LPAR2 (lysophosphatidic acid receptor 2) - Rat Genome Database

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Gene: LPAR2 (lysophosphatidic acid receptor 2) Homo sapiens
Analyze
Symbol: LPAR2
Name: lysophosphatidic acid receptor 2
RGD ID: 1312931
HGNC Page HGNC:3168
Description: Predicted to enable G protein-coupled receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway and regulation of metabolic process. Predicted to act upstream of or within G protein-coupled receptor signaling pathway; positive regulation of MAPK cascade; and positive regulation of Rho protein signal transduction. Located in cell surface and endocytic vesicle.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: EDG-4; EDG4; endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 4; FLJ93869; G protein-coupled receptor; LPA receptor 2; LPA receptor EDG4; LPA-2; LPA2; lysophosphatidic acid receptor Edg-4; lysophosphatidic acid receptor EDG4
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381919,623,655 - 19,628,220 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1919,623,655 - 19,628,930 (-)EnsemblGRCh38hg38GRCh38
GRCh371919,734,464 - 19,739,029 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361919,595,477 - 19,600,017 (-)NCBINCBI36Build 36hg18NCBI36
Build 341919,595,476 - 19,600,017NCBI
Celera1919,638,539 - 19,643,114 (-)NCBICelera
Cytogenetic Map19p13.11NCBI
HuRef1919,296,769 - 19,301,344 (-)NCBIHuRef
CHM1_11919,735,551 - 19,740,126 (-)NCBICHM1_1
T2T-CHM13v2.01919,761,164 - 19,765,730 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:2834384   PMID:9525886   PMID:9804623   PMID:10537322   PMID:10729222   PMID:10818441   PMID:10922489   PMID:10954727   PMID:11024010   PMID:11093753   PMID:12123830   PMID:12477932  
PMID:12668280   PMID:12759391   PMID:14688263   PMID:14702039   PMID:15057824   PMID:15143197   PMID:15489334   PMID:15535846   PMID:15728708   PMID:15755723   PMID:16147992   PMID:16203867  
PMID:16341674   PMID:16344560   PMID:16624523   PMID:16754659   PMID:16904289   PMID:17496233   PMID:17765657   PMID:17965021   PMID:18703779   PMID:18754873   PMID:18976975   PMID:19001604  
PMID:19025891   PMID:19081821   PMID:19116446   PMID:19293149   PMID:19306925   PMID:19860625   PMID:19899077   PMID:20890765   PMID:21134377   PMID:21234797   PMID:21873635   PMID:21964883  
PMID:22359512   PMID:23084965   PMID:23145131   PMID:23275563   PMID:23569130   PMID:23974872   PMID:24061591   PMID:24602016   PMID:24613836   PMID:24950964   PMID:25463482   PMID:26327335  
PMID:26937138   PMID:27124742   PMID:27244685   PMID:27583415   PMID:27805252   PMID:28205098   PMID:28514442   PMID:29621954   PMID:29859140   PMID:30093116   PMID:31115486   PMID:31235682  
PMID:31741433   PMID:32006610   PMID:33347862   PMID:33406026   PMID:33959968   PMID:33961781   PMID:35241179   PMID:35799024   PMID:35857125  


Genomics

Comparative Map Data
LPAR2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381919,623,655 - 19,628,220 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1919,623,655 - 19,628,930 (-)EnsemblGRCh38hg38GRCh38
GRCh371919,734,464 - 19,739,029 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361919,595,477 - 19,600,017 (-)NCBINCBI36Build 36hg18NCBI36
Build 341919,595,476 - 19,600,017NCBI
Celera1919,638,539 - 19,643,114 (-)NCBICelera
Cytogenetic Map19p13.11NCBI
HuRef1919,296,769 - 19,301,344 (-)NCBIHuRef
CHM1_11919,735,551 - 19,740,126 (-)NCBICHM1_1
T2T-CHM13v2.01919,761,164 - 19,765,730 (-)NCBIT2T-CHM13v2.0
Lpar2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39870,275,215 - 70,283,752 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl870,275,079 - 70,283,752 (+)EnsemblGRCm39 Ensembl
GRCm38869,822,565 - 69,831,102 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl869,822,429 - 69,831,102 (+)EnsemblGRCm38mm10GRCm38
MGSCv37872,346,464 - 72,355,001 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36872,751,418 - 72,760,091 (+)NCBIMGSCv36mm8
