ ENSRNOP00000082087

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	12	27,430,563 - 27,435,242 (+)	Ensembl
mRatBN7.2 Ensembl	12	21,794,130 - 21,798,731 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000143593 ⟹ ENSRNOP00000107718

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	12	27,430,128 - 27,435,242 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000165625 ⟹ ENSRNOP00000106875

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	12	27,429,985 - 27,435,242 (+)	Ensembl

RefSeq Acc Id:

XM_006249213 ⟹ XP_006249275

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	27,430,092 - 27,435,243 (+)	NCBI
mRatBN7.2	12	21,793,631 - 21,798,723 (+)	NCBI
Rnor_6.0	12	24,803,204 - 24,808,287 (+)	NCBI
Rnor_5.0	12	26,803,487 - 26,808,557 (+)	NCBI

Sequence:

show sequence

TCAGCTGGTCCTTCCTGGTTCTCTGAATGGAGAAACTCCAAGACTGCACACTCATTCTCCAGCC
TGAAACTGATGGGGACAGGGAAGGGACAGGGAAGGGACAGGGAGAGAGGCCTGGTGGTGAGGAT
AATGGGGTGTCAGTTGAGGAAGCTAAGCTGGGGCTTCTCCTATGGCAAATCTGCTACCCTCAGG
GTCCGATCTGGAAGCTGATCCAGAACCGTATTCACTTGTACCAATTTCTCCTTCTGAAGATGGC
CATCTTTCAGCACTGGGTGTCGGGACTAGCCCAGGAAGCCCGGGGTTCTGGCAGTGACCAGGCC
TGCCTACTTCCAGAAGTCATCATAACCTATGCTCTGGGCTTGGTCCTTCGAGCTGGACTGGCAT
TGCTGTGGGTCCCTATGTGGCTGCTGCTCTGGGGACCCAGGTTGTCATACAGAGTCGGACTGTG
CTGCACCCACACTATGAAGCTGGCCCTGGGGCACCTCTGTGCCTGGGAACCTCCGGGTCTGTCT
CCAGCCACCTTCAGGGACCTGTTTCTATCCTGCCTGCATCGCCTGATGCTGGTGGCCTTGCTGG
TACTGCTGCTAACCTGGAAGCTGTTGCAGAAAGCCCATCACTCCAGTCTGGGCTGGCTGCACAG
CCAGAGTTCTATGCTCCTGGAAGCCCTGGCTTTGCTGAGACGCCTCTACCTGTGGGTGGAGCAC
AGGACCACACTCACTTCCTGGAACCTGGCCTATCTTGTCACTTGGACTACCTGTCTCGCTTCCC
ACCTGCTTCAAGCTGCCTTTGAGCACACAGCCCAACTGGCCCAGGCCCAGGAGGTCTCATTCGA
GGAGACCTCAGAGCCCTCATCTCAGTTCTTAATTCCAGAATCCTCCACCACCGAGTCTGGACCC
CTCCCTTCCCAGCCTGAAACCCCCGGAGAATAAATGTGTCCCCCACCTGCC

hide sequence

RefSeq Acc Id:

XM_017598507 ⟹ XP_017453996

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	27,430,657 - 27,435,243 (+)	NCBI
mRatBN7.2	12	21,794,137 - 21,798,723 (+)	NCBI
Rnor_6.0	12	24,803,700 - 24,808,287 (+)	NCBI

Sequence:

show sequence

TGGCTGGAGGAATGGACGGAGGCCAGACATGGAGGCCGCTCCCCGGGTCAGATTTGGCCTTCCT
AGAATTCTCCTGCAGGTTGGGAAGCTCTCTGCGCTGCTTTCCTCATGATGACAAGGGCAACCAG
GGTCCCAGGCGAGCCCAGGGATTTGGGGGAAGCCAGCCAGCCGTGTGTTCGAATCCCACAGTTA
ATCAGAGGGGAGCTGATCCAGAACCGTATTCACTTGTACCAATTTCTCCTTCTGAAGATGGCCA
TCTTTCAGCACTGGGTGTCGGGACTAGCCCAGGAAGCCCGGGGTTCTGGCAGTGACCAGGCCTG
CCTACTTCCAGAAGTCATCATAACCTATGCTCTGGGCTTGGTCCTTCGAGCTGGACTGGCATTG
CTGTGGGTCCCTATGTGGCTGCTGCTCTGGGGACCCAGGTTGTCATACAGAGTCGGACTGTGCT
GCACCCACACTATGAAGCTGGCCCTGGGGCACCTCTGTGCCTGGGAACCTCCGGGTCTGTCTCC
AGCCACCTTCAGGGACCTGTTTCTATCCTGCCTGCATCGCCTGATGCTGGTGGCCTTGCTGGTA
CTGCTGCTAACCTGGAAGCTGTTGCAGAAAGCCCATCACTCCAGTCTGGGCTGGCTGCACAGCC
AGAGTTCTATGCTCCTGGAAGCCCTGGCTTTGCTGAGACGCCTCTACCTGTGGGTGGAGCACAG
GACCACACTCACTTCCTGGAACCTGGCCTATCTTGTCACTTGGACTACCTGTCTCGCTTCCCAC
CTGCTTCAAGCTGCCTTTGAGCACACAGCCCAACTGGCCCAGGCCCAGGAGGTCTCATTCGAGG
AGACCTCAGAGCCCTCATCTCAGTTCTTAATTCCAGAATCCTCCACCACCGAGTCTGGACCCCT
CCCTTCCCAGCCTGAAACCCCCGGAGAATAAATGTGTCCCCCACCTGCC

