Hectd1 (HECT domain E3 ubiquitin protein ligase 1) - Rat Genome Database

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Gene: Hectd1 (HECT domain E3 ubiquitin protein ligase 1) Rattus norvegicus
Analyze
Symbol: Hectd1
Name: HECT domain E3 ubiquitin protein ligase 1
RGD ID: 1561653
Description: Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process and protein polyubiquitination. Predicted to act upstream of or within several processes, including chordate embryonic development; circulatory system development; and protein ubiquitination. Predicted to be active in nuclear speck. Orthologous to human HECTD1 (HECT domain E3 ubiquitin protein ligase 1); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2-nitrofluorene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: E3 ubiquitin-protein ligase HECTD1; HECT domain containing 1; HECT domain containing E3 ubiquitin protein ligase 1; LOC362736; RGD1561653; similar to HECT domain containing 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8674,916,803 - 75,003,408 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl674,916,803 - 75,003,408 (-)EnsemblGRCr8
mRatBN7.2669,181,429 - 69,268,045 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl669,181,436 - 69,268,053 (-)EnsemblmRatBN7.2
Dahl_SR_JrHsd676,484,300 - 76,574,428 (-)NCBIDahl_SR_JrHsd
Lyon_Normotensive675,902,129 - 75,992,249 (-)NCBILyon_Normotensive
Lyon_Hypertensive673,697,480 - 73,787,607 (-)NCBILyon_Hypertensive
F344_StmMcwi672,800,907 - 72,897,551 (-)NCBIF344_StmMcwi
Rnor_6.0672,509,658 - 72,596,285 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl672,510,255 - 72,596,446 (-)Ensemblrn6Rnor6.0
Rnor_5.0682,073,583 - 82,157,571 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4671,842,842 - 71,930,042 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera668,057,228 - 68,144,745 (-)NCBICelera
Cytogenetic Map6q23NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dimethoxyphenol  (ISO)
2-nitrofluorene  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
acrylamide  (EXP)
antirheumatic drug  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
Brodifacoum  (EXP)
buspirone  (EXP)
cadmium dichloride  (ISO)
caffeine  (ISO)
chloroprene  (EXP)
chlorpyrifos  (ISO)
copper(II) sulfate  (ISO)
cyproconazole  (ISO)
Dibutyl phosphate  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
fenofibrate  (ISO)
fenthion  (ISO)
finasteride  (EXP)
folic acid  (ISO)
FR900359  (ISO)
furfural  (ISO)
geldanamycin  (ISO)
glafenine  (EXP)
hexaconazole  (ISO)
hydrogen peroxide  (ISO)
inulin  (ISO)
ivermectin  (ISO)
mercury dichloride  (ISO)
methapyrilene  (EXP)
methidathion  (ISO)
methylmercury chloride  (ISO)
N-ethyl-N-nitrosourea  (ISO)
nobiletin  (ISO)
oxaliplatin  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
propiconazole  (ISO)
quercetin  (EXP)
resveratrol  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
succimer  (ISO)
sunitinib  (ISO)
thapsigargin  (ISO)
thimerosal  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
torcetrapib  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
tungsten  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
nuclear speck  (IBA)
nucleolus  (IEA,ISO)
nucleoplasm  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9636176   PMID:15755804   PMID:17442300   PMID:22431752   PMID:24855001   PMID:25807483   PMID:31505169   PMID:37096660  


Genomics

Comparative Map Data
Hectd1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8674,916,803 - 75,003,408 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl674,916,803 - 75,003,408 (-)EnsemblGRCr8
mRatBN7.2669,181,429 - 69,268,045 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl669,181,436 - 69,268,053 (-)EnsemblmRatBN7.2
Dahl_SR_JrHsd676,484,300 - 76,574,428 (-)NCBIDahl_SR_JrHsd
Lyon_Normotensive675,902,129 - 75,992,249 (-)NCBILyon_Normotensive
