Siva1 (SIVA1 apoptosis inducing factor) - Rat Genome Database

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Gene: Siva1 (SIVA1 apoptosis inducing factor) Heterocephalus glaber
Analyze
Symbol: Siva1
Name: SIVA1 apoptosis inducing factor
RGD ID: 18912282
Description: ENCODES a protein that exhibits zinc ion binding (ortholog); INVOLVED IN activation-induced cell death of T cells (ortholog); intrinsic apoptotic signaling pathway (ortholog); positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway (ortholog); ASSOCIATED WITH Charcot-Marie-Tooth disease axonal type 2O (ortholog); Coxsackievirus Infections (ortholog); focal segmental glomerulosclerosis 5 (ortholog); FOUND IN mitochondrion (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Apoptosis regulatory protein Siva
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624734530,711 - 535,281 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
mitochondrion  (ISO)
nucleoplasm  (IEA)
nucleus  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:21993625   PMID:30032202  


Genomics

Comparative Map Data
Siva1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624734530,711 - 535,281 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
SIVA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3814104,753,147 - 104,759,654 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl14104,753,147 - 104,768,494 (+)EnsemblGRCh38hg38GRCh38
GRCh3714105,219,484 - 105,225,991 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3614104,290,515 - 104,297,041 (+)NCBINCBI36Build 36hg18NCBI36
Celera1485,274,542 - 85,281,070 (+)NCBICelera
Cytogenetic Map14q32.33NCBI
HuRef1485,416,458 - 85,422,986 (+)NCBIHuRef
CHM1_114105,157,086 - 105,163,614 (+)NCBICHM1_1
T2T-CHM13v2.01498,996,033 - 99,002,540 (+)NCBIT2T-CHM13v2.0
Siva1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912112,611,262 - 112,615,586 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12112,611,113 - 112,615,583 (+)EnsemblGRCm39 Ensembl
GRCm3812112,644,828 - 112,649,152 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12112,644,679 - 112,649,149 (+)EnsemblGRCm38mm10GRCm38
MGSCv3712113,883,039 - 113,887,363 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3612113,092,716 - 113,096,953 (+)NCBIMGSCv36mm8
Celera12113,858,455 - 113,862,779 (+)NCBICelera
Cytogenetic Map12F1NCBI
cM Map1261.2NCBI
Siva1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86137,526,416 - 137,530,790 (+)NCBIGRCr8
mRatBN7.26131,705,323 - 131,709,697 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6131,705,323 - 131,709,690 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6131,874,637 - 131,879,016 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06132,171,743 - 132,176,118 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06131,534,212 - 131,538,589 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06137,209,999 - 137,214,379 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6137,210,052 - 137,214,388 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06146,216,931 - 146,221,556 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46137,631,408 - 137,635,724 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera6129,253,021 - 129,257,273 (+)NCBICelera
Cytogenetic Map6q32NCBI
Siva1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555383,197,983 - 3,202,782 (+)NCBIChiLan1.0ChiLan1.0
SIVA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v215105,935,284 - 105,941,823 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan114105,151,787 - 105,158,327 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01485,404,148 - 85,408,254 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.114105,196,118 - 105,202,678 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl14105,196,118 - 105,202,678 (+)Ensemblpanpan1.1panPan2
SIVA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1872,309,400 - 72,313,726 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl872,309,447 - 72,313,640 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha871,815,163 - 71,819,494 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0872,584,386 - 72,588,709 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl872,583,252 - 72,588,623 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1872,267,010 - 72,271,332 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0872,310,264 - 72,314,586 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0872,709,843 - 72,714,165 (+)NCBIUU_Cfam_GSD_1.0
Siva1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244086401,812,507 - 1,821,101 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936621644,852 - 650,132 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936621641,456 - 650,067 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SIVA1
(Sus scrofa - pig)		 No map positions available.
SIVA1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12482,689,233 - 82,695,073 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2482,689,254 - 82,695,146 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605370,110,198 - 70,116,322 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: XM_004836853   ⟹   XP_004836910
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624734530,711 - 535,271 (-)NCBI
RefSeq Acc Id: XM_004836854   ⟹   XP_004836911
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624734530,711 - 535,281 (-)NCBI
Protein Sequences
Protein RefSeqs XP_004836910 (Get FASTA)   NCBI Sequence Viewer  
  XP_004836911 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EHB01397 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000052643
  ENSHGLP00100039052
GenBank Protein JAO02990 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: XP_004836911   ⟸   XM_004836854
- Peptide Label: isoform X2
RefSeq Acc Id: XP_004836910   ⟸   XM_004836853
- Peptide Label: isoform X1
- UniProtKB: G5AWI6 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000009428 UniProtKB/TrEMBL
  ENSHGLG00100012541 UniProtKB/TrEMBL
Ensembl Transcript ENSHGLT00000061356 UniProtKB/TrEMBL
  ENSHGLT00100059404 UniProtKB/TrEMBL
InterPro Siva UniProtKB/TrEMBL
KEGG Report hgl:101701551 UniProtKB/TrEMBL
NCBI Gene Siva1 ENTREZGENE
PANTHER APOPTOSIS REGULATORY PROTEIN SIVA UniProtKB/TrEMBL
  PTHR14365 UniProtKB/TrEMBL
Pfam Siva UniProtKB/TrEMBL
PIRSF Siva_cd27_bd UniProtKB/TrEMBL
UniProt G5AWI6 ENTREZGENE, UniProtKB/TrEMBL