hide sequence

RefSeq Acc Id:

XM_213758 ⟹ XP_213758

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	27,430,533 - 27,435,243 (+)	NCBI
mRatBN7.2	12	21,794,110 - 21,798,723 (+)	NCBI
Rnor_6.0	12	24,803,689 - 24,808,287 (+)	NCBI
Rnor_5.0	12	26,803,487 - 26,808,557 (+)	NCBI
RGSC_v3.4	12	22,858,647 - 22,863,206 (+)	RGD

Sequence:

show sequence

CCTGCCTCTCCTGGCTGGAGGAATGGACGGAGGCCAGACATGGAGGCCGCTCCCCGGGTCAGAT
TTGGCCTTCCTAGAATTCTCCTGCAGGTTGGGAAGCTCTCTGCGCTGCTGATCCAGAACCGTAT
TCACTTGTACCAATTTCTCCTTCTGAAGATGGCCATCTTTCAGCACTGGGTGTCGGGACTAGCC
CAGGAAGCCCGGGGTTCTGGCAGTGACCAGGCCTGCCTACTTCCAGAAGTCATCATAACCTATG
CTCTGGGCTTGGTCCTTCGAGCTGGACTGGCATTGCTGTGGGTCCCTATGTGGCTGCTGCTCTG
GGGACCCAGGTTGTCATACAGAGTCGGACTGTGCTGCACCCACACTATGAAGCTGGCCCTGGGG
CACCTCTGTGCCTGGGAACCTCCGGGTCTGTCTCCAGCCACCTTCAGGGACCTGTTTCTATCCT
GCCTGCATCGCCTGATGCTGGTGGCCTTGCTGGTACTGCTGCTAACCTGGAAGCTGTTGCAGAA
AGCCCATCACTCCAGTCTGGGCTGGCTGCACAGCCAGAGTTCTATGCTCCTGGAAGCCCTGGCT
TTGCTGAGACGCCTCTACCTGTGGGTGGAGCACAGGACCACACTCACTTCCTGGAACCTGGCCT
ATCTTGTCACTTGGACTACCTGTCTCGCTTCCCACCTGCTTCAAGCTGCCTTTGAGCACACAGC
CCAACTGGCCCAGGCCCAGGAGGTCTCATTCGAGGAGACCTCAGAGCCCTCATCTCAGTTCTTA
ATTCCAGAATCCTCCACCACCGAGTCTGGACCCCTCCCTTCCCAGCCTGAAACCCCCGGAGAAT
AAATGTGTCCCCCACCTGCC

hide sequence

Protein Sequences


Protein RefSeqs	NP_001418911	(Get FASTA)	NCBI Sequence Viewer
	NP_001418912	(Get FASTA)	NCBI Sequence Viewer
	NP_001418913	(Get FASTA)	NCBI Sequence Viewer
	NP_001418914	(Get FASTA)	NCBI Sequence Viewer
	XP_006249275	(Get FASTA)	NCBI Sequence Viewer
	XP_017453996	(Get FASTA)	NCBI Sequence Viewer
	XP_213758	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000034323
	ENSRNOP00000034323.3
	ENSRNOP00000082087
	ENSRNOP00000082087.1
	ENSRNOP00000106875
	ENSRNOP00000106875.1
	ENSRNOP00000107718.1

RefSeq Acc Id:

XP_213758 ⟸ XM_213758

- Peptide Label:

isoform X3

- Sequence:

show sequence

MEAAPRVRFGLPRILLQVGKLSALLIQNRIHLYQFLLLKMAIFQHWVSGLAQEARGSGSDQACL
LPEVIITYALGLVLRAGLALLWVPMWLLLWGPRLSYRVGLCCTHTMKLALGHLCAWEPPGLSPA
TFRDLFLSCLHRLMLVALLVLLLTWKLLQKAHHSSLGWLHSQSSMLLEALALLRRLYLWVEHRT
TLTSWNLAYLVTWTTCLASHLLQAAFEHTAQLAQAQEVSFEETSEPSSQFLIPESSTTESGPLP
SQPETPGE

hide sequence

RefSeq Acc Id:

XP_006249275 ⟸ XM_006249213

- Peptide Label:

isoform X1

- Sequence:

show sequence

MEKLQDCTLILQPETDGDREGTGKGQGERPGGEDNGVSVEEAKLGLLLWQICYPQGPIWKLIQN
RIHLYQFLLLKMAIFQHWVSGLAQEARGSGSDQACLLPEVIITYALGLVLRAGLALLWVPMWLL
LWGPRLSYRVGLCCTHTMKLALGHLCAWEPPGLSPATFRDLFLSCLHRLMLVALLVLLLTWKLL
QKAHHSSLGWLHSQSSMLLEALALLRRLYLWVEHRTTLTSWNLAYLVTWTTCLASHLLQAAFEH
TAQLAQAQEVSFEETSEPSSQFLIPESSTTESGPLPSQPETPGE

hide sequence

RefSeq Acc Id:

XP_017453996 ⟸ XM_017598507

- Peptide Label:

isoform X2

- Sequence:

show sequence

MMTRATRVPGEPRDLGEASQPCVRIPQLIRGELIQNRIHLYQFLLLKMAIFQHWVSGLAQEARG
SGSDQACLLPEVIITYALGLVLRAGLALLWVPMWLLLWGPRLSYRVGLCCTHTMKLALGHLCAW
EPPGLSPATFRDLFLSCLHRLMLVALLVLLLTWKLLQKAHHSSLGWLHSQSSMLLEALALLRRL
YLWVEHRTTLTSWNLAYLVTWTTCLASHLLQAAFEHTAQLAQAQEVSFEETSEPSSQFLIPESS
TTESGPLPSQPETPGE

hide sequence

Ensembl Acc Id:

ENSRNOP00000034323 ⟸ ENSRNOT00000033499

Ensembl Acc Id:

ENSRNOP00000082087 ⟸ ENSRNOT00000114794

Ensembl Acc Id:

ENSRNOP00000107718 ⟸ ENSRNOT00000143593

Ensembl Acc Id:

ENSRNOP00000106875 ⟸ ENSRNOT00000165625

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZKV0-F1-model_v2	AlphaFold	D3ZKV0	1-264	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13698570

Promoter ID:

EPDNEW_R9090

Type:

single initiation site

Name:

Tmem270_1

Description:

transmembrane protein 270

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	12	24,803,694 - 24,803,754	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1561903	AgrOrtholog
BioCyc Gene	G2FUF-19588	BioCyc
Ensembl Genes	ENSRNOG00000001474	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000033499	ENTREZGENE
	ENSRNOT00000033499.7	UniProtKB/TrEMBL
	ENSRNOT00000114794	ENTREZGENE
	ENSRNOT00000114794.2	UniProtKB/TrEMBL
	ENSRNOT00000143593.1	UniProtKB/TrEMBL
	ENSRNOT00000165625	ENTREZGENE
	ENSRNOT00000165625.1	UniProtKB/TrEMBL
InterPro	WBS28	UniProtKB/TrEMBL
NCBI Gene	288604	ENTREZGENE
PANTHER	PTHR37369	UniProtKB/TrEMBL
	TRANSMEMBRANE PROTEIN 270	UniProtKB/TrEMBL
Pfam	WBS28	UniProtKB/TrEMBL
PhenoGen	Tmem270	PhenoGen
RatGTEx	ENSRNOG00000001474	RatGTEx
UniProt	A0A8I6G8Y8	ENTREZGENE, UniProtKB/TrEMBL
	A0ABK0LW46_RAT	UniProtKB/TrEMBL
	A0ABK0LWT0_RAT	UniProtKB/TrEMBL
	D3ZKV0	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2017-05-18	Tmem270	transmembrane protein 270	Wbscr28	Williams-Beuren syndrome chromosome region 28	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2013-02-04	Wbscr28	Williams-Beuren syndrome chromosome region 28	Wbscr28	Williams-Beuren syndrome chromosome region 28 (human)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-02-29	Wbscr28	Williams-Beuren syndrome chromosome region 28 (human)	RGD1561903_predicted	similar to Williams-Beuren syndrome critical region protein 28 isoform A (predicted)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-07	RGD1561903_predicted	similar to Williams-Beuren syndrome critical region protein 28 isoform A (predicted)	LOC288604	similar to Williams-Beuren syndrome critical region protein 28 isoform A	Symbol and Name status set to approved	1299863	APPROVED
2006-02-09	LOC288604	similar to Williams-Beuren syndrome critical region protein 28 isoform A			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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