Lyon_Hypertensive673,697,480 - 73,787,607 (-)NCBILyon_Hypertensive
F344_StmMcwi672,800,907 - 72,897,551 (-)NCBIF344_StmMcwi
Rnor_6.0672,509,658 - 72,596,285 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl672,510,255 - 72,596,446 (-)Ensemblrn6Rnor6.0
Rnor_5.0682,073,583 - 82,157,571 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4671,842,842 - 71,930,042 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera668,057,228 - 68,144,745 (-)NCBICelera
Cytogenetic Map6q23NCBI
HECTD1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381431,100,117 - 31,207,793 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1431,100,115 - 31,208,381 (-)Ensemblhg38GRCh38
GRCh371431,569,323 - 31,676,999 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361430,639,075 - 30,746,440 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341430,639,074 - 30,746,274NCBI
Celera1411,434,814 - 11,542,175 (-)NCBICelera
Cytogenetic Map14q12NCBI
HuRef1411,686,880 - 11,794,092 (-)NCBIHuRef
CHM1_11431,568,490 - 31,675,834 (-)NCBICHM1_1
T2T-CHM13v2.01425,297,934 - 25,405,829 (-)NCBIT2T-CHM13v2.0
Hectd1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391251,790,504 - 51,876,540 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1251,790,505 - 51,876,319 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381251,743,721 - 51,829,757 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1251,743,722 - 51,829,536 (-)Ensemblmm10GRCm38
MGSCv371252,844,709 - 52,930,523 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361252,665,339 - 52,750,973 (-)NCBIMGSCv36mm8
Celera1253,048,069 - 53,133,676 (-)NCBICelera
Cytogenetic Map12B3NCBI
cM Map1222.11NCBI
Hectd1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540929,373,572 - 29,470,623 (+)Ensembl
ChiLan1.0NW_00495540929,373,572 - 29,470,623 (+)NCBIChiLan1.0ChiLan1.0
HECTD1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21532,424,502 - 32,530,532 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11431,641,005 - 31,748,953 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01411,871,973 - 11,979,548 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11430,070,567 - 30,176,915 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1430,070,567 - 30,176,915 (-)EnsemblpanPan2panpan1.1
HECTD1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1810,399,183 - 10,493,074 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl810,400,604 - 10,491,247 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha810,325,552 - 10,419,807 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0810,500,312 - 10,594,712 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl810,500,682 - 10,594,730 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1810,183,683 - 10,277,214 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0810,260,046 - 10,354,820 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0810,544,896 - 10,638,539 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Hectd1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864042,255,912 - 42,347,810 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364945,758,347 - 5,851,952 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364945,761,801 - 5,853,673 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HECTD1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl768,318,417 - 68,422,394 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1768,318,167 - 68,422,403 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2773,199,984 - 73,303,548 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HECTD1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl247,963,597 - 8,071,975 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Hectd1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248201,097,463 - 1,196,499 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248201,097,323 - 1,196,556 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Hectd1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1765,174,787 - 65,263,222 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Hectd1
