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Gene: Lpar2 (lysophosphatidic acid receptor 2) Rattus norvegicus

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Symbol:

Lpar2

Name:

lysophosphatidic acid receptor 2

RGD ID:

1561336

Description:

Predicted to enable G protein-coupled receptor activity and PDZ domain binding activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. Predicted to act upstream of or within G protein-coupled receptor signaling pathway; positive regulation of MAPK cascade; and positive regulation of Rho protein signal transduction. Predicted to be located in cell surface and endocytic vesicle. Predicted to be active in cytoplasm; glutamatergic synapse; and presynaptic active zone membrane. Orthologous to human LPAR2 (lysophosphatidic acid receptor 2); INTERACTS WITH (+)-schisandrin B; 6-propyl-2-thiouracil; acetamide.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

Edg4; endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor 4; LOC498609; Pbx4; pre-B-cell leukemia transcription factor 4; RGD1561336; similar to endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor 4

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	LPAR2 (lysophosphatidic acid receptor 2)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther
Mus musculus (house mouse):	Lpar2 (lysophosphatidic acid receptor 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Lpar2 (lysophosphatidic acid receptor 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	LPAR2 (lysophosphatidic acid receptor 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	LPAR2 (lysophosphatidic acid receptor 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Lpar2 (lysophosphatidic acid receptor 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	LPAR2 (lysophosphatidic acid receptor 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	LPAR2 (lysophosphatidic acid receptor 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Lpar2 (lysophosphatidic acid receptor 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Lpar2 (lysophosphatidic acid receptor 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	LPAR2 (lysophosphatidic acid receptor 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	LPAR2 (lysophosphatidic acid receptor 2)	Alliance	DIOPT (HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Lpar2 (lysophosphatidic acid receptor 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	lpar2b (lysophosphatidic acid receptor 2b)	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)
Danio rerio (zebrafish):	lpar2a (lysophosphatidic acid receptor 2a)	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	lpar2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	lpar2	Alliance	DIOPT (OrthoFinder\|PANTHER)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	16	19,625,974 - 19,633,905 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	16	19,625,983 - 19,633,905 (-)	Ensembl				GRCr8
mRatBN7.2	16	19,592,067 - 19,599,998 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	16	19,595,655 - 19,599,998 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	16	19,633,944 - 19,641,804 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	16	20,771,896 - 20,779,773 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	16	19,686,925 - 19,694,785 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	16	21,343,313 - 21,348,913 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	16	21,344,456 - 21,348,391 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	16	21,257,145 - 21,262,902 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	16	20,079,826 - 20,085,307 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	16	19,783,465 - 19,789,027 (-)	NCBI		Celera
Cytogenetic Map	16	p14	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

1,1-dichloroethene (ISO)

1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene (ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4,4'-trichlorobiphenyl (ISO)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

all-trans-retinoic acid (ISO)

amitrole (EXP)

antirheumatic drug (ISO)

aristolochic acid A (ISO)

arsenous acid (ISO)

Azoxymethane (ISO)

azoxystrobin (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

bisphenol AF (EXP)

cadmium dichloride (ISO)

chlorpyrifos (ISO)

copper atom (ISO)

copper(0) (ISO)

Cuprizon (EXP)

deguelin (ISO)

dextran sulfate (ISO)

diarsenic trioxide (ISO)

diquat (ISO)

dorsomorphin (ISO)

elemental selenium (ISO)

genistein (ISO)

gentamycin (EXP)

L-ascorbic acid (ISO)

lead(0) (ISO)

lipopolysaccharide (ISO)

methimazole (EXP)

methotrexate (ISO)

Nor-9-carboxy-delta9-THC (ISO)

ozone (ISO)

PCB138 (ISO)

perfluorohexanesulfonic acid (ISO)

phenobarbital (EXP)

picoxystrobin (ISO)

SB 431542 (ISO)

selenium atom (ISO)

temozolomide (ISO)

tetrachloroethene (ISO)

tetrachloromethane (EXP)

titanium dioxide (ISO)

trichloroethene (EXP)

triphenyl phosphate (ISO)

valproic acid (ISO)

vitamin E (ISO)

vorinostat (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

G protein-coupled receptor signaling pathway (IEA,ISO)

positive regulation of MAPK cascade (ISO)

positive regulation of Rho protein signal transduction (ISO)

signal transduction (IEA)

