Rgs9bp (regulator of G protein signaling 9 binding protein) - Rat Genome Database

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Gene: Rgs9bp (regulator of G protein signaling 9 binding protein) Rattus norvegicus
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Symbol: Rgs9bp
Name: regulator of G protein signaling 9 binding protein
RGD ID: 1561747
Description: Predicted to be involved in G protein-coupled receptor signaling pathway and detection of light stimulus involved in visual perception. Predicted to be located in rod photoreceptor outer segment. Predicted to be active in neuron projection. Human ortholog(s) of this gene implicated in bradyopsia 2. Orthologous to human RGS9BP (regulator of G protein signaling 9 binding protein); PARTICIPATES IN visual phototransduction pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 6-propyl-2-thiouracil; acetamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC499132; regulator of G-protein signaling 9-binding protein; regulator of G-protein signalling 9 binding protein; RGD1561747; similar to RGS9-1 anchor protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8197,386,326 - 97,387,039 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl197,386,326 - 97,387,039 (-)EnsemblGRCr8
mRatBN7.2188,249,438 - 88,250,151 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl188,249,438 - 88,250,151 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx193,654,417 - 93,655,130 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01102,120,366 - 102,121,079 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0195,412,700 - 95,413,413 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0191,855,270 - 91,855,983 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl191,855,270 - 91,855,983 (-)Ensemblrn6Rnor6.0
Rnor_5.0192,983,020 - 92,983,733 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4188,115,883 - 88,116,596 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera182,599,223 - 82,599,936 (-)NCBICelera
Cytogenetic Map1q21NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Photoreceptor signaling: supporting vision across a wide range of light intensities. Arshavsky VY and Burns ME, J Biol Chem. 2012 Jan 13;287(3):1620-6. Epub 2011 Nov 10.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:14625292   PMID:23555598  


Genomics

Comparative Map Data
Rgs9bp
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8197,386,326 - 97,387,039 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl197,386,326 - 97,387,039 (-)EnsemblGRCr8
mRatBN7.2188,249,438 - 88,250,151 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl188,249,438 - 88,250,151 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx193,654,417 - 93,655,130 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01102,120,366 - 102,121,079 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0195,412,700 - 95,413,413 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0191,855,270 - 91,855,983 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl191,855,270 - 91,855,983 (-)Ensemblrn6Rnor6.0
Rnor_5.0192,983,020 - 92,983,733 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4188,115,883 - 88,116,596 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera182,599,223 - 82,599,936 (-)NCBICelera
Cytogenetic Map1q21NCBI
RGS9BP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381932,675,848 - 32,678,300 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1932,675,848 - 32,678,300 (+)Ensemblhg38GRCh38
GRCh371933,166,754 - 33,169,206 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361937,858,153 - 37,861,046 (+)NCBIBuild 36Build 36hg18NCBI36
Celera1929,859,945 - 29,862,839 (+)NCBICelera
Cytogenetic Map19q13.11NCBI
HuRef1929,669,560 - 29,672,454 (+)NCBIHuRef
CHM1_11933,167,594 - 33,170,488 (+)NCBICHM1_1
T2T-CHM13v2.01935,194,580 - 35,197,034 (+)NCBIT2T-CHM13v2.0
Rgs9bp
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39735,278,418 - 35,285,007 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl735,278,418 - 35,285,007 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38735,578,993 - 35,585,582 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl735,578,993 - 35,585,582 (-)Ensemblmm10GRCm38
MGSCv37736,364,012 - 36,370,601 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36735,287,766 - 35,294,304 (-)NCBIMGSCv36mm8
Celera730,707,740 - 30,714,332 (-)NCBICelera
Cytogenetic Map7B2NCBI
cM Map721.37NCBI
Rgs9bp
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554685,312,880 - 5,313,587 (-)Ensembl
ChiLan1.0NW_0049554685,311,318 - 5,313,612 (-)NCBIChiLan1.0ChiLan1.0
RGS9BP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22038,648,280 - 38,654,878 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11940,645,077 - 40,651,653 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01929,595,159 - 29,597,612 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11938,342,812 - 38,345,706 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1938,343,663 - 38,344,370 (+)EnsemblpanPan2panpan1.1
RGS9BP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11119,316,799 - 119,322,856 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1119,321,909 - 119,322,625 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1118,716,712 - 118,722,529 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01119,917,718 - 119,923,531 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1119,922,821 - 119,923,531 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11119,481,003 - 119,486,813 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01119,101,074 - 119,106,893 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01120,161,043 - 120,166,863 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Rgs9bp
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244093498,601,570 - 8,603,649 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365703,042,773 - 3,043,480 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365703,042,233 - 3,043,884 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RGS9BP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl642,560,113 - 42,565,154 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1642,560,059 - 42,563,179 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2638,170,058 - 38,172,175 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RGS9BP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1627,724,956 - 27,727,801 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl627,725,881 - 27,726,588 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660735,300,966 - 5,303,735 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rgs9bp
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247947,545,852 - 7,546,559 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247947,545,832 - 7,552,478 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Rgs9bp
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v12163,078,313 - 163,079,430 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Rgs9bp
2 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:124
Count of miRNA genes:100
Interacting mature miRNAs:104
Transcripts:ENSRNOT00000017172
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)151940904101229020Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)187889942132889942Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
2300324Fetw1Fetal weight QTL 112.10.005fetal growth trait (VT:0004201)fetal body weight (CMO:0002080)192963855109494029Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)187785026142582336Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183019780128019780Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)166404680111404680Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
631512Scl6Serum cholesterol level QTL 69.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)18126986099645535Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)193903998191260518Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)166400974132889942Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)184107164115183752Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)191302413136302413Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)186622262131622262Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)158769992103769992Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)166077886111077886Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of, or within a discrete space in an open field apparatus (CMO:0001514)192683681137683681Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)152891222109116986Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)186993904131993904Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)187558587132558587Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)192683681137683681Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)196717367160111531Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
9 1 52 122 85 81 55 25 55 6 234 97 3 99 72 50 26 13 13