Celera872,373,530 - 72,382,072 (+)NCBICelera
Cytogenetic Map8B3.3NCBI
cM Map833.91NCBI
Lpar2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81619,625,974 - 19,633,905 (-)NCBIGRCr8
mRatBN7.21619,592,067 - 19,599,998 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1619,595,655 - 19,599,998 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1619,633,944 - 19,641,804 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01620,771,896 - 20,779,773 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01619,686,925 - 19,694,785 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01621,343,313 - 21,348,913 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1621,344,456 - 21,348,391 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01621,257,145 - 21,262,902 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41620,079,826 - 20,085,307 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1619,783,465 - 19,789,027 (-)NCBICelera
Cytogenetic Map16p14NCBI
Lpar2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555242,390,598 - 2,394,877 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555242,390,354 - 2,395,436 (+)NCBIChiLan1.0ChiLan1.0
LPAR2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22024,484,829 - 24,489,696 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11923,491,289 - 23,496,154 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01919,060,927 - 19,065,792 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11920,057,179 - 20,062,171 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1920,057,179 - 20,061,260 (-)Ensemblpanpan1.1panPan2
LPAR2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12043,646,642 - 43,650,270 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2043,647,653 - 43,650,710 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2043,562,238 - 43,565,865 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02044,132,323 - 44,135,954 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2044,133,607 - 44,136,385 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12043,370,025 - 43,373,646 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02043,779,532 - 43,783,139 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02044,055,222 - 44,058,857 (+)NCBIUU_Cfam_GSD_1.0
Lpar2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118202,323,008 - 202,326,916 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365961,872,862 - 1,878,402 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365961,872,919 - 1,878,304 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LPAR2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl258,298,271 - 58,300,844 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1258,296,381 - 58,300,869 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2258,395,164 - 58,399,454 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap2q2.1NCBI
LPAR2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1618,082,907 - 18,088,240 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl618,082,784 - 18,087,145 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660741,210,591 - 1,216,133 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lpar2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249082,349,477 - 2,357,633 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249082,349,783 - 2,357,969 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in LPAR2
21 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 19p13.11-q13.11(chr19:17176767-34924150)x3 copy number gain See cases [RCV000050635] Chr19:17176767..34924150 [GRCh38]
Chr19:17287576..35415054 [GRCh37]
Chr19:17148576..40106894 [NCBI36]
Chr19:19p13.11-q13.11		 pathogenic
GRCh38/hg38 19p13.12-q11(chr19:13974677-27839676)x3 copy number gain See cases [RCV000052912] Chr19:13974677..27839676 [GRCh38]
Chr19:14085489..28330584 [GRCh37]
Chr19:13946489..33022424 [NCBI36]
Chr19:19p13.12-q11		 pathogenic