Cellular Component

cell surface (ISO)

endocytic vesicle (ISO)

glutamatergic synapse (ISO)

membrane (IEA)

plasma membrane (IEA)

presynaptic active zone membrane (ISO)

Molecular Function

G protein-coupled receptor activity (IEA)

lysophosphatidic acid receptor activity (IEA)

PDZ domain binding (ISO)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:15755723	PMID:19306925	PMID:19766573	PMID:26027517	PMID:26473723

Genomics

Comparative Map Data

Lpar2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	16	19,625,974 - 19,633,905 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	16	19,625,983 - 19,633,905 (-)	Ensembl				GRCr8
mRatBN7.2	16	19,592,067 - 19,599,998 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	16	19,595,655 - 19,599,998 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	16	19,633,944 - 19,641,804 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	16	20,771,896 - 20,779,773 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	16	19,686,925 - 19,694,785 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	16	21,343,313 - 21,348,913 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	16	21,344,456 - 21,348,391 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	16	21,257,145 - 21,262,902 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	16	20,079,826 - 20,085,307 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	16	19,783,465 - 19,789,027 (-)	NCBI		Celera
Cytogenetic Map	16	p14	NCBI

LPAR2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	19,623,655 - 19,628,220 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	19	19,623,639 - 19,628,930 (-)	Ensembl			hg38	GRCh38
GRCh37	19	19,734,464 - 19,739,029 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	19,595,477 - 19,600,017 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	19	19,595,476 - 19,600,017	NCBI
Celera	19	19,638,539 - 19,643,114 (-)	NCBI		Celera
Cytogenetic Map	19	p13.11	NCBI
HuRef	19	19,296,769 - 19,301,344 (-)	NCBI		HuRef
CHM1_1	19	19,735,551 - 19,740,126 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	19	19,761,164 - 19,765,730 (-)	NCBI		T2T-CHM13v2.0

Lpar2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	70,275,215 - 70,283,752 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	8	70,275,079 - 70,283,752 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	8	69,822,565 - 69,831,102 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	69,822,429 - 69,831,102 (+)	Ensembl			mm10	GRCm38
MGSCv37	8	72,346,464 - 72,355,001 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	8	72,751,418 - 72,760,091 (+)	NCBI		MGSCv36	mm8
Celera	8	72,373,530 - 72,382,072 (+)	NCBI		Celera
Cytogenetic Map	8	B3.3	NCBI
cM Map	8	33.91	NCBI

Lpar2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955524	2,390,598 - 2,394,877 (+)	Ensembl
ChiLan1.0	NW_004955524	2,390,354 - 2,395,436 (+)	NCBI	ChiLan1.0	ChiLan1.0

LPAR2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	20	24,484,829 - 24,489,696 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	19	23,491,289 - 23,496,154 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	19	19,060,927 - 19,065,792 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	19	20,057,179 - 20,062,171 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	19	20,057,179 - 20,061,260 (-)	Ensembl			panPan2	panpan1.1

LPAR2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	43,646,642 - 43,650,270 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	20	43,647,653 - 43,650,710 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	20	43,562,238 - 43,565,865 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	20	44,132,323 - 44,135,954 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	20	44,133,607 - 44,136,385 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	20	43,370,025 - 43,373,646 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	20	43,779,532 - 43,783,139 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	20	44,055,222 - 44,058,857 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Lpar2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	202,323,008 - 202,326,916 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936596	1,872,862 - 1,878,402 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936596	1,872,919 - 1,878,304 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

LPAR2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	58,298,271 - 58,300,844 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	2	58,296,381 - 58,300,869 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	58,395,164 - 58,399,454 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3
Pig Cytomap	2	q2.1	NCBI

