Trim67 (tripartite motif-containing 67) - Rat Genome Database

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Pathways
Gene: Trim67 (tripartite motif-containing 67) Rattus norvegicus
Analyze
Symbol: Trim67
Name: tripartite motif-containing 67
RGD ID: 1560667
Description: Predicted to enable zinc ion binding activity. Predicted to act upstream of or within negative regulation of Ras protein signal transduction; positive regulation of neuron projection development; and positive regulation of ubiquitin-dependent protein catabolic process. Predicted to be located in cytoskeleton. Predicted to be active in cytoplasm. Orthologous to human TRIM67 (tripartite motif containing 67); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; atrazine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC307938; RGD1560667; similar to TRIM9-like protein TNL; tripartite motif-containing protein 67
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81969,659,857 - 69,703,290 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1969,661,777 - 69,698,805 (+)EnsemblGRCr8
mRatBN7.21952,763,991 - 52,805,906 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1952,764,387 - 52,800,422 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1959,549,174 - 59,585,129 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01960,399,955 - 60,436,190 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01962,475,634 - 62,511,589 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01957,554,665 - 57,593,401 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1957,556,694 - 57,592,722 (+)Ensemblrn6Rnor6.0
Rnor_5.01968,269,485 - 68,305,962 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41954,976,864 - 55,011,687 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1952,132,268 - 52,167,552 (+)NCBICelera
Cytogenetic Map19q12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IEA,ISO)
cytoskeleton  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:22337885  


Genomics

Comparative Map Data
Trim67
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81969,659,857 - 69,703,290 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1969,661,777 - 69,698,805 (+)EnsemblGRCr8
mRatBN7.21952,763,991 - 52,805,906 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1952,764,387 - 52,800,422 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1959,549,174 - 59,585,129 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01960,399,955 - 60,436,190 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01962,475,634 - 62,511,589 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01957,554,665 - 57,593,401 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1957,556,694 - 57,592,722 (+)Ensemblrn6Rnor6.0
Rnor_5.01968,269,485 - 68,305,962 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41954,976,864 - 55,011,687 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1952,132,268 - 52,167,552 (+)NCBICelera
Cytogenetic Map19q12NCBI
TRIM67
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381231,162,058 - 231,221,565 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1231,162,058 - 231,221,565 (+)Ensemblhg38GRCh38
GRCh371231,297,804 - 231,357,311 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361229,365,297 - 229,423,937 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341227,605,408 - 227,664,049NCBI
Celera1204,563,541 - 204,622,189 (+)NCBICelera
Cytogenetic Map1q42.2NCBI
HuRef1201,782,019 - 201,840,709 (+)NCBIHuRef
CHM1_11232,572,265 - 232,630,965 (+)NCBICHM1_1
T2T-CHM13v2.01230,544,922 - 230,604,828 (+)NCBIT2T-CHM13v2.0
Trim67
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398125,519,758 - 125,561,443 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8125,519,831 - 125,561,452 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm388124,791,317 - 124,834,713 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8124,793,092 - 124,834,713 (+)Ensemblmm10GRCm38
MGSCv378127,316,919 - 127,358,604 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv368127,317,652 - 127,353,278 (+)NCBIMGSCv36mm8
Celera8129,107,947 - 129,147,602 (+)NCBICelera
Cytogenetic Map8E2NCBI
cM Map872.81NCBI
Trim67
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554927,543,916 - 7,578,886 (-)Ensembl
ChiLan1.0NW_0049554927,538,492 - 7,578,257 (-)NCBIChiLan1.0ChiLan1.0
TRIM67