NM_016573.3(GMIP):c.2898C>G (p.Ala966=) single nucleotide variant Malignant melanoma [RCV000072029] Chr19:19629978 [GRCh38]
Chr19:19740787 [GRCh37]
Chr19:19601787 [NCBI36]
Chr19:19p13.11		 not provided
GRCh38/hg38 19p13.2-q13.31(chr19:11227942-44626354)x3 copy number gain See cases [RCV000133888] Chr19:11227942..44626354 [GRCh38]
Chr19:11338618..45129651 [GRCh37]
Chr19:11199618..49821491 [NCBI36]
Chr19:19p13.2-q13.31		 pathogenic
GRCh38/hg38 19p13.12-12(chr19:15133594-24193591)x3 copy number gain See cases [RCV000136696] Chr19:15133594..24193591 [GRCh38]
Chr19:15244405..24376393 [GRCh37]
Chr19:15105405..24168233 [NCBI36]
Chr19:19p13.12-12		 pathogenic|likely pathogenic
chr19:19230868-24115369 complex variant complex Breast ductal adenocarcinoma [RCV000207223] Chr19:19230868..24115369 [GRCh37]
Chr19:19p13.11-12		 uncertain significance
GRCh37/hg19 19p13.11-11(chr19:16526787-24631604)x3 copy number gain not provided [RCV000752593] Chr19:16526787..24631604 [GRCh37]
Chr19:19p13.11-11		 pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:260912-58956888)x3 copy number gain See cases [RCV000511289] Chr19:260912..58956888 [GRCh37]
Chr19:19p13.3-q13.43		 pathogenic|uncertain significance
NM_001395660.1(LPAR2):c.121G>T (p.Val41Leu) single nucleotide variant Inborn genetic diseases [RCV003267622] Chr19:19627155 [GRCh38]
Chr19:19737964 [GRCh37]
Chr19:19p13.11		 uncertain significance
GRCh37/hg19 19p13.3-q13.43(chr19:260912-58956888) copy number gain See cases [RCV000512296] Chr19:260912..58956888 [GRCh37]
Chr19:19p13.3-q13.43		 pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:68029-59110290)x3 copy number gain not provided [RCV000752439] Chr19:68029..59110290 [GRCh37]
Chr19:19p13.3-q13.43		 pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:260912-59097160)x3 copy number gain not provided [RCV000752444] Chr19:260912..59097160 [GRCh37]
Chr19:19p13.3-q13.43		 pathogenic
NM_004720.6(LPAR2):c.707C>T (p.Thr236Met) single nucleotide variant not provided [RCV000973224] Chr19:19626578 [GRCh38]
Chr19:19737387 [GRCh37]
Chr19:19p13.11		 benign
NM_004720.6(LPAR2):c.873T>C (p.Asn291=) single nucleotide variant not provided [RCV000971341] Chr19:19624439 [GRCh38]
Chr19:19735248 [GRCh37]
Chr19:19p13.11		 benign
NM_001395660.1(LPAR2):c.884G>A (p.Arg295Gln) single nucleotide variant Inborn genetic diseases [RCV003244713] Chr19:19624419 [GRCh38]
Chr19:19735228 [GRCh37]
Chr19:19p13.11		 uncertain significance
GRCh37/hg19 19p13.11(chr19:19709006-19793143)x1 copy number loss not provided [RCV000848096] Chr19:19709006..19793143 [GRCh37]
Chr19:19p13.11		 uncertain significance
GRCh37/hg19 19p13.11(chr19:19560981-19962412)x3 copy number gain not provided [RCV000849580] Chr19:19560981..19962412 [GRCh37]
Chr19:19p13.11		 uncertain significance
NM_004720.6(LPAR2):c.102C>T (p.Val34=) single nucleotide variant not provided [RCV000955553] Chr19:19627183 [GRCh38]
Chr19:19737992 [GRCh37]
Chr19:19p13.11		 benign
NM_004720.6(LPAR2):c.414G>A (p.Leu138=) single nucleotide variant not provided [RCV000888862] Chr19:19626871 [GRCh38]
Chr19:19737680 [GRCh37]
Chr19:19p13.11		 benign
NM_004720.6(LPAR2):c.540C>T (p.Arg180=) single nucleotide variant not provided [RCV000908826] Chr19:19626745 [GRCh38]
Chr19:19737554 [GRCh37]
Chr19:19p13.11		 benign
GRCh37/hg19 19p13.12-12(chr19:14286624-20956753)x3 copy number gain not provided [RCV001259370] Chr19:14286624..20956753 [GRCh37]
Chr19:19p13.12-12		 pathogenic
GRCh37/hg19 19p13.11-q13.2(chr19:19546923-41313229)x3 copy number gain Specific learning disability [RCV001801194] Chr19:19546923..41313229 [GRCh37]
Chr19:19p13.11-q13.2		 pathogenic
NM_001395660.1(LPAR2):c.617C>A (p.Thr206Asn) single nucleotide variant Inborn genetic diseases [RCV003275999] Chr19:19626659 [GRCh38]
Chr19:19737468 [GRCh37]
Chr19:19p13.11		 uncertain significance
NM_001395660.1(LPAR2):c.-1C>G single nucleotide variant Inborn genetic diseases [RCV002902752] Chr19:19627276 [GRCh38]