LPAR2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	18,082,907 - 18,088,240 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	6	18,082,784 - 18,087,145 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666074	1,210,591 - 1,216,133 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Lpar2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624908	2,349,477 - 2,357,633 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624908	2,349,783 - 2,357,969 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Lpar2
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	13	12,084,722 - 12,089,667 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Lpar2
42 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	74
Count of miRNA genes:	62
Interacting mature miRNAs:	65
Transcripts:	ENSRNOT00000068554
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1549842	Bp248	Blood pressure QTL 248		0.01	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	16	387123	45387123	Rat
2307172	Activ4	Activity QTL 4	3.71	0.00023	locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	16	1	33425095	Rat
1354584	Despr6	Despair related QTL 6	3.1	0.0067	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	16	1	39568015	Rat
737819	Hcas4	Hepatocarcinoma susceptibility QTL 4	4.43		liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	16	4234212	53708481	Rat
631517	Scl9	Serum cholesterol level QTL 9	3.3		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	16	15748006	25801629	Rat
1354625	Despr7	Despair related QTL 7	3.16	0.016	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	16	4744222	49744222	Rat
61405	Niddm6	Non-insulin dependent diabetes mellitus QTL 6	3.66	0.001	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	16	1	26734272	Rat
631830	Alc7	Alcohol consumption QTL 7	2.9		consumption behavior trait (VT:0002069)	ethanol drink intake rate (CMO:0001407)	16	1	26734272	Rat
7411664	Foco30	Food consumption QTL 30	11	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	16	4354822	49354822	Rat
1600378	Arunc4	Aerobic running capacity QTL 4		0.03	exercise endurance trait (VT:0002332)	longest distance run on treadmill (CMO:0001406)	16	387123	45387123	Rat
70183	BpQTLcluster13	Blood pressure QTL cluster 13	3.654		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	16	4234212	49757901	Rat
737826	Alc11	Alcohol consumption QTL 11	3.2		consumption behavior trait (VT:0002069)	ethanol drink intake rate (CMO:0001407)	16	4234212	66955197	Rat
1600369	Hcas8	Hepatocarcinoma susceptibility QTL 8			liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	16	16278184	27244292	Rat
2303566	Bw90	Body weight QTL 90	2		body mass (VT:0001259)	body weight (CMO:0000012)	16	1	39568015	Rat
2312663	Slep9	Serum leptin concentration QTL 9		0.001	blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	16	839086	66195506	Rat
2306902	Bp339	Blood pressure QTL 339		0.01	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	16	3386790	49757901	Rat
1300133	Rf24	Renal function QTL 24	3.64		blood creatinine amount (VT:0005328)	creatinine clearance (CMO:0000765)	16	3386790	26128267	Rat
2312660	Bw95	Body weight QTL 95		0.05	inguinal fat pad mass (VT:0010424)	inguinal fat pad weight to body weight ratio (CMO:0001253)	16	839086	66195506	Rat
2312666	Insul16	Insulin level QTL 16		0.01	blood insulin amount (VT:0001560)	serum insulin level (CMO:0000358)	16	839086	66195506	Rat
634355	Rends4	Renal damage susceptibility QTL 4		0.05	kidney blood vessel morphology trait (VT:0000530)	organ lesion measurement (CMO:0000677)	16	1	26734272	Rat
70205	Gcr3	Gastric cancer resistance QTL 3	2.3		stomach morphology trait (VT:0000470)	stomach tumor diameter (CMO:0001889)	16	17730818	72536785	Rat
2293343	Glom16	Glomerulus QTL 16	7.4		kidney glomerulus integrity trait (VT:0010546)	kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)	16	839086	52786090	Rat
2301406	Kidm39	Kidney mass QTL 39		0.002	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	16	15905802	60905802	Rat
2312669	Stl23	Serum triglyceride level QTL 23		0.01	blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	16	839086	66195506	Rat
6903319	Bw114	Body weight QTL 114	2.7	0.0037	body mass (VT:0001259)	body weight (CMO:0000012)	16	3301683	48301683	Rat

Markers in Region

RH132663

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	16	19,600,753 - 19,600,952 (+)	MAPPER	mRatBN7.2
Rnor_6.0	16	21,349,683 - 21,349,881	NCBI	Rnor6.0
Rnor_5.0	16	21,263,672 - 21,263,870	UniSTS	Rnor5.0
RGSC_v3.4	16	20,086,077 - 20,086,275	UniSTS	RGSC3.4
Celera	16	19,789,783 - 19,789,981	UniSTS
RH 3.4 Map	16	239.92	UniSTS
Cytogenetic Map	16	p14	UniSTS

PMC134025P1

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	16	19,598,320 - 19,598,631 (+)	MAPPER	mRatBN7.2
Rnor_6.0	16	21,347,235 - 21,347,545	NCBI	Rnor6.0
Rnor_5.0	16	21,261,224 - 21,261,534	UniSTS	Rnor5.0
RGSC_v3.4	16	20,083,629 - 20,083,939	UniSTS	RGSC3.4
Celera	16	19,787,350 - 19,787,660	UniSTS
Cytogenetic Map	16	p14	UniSTS