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2117,983,930 - 18,044,747 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1118,187,559 - 18,247,407 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01206,710,490 - 206,770,111 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11211,734,311 - 211,789,842 (+)NCBIPanPan1.1PanPan1.1panPan2
TRIM67
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.148,211,013 - 8,259,907 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl48,213,308 - 8,259,342 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha48,202,830 - 8,252,031 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.048,235,963 - 8,285,169 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl48,238,783 - 8,284,632 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.148,239,440 - 8,289,002 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.048,363,230 - 8,411,712 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.048,590,060 - 8,640,369 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Trim67
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934443,288,901 - 43,327,893 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648419,456,759 - 19,492,103 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493648419,456,756 - 19,495,047 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TRIM67
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1459,260,065 - 59,302,591 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11459,260,070 - 59,303,244 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21463,924,060 - 63,967,518 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TRIM67
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12568,434,458 - 68,488,471 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2568,434,543 - 68,487,727 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605570,340,169 - 70,395,834 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Trim67
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477518,465,786 - 18,498,937 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462477518,460,463 - 18,499,349 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Trim67
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11744,316,747 - 44,352,395 (+)NCBIRrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:71
Count of miRNA genes:66
Interacting mature miRNAs:71
Transcripts:ENSRNOT00000032359
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313395Anxrr26Anxiety related response QTL 26aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)194438513474246245Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)193253961574246245Rat
5135224Leukc1Leukocyte quantity QTL 1eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)196124916174246245Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)193177788874246245Rat
631840Niddm38Non-insulin dependent diabetes mellitus QTL 383.86blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)191032907674246245Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)194622677874246245Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19219431774246245Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)193236531174246245Rat
1549835Tcas7Tongue tumor susceptibility QTL 70.001tongue integrity trait (VT:0010553)squamous cell carcinoma of the head and neck tumor number (CMO:0001876)194172254674246245Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)193628974246245Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19219431774246245Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191083361874246245Rat

Markers in Region
D19Got125  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21952,781,723 - 52,781,856 (+)MAPPERmRatBN7.2
Rnor_6.01957,574,032 - 57,574,164NCBIRnor6.0
Rnor_5.01968,287,272 - 68,287,404UniSTSRnor5.0
RGSC_v3.41954,993,116 - 54,993,248UniSTSRGSC3.4
Celera1952,148,929 - 52,149,062UniSTS
Cytogenetic Map19q12UniSTS
BF396236  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21952,774,548 - 52,774,671 (+)MAPPERmRatBN7.2
Rnor_6.01957,566,856 - 57,566,978NCBIRnor6.0
Rnor_5.01968,280,096 - 68,280,218UniSTSRnor5.0
RGSC_v3.41954,987,026 - 54,987,148UniSTSRGSC3.4
RH 3.4 Map19738.9UniSTS
Cytogenetic Map19q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
8 5 43 159 49 45 18 23 18 6 183 96 7 134 59 68 27 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000032359   ⟹   ENSRNOP00000032148
