Plcxd1 (phosphatidylinositol-specific phospholipase C, X domain containing 1) - Rat Genome Database

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Gene: Plcxd1 (phosphatidylinositol-specific phospholipase C, X domain containing 1) Rattus norvegicus
Analyze
Symbol: Plcxd1
Name: phosphatidylinositol-specific phospholipase C, X domain containing 1
RGD ID: 1560935
Description: Predicted to enable phosphoric diester hydrolase activity. Predicted to be involved in lipid metabolic process. Orthologous to human PLCXD1 (phosphatidylinositol specific phospholipase C X domain containing 1); INTERACTS WITH bisphenol A; thioacetamide; trichloroethene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC100909600; LOC304575; PI-PLC X domain-containing protein 1; PI-PLC X domain-containing protein 1-like; RGD1560935; similar to RIKEN cDNA A330045H12 gene
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81252,238,450 - 52,241,884 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1252,238,623 - 52,241,865 (-)EnsemblGRCr8
mRatBN7.21246,578,917 - 46,582,181 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1246,579,225 - 46,582,392 (-)EnsemblmRatBN7.2
Rnor_6.01252,674,837 - 52,678,047 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1252,641,222 - 52,676,608 (-)Ensemblrn6Rnor6.0
Rnor_5.01254,377,827 - 54,380,971 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41246,726,350 - 46,729,517 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1248,134,745 - 48,137,955 (-)NCBICelera
Cytogenetic Map12q16NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:15632090  


Genomics

Comparative Map Data
Plcxd1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81252,238,450 - 52,241,884 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1252,238,623 - 52,241,865 (-)EnsemblGRCr8
mRatBN7.21246,578,917 - 46,582,181 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1246,579,225 - 46,582,392 (-)EnsemblmRatBN7.2
Rnor_6.01252,674,837 - 52,678,047 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1252,641,222 - 52,676,608 (-)Ensemblrn6Rnor6.0
Rnor_5.01254,377,827 - 54,380,971 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41246,726,350 - 46,729,517 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1248,134,745 - 48,137,955 (-)NCBICelera
Cytogenetic Map12q16NCBI
PLCXD1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38Y276,356 - 303,356 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38X276,356 - 303,356 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX276,322 - 303,358 (+)Ensemblhg38GRCh38
GRCh38.p14 EnsemblY276,322 - 303,358 (+)Ensemblhg38GRCh38
GRCh37X193,023 - 220,023 (+)NCBIGRCh37GRCh37hg19GRCh37
GRCh37Y143,023 - 170,023 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36Y132,991 - 160,020 (+)NCBIBuild 36Build 36hg18NCBI36
Build 36X132,991 - 160,020 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34Y132,991 - 160,020NCBI
CeleraX820,894 - 846,333 (-)NCBICelera
Cytogenetic MapX;YNCBI
CHM1_1X172,967 - 203,581 (+)NCBICHM1_1
T2T-CHM13v2.0Y103,034 - 130,734 (+)NCBIT2T-CHM13v2.0
T2T-CHM13v2.0X103,482 - 131,585 (+)NCBIT2T-CHM13v2.0
Plcxd1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395110,247,661 - 110,253,819 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5110,247,835 - 110,253,819 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm385110,099,969 - 110,105,953 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5110,099,969 - 110,105,953 (+)Ensemblmm10GRCm38
MGSCv375110,528,988 - 110,534,972 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv365110,340,271 - 110,344,117 (+)NCBIMGSCv36mm8
Celera5107,226,443 - 107,232,426 (+)NCBICelera
Cytogenetic Map5FNCBI
cM Map553.3NCBI
Plcxd1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955499574,421 - 585,386 (+)NCBIChiLan1.0ChiLan1.0
LOC100969907
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X91,010 - 111,582 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1-v2Y46,873,352 - 46,897,697 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X94,666 - 116,153 (+)NCBINHGRI_mPanPan1
NHGRI_mPanPan1Y56,969 - 82,221 (+)NCBINHGRI_mPanPan1
PLCXD1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X340,475 - 348,249 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX55,695 - 72,144 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0X22,687 - 39,027 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX25,125 - 40,747 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X19,729 - 32,171 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X27,446 - 43,705 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X29,347 - 42,691 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Plcxd1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404953147,387 - 153,807 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366444,222,930 - 4,234,695 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366444,222,937 - 4,229,227 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOC110257938
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1Y6,971,001 - 6,985,133 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
PLCXD1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_02366605631,112 - 58,050 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Plcxd1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624834267,654 - 272,505 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624834247,910 - 273,053 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Plcxd1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11644,257,562 - 44,260,433 (-)NCBIRrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:158
Count of miRNA genes:90
Interacting mature miRNAs:96
Transcripts:ENSRNOT00000072507, ENSRNOT00000073986
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631560Apr1Acute phase response QTL 16.1orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)122480502252308831Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121613502952308831Rat
70213Niddm27Non-insulin dependent diabetes mellitus QTL 273.72blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121120049452308831Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049452308831Rat
1331763Wbc2White blood cell count QTL 23.162leukocyte quantity (VT:0000217)total white blood cell count (CMO:0000365)121120049452308831Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)61120049452308831Rat
7411643Foco20Food consumption QTL 200.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)122598935552308831Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121847304152308831Rat
2303569Gluco44Glucose level QTL 442blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121847304152308831Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)121526424852308831Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049752308831Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)121174352852308831Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049452308831Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121613502952308831Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
1331786Kidm11Kidney mass QTL 113.571kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)121618743852308831Rat
631543Bp83Blood pressure QTL 835.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)124413955852308831Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
14 10 116 39 35 18 26 18 6 133 46 1 101 55 63 17 8 8