Sequence


Ensembl Acc Id: ENSRNOT00000017172   ⟹   ENSRNOP00000017172
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl197,386,326 - 97,387,039 (-)Ensembl
mRatBN7.2 Ensembl188,249,438 - 88,250,151 (-)Ensembl
Rnor_6.0 Ensembl191,855,270 - 91,855,983 (-)Ensembl
RefSeq Acc Id: NM_001109142   ⟹   NP_001102612
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8197,386,326 - 97,387,039 (-)NCBI
mRatBN7.2188,249,438 - 88,250,151 (-)NCBI
Rnor_6.0191,855,270 - 91,855,983 (-)NCBI
Rnor_5.0192,983,020 - 92,983,733 (-)NCBI
RGSC_v3.4188,115,883 - 88,116,596 (-)RGD
Celera182,599,223 - 82,599,936 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001102612 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM07614 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000017172
  ENSRNOP00000017172.1
RefSeq Acc Id: NP_001102612   ⟸   NM_001109142
- UniProtKB: D3ZC97 (UniProtKB/TrEMBL),   A6JAC0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000017172   ⟸   ENSRNOT00000017172

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZC97-F1-model_v2 AlphaFold D3ZC97 1-237 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1561747 AgrOrtholog
BioCyc Gene G2FUF-59968 BioCyc
Ensembl Genes ENSRNOG00000012877 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000017172 ENTREZGENE
  ENSRNOT00000017172.4 UniProtKB/TrEMBL
Gene3D-CATH 1.20.58.70 UniProtKB/TrEMBL
InterPro RGS7BP/RGS9BP UniProtKB/TrEMBL
KEGG Report rno:499132 UniProtKB/TrEMBL
NCBI Gene 499132 ENTREZGENE
PANTHER PTHR21029 UniProtKB/TrEMBL
PhenoGen Rgs9bp PhenoGen
RatGTEx ENSRNOG00000012877 RatGTEx
UniProt A6JAC0 ENTREZGENE, UniProtKB/TrEMBL
  D3ZC97 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-09 Rgs9bp  regulator of G protein signaling 9 binding protein  Rgs9bp  regulator of G-protein signalling 9 binding protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-29 Rgs9bp  regulator of G-protein signalling 9 binding protein  RGD1561747_predicted  similar to RGS9-1 anchor protein (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1561747_predicted  similar to RGS9-1 anchor protein (predicted)  LOC499132  similar to RGS9-1 anchor protein  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC499132  similar to RGS9-1 anchor protein      Symbol and Name status set to provisional 70820 PROVISIONAL