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1969,661,777 - 69,698,805 (+)Ensembl
mRatBN7.2 Ensembl1952,764,387 - 52,800,422 (+)Ensembl
Rnor_6.0 Ensembl1957,556,694 - 57,592,722 (+)Ensembl
RefSeq Acc Id: NM_001135715   ⟹   NP_001129187
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81969,661,777 - 69,697,804 (+)NCBI
mRatBN7.21952,764,387 - 52,800,422 (+)NCBI
Rnor_6.01957,556,694 - 57,592,722 (+)NCBI
Rnor_5.01968,269,485 - 68,305,962 (+)NCBI
RGSC_v3.41954,976,864 - 55,011,687 (+)RGD
Celera1952,132,268 - 52,167,552 (+)RGD
Sequence:
RefSeq Acc Id: XM_017601304   ⟹   XP_017456793
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81969,659,857 - 69,703,290 (+)NCBI
mRatBN7.21952,763,991 - 52,805,906 (+)NCBI
Rnor_6.01957,554,665 - 57,593,401 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063278073   ⟹   XP_063134143
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81969,659,857 - 69,697,268 (+)NCBI
RefSeq Acc Id: XM_063278074   ⟹   XP_063134144
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81969,659,857 - 69,697,267 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001129187 (Get FASTA)   NCBI Sequence Viewer  
  XP_017456793 (Get FASTA)   NCBI Sequence Viewer  
  XP_063134143 (Get FASTA)   NCBI Sequence Viewer  
  XP_063134144 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL96740 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000032148
  ENSRNOP00000032148.5
RefSeq Acc Id: NP_001129187   ⟸   NM_001135715
- UniProtKB: D3ZTX1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017456793   ⟸   XM_017601304
- Peptide Label: isoform X3
- Sequence:
Ensembl Acc Id: ENSRNOP00000032148   ⟸   ENSRNOT00000032359
RefSeq Acc Id: XP_063134143   ⟸   XM_063278073
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063134144   ⟸   XM_063278074
- Peptide Label: isoform X2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZTX1-F1-model_v2 AlphaFold D3ZTX1 1-770 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1560667 AgrOrtholog
BioCyc Gene G2FUF-5230 BioCyc
Ensembl Genes ENSRNOG00000019024 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000032359 ENTREZGENE
  ENSRNOT00000032359.6 UniProtKB/TrEMBL
Gene3D-CATH 1.20.5.170 UniProtKB/TrEMBL
  2.60.120.920 UniProtKB/TrEMBL
  2.60.40.10 UniProtKB/TrEMBL
  3.30.40.10 UniProtKB/TrEMBL
  4.10.830.40 UniProtKB/TrEMBL
  Classic Zinc Finger UniProtKB/TrEMBL
InterPro B30.2/SPRY_sf UniProtKB/TrEMBL
  B302 UniProtKB/TrEMBL
  Bbox_C UniProtKB/TrEMBL
  ConA-like_dom UniProtKB/TrEMBL
  COS_domain UniProtKB/TrEMBL
  E3_ligase_FN3/SPRY UniProtKB/TrEMBL
  FN3_sf UniProtKB/TrEMBL
  FN_III UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  SPRY_rcpt UniProtKB/TrEMBL
  Znf_B-box UniProtKB/TrEMBL
  Znf_RING UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/TrEMBL
  Znf_RING_CS UniProtKB/TrEMBL
KEGG Report rno:307938 UniProtKB/TrEMBL
NCBI Gene 307938 ENTREZGENE
PANTHER E3 UBIQUITIN-PROTEIN LIGASE TRIM36-RELATED UniProtKB/TrEMBL
  TRIPARTITE MOTIF-CONTAINING PROTEIN 67 UniProtKB/TrEMBL
Pfam ANCHR-like_BBOX UniProtKB/TrEMBL
  fn3 UniProtKB/TrEMBL
  SPRY UniProtKB/TrEMBL
  zf-B_box UniProtKB/TrEMBL
PhenoGen Trim67 PhenoGen
PROSITE B302_SPRY UniProtKB/TrEMBL
  COS UniProtKB/TrEMBL
  FN3 UniProtKB/TrEMBL
  ZF_BBOX UniProtKB/TrEMBL
  ZF_RING_1 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000019024 RatGTEx
SMART BBC UniProtKB/TrEMBL
  BBOX UniProtKB/TrEMBL
  FN3 UniProtKB/TrEMBL
  RING UniProtKB/TrEMBL
  SPRY UniProtKB/TrEMBL
Superfamily-SCOP B-box zinc-binding domain UniProtKB/TrEMBL
  ConA_like_lec_gl UniProtKB/TrEMBL
  FN_III-like UniProtKB/TrEMBL
  RING/U-box UniProtKB/TrEMBL
UniProt D3ZTX1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-12-01 Trim67  tripartite motif-containing 67  RGD1560667  similar to TRIM9-like protein TNL   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1560667  similar to TRIM9-like protein TNL   RGD1560667_predicted  similar to TRIM9-like protein TNL (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1560667_predicted  similar to TRIM9-like protein TNL (predicted)  LOC307938  similar to TRIM9-like protein TNL  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC307938  similar to TRIM9-like protein TNL      Symbol and Name status set to provisional 70820 PROVISIONAL