Deptor (DEP domain containing MTOR-interacting protein) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Deptor (DEP domain containing MTOR-interacting protein) Rattus norvegicus
Analyze
Symbol: Deptor
Name: DEP domain containing MTOR-interacting protein
RGD ID: 1561030
Description: Predicted to enable GTPase regulator activity; phosphatidic acid binding activity; and protein serine/threonine kinase inhibitor activity. Predicted to be involved in several processes, including negative regulation of TOR signaling; negative regulation of cell size; and regulation of extrinsic apoptotic signaling pathway. Predicted to act upstream of or within several processes, including TORC1 signaling; autophagosome assembly; and negative regulation of autophagy. Predicted to be located in lysosome and membrane. Predicted to be active in lysosomal membrane and plasma membrane. Orthologous to human DEPTOR (DEP domain containing MTOR interacting protein); PARTICIPATES IN mTOR signaling pathway; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: DEP domain containing 6; Depdc6; hypothetical protein LOC100359815; LOC100359815; LOC102547145; LOC314979; RGD1561030; similar to DEP domain containing 6; uncharacterized LOC102547145
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8788,404,745 - 88,574,065 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl788,404,620 - 88,574,041 (+)EnsemblGRCr8
mRatBN7.2786,514,859 - 86,668,817 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl786,514,988 - 86,667,773 (+)EnsemblmRatBN7.2
Rnor_6.0794,795,161 - 95,000,750 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl794,795,214 - 94,995,809 (+)Ensemblrn6Rnor6.0
Rnor_5.0795,520,754 - 95,625,869 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4791,675,825 - 91,742,576 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera783,308,700 - 83,462,454 (+)NCBICelera
Cytogenetic Map7q32NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,2-dichloroethane  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (ISO)
amphotericin B  (ISO)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
bafilomycin A1  (EXP)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bicalutamide  (ISO)
bilirubin IXalpha  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
buspirone  (EXP)
Butylbenzyl phthalate  (ISO)
cadmium dichloride  (EXP,ISO)
cannabidiol  (EXP,ISO)
carbon nanotube  (ISO)
chloroprene  (EXP)
choline  (ISO)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
cytarabine  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
diethylstilbestrol  (ISO)
dimethyl sulfoxide  (ISO)
Doramectin  (EXP)
dorsomorphin  (EXP,ISO)
endosulfan  (EXP)
Enterolactone  (ISO)
entinostat  (ISO)
epoxiconazole  (ISO)
fenthion  (ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
genistein  (ISO)
hydroquinone  (ISO)
indometacin  (ISO)
L-methionine  (ISO)
lead(0)  (ISO)
lidocaine  (EXP)
lipopolysaccharide  (ISO)
menadione  (ISO)
metformin  (ISO)
methapyrilene  (ISO)
methoxychlor  (EXP)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
nickel atom  (ISO)
nickel dichloride  (EXP)
okadaic acid  (ISO)
ozone  (ISO)
panobinostat  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
pioglitazone  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
progesterone  (ISO)
propiconazole  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sirolimus  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sotorasib  (ISO)
succimer  (ISO)
sulforaphane  (ISO)
tamoxifen  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trametinib  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)
zearalenone  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. mTOR signaling in growth control and disease. Laplante M and Sabatini DM, Cell. 2012 Apr 13;149(2):274-93. doi: 10.1016/j.cell.2012.03.017.
3. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
4. GOA pipeline RGD automated data pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:19446321   PMID:25159114   PMID:29397070   PMID:31176743  


Genomics

Comparative Map Data
Deptor
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8788,404,745 - 88,574,065 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl788,404,620 - 88,574,041 (+)EnsemblGRCr8
mRatBN7.2786,514,859 - 86,668,817 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl786,514,988 - 86,667,773 (+)EnsemblmRatBN7.2
Rnor_6.0794,795,161 - 95,000,750 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl794,795,214 - 94,995,809 (+)Ensemblrn6Rnor6.0
Rnor_5.0795,520,754 - 95,625,869 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4791,675,825 - 91,742,576 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera783,308,700 - 83,462,454 (+)NCBICelera
Cytogenetic Map7q32NCBI
DEPTOR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh388119,873,722 - 120,050,918 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl8119,873,717 - 120,050,918 (+)Ensemblhg38GRCh38
GRCh378120,885,962 - 121,063,157 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 368120,955,146 - 121,131,939 (+)NCBIBuild 36Build 36hg18NCBI36
Build 348120,955,145 - 121,131,937NCBI
Celera8117,075,022 - 117,252,280 (+)NCBICelera
Cytogenetic Map8q24.12NCBI
HuRef8116,206,531 - 116,383,857 (+)NCBIHuRef
CHM1_18120,926,730 - 121,103,852 (+)NCBICHM1_1
T2T-CHM13v2.08121,002,533 - 121,179,716 (+)NCBIT2T-CHM13v2.0
Deptor
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391554,975,824 - 55,122,667 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1554,975,713 - 55,122,667 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381555,112,317 - 55,259,273 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1555,112,317 - 55,259,271 (+)Ensemblmm10GRCm38
MGSCv371554,944,038 - 55,085,757 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361554,942,566 - 55,084,285 (+)NCBIMGSCv36mm8
Celera1556,652,905 - 56,794,634 (+)NCBICelera
Cytogenetic Map15D1NCBI
cM Map1521.96NCBI
Deptor
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541725,538,578 - 25,566,772 (+)Ensembl
ChiLan1.0NW_00495541725,538,609 - 25,563,374 (+)NCBIChiLan1.0ChiLan1.0
DEPTOR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v27137,299,270 - 137,484,402 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan18112,811,180 - 112,996,385 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v08116,563,935 - 116,743,843 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.18119,311,942 - 119,492,127 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl8119,311,942 - 119,492,127 (+)EnsemblpanPan2panpan1.1
DEPTOR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11318,859,526 - 18,993,464 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1318,859,634 - 18,988,583 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1318,872,396 - 19,007,464 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01319,188,815 - 19,323,823 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1319,188,882 - 19,320,795 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11318,915,849 - 19,051,161 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01319,015,161 - 19,150,366 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01319,246,027 - 19,381,218 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Deptor
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530319,272,854 - 19,411,349 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647026,704,021 - 26,837,470 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647026,698,707 - 26,837,470 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DEPTOR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl418,976,743 - 19,180,117 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1418,969,509 - 19,180,131 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2420,001,488 - 20,186,277 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DEPTOR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.18114,442,212 - 114,626,411 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl8114,442,379 - 114,625,171 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603925,660,666 - 25,847,582 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Deptor
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476317,935,108 - 17,956,909 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462476317,935,171 - 17,956,858 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Deptor
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11229,525,493 - 229,664,048 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Deptor
1646 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:141
Count of miRNA genes:103
Interacting mature miRNAs:113
Transcripts:ENSRNOT00000005722, ENSRNOT00000064270
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10053722Scort27Serum corticosterone level QTL 272.410.0083blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)74511390390113903Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)782111245123048330Rat
2317035Aia16Adjuvant induced arthritis QTL 162.71joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)771103011106126789Rat