Chr19:19738085 [GRCh37]
Chr19:19p13.11		 uncertain significance
NM_001395660.1(LPAR2):c.1021C>T (p.His341Tyr) single nucleotide variant Inborn genetic diseases [RCV002728749] Chr19:19624282 [GRCh38]
Chr19:19735091 [GRCh37]
Chr19:19p13.11		 uncertain significance
NM_001395660.1(LPAR2):c.227T>G (p.Leu76Arg) single nucleotide variant Inborn genetic diseases [RCV002950499] Chr19:19627049 [GRCh38]
Chr19:19737858 [GRCh37]
Chr19:19p13.11		 uncertain significance
NM_001395660.1(LPAR2):c.520C>T (p.Arg174Cys) single nucleotide variant Inborn genetic diseases [RCV002911702] Chr19:19626756 [GRCh38]
Chr19:19737565 [GRCh37]
Chr19:19p13.11		 uncertain significance
NM_001395660.1(LPAR2):c.565G>A (p.Val189Ile) single nucleotide variant Inborn genetic diseases [RCV002930666] Chr19:19626711 [GRCh38]
Chr19:19737520 [GRCh37]
Chr19:19p13.11		 uncertain significance
NM_001395660.1(LPAR2):c.638G>T (p.Arg213Leu) single nucleotide variant Inborn genetic diseases [RCV002873216] Chr19:19626638 [GRCh38]
Chr19:19737447 [GRCh37]
Chr19:19p13.11		 uncertain significance
NM_001395660.1(LPAR2):c.306C>A (p.Phe102Leu) single nucleotide variant Inborn genetic diseases [RCV002665830] Chr19:19626970 [GRCh38]
Chr19:19737779 [GRCh37]
Chr19:19p13.11		 uncertain significance
NM_001395660.1(LPAR2):c.397G>A (p.Val133Met) single nucleotide variant Inborn genetic diseases [RCV002702726] Chr19:19626879 [GRCh38]
Chr19:19737688 [GRCh37]
Chr19:19p13.11		 uncertain significance
NM_001395660.1(LPAR2):c.952G>A (p.Glu318Lys) single nucleotide variant Inborn genetic diseases [RCV002672873] Chr19:19624351 [GRCh38]
Chr19:19735160 [GRCh37]
Chr19:19p13.11		 uncertain significance
NM_001395660.1(LPAR2):c.641G>T (p.Arg214Leu) single nucleotide variant Inborn genetic diseases [RCV002747697] Chr19:19626635 [GRCh38]
Chr19:19737444 [GRCh37]
Chr19:19p13.11		 uncertain significance
NM_001395660.1(LPAR2):c.620G>A (p.Arg207His) single nucleotide variant Inborn genetic diseases [RCV003203658] Chr19:19626656 [GRCh38]
Chr19:19737465 [GRCh37]
Chr19:19p13.11		 uncertain significance
NM_001395660.1(LPAR2):c.422G>A (p.Arg141His) single nucleotide variant Inborn genetic diseases [RCV003200784] Chr19:19626854 [GRCh38]
Chr19:19737663 [GRCh37]
Chr19:19p13.11		 uncertain significance
NM_001395660.1(LPAR2):c.364A>G (p.Ile122Val) single nucleotide variant Inborn genetic diseases [RCV003360469] Chr19:19626912 [GRCh38]
Chr19:19737721 [GRCh37]
Chr19:19p13.11		 uncertain significance
GRCh37/hg19 19p13.11-12(chr19:18926463-21100330)x1 copy number loss not specified [RCV003986109] Chr19:18926463..21100330 [GRCh37]
Chr19:19p13.11-12		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2804
Count of miRNA genes:797
Interacting mature miRNAs:929
Transcripts:ENST00000407877, ENST00000542587, ENST00000586703, ENST00000588233, ENST00000588461, ENST00000589311, ENST00000590629, ENST00000591042, ENST00000592061
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
EDG4  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371919,737,474 - 19,737,838UniSTSGRCh37
Celera1919,641,549 - 19,641,913UniSTS
HuRef1919,299,779 - 19,300,143UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 780 827 848 141 1615 36 1631 39 340 138 1062 1491 118 267 735 1
Low 1654 2012 860 469 332 415 2289 1609 3300 279 387 117 53 1 937 1620 2 1
Below cutoff 2 145 17 13 3 14 435 543 74 1 7 3 1 433 2

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000407877   ⟹   ENSP00000384665
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1919,623,655 - 19,628,220 (-)Ensembl
RefSeq Acc Id: ENST00000542587   ⟹   ENSP00000443256
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1919,623,669 - 19,628,930 (-)Ensembl
RefSeq Acc Id: ENST00000586703   ⟹   ENSP00000465280
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1919,623,668 - 19,628,208 (-)Ensembl
RefSeq Acc Id: ENST00000588233   ⟹   ENSP00000466112
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1919,627,061 - 19,628,761 (-)Ensembl
