Slc7a15 (solute carrier family 7 (cationic amino acid transporter, y+ system), member 15) - Rat Genome Database

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Gene: Slc7a15 (solute carrier family 7 (cationic amino acid transporter, y+ system), member 15) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Slc7a15
Name: solute carrier family 7 (cationic amino acid transporter, y+ system), member 15
RGD ID: 1560726
Description: Predicted to enable L-amino acid transmembrane transporter activity. Predicted to be involved in amino acid transmembrane transport. Predicted to act upstream of or within amino acid transport. Predicted to be located in membrane. Predicted to be part of protein-containing complex; INTERACTS WITH 1-naphthyl isothiocyanate; acetamide; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC298873; RGD1560726; similar to hypothetical protein 9030221C07
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8637,123,019 - 37,135,601 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl637,123,019 - 37,134,501 (-)EnsemblGRCr8
mRatBN7.2631,403,747 - 31,415,231 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl631,403,747 - 31,415,231 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx631,695,809 - 31,707,295 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0632,011,658 - 32,023,146 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0631,486,273 - 31,497,759 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd638,565,920 - 38,577,404 (-)NCBIDahl_SR_JrHsd
Lyon_Normotensive638,002,205 - 38,013,687 (-)NCBILyon_Normotensive
Lyon_Hypertensive635,798,022 - 35,809,504 (-)NCBILyon_Hypertensive
F344_StmMcwi635,014,949 - 35,026,431 (-)NCBIF344_StmMcwi
Rnor_6.0633,728,107 - 33,739,115 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl633,728,107 - 33,738,825 (-)Ensemblrn6Rnor6.0
Rnor_5.0643,511,030 - 43,521,748 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4632,091,833 - 32,103,160 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera630,852,268 - 30,863,734 (-)NCBICelera
Cytogenetic Map6q14NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Variants

.
Variants in Slc7a15
95 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:469
Count of miRNA genes:251
Interacting mature miRNAs:306
Transcripts:ENSRNOT00000039492
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8552962Pigfal16Plasma insulin-like growth factor 1 level QTL 169.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)6197587946975879Rat
10401812Kidm54Kidney mass QTL 54kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)62009763565097635Rat
8552910Pigfal5Plasma insulin-like growth factor 1 level QTL 54.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)62265388967653889Rat
10401800Kidm49Kidney mass QTL 49kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)62009763565097635Rat
1300164Rf15Renal function QTL 153.12renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6323998948239989Rat
1331779Rf38Renal function QTL 382.876kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)63118500276185002Rat
9589129Insul24Insulin level QTL 2419.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)6197587946975879Rat
7411603Foco13Food consumption QTL 135.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6197587946975879Rat
1598843Cm63Cardiac mass QTL 632.6heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)6144788383Rat
7411542Bw127Body weight QTL 1275.50.001body mass (VT:0001259)body weight gain (CMO:0000420)6197587946975879Rat
2292616Ept15Estrogen-induced pituitary tumorigenesis QTL 154.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)6144788383Rat
9589048Scfw3Subcutaneous fat weight QTL 34.570.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)6197587946975879Rat
2293839Kiddil2Kidney dilation QTL 24.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62661831486868070Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)620859430113082285Rat
2301964Bp323Blood pressure QTL 3234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6186868070Rat
2293709Bss23Bone structure and strength QTL 235.180.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)6323998948239989Rat
2293650Bss31Bone structure and strength QTL 315.050.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)6323998948239989Rat
1578665Bss16Bone structure and strength QTL 164.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)63332884178328841Rat
2293841Kiddil4Kidney dilation QTL 44.4kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62661831486868070Rat
1300128Rf16Renal function QTL 163.89renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6140163351Rat
1641898Colcr4Colorectal carcinoma resistance QTL43.710.0007intestine integrity trait (VT:0010554)well differentiated malignant colorectal tumor surface area measurement (CMO:0002077)63093763275937632Rat
1578668Bmd14Bone mineral density QTL 143.8femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)63332884178328841Rat
70199Coreg1Compensatory renal growth QTL 111.8kidney mass (VT:0002707)compensatory renal growth score (CMO:0001894)61459947363457687Rat
2301972Bp325Blood pressure QTL 3254.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)61608937261967788Rat
1358190Ept1Estrogen-induced pituitary tumorigenesis QTL 14.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)6144788383Rat
2293656Bss28Bone structure and strength QTL 286.790.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)6323998948239989Rat
1354664Slep2Serum leptin concentration QTL 24.49blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)62228825767288257Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 32 76 65 64 33 27 33 6 211 91 9 48 63 84 31 3 3

