Dner (delta/notch-like EGF repeat containing) - Rat Genome Database

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Gene: Dner (delta/notch-like EGF repeat containing) Rattus norvegicus
Analyze
Symbol: Dner
Name: delta/notch-like EGF repeat containing
RGD ID: 1359385
Description: Predicted to enable Notch binding activity. Predicted to be involved in central nervous system development. Predicted to act upstream of or within Notch receptor processing; glial cell differentiation; and skeletal muscle fiber development. Predicted to be located in several cellular components, including dendrite; early endosome; and neuronal cell body. Orthologous to human DNER (delta/notch like EGF repeat containing); PARTICIPATES IN Notch signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: delta and Notch-like epidermal growth factor-related receptor; delta/notch-like EGF-related receptor; LOC316573; similar to Dner protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8993,035,108 - 93,350,568 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl993,035,108 - 93,350,568 (-)EnsemblGRCr8
mRatBN7.2985,586,985 - 85,902,461 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl985,586,987 - 85,902,637 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx994,015,224 - 94,317,755 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0999,143,722 - 99,446,238 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0997,530,682 - 97,831,070 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0991,965,866 - 92,291,172 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl991,965,866 - 92,291,220 (-)Ensemblrn6Rnor6.0
Rnor_5.0991,700,319 - 92,023,695 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4983,716,070 - 83,821,294 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera983,016,881 - 83,326,945 (-)NCBICelera
RGSC_v3.1983,899,837 - 84,004,713 (-)NCBI
Cytogenetic Map9q35NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1-nitropyrene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-palmitoylglycerol  (ISO)
3,4-dichloroaniline  (ISO)
3-Chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
amphetamine  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
CGP 52608  (ISO)
chenodeoxycholic acid  (ISO)
chromium atom  (ISO)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
deoxycholic acid  (ISO)
dibutyl phthalate  (ISO)
diclofenac  (ISO)
diethyl phthalate  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dioxygen  (EXP)
diuron  (ISO)
Domiphen bromide  (ISO)
dorsomorphin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
epichlorohydrin  (ISO)
ethanol  (ISO)
ferroheme b  (ISO)
folic acid  (ISO)
genistein  (ISO)
glucose  (ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glyphosate  (EXP)
heme b  (ISO)
hydroquinone  (ISO)
ivermectin  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
medroxyprogesterone acetate  (ISO)
methimazole  (EXP)
methoxychlor  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
nickel atom  (ISO)
okadaic acid  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pioglitazone  (ISO)
potassium chromate  (ISO)
progesterone  (ISO)
propanal  (ISO)
SB 431542  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
tartrazine  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
trichostatin A  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
dendrite  (IEA,ISO)
early endosome  (IEA,ISO)
neuronal cell body  (IEA,ISO)
plasma membrane  (IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
4. GOA pipeline RGD automated data pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:11950833   PMID:15965470  


Genomics

Comparative Map Data
Dner
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8993,035,108 - 93,350,568 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl993,035,108 - 93,350,568 (-)EnsemblGRCr8
mRatBN7.2985,586,985 - 85,902,461 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl985,586,987 - 85,902,637 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx994,015,224 - 94,317,755 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0999,143,722 - 99,446,238 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0997,530,682 - 97,831,070 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0991,965,866 - 92,291,172 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl991,965,866 - 92,291,220 (-)Ensemblrn6Rnor6.0
Rnor_5.0991,700,319 - 92,023,695 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4983,716,070 - 83,821,294 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera983,016,881 - 83,326,945 (-)NCBICelera
RGSC_v3.1983,899,837 - 84,004,713 (-)NCBI
Cytogenetic Map9q35NCBI
DNER
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382229,357,629 - 229,714,555 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2229,357,629 - 229,714,581 (-)Ensemblhg38GRCh38
GRCh372230,222,345 - 230,579,271 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362229,930,589 - 230,287,530 (-)NCBIBuild 36Build 36hg18NCBI36
Celera2223,997,841 - 224,354,753 (-)NCBICelera
Cytogenetic Map2q36.3NCBI
HuRef2222,063,233 - 222,419,423 (-)NCBIHuRef