RefSeq Acc Id: ENST00000588461   ⟹   ENSP00000466940
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1919,627,224 - 19,628,529 (-)Ensembl
RefSeq Acc Id: ENST00000589311
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1919,627,848 - 19,628,550 (-)Ensembl
RefSeq Acc Id: ENST00000590629
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1919,627,505 - 19,628,221 (-)Ensembl
RefSeq Acc Id: ENST00000591042   ⟹   ENSP00000468132
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1919,627,044 - 19,628,215 (-)Ensembl
RefSeq Acc Id: ENST00000592061   ⟹   ENSP00000465206
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1919,627,209 - 19,627,800 (-)Ensembl
RefSeq Acc Id: NM_001395660   ⟹   NP_001382589
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381919,623,655 - 19,628,220 (-)NCBI
T2T-CHM13v2.01919,761,164 - 19,765,730 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: ENSP00000443256   ⟸   ENST00000542587
RefSeq Acc Id: ENSP00000465280   ⟸   ENST00000586703
RefSeq Acc Id: ENSP00000466940   ⟸   ENST00000588461
RefSeq Acc Id: ENSP00000466112   ⟸   ENST00000588233
RefSeq Acc Id: ENSP00000384665   ⟸   ENST00000407877
RefSeq Acc Id: ENSP00000468132   ⟸   ENST00000591042
RefSeq Acc Id: ENSP00000465206   ⟸   ENST00000592061
RefSeq Acc Id: NP_001382589   ⟸   NM_001395660
- UniProtKB: Q9HBW0 (UniProtKB/Swiss-Prot),   O00543 (UniProtKB/Swiss-Prot),   O43431 (UniProtKB/Swiss-Prot),   B2RE65 (UniProtKB/TrEMBL),   B3KVP9 (UniProtKB/TrEMBL)
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9HBW0-F1-model_v2 AlphaFold Q9HBW0 1-348 view protein structure

Promoters
RGD ID:6814644
Promoter ID:HG_XEF:3965
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lymphoblastoid
Transcripts:NM_001007474,   NM_001094167,   NM_001109109,   NM_001115081,   NM_001162401
Position:
Human AssemblyChrPosition (strand)Source
Build 361919,599,231 - 19,599,887 (-)MPROMDB
RGD ID:6795764
Promoter ID:HG_KWN:29371
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   HeLa_S3,   K562,   Lymphoblastoid
Transcripts:NM_004720,   UC002NNA.2,   UC002NNC.2
Position:
Human AssemblyChrPosition (strand)Source
Build 361919,599,961 - 19,601,512 (-)MPROMDB
RGD ID:7239263
Promoter ID:EPDNEW_H25378
Type:initiation region
Name:LPAR2_1
Description:lysophosphatidic acid receptor 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381919,628,220 - 19,628,280EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:3168 AgrOrtholog
COSMIC LPAR2 COSMIC
Ensembl Genes ENSG00000064547 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000407877 ENTREZGENE
  ENST00000407877.8 UniProtKB/Swiss-Prot
  ENST00000542587.5 UniProtKB/Swiss-Prot
  ENST00000586703.1 UniProtKB/Swiss-Prot
  ENST00000588233.1 UniProtKB/TrEMBL
  ENST00000588461.1 UniProtKB/TrEMBL
  ENST00000591042.1 UniProtKB/TrEMBL
  ENST00000592061.1 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000064547 GTEx
HGNC ID HGNC:3168 ENTREZGENE
Human Proteome Map LPAR2 Human Proteome Map
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LPA_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LPA_rcpt_EDG4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 9170 ENTREZGENE
OMIM 605110 OMIM
PANTHER G-PROTEIN COUPLED RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LYSOPHOSPHATIDIC ACID RECEPTOR 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA162394202 PharmGKB
PRINTS EDG4RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LPARECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt B2RE65 ENTREZGENE, UniProtKB/TrEMBL
  B3KVP9 ENTREZGENE, UniProtKB/TrEMBL
  K7EJJ9_HUMAN UniProtKB/TrEMBL
  K7ELJ6_HUMAN UniProtKB/TrEMBL
  K7ENG7_HUMAN UniProtKB/TrEMBL
  K7ER68_HUMAN UniProtKB/TrEMBL
  L8E990_HUMAN UniProtKB/TrEMBL
  LPAR2_HUMAN UniProtKB/Swiss-Prot
  O00543 ENTREZGENE
  O43431 ENTREZGENE
  Q9HBW0 ENTREZGENE
UniProt Secondary O00543 UniProtKB/Swiss-Prot
  O43431 UniProtKB/Swiss-Prot