Sequence


Ensembl Acc Id: ENSRNOT00000039492   ⟹   ENSRNOP00000032952
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl637,123,019 - 37,134,501 (-)Ensembl
mRatBN7.2 Ensembl631,403,747 - 31,415,231 (-)Ensembl
Rnor_6.0 Ensembl633,728,107 - 33,738,825 (-)Ensembl
RefSeq Acc Id: NM_001106714   ⟹   NP_001100184
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8637,123,019 - 37,134,501 (-)NCBI
mRatBN7.2631,403,747 - 31,415,231 (-)NCBI
Dahl_SR_JrHsd638,565,920 - 38,577,404 (-)NCBI
Lyon_Normotensive638,002,205 - 38,013,687 (-)NCBI
Lyon_Hypertensive635,798,022 - 35,809,504 (-)NCBI
F344_StmMcwi635,014,949 - 35,026,431 (-)NCBI
Rnor_6.0633,728,107 - 33,738,825 (-)NCBI
Rnor_5.0643,511,030 - 43,521,748 (-)NCBI
RGSC_v3.4632,091,833 - 32,103,160 (-)RGD
Celera630,852,268 - 30,863,734 (-)RGD
Sequence:
RefSeq Acc Id: XM_008764578   ⟹   XP_008762800
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8637,131,996 - 37,135,601 (-)NCBI
mRatBN7.2631,413,665 - 31,415,209 (-)NCBI
Rnor_6.0633,737,277 - 33,739,115 (-)NCBI
Sequence:
RefSeq Acc Id: NP_001100184   ⟸   NM_001106714
- UniProtKB: D3ZI89 (UniProtKB/TrEMBL),   A6HAM1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008762800   ⟸   XM_008764578
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000032952   ⟸   ENSRNOT00000039492

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZI89-F1-model_v2 AlphaFold D3ZI89 1-488 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1560726 AgrOrtholog
BioCyc Gene G2FUF-38177 BioCyc
Ensembl Genes ENSRNOG00000006119 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000039492 ENTREZGENE
  ENSRNOT00000039492.5 UniProtKB/TrEMBL
Gene3D-CATH Amino acid/polyamine transporter I UniProtKB/TrEMBL
InterPro AA/rel_permease1 UniProtKB/TrEMBL
  AminoAcid_Transporter UniProtKB/TrEMBL
KEGG Report rno:298873 UniProtKB/TrEMBL
NCBI Gene 298873 ENTREZGENE
PANTHER AMINO ACID TRANSPORTER UniProtKB/TrEMBL
  AROMATIC-PREFERRING AMINO ACID TRANSPORTER UniProtKB/TrEMBL
Pfam AA_permease_2 UniProtKB/TrEMBL
PhenoGen Slc7a15 PhenoGen
PIRSF AA_transporter UniProtKB/TrEMBL
RatGTEx ENSRNOG00000006119 RatGTEx
UniProt A6HAM1 ENTREZGENE, UniProtKB/TrEMBL
  D3ZI89 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-28 Slc7a15  solute carrier family 7 (cationic amino acid transporter, y+ system), member 15  RGD1560726_predicted  similar to hypothetical protein 9030221C07 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1560726_predicted  similar to hypothetical protein 9030221C07 (predicted)  LOC298873  similar to hypothetical protein 9030221C07  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC298873  similar to hypothetical protein 9030221C07      Symbol and Name status set to provisional 70820 PROVISIONAL