CHM1_12230,228,171 - 230,585,124 (-)NCBICHM1_1
T2T-CHM13v2.02229,840,190 - 230,197,123 (-)NCBIT2T-CHM13v2.0
Dner
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39184,347,560 - 84,673,942 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl184,347,560 - 84,673,942 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38184,369,839 - 84,696,221 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl184,369,839 - 84,696,221 (-)Ensemblmm10GRCm38
MGSCv37184,366,414 - 84,692,796 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36184,248,864 - 84,575,246 (-)NCBIMGSCv36mm8
Celera184,429,076 - 84,756,047 (-)NCBICelera
Cytogenetic Map1C5NCBI
cM Map143.4NCBI
Dner
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554535,307,256 - 5,615,609 (+)Ensembl
ChiLan1.0NW_0049554535,307,256 - 5,615,550 (+)NCBIChiLan1.0ChiLan1.0
DNER
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213131,978,893 - 132,337,732 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B131,993,860 - 132,352,692 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B116,604,193 - 116,963,026 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B235,409,108 - 235,642,158 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B235,409,108 - 235,642,161 (-)EnsemblpanPan2panpan1.1
DNER
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12541,709,570 - 41,887,705 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2541,710,420 - 42,019,885 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2542,333,402 - 42,646,081 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02541,964,886 - 42,276,304 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2541,964,888 - 42,276,509 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12541,894,543 - 42,207,390 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02541,734,881 - 42,047,810 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02541,908,081 - 42,221,461 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Dner
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303183,901,774 - 184,204,798 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365256,735,049 - 7,037,042 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365256,734,924 - 7,037,947 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DNER
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15130,415,061 - 130,754,048 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.115130,414,159 - 130,754,043 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215144,454,568 - 144,601,085 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DNER
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110115,357,097 - 115,739,992 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl10115,357,084 - 115,739,777 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604083,717,051 - 84,079,196 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dner
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248433,237,270 - 3,552,551 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248433,238,390 - 3,552,566 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Dner
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v14157,122,078 - 157,401,849 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Dner
2629 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:209
Count of miRNA genes:148
Interacting mature miRNAs:165
Transcripts:ENSRNOT00000022564
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)956047863101047863Rat
1582203Gluco19Glucose level QTL 193.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)963376862108376862Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)965657365108376720Rat
724547Cm21Cardiac mass QTL 212.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)986720043110356905Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)94445825699506504Rat
2303178Bp334Blood pressure QTL 3343.70.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)986720043121768150Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)964220169109220169Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)964220169109220169Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)944458256121768150Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)964220169109220169Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)968875497121768150Rat
1354626Bvd1Brain ventricular dilatation QTL 13.730.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)983161999118999486Rat
4889852Pur26Proteinuria QTL 26150.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)985262459109044727Rat
7794784Mcs31Mammary carcinoma susceptibility QTL 312.98mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)985262459118999486Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)948718864108376862Rat
1578757Pur6Proteinuria QTL 63.30.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)964220169109220169Rat
4889943Bss90Bone structure and strength QTL 904.1tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)95450650499506504Rat

Markers in Region
RH130400  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2985,641,839 - 85,642,019 (+)MAPPERmRatBN7.2