1357336Gluco6Glucose level QTL 63.4blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)75170064396700643Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)731770293110435881Rat
70159Bp61Blood pressure QTL 610.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)773618702118618702Rat
1298525Cm1Cardiac mass QTL 12.7heart mass (VT:0007028)heart wet weight (CMO:0000069)756625161101625161Rat
1357338Stl17Serum triglyceride level QTL 173.23blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)771621154114982716Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)746307490127866166Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)785043242130043242Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)785497398130497398Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)783626689128626689Rat
631529Tls2T-lymphoma susceptibility QTL 200.001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)782111382132099989Rat
1559283Emca4Estrogen-induced mammary cancer QTL 43.7mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)763889858108889858Rat
1300151Bp181Blood pressure QTL 1813.36arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)755498584105834451Rat
738030Anxrr8Anxiety related response QTL 84.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)74847504993475049Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)71011291699900612Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)71104117804Rat
7411607Foco15Food consumption QTL 150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)777807807122807807Rat
631201Panci1Pancreas inflammation QTL 100.001pancreas integrity trait (VT:0010560)percentage of study population displaying chronic pancreatitis at a point in time (CMO:0001214)773557047118557047Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)71509236116977875Rat
1331768Kidm10Kidney mass QTL 104.62096kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)782111245123048330Rat
1641908Teswt1Testicular weight QTL 13.28testis mass (VT:1000644)both testes wet weight (CMO:0000175)78211124596700643Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)740540077123682549Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)749682832115766396Rat
10450862Kidm55Kidney mass QTL 554.9kidney mass (VT:0002707)kidney weight (CMO:0000081)772725037117725037Rat
724537Niddm52Non-insulin dependent diabetes mellitus QTL 520.02blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)78211124595485241Rat
1298528Bp169Blood pressure QTL 1690.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)762963207107963207Rat
1331746Kidm9Kidney mass QTL 93.934kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)782111245134948181Rat
1576303Ept7Estrogen-induced pituitary tumorigenesis QTL 73.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)763889858108889858Rat
7411654Foco25Food consumption QTL 259.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)777807807122807807Rat
10450856Livw4Liver weight QTL 43.8liver mass (VT:0003402)liver weight (CMO:0000092)772725037117725037Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)749682832115766396Rat
10402855Bp379Blood pressure QTL 3790.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)778682549123682549Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)749682832115766396Rat
2303582Gluco53Glucose level QTL 533blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)74860308793603087Rat
631540Bw9Body weight QTL 94.5body mass (VT:0001259)body weight (CMO:0000012)771621154119349044Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)771827901136544683Rat

Markers in Region
D15Mit183  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2786,591,855 - 86,592,031 (+)MAPPERmRatBN7.2
Rnor_6.0794,923,611 - 94,923,786NCBIRnor6.0
Rnor_5.0795,548,730 - 95,548,905UniSTSRnor5.0
RGSC_v3.4791,670,316 - 91,670,491UniSTSRGSC3.4
Cytogenetic Map7q31UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 163 91 90 59 91 59 6 355 191 11 142 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000005722   ⟹   ENSRNOP00000005722
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl788,404,703 - 88,574,041 (+)Ensembl
mRatBN7.2 Ensembl786,514,988 - 86,663,778 (+)Ensembl
Rnor_6.0 Ensembl794,795,214 - 94,995,809 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000095532   ⟹   ENSRNOP00000093077
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl788,404,745 - 88,558,561 (+)Ensembl
mRatBN7.2 Ensembl786,514,992 - 86,667,773 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000105476   ⟹   ENSRNOP00000097828
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl788,404,620 - 88,554,423 (+)Ensembl
mRatBN7.2 Ensembl786,561,637 - 86,663,778 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000119008   ⟹   ENSRNOP00000080538
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl788,451,392 - 88,558,561 (+)Ensembl
mRatBN7.2 Ensembl786,514,988 - 86,666,888 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000124038   ⟹   ENSRNOP00000106103
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl788,448,710 - 88,558,561 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000131997   ⟹   ENSRNOP00000112826
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl788,404,620 - 88,554,530 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000141778   ⟹   ENSRNOP00000112693