252 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:89
Count of miRNA genes:78
Interacting mature miRNAs:85
Transcripts:ENSRNOT00000008459
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9590290Uminl2Urine mineral level QTL 23.960.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)64451097489510974Rat
2293088Iddm28Insulin dependent diabetes mellitus QTL 285.21blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)668767270135411972Rat
4889933Bss88Bone structure and strength QTL 883.8tibia size trait (VT:0100001)tibia total bone volume (CMO:0001724)65368492198684921Rat
634307Bp141Blood pressure QTL 1414arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)64095756485957564Rat
1331743Uae28Urinary albumin excretion QTL 284.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)64515378690153786Rat
5684992Bmd83Bone mineral density QTL 824.8tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)65368492198684921Rat
1331779Rf38Renal function QTL 382.876kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)63118500276185002Rat
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)671278722116278722Rat
70176Mcsm1Mammary carcinoma susceptibility modifier QTL 1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)664367996109367996Rat
1558641Cm47Cardiac mass QTL 472.90.001heart mass (VT:0007028)heart wet weight (CMO:0000069)66345744194939581Rat
737827Hcar11Hepatocarcinoma resistance QTL 114.4liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)646050607116278722Rat
724513Uae14Urinary albumin excretion QTL 146.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)64604735391047353Rat
2293839Kiddil2Kidney dilation QTL 24.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62661831486868070Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)620859430113082285Rat
9590140Scort4Serum corticosterone level QTL 414.490.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)64451097489510974Rat
2301964Bp323Blood pressure QTL 3234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6186868070Rat
9590306Scort18Serum corticosterone level QTL 182.880.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)64451097489510974Rat
1578665Bss16Bone structure and strength QTL 164.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)63332884178328841Rat
2293841Kiddil4Kidney dilation QTL 44.4kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62661831486868070Rat
4889848Pur25Proteinuria QTL 25140.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)66303731995934232Rat
1641898Colcr4Colorectal carcinoma resistance QTL43.710.0007intestine integrity trait (VT:0010554)well differentiated malignant colorectal tumor surface area measurement (CMO:0002077)63093763275937632Rat
1578668Bmd14Bone mineral density QTL 143.8femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)63332884178328841Rat
6893340Cm77Cardiac mass QTL 770.260.57heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)63902865986867923Rat
5684963Bss99Bone structure and strength QTL 993.1tibia area (VT:1000281)tibia area measurement (CMO:0001382)65368492198684921Rat
1300143Rf14Renal function QTL 142.92renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)64016318385163183Rat
6893332Cm74Cardiac mass QTL 740.40.64heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)66345744194939581Rat

Markers in Region
RH142634  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2669,227,653 - 69,227,760 (+)MAPPERmRatBN7.2
Rnor_6.0672,556,153 - 72,556,259NCBIRnor6.0
Rnor_5.0682,119,002 - 82,119,108UniSTSRnor5.0
RGSC_v3.4671,889,508 - 71,889,614UniSTSRGSC3.4
Celera668,104,576 - 68,104,682UniSTS
RH 3.4 Map6507.1UniSTS
Cytogenetic Map6q22UniSTS
AI844876  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2669,234,966 - 69,235,105 (+)MAPPERmRatBN7.2