Rnor_6.0992,020,957 - 92,021,136NCBIRnor6.0
Rnor_5.0991,755,410 - 91,755,589UniSTSRnor5.0
RGSC_v3.4983,771,247 - 83,771,426UniSTSRGSC3.4
Celera983,071,735 - 83,071,914UniSTS
Cytogenetic Map9q34-q35UniSTS
BE099443  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2985,626,742 - 85,626,896 (+)MAPPERmRatBN7.2
Rnor_6.0992,005,628 - 92,005,781NCBIRnor6.0
Rnor_5.0991,740,081 - 91,740,234UniSTSRnor5.0
RGSC_v3.4983,756,182 - 83,756,335UniSTSRGSC3.4
Celera983,056,639 - 83,056,792UniSTS
Cytogenetic Map9q34-q35UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 10 67 162 62 61 34 51 34 6 249 145 8 137 47 88 27 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000022564
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl993,035,702 - 93,134,407 (-)Ensembl
mRatBN7.2 Ensembl985,587,579 - 85,686,288 (-)Ensembl
Rnor_6.0 Ensembl991,966,459 - 92,065,402 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000093357   ⟹   ENSRNOP00000076139
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl993,035,108 - 93,350,568 (-)Ensembl
mRatBN7.2 Ensembl985,586,987 - 85,902,637 (-)Ensembl
Rnor_6.0 Ensembl991,965,866 - 92,291,220 (-)Ensembl
RefSeq Acc Id: NM_001399331   ⟹   NP_001386260
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8993,035,108 - 93,350,568 (-)NCBI
mRatBN7.2985,586,985 - 85,902,461 (-)NCBI
RefSeq Acc Id: XM_039084678   ⟹   XP_038940606
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8993,035,108 - 93,134,435 (-)NCBI
mRatBN7.2985,586,985 - 85,686,310 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001386260 (Get FASTA)   NCBI Sequence Viewer  
  XP_038940606 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH86329 (Get FASTA)   NCBI Sequence Viewer  
  EDL75534 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000076139
  ENSRNOP00000076139.1
  ENSRNOP00000088607
  ENSRNOP00000088607.1
Ensembl Acc Id: ENSRNOP00000076139   ⟸   ENSRNOT00000093357
RefSeq Acc Id: XP_038940606   ⟸   XM_039084678
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A870 (UniProtKB/TrEMBL),   Q5U215 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001386260   ⟸   NM_001399331
- Peptide Label: precursor
- UniProtKB: A0A1W2Q656 (UniProtKB/TrEMBL),   A6JWC6 (UniProtKB/TrEMBL)
Protein Domains
EGF-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A1W2Q656-F1-model_v2 AlphaFold A0A1W2Q656 1-746 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696809
Promoter ID:EPDNEW_R7333
Type:initiation region
Name:Dner_1
Description:delta/notch-like EGF repeat containing
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R7334  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0992,065,377 - 92,065,437EPDNEW
RGD ID:13696810
Promoter ID:EPDNEW_R7334
Type:initiation region
Name:Dner_2
Description:delta/notch-like EGF repeat containing
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R7333  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0992,290,820 - 92,290,880EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1359385 AgrOrtholog
BioCyc Gene G2FUF-26956 BioCyc
Ensembl Genes ENSRNOG00000016640 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000022564 ENTREZGENE
  ENSRNOT00000022564.8 UniProtKB/TrEMBL
  ENSRNOT00000093357 ENTREZGENE
  ENSRNOT00000093357.3 UniProtKB/TrEMBL
Gene3D-CATH Laminin UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7135168 IMAGE-MGC_LOAD
InterPro DNER_C UniProtKB/TrEMBL
  EGF-like_Ca-bd_dom UniProtKB/TrEMBL
  EGF-like_CS UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/TrEMBL
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/TrEMBL
  EGF_Ca-bd_CS UniProtKB/TrEMBL
  Growth_fac_rcpt_ UniProtKB/TrEMBL
  Notch_Cell-Fate_Det UniProtKB/TrEMBL
MGC_CLONE MGC:105904 IMAGE-MGC_LOAD
NCBI Gene 316573 ENTREZGENE
PANTHER CRUMBS FAMILY MEMBER UniProtKB/TrEMBL
  CYTOCHROME C OXIDASE POLYPEPTIDE VIC-2 UniProtKB/TrEMBL
  EGF-LIKE DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
  EGF-LIKE DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
  UNINFLATABLE, ISOFORM C UniProtKB/TrEMBL
Pfam DNER_C UniProtKB/TrEMBL
  EGF UniProtKB/TrEMBL
  hEGF UniProtKB/TrEMBL
PhenoGen Dner PhenoGen
PRINTS EGFBLOOD UniProtKB/TrEMBL
PROSITE ASX_HYDROXYL UniProtKB/TrEMBL
  EGF_1 UniProtKB/TrEMBL
  EGF_2 UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
RatGTEx ENSRNOG00000016640 RatGTEx
SMART EGF UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
Superfamily-SCOP EGF/Laminin UniProtKB/TrEMBL
  SSF57184 UniProtKB/TrEMBL
UniProt A0A1W2Q656 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A870 ENTREZGENE, UniProtKB/TrEMBL
  A6JWC6 ENTREZGENE, UniProtKB/TrEMBL
  Q5U215 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-11-11 Dner  delta/notch-like EGF repeat containing  Dner  delta/notch-like EGF-related receptor  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-05 Dner  delta/notch-like EGF-related receptor  LOC316573  similar to Dner protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-07-29 LOC316573  similar to Dner protein      Symbol and Name status set to provisional 70820 PROVISIONAL