PMC134025P2

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	16	19,598,320 - 19,598,813 (+)	MAPPER	mRatBN7.2
Rnor_6.0	16	21,347,235 - 21,347,727	NCBI	Rnor6.0
Rnor_5.0	16	21,261,224 - 21,261,716	UniSTS	Rnor5.0
RGSC_v3.4	16	20,083,629 - 20,084,121	UniSTS	RGSC3.4
Celera	16	19,787,350 - 19,787,842	UniSTS
Cytogenetic Map	16	p14	UniSTS

PMC134025P3

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	16	19,598,563 - 19,598,813 (+)	MAPPER	mRatBN7.2
Rnor_6.0	16	21,347,478 - 21,347,727	NCBI	Rnor6.0
Rnor_5.0	16	21,261,467 - 21,261,716	UniSTS	Rnor5.0
RGSC_v3.4	16	20,083,872 - 20,084,121	UniSTS	RGSC3.4
Celera	16	19,787,593 - 19,787,842	UniSTS
Cytogenetic Map	16	p14	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	3	58	153	91	90	59	87	59	6	330	172	11	132	81	92	31	15	15

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001109109	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH474031	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000016	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000068554 ⟹ ENSRNOP00000058977

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	16	21,345,289 - 21,347,968 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000083537 ⟹ ENSRNOP00000073244

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	16	19,595,655 - 19,599,998 (-)	Ensembl
Rnor_6.0 Ensembl	16	21,344,456 - 21,348,391 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000137486 ⟹ ENSRNOP00000105420

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	16	19,625,983 - 19,633,905 (-)	Ensembl

RefSeq Acc Id:

NM_001109109 ⟹ NP_001102579

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	16	19,625,974 - 19,633,905 (-)	NCBI
mRatBN7.2	16	19,592,067 - 19,599,998 (-)	NCBI
Rnor_6.0	16	21,343,313 - 21,348,913 (-)	NCBI
Rnor_5.0	16	21,257,145 - 21,262,902 (-)	NCBI
RGSC_v3.4	16	20,079,826 - 20,085,307 (-)	RGD
Celera	16	19,783,465 - 19,789,027 (-)	RGD

Sequence:

show sequence

CGCCCGCTGCGCAACCGCTGGGTTGCAGGGCCATGGGTCTCAGTCCTGCCTCGACCCACCGCAA
GCCCGCCCAATCTGCCGCTTGACTGGAGGCCCAGGTGGCCACCATGGGCCAGTGCTACTACAAT
GAGACCATCGGCTTTTTCTATAATAACAGCGGCAAGGAGCTCAGCCTTCACTGGCGCCCCAAAG
ATGTGGTGGTGGTGGCCCTGGGGCTGACAGTCAGTGTGCTGGTATTGCTGACCAACCTGCTGGT
TATTGCAGCCATTGCCTCCAACCGACGCTTCCACCAGCCCATATACTACCTGCTTGGCAACTTG
GCTGCAGCTGACCTCTTCGCTGGCATGGCCTACCTCTTCCTCATGTTCCATACTGGCCCCCGCA
CCGCCAGGCTCTCCATCAAAGGCTGGTTCCTGCGACAGGGCCTGCTGGACACCAGCCTCACGGC
ATCGGTGGCCACGTTGCTGGCCATTGCTGTGGAACGGCACCGCAGTGTGATGGCTGTGCAGCTG
CACAGCCGCTTGCCCCGGGGTCGTGTGGTCACACTCATCGTGGGAGTGTGGGTGGCTGCGCTGG
GTCTGGGGTTGCTGCCTGCACACTTCTGGCACTGCCTCTGTGACTTGGACAGCTGCTCACGAAT
GGTGCCCCTGTTCAGCCGCTCCTACCTGGCTGTGTGGGCCCTATCCAGCCTGCTTGTCTTCCTA
CTCATGGTAGCCGTCTACACACGAATTTTCTTCTTTGTGCGCAGACGGGTTGAACGCATGGCAG
AGCACGTCAGCTGCCATCCCCGCTACCGAGAGACAACGCTCAGCCTAGTCAAGACAGTTGTCAT
CATTCTGGGGGCATTTGTGGTGTGCTGGACACCGGGGCCAGGTGGTGCTGCTCTTGGACGGTCT
GGACTGTAAATCCTGCAACGTTCTGGCTGTGGAGAAGTACTTCCTGCTCCTGGCCGAGGCCAAC
TCCCTGGTCAACGCGGTGGTGTACTCGTGCCGAGACGCTGAGATGCGCCGTACCTTCCGCCGCC
TTCTCTGTTGCACGTGTCTCCGCTGGTCGCACCACAAGTCTGCCCATTATTCATCCTCTGCCCG
GACAGGTGCCAGCACCCGGATCATGCTTCCTGAGAATGGCCACCCACTGATGGACTCCACCCTT
TAGTACCTTGGACCGAGGCAGGAGGCAGGAGCTTCAGTGGCAGCCCACGGCCACTCGAAGAGCC
CCTGAGTCAAGCCCGCCCAGCAGATGCATGGCTCTGCCCCAGGACACAGGGATTCGGGGACATC
TCCATGCACCTGGGGAGAGCATCCAAATGGGACTTGGCAATCCGGCTCTCAATCATCTCAGGTT
TTAGGGTTTTTAACAGACATTTTCATATTTTTACTGTACATCTCTGGCATGTCTGTGGACTGCT
GCTTCCTCCGTGGTGCTGTAACTGTTGAGATAGAAGAGGTGAGAGCTGTCTCAGGTTAATACCA
CCCACTGTTACAGGGTAGACTGAAGGCTACTGCCTTCCTGAGGCTACTGCCTTCCTGAGGCTAC
TGCCTTCCTGAGGCTACTGCCTTCCTGAGGCTACTGCCTTCCTGAGGCTACTGCCTTCCTGAGG
CTACTGCCTTCCTGAGGCTACTTTCTGTTGTTCTGTTTTGCTTTTGAGACAGGATCTCATATAG
CCTATGCTGGCCTTGAATTCACTGTGTAACTGAGGATGGCCTTGAACTCTTGATGGTCCTGACT
CCACTCCCAAGTGCTGTACGGAAGCTGATTGCTCAGAAGCACTGAGCAGCCTGAGGGCTCACCT
GCCTCCCCTTAGTTCGAGGGACCCGCAATACAGAGCAAGCCTTTCTTTTTTTTTTTTTTTTTTT
TAATAAGCAAAGGCGAGGTTTATTACGGAGATCTATTGCGGAGATCTCTGGGCTGACATGTATC
CTGCGCAGGAGACAGAGGTGTCGACCCAGAGCAAGCCTTTCCACTCTGAGGTACAGACCTGGGT
TTTGGTTCAGTTTGGTTTGTTTTTGTTTTTCTGCTGGTTGGTTGGTGTTTTGCCATTAATTCAG
TCAGTCTGTCCCAGTGTCCTGGAATTATCTATTATGACTCAGGGCTGCCAAGAATCCTTCAACA
TGGAATCCCGTGGCCTAGGCTAGCCTTGAACTTGCTGTATAGATAGGCAGGTCTTGAAATCCAT
TGTCCTGCCTCAGAGTCCTGTATGTCTCTTCCTGGAGTGTTACAAATATTCCTTTCCTTTTGCC
TCTGTCCTGCCTCCAACTGTCCTATCTCCTTCTCAAAGAACCTAGGTTGATTTCCTGTTTGTGT
AATCCTGCTTTTCCTTCTGCTGGCCCCCAGACCCCCTTGCTTTTCGACTCAGAATATCACAGTG
TACCCAGCCCATCCTAGAACTTACCATGCAGCTCAGGATAACTTCAAAGTCGCAGCTGTCTTCC
TGCCCTGGCTCCCTGGGTACTGGGATGACAAGCTATATTGAAATGCGGCCTGTGTCTGACTGTA
CATCGTGGAAAAGCATAGATATACCAGGAGGGACCAGGAAACTCCATGAGGAAGGGGCCTGAGT
GGAGCCTAGAATTAAGTCACAAGCTTACCTGGACTCTCGCCTTCTGAGTCCCCCGAGACCTCAG
ATATGCCAGGCCTGAGGTCAGCCCCCTCCCTGCCTAGGAAGCCTCCTGTCAGGCAGTGTGAGCC
GCTGTGAACTTGGTTCCCTGCTCCCTCTCACCAGAGAGGAGTCAGGGTTATGCTCTCACCTCGG
ATTCCCATGCCGAATAGCAGCAGGAATTTGAAGCTCTGTCTTATCTGAGGCCAAATTCTTAAGG
CATTAAAGCATCCATTTCTA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001102579	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL90623	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000105420
	ENSRNOP00000105420.1