Rnor_6.0672,563,467 - 72,563,605NCBIRnor6.0
Rnor_5.0682,126,316 - 82,126,454UniSTSRnor5.0
RGSC_v3.4671,896,825 - 71,896,963UniSTSRGSC3.4
Celera668,111,891 - 68,112,029UniSTS
Cytogenetic Map6q22UniSTS
RH139635  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2669,183,205 - 69,183,408 (+)MAPPERmRatBN7.2
Rnor_6.0672,511,435 - 72,511,637NCBIRnor6.0
Rnor_5.0682,075,360 - 82,075,562UniSTSRnor5.0
RGSC_v3.4671,844,358 - 71,844,560UniSTSRGSC3.4
Celera668,059,005 - 68,059,207UniSTS
RH 3.4 Map6509.6UniSTS
Cytogenetic Map6q22UniSTS
BI275482  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2669,181,547 - 69,181,744 (+)MAPPERmRatBN7.2
Rnor_6.0672,509,777 - 72,509,973NCBIRnor6.0
Rnor_5.0682,073,702 - 82,073,898UniSTSRnor5.0
RGSC_v3.4671,842,700 - 71,842,896UniSTSRGSC3.4
Celera668,057,347 - 68,057,543UniSTS
RH 3.4 Map6511.9UniSTS
Cytogenetic Map6q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000008459   ⟹   ENSRNOP00000008459
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl674,916,803 - 75,003,408 (-)Ensembl
mRatBN7.2 Ensembl669,181,436 - 69,268,053 (-)Ensembl
Rnor_6.0 Ensembl672,510,255 - 72,596,446 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000108705   ⟹   ENSRNOP00000079874
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl674,916,803 - 75,003,408 (-)Ensembl
mRatBN7.2 Ensembl669,181,436 - 69,268,053 (-)Ensembl
RefSeq Acc Id: NM_001419838   ⟹   NP_001406767
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8674,916,803 - 75,003,408 (-)NCBI
mRatBN7.2669,181,429 - 69,268,045 (-)NCBI
Dahl_SR_JrHsd676,484,300 - 76,574,428 (-)NCBI
Lyon_Normotensive675,902,129 - 75,992,249 (-)NCBI
Lyon_Hypertensive673,697,480 - 73,787,607 (-)NCBI
F344_StmMcwi672,800,907 - 72,897,551 (-)NCBI
RefSeq Acc Id: NM_001419839   ⟹   NP_001406768
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8674,916,803 - 75,003,408 (-)NCBI
mRatBN7.2669,181,429 - 69,268,045 (-)NCBI
Dahl_SR_JrHsd676,484,300 - 76,574,428 (-)NCBI
Lyon_Normotensive675,902,129 - 75,992,249 (-)NCBI
Lyon_Hypertensive673,697,480 - 73,787,607 (-)NCBI
F344_StmMcwi672,800,907 - 72,897,551 (-)NCBI
RefSeq Acc Id: NM_001419840   ⟹   NP_001406769
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8674,916,803 - 75,003,408 (-)NCBI
mRatBN7.2669,181,429 - 69,268,045 (-)NCBI
Dahl_SR_JrHsd676,484,300 - 76,574,428 (-)NCBI
Lyon_Normotensive675,902,129 - 75,992,249 (-)NCBI
Lyon_Hypertensive673,697,480 - 73,787,607 (-)NCBI
F344_StmMcwi672,800,907 - 72,897,551 (-)NCBI
RefSeq Acc Id: XM_006240087   ⟹   XP_006240149
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8674,916,808 - 75,003,167 (-)NCBI
mRatBN7.2669,181,446 - 69,267,803 (-)NCBI
Rnor_6.0672,509,675 - 72,596,285 (-)NCBI
Rnor_5.0682,073,583 - 82,157,571 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039113180   ⟹   XP_038969108
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8674,916,808 - 75,003,167 (-)NCBI
mRatBN7.2669,181,579 - 69,267,803 (-)NCBI
RefSeq Acc Id: XM_063262104   ⟹   XP_063118174
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8674,916,808 - 75,003,167 (-)NCBI
RefSeq Acc Id: XM_063262105   ⟹   XP_063118175
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8674,916,808 - 75,003,167 (-)NCBI
RefSeq Acc Id: XM_063262106   ⟹   XP_063118176
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8674,916,808 - 75,003,167 (-)NCBI
RefSeq Acc Id: XM_063262107   ⟹   XP_063118177
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8674,916,808 - 75,003,167 (-)NCBI
RefSeq Acc Id: XP_006240149   ⟸   XM_006240087
- Peptide Label: isoform X2
- Sequence:
Ensembl Acc Id: ENSRNOP00000008459   ⟸   ENSRNOT00000008459
RefSeq Acc Id: XP_038969108   ⟸   XM_039113180
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000079874   ⟸   ENSRNOT00000108705
RefSeq Acc Id: NP_001406768   ⟸   NM_001419839
- Peptide Label: isoform 2
