Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Siva1 | Rat | (+)-catechin | multiple interactions | ISO | SIVA1 (Homo sapiens) | 6480464 | [Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of SIVA1 mRNA | CTD | PMID:24763279 | Siva1 | Rat | (1->4)-beta-D-glucan | multiple interactions | ISO | Siva1 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of SIVA1 mRNA | CTD | PMID:36331819 | Siva1 | Rat | (S)-nicotine | decreases expression | ISO | SIVA1 (Homo sapiens) | 6480464 | Nicotine results in decreased expression of SIVA1 mRNA | CTD | PMID:16949557 | Siva1 | Rat | 1,2-dimethylhydrazine | multiple interactions | ISO | Siva1 (Mus musculus) | 6480464 | [1,2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of SIVA1 mRNA | CTD | PMID:22206623 | Siva1 | Rat | 17alpha-ethynylestradiol | decreases expression | EXP | | 6480464 | Ethinyl Estradiol results in decreased expression of SIVA1 mRNA | CTD | PMID:17557909 | Siva1 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | EXP | | 6480464 | AHR protein alternative form affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of SIVA1 mRNA] | CTD | PMID:21215274 | Siva1 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of SIVA1 mRNA | CTD | PMID:33387578 | Siva1 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of SIVA1 mRNA | CTD | PMID:34747641 | Siva1 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of SIVA1 mRNA | CTD | PMID:21215274 | Siva1 | Rat | 2,6-dinitrotoluene | affects expression | EXP | | 6480464 | 2,6-dinitrotoluene affects the expression of SIVA1 mRNA | CTD | PMID:21346803 | Siva1 | Rat | 2-hydroxypropanoic acid | decreases expression | ISO | SIVA1 (Homo sapiens) | 6480464 | Lactic Acid results in decreased expression of SIVA1 mRNA | CTD | PMID:30851411 | Siva1 | Rat | 3-methylcholanthrene | increases expression | ISO | Siva1 (Mus musculus) | 6480464 | Methylcholanthrene results in increased expression of SIVA1 mRNA | CTD | PMID:20713471 | Siva1 | Rat | acetamide | increases expression | EXP | | 6480464 | acetamide results in increased expression of SIVA1 mRNA | CTD | PMID:31881176 | Siva1 | Rat | acrolein | multiple interactions | ISO | SIVA1 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of more ... | CTD | PMID:32699268 | Siva1 | Rat | aflatoxin B1 | increases expression | ISO | Siva1 (Mus musculus) | 6480464 | Aflatoxin B1 results in increased expression of SIVA1 mRNA | CTD | PMID:19770486 | Siva1 | Rat | alpha-pinene | multiple interactions | ISO | SIVA1 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of more ... | CTD | PMID:32699268 | Siva1 | Rat | amiodarone | increases expression | ISO | Siva1 (Mus musculus) | 6480464 | Amiodarone results in increased expression of SIVA1 mRNA | CTD | PMID:24535564 | Siva1 | Rat | Aroclor 1254 | increases expression | ISO | Siva1 (Mus musculus) | 6480464 | Chlorodiphenyl (54% Chlorine) results in increased expression of SIVA1 mRNA | CTD | PMID:23650126 | Siva1 | Rat | arsane | increases methylation | ISO | SIVA1 (Homo sapiens) | 6480464 | Arsenic results in increased methylation of SIVA1 promoter | CTD | PMID:21291286 | Siva1 | Rat | arsenic atom | increases methylation | ISO | SIVA1 (Homo sapiens) | 6480464 | Arsenic results in increased methylation of SIVA1 promoter | CTD | PMID:21291286 | Siva1 | Rat | arsenite(3-) | multiple interactions | ISO | SIVA1 (Homo sapiens) | 6480464 | arsenite promotes the reaction [G3BP1 protein binds to SIVA1 mRNA] | CTD | PMID:32406909 | Siva1 | Rat | beauvericin | decreases expression | ISO | SIVA1 (Homo sapiens) | 6480464 | beauvericin results in decreased expression of SIVA1 mRNA | CTD | PMID:29203277 | Siva1 | Rat | benzo[a]pyrene | decreases expression | ISO | SIVA1 