RefSeq Acc Id:

NP_001102579 ⟸ NM_001109109

- UniProtKB:

A0A0G2K505 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MGQCYYNETIGFFYNNSGKELSLHWRPKDVVVVALGLTVSVLVLLTNLLVIAAIASNRRFHQPI
YYLLGNLAAADLFAGMAYLFLMFHTGPRTARLSIKGWFLRQGLLDTSLTASVATLLAIAVERHR
SVMAVQLHSRLPRGRVVTLIVGVWVAALGLGLLPAHFWHCLCDLDSCSRMVPLFSRSYLAVWAL
SSLLVFLLMVAVYTRIFFFVRRRVERMAEHVSCHPRYRETTLSLVKTVVIILGAFVVCWTPGPG
GAALGRSGL

hide sequence

Ensembl Acc Id:

ENSRNOP00000058977 ⟸ ENSRNOT00000068554

Ensembl Acc Id:

ENSRNOP00000073244 ⟸ ENSRNOT00000083537

Ensembl Acc Id:

ENSRNOP00000105420 ⟸ ENSRNOT00000137486

Protein Domains

G-protein coupled receptors family 1 profile

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-A0A0G2K505-F1-model_v2	AlphaFold	A0A0G2K505	1-348	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1561336	AgrOrtholog
BioCyc Gene	G2FUF-11741	BioCyc
Ensembl Genes	ENSRNOG00000010758	Ensembl
	ENSRNOG00000090786	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000137486	ENTREZGENE
	ENSRNOT00000137486.1	UniProtKB/TrEMBL
Gene3D-CATH	Rhodopsin 7-helix transmembrane proteins	UniProtKB/TrEMBL
InterPro	GPCR_Rhodpsn	UniProtKB/TrEMBL
	GPCR_Rhodpsn_7TM	UniProtKB/TrEMBL
	LPA_rcpt	UniProtKB/TrEMBL
	LPA_rcpt_EDG4	UniProtKB/TrEMBL
KEGG Report	rno:498609	UniProtKB/TrEMBL
NCBI Gene	498609	ENTREZGENE
PANTHER	G-PROTEIN COUPLED RECEPTOR	UniProtKB/TrEMBL
Pfam	7tm_1	UniProtKB/TrEMBL
PhenoGen	Lpar2	PhenoGen
PRINTS	EDG4RECEPTOR	UniProtKB/TrEMBL
	GPCRRHODOPSN	UniProtKB/TrEMBL
	LPARECEPTOR	UniProtKB/TrEMBL
PROSITE	G_PROTEIN_RECEP_F1_1	UniProtKB/TrEMBL
	G_PROTEIN_RECEP_F1_2	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000010758	RatGTEx
	ENSRNOG00000090786	RatGTEx
Superfamily-SCOP	Family A G protein-coupled receptor-like	UniProtKB/TrEMBL
UniProt	A0A0G2K505	ENTREZGENE
	A0ABK0LT65_RAT	UniProtKB/TrEMBL
	A6KAB4_RAT	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-04-25	Lpar2	lysophosphatidic acid receptor 2	Edg4	endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor 4	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-03-06	Edg4	endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor 4	Pbx4_predicted	pre-B-cell leukemia transcription factor 4 (predicted)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-09-26	Pbx4_predicted	pre-B-cell leukemia transcription factor 4 (predicted)	RGD1561336_predicted	similar to endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor 4 (predicted)	Symbol and Name updated to reflect Human and Mouse nomenclature	1299863	APPROVED
2006-09-26	Edg4_predicted	endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor 4 (predicted)	RGD1561336_predicted	similar to endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor 4 (predicted)	Symbol and Name updated to reflect Human and Mouse nomenclature	1299863	APPROVED
2006-03-10	RGD1561336_predicted	similar to endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor 4 (predicted)			Name updated	1299863	APPROVED
2006-03-07	RGD1561336_predicted	similar to endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor 4 (predicted)	LOC498609	similar to endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor 4	Symbol and Name status set to approved	1299863	APPROVED
2006-02-09	LOC498609	similar to endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor 4			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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