Myo3a (myosin IIIA) - Rat Genome Database

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Gene: Myo3a (myosin IIIA) Rattus norvegicus
Analyze
Symbol: Myo3a
Name: myosin IIIA
RGD ID: 1560083
Description: Predicted to enable several functions, including ADP binding activity; calmodulin binding activity; and plus-end directed microfilament motor activity. Predicted to be involved in several processes, including inner ear morphogenesis; positive regulation of filopodium assembly; and sensory perception of sound. Predicted to act upstream of or within inner ear development. Predicted to be located in cytoplasm and filopodium. Predicted to be part of filamentous actin. Predicted to be active in filopodium tip; photoreceptor inner segment; and stereocilium tip. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 90 and autosomal recessive nonsyndromic deafness 30. Orthologous to human MYO3A (myosin IIIA); PARTICIPATES IN auditory mechanotransduction pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; atrazine; vinclozolin.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC498806; myosin-IIIa; RGD1560083; similar to myosin IIIA
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81789,451,567 - 89,667,654 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1789,451,567 - 89,667,654 (+)EnsemblGRCr8
mRatBN7.21784,543,465 - 84,759,562 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1784,543,552 - 84,759,042 (+)EnsemblmRatBN7.2
Rnor_6.01788,952,635 - 89,167,538 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1788,963,981 - 89,167,018 (+)Ensemblrn6Rnor6.0
Rnor_5.01790,644,728 - 90,848,287 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41795,974,131 - 96,255,016 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1784,131,602 - 84,345,464 (-)NCBICelera
Cytogenetic Map17q12.3NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
actin cytoskeleton  (IEA,ISO)
cytoplasm  (IEA,ISO)
cytoskeleton  (IEA)
filamentous actin  (IEA,ISO)
filopodium  (IEA,ISO)
filopodium tip  (IBA,IEA,ISO)
myosin complex  (IEA)
photoreceptor inner segment  (IBA,IEA,ISO)
stereocilium  (IEA)
stereocilium tip  (IBA,IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Mechanotransduction by hair cells: models, molecules, and mechanisms. Gillespie PG and Muller U, Cell. 2009 Oct 2;139(1):33-44. doi: 10.1016/j.cell.2009.09.010.
3. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
4. GOA pipeline RGD automated data pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Comprehensive gene review and curation RGD comprehensive gene curation
8. From flies' eyes to our ears: mutations in a human class III myosin cause progressive nonsyndromic hearing loss DFNB30. Walsh T, etal., Proc Natl Acad Sci U S A. 2002 May 28;99(11):7518-23.
Additional References at PubMed
PMID:1262820   PMID:12672820   PMID:17021180   PMID:19287378   PMID:19332056   PMID:21165622   PMID:21895655   PMID:22264607   PMID:25822849   PMID:26754646  


Genomics

Comparative Map Data
Myo3a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81789,451,567 - 89,667,654 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1789,451,567 - 89,667,654 (+)EnsemblGRCr8
mRatBN7.21784,543,465 - 84,759,562 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1784,543,552 - 84,759,042 (+)EnsemblmRatBN7.2
Rnor_6.01788,952,635 - 89,167,538 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1788,963,981 - 89,167,018 (+)Ensemblrn6Rnor6.0
Rnor_5.01790,644,728 - 90,848,287 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41795,974,131 - 96,255,016 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1784,131,602 - 84,345,464 (-)NCBICelera
Cytogenetic Map17q12.3NCBI
MYO3A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381025,934,229 - 26,212,532 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1025,934,214 - 26,212,533 (+)Ensemblhg38GRCh38
GRCh371026,223,158 - 26,501,461 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361026,263,008 - 26,541,471 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341026,263,201 - 26,541,461NCBI
Celera1025,934,775 - 26,213,211 (+)NCBICelera
Cytogenetic Map10p12.1NCBI
HuRef1025,882,877 - 26,160,876 (+)NCBIHuRef
CHM1_11026,223,961 - 26,502,366 (+)NCBICHM1_1
T2T-CHM13v2.01025,959,075 - 26,237,044 (+)NCBIT2T-CHM13v2.0
Myo3a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39222,232,360 - 22,508,693 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl222,232,316 - 22,508,264 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38222,227,503 - 22,618,252 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl222,227,503 - 22,618,252 (+)Ensemblmm10GRCm38
MGSCv37222,397,933 - 22,473,772 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv37222,149,130 - 22,345,058 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36222,145,268 - 22,326,670 (+)NCBIMGSCv36mm8
Celera222,084,521 - 22,348,339 (+)NCBICelera
Cytogenetic Map2A3NCBI
cM Map215.15NCBI
Myo3a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554293,172,996 - 3,358,688 (-)Ensembl
ChiLan1.0NW_0049554293,172,457 - 3,358,688 (-)NCBIChiLan1.0ChiLan1.0
MYO3A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2838,626,432 - 38,911,867 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11038,631,757 - 38,917,192 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01026,104,588 - 26,389,942 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11026,469,742 - 26,754,989 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1026,469,742 - 26,754,989 (+)EnsemblpanPan2panpan1.1
MYO3A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.127,455,125 - 7,695,483 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl27,455,625 - 7,696,043 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha26,179,179 - 6,283,009 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
Dog10K_Boxer_Tasha26,315,895 - 6,383,364 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.025,651,655 - 5,891,742 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl25,652,155 - 5,892,411 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.125,021,608 - 5,261,003 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.025,101,017 - 5,341,262 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.025,266,724 - 5,512,877 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Myo3a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934425,343,749 - 25,558,593 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364841,509,235 - 1,723,554 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364841,509,248 - 1,723,717 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MYO3A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11049,392,119 - 49,623,575 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21054,693,394 - 54,927,747 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MYO3A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1925,635,918 - 25,902,552 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605131,626,230 - 31,887,932 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Myo3a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247962,774,153 - 2,983,853 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Myo3a
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1141,939,394 - 2,125,796 (-)NCBIRrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:40
Count of miRNA genes:38
Interacting mature miRNAs:40
Transcripts:ENSRNOT00000025053
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300131Bp193Blood pressure QTL 1933.3arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)176855004093515804Rat
1300148Bp192Blood pressure QTL 1923.47arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)174605012691050126Rat
61466Niddm12Non-insulin dependent diabetes mellitus QTL 123.20.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)176515487293515804Rat
4889894Eae33Experimental allergic encephalomyelitis QTL 335.20.0001nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)175560459793006569Rat
2317038Ginf3Gastrointestinal inflammation QTL 32.890.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)175482950393515804Rat