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased expression of SIVA1 mRNA | CTD | PMID:20106945 | Siva1 | Rat | benzo[a]pyrene | increases methylation | ISO | SIVA1 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of SIVA1 promoter | CTD | PMID:27901495 | Siva1 | Rat | benzo[a]pyrene | increases expression | ISO | Siva1 (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased expression of SIVA1 mRNA | CTD | PMID:19770486 | Siva1 | Rat | bis(2-ethylhexyl) phthalate | decreases expression | ISO | SIVA1 (Homo sapiens) | 6480464 | Diethylhexyl Phthalate results in decreased expression of SIVA1 mRNA | CTD | PMID:28412506 | Siva1 | Rat | bisphenol A | affects expression | EXP | | 6480464 | bisphenol A affects the expression of SIVA1 mRNA | CTD | PMID:25181051 | Siva1 | Rat | bisphenol A | increases expression | ISO | Siva1 (Mus musculus) | 6480464 | bisphenol A results in increased expression of SIVA1 mRNA | CTD | PMID:33221593 | Siva1 | Rat | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of SIVA1 mRNA | CTD | PMID:32145629 | Siva1 | Rat | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of SIVA1 protein | CTD | PMID:32145629 | Siva1 | Rat | bisphenol A | affects expression | ISO | SIVA1 (Homo sapiens) | 6480464 | bisphenol A affects the expression of SIVA1 mRNA | CTD | PMID:30903817 | Siva1 | Rat | bortezomib | decreases expression | ISO | SIVA1 (Homo sapiens) | 6480464 | Bortezomib results in decreased expression of SIVA1 mRNA | CTD | PMID:17659339 | Siva1 | Rat | butan-1-ol | multiple interactions | ISO | SIVA1 (Homo sapiens) | 6480464 | [[Gasoline co-treated with 1-Butanol] results in increased abundance of [Particulate Matter co-treated with Polycyclic Aromatic more ... | CTD | PMID:29432896 | Siva1 | Rat | calcitriol | decreases expression | ISO | SIVA1 (Homo sapiens) | 6480464 | Calcitriol results in decreased expression of SIVA1 mRNA | CTD | PMID:21592394 | Siva1 | Rat | calcitriol | multiple interactions | ISO | SIVA1 (Homo sapiens) | 6480464 | [Testosterone co-treated with Calcitriol] results in decreased expression of SIVA1 mRNA | CTD | PMID:21592394 | Siva1 | Rat | cannabidiol | decreases expression | ISO | SIVA1 (Homo sapiens) | 6480464 | Cannabidiol results in decreased expression of SIVA1 mRNA | CTD | PMID:27932991 | Siva1 | Rat | carbon nanotube | increases expression | ISO | Siva1 (Mus musculus) | 6480464 | Nanotubes, Carbon analog results in increased expression of SIVA1 mRNA; Nanotubes, Carbon results in increased more ... | CTD | PMID:25554681|PMID:25620056 | Siva1 | Rat | CGP 52608 | multiple interactions | ISO | SIVA1 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to SIVA1 gene] | CTD | PMID:28238834 | Siva1 | Rat | chloroacetaldehyde | increases expression | ISO | SIVA1 (Homo sapiens) | 6480464 | chloroacetaldehyde results in increased expression of SIVA1 mRNA | CTD | PMID:25596134 | Siva1 | Rat | choline | multiple interactions | ISO | Siva1 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation more ... | CTD | PMID:20938992 | Siva1 | Rat | chromium(6+) | affects expression | ISO | Siva1 (Mus musculus) | 6480464 | chromium hexavalent ion affects the expression of SIVA1 mRNA | CTD | PMID:28472532 | Siva1 | Rat | chromium(6+) | multiple interactions | ISO | SIVA1 (Homo sapiens) | 6480464 | [zinc chromate results in increased abundance of chromium hexavalent ion] which results in decreased expression more ... | CTD | PMID:38479592 | Siva1 | Rat | cidofovir anhydrous | increases expression | ISO | SIVA1 (Homo sapiens) | 6480464 | Cidofovir results in increased expression of SIVA1 mRNA | CTD | PMID:25596134 | Siva1 | Rat | ciguatoxin CTX1B | affects expression | ISO | Siva1 (Mus musculus) | 6480464 | Ciguatoxins affects the expression of SIVA1 mRNA | CTD | PMID:18353800 | Siva1 | Rat | cisplatin | multiple interactions | ISO | SIVA1 (Homo sapiens) | 6480464 | Cisplatin inhibits the reaction [Piroxicam results in decreased expression of SIVA1 mRNA] | CTD | PMID:21858171 | Siva1 | Rat | cisplatin | increases expression | ISO | SIVA1 (Homo sapiens) | 6480464 | Cisplatin results in increased expression of SIVA1 mRNA | CTD | PMID:25596134|PMID:27594783 | Siva1 | Rat | clodronic acid | increases expression | ISO | SIVA1 (Homo sapiens) | 6480464 | Clodronic Acid results in increased expression of SIVA1 mRNA | CTD | PMID:25596134 | Siva1 | Rat | cobalt dichloride | decreases expression | ISO | SIVA1 (Homo sapiens) | 6480464 | cobaltous chloride results in decreased expression of SIVA1 mRNA | CTD | PMID:19376846 | Siva1 | Rat | cocaine | affects expression | ISO | Siva1 (Mus musculus) | 6480464 | Cocaine affects the expression of SIVA1 mRNA | CTD | PMID:15681117 | Siva1 | Rat | copper(II) sulfate | decreases expression | ISO | SIVA1 (Homo sapiens) | 6480464 | Copper Sulfate results in decreased expression of SIVA1 mRNA | CTD | PMID:19549813 | Siva1 | Rat | crocidolite asbestos | increases expression | ISO | Siva1 (Mus musculus) | 6480464 | Asbestos, Crocidolite results in increased expression of SIVA1 mRNA | CTD | PMID:29279043 | Siva1 | Rat | cyclosporin A | decreases expression | ISO | SIVA1 (Homo sapiens) | 6480464 | Cyclosporine results in decreased expression of SIVA1 mRNA | CTD | PMID:25562108|PMID:25596134 | Siva1 | Rat | cyclosporin A | increases expression | EXP | | 6480464 | Cyclosporine results in increased expression of SIVA1 mRNA | CTD | PMID:25596134 | Siva1 | Rat | DDE | increases expression | ISO | SIVA1 (Homo sapiens) | 6480464 | Dichlorodiphenyl Dichloroethylene results in increased expression of SIVA1 mRNA | CTD | PMID:38568856 | Siva1 | Rat | dicrotophos | decreases expression | ISO | SIVA1 (Homo sapiens) | 6480464 | dicrotophos results in decreased expression of SIVA1 mRNA | CTD | PMID:28302478 | Siva1 | Rat | diethylstilbestrol | increases expression | ISO | Siva1 (Mus musculus) | 6480464 | Diethylstilbestrol results in increased expression of SIVA1 mRNA | CTD | PMID:14648872 | Siva1 | Rat | dioxygen | decreases expression | ISO | SIVA1 (Homo sapiens) | 6480464 | Oxygen deficiency results in decreased expression of SIVA1 mRNA | CTD | PMID:25596134 | Siva1 | Rat | endosulfan | increases expression | EXP | | 6480464 | Endosulfan results in increased expression of SIVA1 mRNA | CTD | PMID:29391264 | Siva1 | Rat | fenofibrate | decreases expression | EXP | | 6480464 | Fenofibrate results in decreased expression of SIVA1 mRNA | CTD | PMID:25596134 | Siva1 | Rat | fipronil | decreases expression | EXP | | 6480464 | fipronil results in decreased expression of SIVA1 mRNA | CTD | PMID:34044035 | Siva1 | Rat | folic acid | multiple interactions | ISO | Siva1 (Mus musculus) | 6480464 | [1,2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of SIVA1 mRNA; [Methionine deficiency co-treated more ... | CTD | PMID:20938992|PMID:22206623 | Siva1 | Rat | gentamycin | decreases expression | EXP | | 6480464 | Gentamicins results in decreased expression of SIVA1 mRNA | CTD | PMID:33387578 | Siva1 | Rat | ifosfamide | increases expression | ISO | SIVA1 (Homo sapiens) | 6480464 | Ifosfamide results in increased expression of SIVA1 mRNA | CTD | PMID:25596134 | Siva1 | Rat | inulin | multiple interactions | ISO | Siva1 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Inulin] results in increased expression of SIVA1 mRNA | CTD | PMID:36331819 | Siva1 | Rat | isoprenaline | decreases expression | ISO | Siva1 (Mus musculus) | 6480464 | Isoproterenol