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl788,447,117 - 88,558,561 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000145579   ⟹   ENSRNOP00000100148
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl788,450,737 - 88,558,561 (+)Ensembl
RefSeq Acc Id: NM_001427213   ⟹   NP_001414142
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8788,404,745 - 88,558,561 (+)NCBI
RefSeq Acc Id: XM_017595234   ⟹   XP_017450723
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8788,404,767 - 88,558,561 (+)NCBI
mRatBN7.2786,514,859 - 86,668,817 (+)NCBI
Rnor_6.0794,795,161 - 95,000,750 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063263556   ⟹   XP_063119626
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8788,404,767 - 88,574,065 (+)NCBI
RefSeq Acc Id: XM_063263557   ⟹   XP_063119627
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8788,404,767 - 88,574,065 (+)NCBI
RefSeq Acc Id: XP_017450723   ⟸   XM_017595234
- Peptide Label: isoform X3
- Sequence:
Ensembl Acc Id: ENSRNOP00000005722   ⟸   ENSRNOT00000005722
Ensembl Acc Id: ENSRNOP00000097828   ⟸   ENSRNOT00000105476
Ensembl Acc Id: ENSRNOP00000093077   ⟸   ENSRNOT00000095532
Ensembl Acc Id: ENSRNOP00000080538   ⟸   ENSRNOT00000119008
RefSeq Acc Id: NP_001414142   ⟸   NM_001427213
- UniProtKB: A6HRG9 (UniProtKB/TrEMBL),   F1M8Y4 (UniProtKB/TrEMBL),   A0A8I5ZQX9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063119626   ⟸   XM_063263556
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AIZ7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063119627   ⟸   XM_063263557
- Peptide Label: isoform X2
Ensembl Acc Id: ENSRNOP00000112693   ⟸   ENSRNOT00000141778
Ensembl Acc Id: ENSRNOP00000106103   ⟸   ENSRNOT00000124038
Ensembl Acc Id: ENSRNOP00000100148   ⟸   ENSRNOT00000145579
Ensembl Acc Id: ENSRNOP00000112826   ⟸   ENSRNOT00000131997
Protein Domains
DEP   PDZ

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1M8Y4-F1-model_v2 AlphaFold F1M8Y4 1-409 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695355
Promoter ID:EPDNEW_R5860
Type:multiple initiation site
Name:Deptor_1
Description:DEP domain containing MTOR-interacting protein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0794,795,310 - 94,795,370EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1561030 AgrOrtholog
BioCyc Gene G2FUF-33380 BioCyc
Ensembl Genes ENSRNOG00000004328 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000005722 ENTREZGENE
  ENSRNOT00000005722.10 UniProtKB/TrEMBL
  ENSRNOT00000095532 ENTREZGENE
  ENSRNOT00000095532.2 UniProtKB/TrEMBL
  ENSRNOT00000105476.2 UniProtKB/TrEMBL
  ENSRNOT00000119008.2 UniProtKB/TrEMBL
  ENSRNOT00000124038.1 UniProtKB/TrEMBL
  ENSRNOT00000131997.1 UniProtKB/TrEMBL
  ENSRNOT00000141778.1 UniProtKB/TrEMBL
  ENSRNOT00000145579.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.10 UniProtKB/TrEMBL
  2.30.42.10 UniProtKB/TrEMBL
InterPro DEP_dom UniProtKB/TrEMBL
  DEPTOR_DEP_1 UniProtKB/TrEMBL
  DEPTOR_DEP_2 UniProtKB/TrEMBL
  mTOR-Rac_regulators UniProtKB/TrEMBL
  PDZ/DHR/GLGF UniProtKB/TrEMBL
  PDZ_sf UniProtKB/TrEMBL
  WH-like_DNA-bd_sf UniProtKB/TrEMBL
  WH_DNA-bd_sf UniProtKB/TrEMBL
NCBI Gene 314979 ENTREZGENE
PANTHER DEP DOMAIN PROTEIN UniProtKB/TrEMBL
  PTHR22829:SF18 UniProtKB/TrEMBL
Pfam DEP UniProtKB/TrEMBL
PhenoGen Deptor PhenoGen
PROSITE DEP UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
RatGTEx ENSRNOG00000004328 RatGTEx
SMART DEP UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
Superfamily-SCOP PDZ UniProtKB/TrEMBL
  SSF46785 UniProtKB/TrEMBL
UniProt A0A8I5ZQX9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AIZ7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6B6C9_RAT UniProtKB/TrEMBL
  A0ABK0L7I8_RAT UniProtKB/TrEMBL
  A0ABK0L7P9_RAT UniProtKB/TrEMBL
  A0ABK0LNZ2_RAT UniProtKB/TrEMBL
  A0ABK0M1L5_RAT UniProtKB/TrEMBL
  A6HRG9 ENTREZGENE, UniProtKB/TrEMBL
  F1M8Y4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-07-29 Deptor  DEP domain containing MTOR-interacting protein  LOC102547145  uncharacterized LOC102547145  Data merged from RGD:7615485 737654 PROVISIONAL
2015-07-29 Deptor  DEP domain containing MTOR-interacting protein  LOC100359815  hypothetical protein LOC100359815  Data merged from RGD:2323326 737654 PROVISIONAL
2013-12-18 LOC102547145  uncharacterized LOC102547145      Symbol and Name status set to provisional 70820 PROVISIONAL
2011-08-02 Deptor  DEP domain containing MTOR-interacting protein  Depdc6  DEP domain containing 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-05-06 LOC100359815  hypothetical protein LOC100359815      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-09-16 Depdc6  DEP domain containing 6   RGD1561030  similar to DEP domain containing 6   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1561030  similar to DEP domain containing 6   RGD1561030_predicted  similar to DEP domain containing 6 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1561030_predicted  similar to DEP domain containing 6 (predicted)  LOC314979  similar to DEP domain containing 6  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC314979  similar to DEP domain containing 6      Symbol and Name status set to provisional 70820 PROVISIONAL