Markers in Region
D17Got108  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21784,749,453 - 84,749,615 (+)MAPPERmRatBN7.2
mRatBN7.2962,908,046 - 62,908,187 (+)MAPPERmRatBN7.2
Rnor_6.0968,289,304 - 68,289,444NCBIRnor6.0
Rnor_6.01789,157,430 - 89,157,591NCBIRnor6.0
Rnor_5.01790,838,179 - 90,838,340UniSTSRnor5.0
Rnor_5.0968,100,560 - 68,100,700UniSTSRnor5.0
RGSC_v3.41796,245,427 - 96,245,589RGDRGSC3.4
RGSC_v3.4960,113,903 - 60,114,043UniSTSRGSC3.4
RGSC_v3.41796,245,428 - 96,245,589UniSTSRGSC3.4
Celera1784,141,553 - 84,141,714UniSTS
Celera960,331,144 - 60,331,284UniSTS
RGSC_v3.11796,256,261 - 96,256,422RGD
RH 3.4 Map17841.7RGD
RH 3.4 Map17841.7UniSTS
RH 2.0 Map17724.6RGD
Cytogenetic Map9q31UniSTS
Cytogenetic Map17q12.3UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
10 4 24 125 53 52 21 13 21 6 150 58 4 107 57 76 31 7 7

Sequence


Ensembl Acc Id: ENSRNOT00000025053   ⟹   ENSRNOP00000025053
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1789,451,567 - 89,667,654 (+)Ensembl
mRatBN7.2 Ensembl1784,543,552 - 84,759,042 (+)Ensembl
Rnor_6.0 Ensembl1788,963,981 - 89,167,018 (+)Ensembl
RefSeq Acc Id: NM_001419731   ⟹   NP_001406660
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81789,451,567 - 89,667,654 (+)NCBI
mRatBN7.21784,543,465 - 84,759,562 (+)NCBI
RefSeq Acc Id: XM_063276705   ⟹   XP_063132775
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81789,539,500 - 89,667,654 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001406660 (Get FASTA)   NCBI Sequence Viewer  
  XP_063132775 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL83942 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000025053
  ENSRNOP00000025053.6
Ensembl Acc Id: ENSRNOP00000025053   ⟸   ENSRNOT00000025053
RefSeq Acc Id: NP_001406660   ⟸   NM_001419731
- UniProtKB: A6KS04 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063132775   ⟸   XM_063276705
- Peptide Label: isoform X1
Protein Domains
Myosin motor   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZZK7-F1-model_v2 AlphaFold D3ZZK7 1-1621 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1560083 AgrOrtholog
BioCyc Gene G2FUF-8490 BioCyc
Ensembl Genes ENSRNOG00000018478 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000025053 ENTREZGENE
  ENSRNOT00000025053.7 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.820 UniProtKB/TrEMBL
  1.20.5.190 UniProtKB/TrEMBL
  1.20.58.530 UniProtKB/TrEMBL
  3.40.850.10 UniProtKB/TrEMBL
  6.20.240.20 UniProtKB/TrEMBL
  Myosin VI head, motor domain, U50 subdomain UniProtKB/TrEMBL
  Phosphorylase Kinase, domain 1 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro IQ_CaM-bd_region UniProtKB/TrEMBL
  Kinase-like_dom UniProtKB/TrEMBL
  Kinesin_motor_dom_sf UniProtKB/TrEMBL
  Myosin-III_kinase_activity UniProtKB/TrEMBL
  Myosin_head_motor_dom UniProtKB/TrEMBL
  MYSc_Myo3 UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
NCBI Gene 498806 ENTREZGENE
PANTHER AGAP011099-PA UniProtKB/TrEMBL
  MYOSIN-IIIA UniProtKB/TrEMBL
Pfam Myosin_head UniProtKB/TrEMBL
  PF00612 UniProtKB/TrEMBL
  Pkinase UniProtKB/TrEMBL
PhenoGen Myo3a PhenoGen
PRINTS MYOSINHEAVY UniProtKB/TrEMBL
PROSITE MYOSIN_MOTOR UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PS50096 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000018478 RatGTEx
SMART MYSc UniProtKB/TrEMBL
  S_TKc UniProtKB/TrEMBL
  SM00015 UniProtKB/TrEMBL
Superfamily-SCOP Kinase_like UniProtKB/TrEMBL
  SSF52540 UniProtKB/TrEMBL
UniProt A6KS04 ENTREZGENE, UniProtKB/TrEMBL
  D3ZZK7_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-04-23 Myo3a  myosin IIIA  RGD1560083  similar to myosin IIIA  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1560083  similar to myosin IIIA   RGD1560083_predicted  similar to myosin IIIA (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1560083_predicted  similar to myosin IIIA (predicted)  LOC498806  similar to myosin IIIA  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC498806  similar to myosin IIIA      Symbol and Name status set to provisional 70820 PROVISIONAL