results in decreased expression of SIVA1 mRNA | CTD | PMID:20003209 | Siva1 | Rat | L-methionine | multiple interactions | ISO | Siva1 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation more ... | CTD | PMID:20938992 | Siva1 | Rat | lead(0) | affects expression | ISO | SIVA1 (Homo sapiens) | 6480464 | Lead affects the expression of SIVA1 mRNA | CTD | PMID:28903495 | Siva1 | Rat | metformin | decreases expression | EXP | | 6480464 | Metformin results in decreased expression of SIVA1 mRNA | CTD | PMID:25596134 | Siva1 | Rat | methyl methanesulfonate | increases expression | ISO | SIVA1 (Homo sapiens) | 6480464 | Methyl Methanesulfonate results in increased expression of SIVA1 mRNA | CTD | PMID:23649840 | Siva1 | Rat | mitomycin C | increases expression | ISO | Siva1 (Mus musculus) | 6480464 | Mitomycin results in increased expression of SIVA1 mRNA | CTD | PMID:25270620 | Siva1 | Rat | nicotine | decreases expression | ISO | SIVA1 (Homo sapiens) | 6480464 | Nicotine results in decreased expression of SIVA1 mRNA | CTD | PMID:16949557 | Siva1 | Rat | oxaliplatin | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] results in decreased expression of SIVA1 mRNA | CTD | PMID:25729387 | Siva1 | Rat | ozone | multiple interactions | ISO | SIVA1 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of more ... | CTD | PMID:32699268|PMID:35430440 | Siva1 | Rat | ozone | multiple interactions | ISO | Siva1 (Mus musculus) | 6480464 | [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in increased more ... | CTD | PMID:34911549 | Siva1 | Rat | paracetamol | affects expression | ISO | SIVA1 (Homo sapiens) | 6480464 | Acetaminophen affects the expression of SIVA1 mRNA | CTD | PMID:25704631 | Siva1 | Rat | paracetamol | increases expression | EXP | | 6480464 | Acetaminophen results in increased expression of SIVA1 mRNA | CTD | PMID:33387578 | Siva1 | Rat | perfluorooctane-1-sulfonic acid | multiple interactions | ISO | Siva1 (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of SIVA1 mRNA; [perfluorooctane sulfonic more ... | CTD | PMID:36331819 | Siva1 | Rat | phenobarbital | increases expression | ISO | Siva1 (Mus musculus) | 6480464 | Phenobarbital results in increased expression of SIVA1 mRNA | CTD | PMID:19482888 | Siva1 | Rat | phenobarbital | affects expression | ISO | Siva1 (Mus musculus) | 6480464 | Phenobarbital affects the expression of SIVA1 mRNA | CTD | PMID:23091169 | Siva1 | Rat | phenobarbital | affects expression | ISO | SIVA1 (Homo sapiens) | 6480464 | Phenobarbital affects the expression of SIVA1 mRNA | CTD | PMID:19159669 | Siva1 | Rat | phenobarbital | multiple interactions | ISO | Siva1 (Mus musculus) | 6480464 | NR1I3 protein affects the reaction [Phenobarbital results in increased expression of SIVA1 mRNA] | CTD | PMID:19482888 | Siva1 | Rat | pirinixic acid | increases expression | ISO | Siva1 (Mus musculus) | 6480464 | pirinixic acid results in increased expression of SIVA1 mRNA | CTD | PMID:23811191 | Siva1 | Rat | piroxicam | multiple interactions | ISO | SIVA1 (Homo sapiens) | 6480464 | Cisplatin inhibits the reaction [Piroxicam results in decreased expression of SIVA1 mRNA] | CTD | PMID:21858171 | Siva1 | Rat | piroxicam | decreases expression | ISO | SIVA1 (Homo sapiens) | 6480464 | Piroxicam results in decreased expression of SIVA1 mRNA | CTD | PMID:21858171 | Siva1 | Rat | rac-lactic acid | decreases expression | ISO | SIVA1 (Homo sapiens) | 6480464 | Lactic Acid results in decreased expression of SIVA1 mRNA | CTD | PMID:30851411 | Siva1 | Rat | sodium arsenite | decreases expression | ISO | Siva1 (Mus musculus) | 6480464 | sodium arsenite results in decreased expression of SIVA1 mRNA | CTD | PMID:16014739 | Siva1 | Rat | sodium arsenite | increases expression | ISO | SIVA1 (Homo sapiens) | 6480464 | sodium arsenite results in increased expression of SIVA1 mRNA | CTD | PMID:39719251 | Siva1 | Rat | sodium arsenite | affects expression | ISO | SIVA1 (Homo sapiens) | 6480464 | sodium arsenite affects the expression of SIVA1 mRNA | CTD | PMID:34032870 | Siva1 | Rat | sodium arsenite | decreases expression | ISO | SIVA1 (Homo sapiens) | 6480464 | sodium arsenite results in decreased expression of SIVA1 mRNA | CTD | PMID:38568856 | Siva1 | Rat | testosterone | decreases expression | ISO | Siva1 (Mus musculus) | 6480464 | Testosterone results in decreased expression of SIVA1 mRNA | CTD | PMID:21669218 | Siva1 | Rat | testosterone | decreases expression | ISO | SIVA1 (Homo sapiens) | 6480464 | Testosterone results in decreased expression of SIVA1 mRNA | CTD | PMID:21592394 | Siva1 | Rat | testosterone | multiple interactions | ISO | SIVA1 (Homo sapiens) | 6480464 | [Testosterone co-treated with Calcitriol] results in decreased expression of SIVA1 mRNA | CTD | PMID:21592394 | Siva1 | Rat | tetrachloromethane | increases expression | ISO | Siva1 (Mus musculus) | 6480464 | Carbon Tetrachloride results in increased expression of SIVA1 mRNA | CTD | PMID:31919559 | Siva1 | Rat | thiram | decreases expression | ISO | SIVA1 (Homo sapiens) | 6480464 | Thiram results in decreased expression of SIVA1 mRNA | CTD | PMID:38568856 | Siva1 | Rat | titanium dioxide | decreases methylation | ISO | Siva1 (Mus musculus) | 6480464 | titanium dioxide results in decreased methylation of SIVA1 gene | CTD | PMID:35295148 | Siva1 | Rat | toluene | decreases expression | EXP | | 6480464 | Toluene results in decreased expression of SIVA1 mRNA | CTD | PMID:22967744 | Siva1 | Rat | topotecan | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] results in decreased expression of SIVA1 mRNA | CTD | PMID:25729387 | Siva1 | Rat | topotecan | decreases expression | EXP | | 6480464 | Topotecan results in decreased expression of SIVA1 mRNA | CTD | PMID:25729387 | Siva1 | Rat | trimellitic anhydride | increases expression | ISO | Siva1 (Mus musculus) | 6480464 | trimellitic anhydride results in increased expression of SIVA1 mRNA | CTD | PMID:19042947 | Siva1 | Rat | triphenyl phosphate | affects expression | ISO | SIVA1 (Homo sapiens) | 6480464 | triphenyl phosphate affects the expression of SIVA1 mRNA | CTD | PMID:37042841 | Siva1 | Rat | tungsten | increases expression | ISO | Siva1 (Mus musculus) | 6480464 | Tungsten results in increased expression of SIVA1 mRNA | CTD | PMID:30912803 | Siva1 | Rat | urethane | decreases expression | ISO | SIVA1 (Homo sapiens) | 6480464 | Urethane results in decreased expression of SIVA1 mRNA | CTD | PMID:28818685 | Siva1 | Rat | valproic acid | increases expression | ISO | Siva1 (Mus musculus) | 6480464 | Valproic Acid results in increased expression of SIVA1 mRNA | CTD | PMID:24535564 | Siva1 | Rat | valproic acid | affects expression | ISO | SIVA1 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of SIVA1 mRNA | CTD | PMID:25979313 | Siva1 | Rat | valproic acid | increases expression | ISO | SIVA1 (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of SIVA1 mRNA | CTD | PMID:29154799 | Siva1 | Rat | vincristine | decreases expression | ISO | SIVA1 (Homo sapiens) | 6480464 | Vincristine results in decreased expression of SIVA1 mRNA | CTD | PMID:23649840 | Siva1 | Rat | zinc atom | affects binding | ISO | SIVA1 (Homo sapiens) | 6480464 | Zinc binds to SIVA1 protein | CTD | PMID:16683188 | Siva1 | Rat | zinc(0) | affects binding | ISO | SIVA1 (Homo sapiens) | 6480464 | Zinc binds to SIVA1 protein | CTD | PMID:16683188 | |






