Sequence


Ensembl Acc Id: ENSRNOT00000072507   ⟹   ENSRNOP00000065030
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1252,641,222 - 52,676,608 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000073986   ⟹   ENSRNOP00000064541
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1252,238,623 - 52,241,865 (-)Ensembl
mRatBN7.2 Ensembl1246,579,225 - 46,582,392 (-)Ensembl
Rnor_6.0 Ensembl1252,641,222 - 52,644,260 (-)Ensembl
RefSeq Acc Id: NM_001427696   ⟹   NP_001414625
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81252,238,622 - 52,241,865 (-)NCBI
RefSeq Acc Id: XM_063270978   ⟹   XP_063127048
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81252,238,450 - 52,240,803 (-)NCBI
RefSeq Acc Id: XM_063270979   ⟹   XP_063127049
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81252,239,486 - 52,241,884 (-)NCBI
RefSeq Acc Id: XR_010056361
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81252,239,027 - 52,241,884 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001414625 (Get FASTA)   NCBI Sequence Viewer  
  XP_063127048 (Get FASTA)   NCBI Sequence Viewer  
  XP_063127049 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM14081 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000064541
  ENSRNOP00000064541.4
Ensembl Acc Id: ENSRNOP00000065030   ⟸   ENSRNOT00000072507
Ensembl Acc Id: ENSRNOP00000064541   ⟸   ENSRNOT00000073986
RefSeq Acc Id: XP_063127048   ⟸   XM_063270978
- Peptide Label: isoform X1
RefSeq Acc Id: NP_001414625   ⟸   NM_001427696
- UniProtKB: A6J2E2 (UniProtKB/TrEMBL),   M0R583 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063127049   ⟸   XM_063270979
- Peptide Label: isoform X2
Protein Domains
Phosphatidylinositol-specific phospholipase C X

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0R583-F1-model_v2 AlphaFold M0R583 1-320 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1560935 AgrOrtholog
Ensembl Genes ENSRNOG00000049866 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000073986 ENTREZGENE
  ENSRNOT00000073986.4 UniProtKB/TrEMBL
Gene3D-CATH 3.20.20.190 UniProtKB/TrEMBL
InterPro PI-PLC_domain UniProtKB/TrEMBL
  PLC-like_Pdiesterase_TIM-brl UniProtKB/TrEMBL
  PLCXD1/2/3 UniProtKB/TrEMBL
  PLipase_C_PInositol-sp_X_dom UniProtKB/TrEMBL
NCBI Gene Plcxd1 ENTREZGENE
PANTHER PI-PLC X DOMAIN-CONTAINING PROTEIN 1 UniProtKB/TrEMBL
  UNCHARACTERIZED UniProtKB/TrEMBL
PhenoGen Plcxd1 PhenoGen
PROSITE PIPLC_X_DOMAIN UniProtKB/TrEMBL
RatGTEx ENSRNOG00000049866 RatGTEx
SMART PLCXc UniProtKB/TrEMBL
Superfamily-SCOP PLC-like_Pdiesterase_TIM-brl UniProtKB/TrEMBL
UniProt A6J2E2 ENTREZGENE, UniProtKB/TrEMBL
  M0R583 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Plcxd1  phosphatidylinositol-specific phospholipase C, X domain containing 1  LOC100909600  PI-PLC X domain-containing protein 1-like  Data merged from RGD:6502568 737654 PROVISIONAL
2012-07-05 LOC100909600  PI-PLC X domain-containing protein 1-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-02-28 Plcxd1  phosphatidylinositol-specific phospholipase C, X domain containing 1  RGD1560935_predicted  similar to RIKEN cDNA A330045H12 gene (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1560935_predicted  similar to RIKEN cDNA A330045H12 gene (predicted)  LOC304575  similar to RIKEN cDNA A330045H12 gene  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC304575  similar to RIKEN cDNA A330045H12 gene      Symbol and Name status set to provisional 70820 PROVISIONAL