RefSeq Acc Id: NP_001406769   ⟸   NM_001419840
- Peptide Label: isoform 3
- UniProtKB: A0A8I5ZNU0 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001406767   ⟸   NM_001419838
- Peptide Label: isoform 1
- UniProtKB: D3ZLS5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063118174   ⟸   XM_063262104
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063118175   ⟸   XM_063262105
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063118177   ⟸   XM_063262107
- Peptide Label: isoform X6
RefSeq Acc Id: XP_063118176   ⟸   XM_063262106
- Peptide Label: isoform X5
Protein Domains
HECT   MIB/HERC2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZLS5-F1-model_v2 AlphaFold D3ZLS5 1-2610 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694589
Promoter ID:EPDNEW_R5112
Type:initiation region
Name:Hectd1_2
Description:HECT domain E3 ubiquitin protein ligase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R5113  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0672,596,310 - 72,596,370EPDNEW
RGD ID:13694590
Promoter ID:EPDNEW_R5113
Type:initiation region
Name:Hectd1_1
Description:HECT domain E3 ubiquitin protein ligase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R5112  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0672,596,539 - 72,596,599EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1561653 AgrOrtholog
BioCyc Gene G2FUF-37583 BioCyc
Ensembl Genes ENSRNOG00000006905 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000008459 ENTREZGENE
  ENSRNOT00000008459.9 UniProtKB/TrEMBL
  ENSRNOT00000108705 ENTREZGENE
  ENSRNOT00000108705.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.720.80 UniProtKB/TrEMBL
  1.25.10.10 UniProtKB/TrEMBL
  1.25.40.20 UniProtKB/TrEMBL
  Galactose-binding domain-like UniProtKB/TrEMBL
  Hect, E3 ligase catalytic domain UniProtKB/TrEMBL
  Hect, E3 ligase catalytic domain UniProtKB/TrEMBL
  Hect, E3 ligase catalytic domains UniProtKB/TrEMBL
  SH3 Domains UniProtKB/TrEMBL
InterPro Ankyrin_rpt UniProtKB/TrEMBL
  Ankyrin_rpt-contain_sf UniProtKB/TrEMBL
  ARM-like UniProtKB/TrEMBL
  ARM-type_fold UniProtKB/TrEMBL
  FKBP3_BTHB UniProtKB/TrEMBL
  Galactose-bd-like UniProtKB/TrEMBL
  HECT UniProtKB/TrEMBL
  Hect_E3_ubiquitin_ligase UniProtKB/TrEMBL
  HECTD1/TRIP12-like UniProtKB/TrEMBL
  Mib_Herc2 UniProtKB/TrEMBL
  Mib_Herc2_sf UniProtKB/TrEMBL
  Sad1_UNC_C UniProtKB/TrEMBL
NCBI Gene 362736 ENTREZGENE
PANTHER E3 UBIQUITIN-PROTEIN LIGASE HECTD1 UniProtKB/TrEMBL
  PTHR45670 UniProtKB/TrEMBL
Pfam Ank_2 UniProtKB/TrEMBL
  BTHB UniProtKB/TrEMBL
  HECT UniProtKB/TrEMBL
  MIB_HERC2 UniProtKB/TrEMBL
  Sad1_UNC UniProtKB/TrEMBL
PhenoGen Hectd1 PhenoGen
PROSITE ANK_REP_REGION UniProtKB/TrEMBL
  ANK_REPEAT UniProtKB/TrEMBL
  HECT UniProtKB/TrEMBL
  MIB_HERC2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000006905 RatGTEx
SMART ANK UniProtKB/TrEMBL
  HECTc UniProtKB/TrEMBL
Superfamily-SCOP ANK UniProtKB/TrEMBL
  ARM-type_fold UniProtKB/TrEMBL
  Gal_bind_like UniProtKB/TrEMBL
  HECT UniProtKB/TrEMBL
  SSF159034 UniProtKB/TrEMBL
UniProt A0A8I5ZNU0 ENTREZGENE, UniProtKB/TrEMBL
  D3ZLS5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-15 Hectd1  HECT domain E3 ubiquitin protein ligase 1  Hectd1  HECT domain containing E3 ubiquitin protein ligase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-17 Hectd1  HECT domain containing E3 ubiquitin protein ligase 1  Hectd1  HECT domain containing 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-29 Hectd1  HECT domain containing 1  RGD1561653_predicted  similar to HECT domain containing 1 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1561653_predicted  similar to HECT domain containing 1 (predicted)  LOC362736  similar to HECT domain containing 1  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC362736  similar to HECT domain containing 1      Symbol and Name status set to provisional 70820 PROVISIONAL