Mavs (mitochondrial antiviral signaling protein) - Rat Genome Database

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Gene: Mavs (mitochondrial antiviral signaling protein) Rattus norvegicus
Analyze
Symbol: Mavs
Name: mitochondrial antiviral signaling protein
RGD ID: 1359371
Description: Predicted to enable several functions, including CARD domain binding activity; molecular condensate scaffold activity; and protein serine/threonine kinase binding activity. Predicted to be involved in several processes, including cellular response to exogenous dsRNA; positive regulation of cytokine production; and regulation of defense response. Predicted to act upstream of or within several processes, including antiviral innate immune response; cytoplasmic pattern recognition receptor signaling pathway; and mRNA transcription. Predicted to be located in mitochondrion and peroxisomal membrane. Predicted to be active in mitochondrial outer membrane. Orthologous to human MAVS (mitochondrial antiviral signaling protein); PARTICIPATES IN hepatitis C pathway; influenza A pathway; measles pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: interferon beta promoter stimulator protein 1; interferon-beta promoter stimulator protein 1; IPS-1; MGC93707; mitochondrial antiviral-signaling protein; similar to RIKEN cDNA D430028G21; virus-induced signaling adapter; virus-induced signaling adaptor; virus-induced-signaling adapter; Visa
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83138,904,673 - 138,919,129 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3138,904,771 - 138,919,126 (+)EnsemblGRCr8
mRatBN7.23118,451,650 - 118,466,094 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3118,451,743 - 118,466,094 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3122,346,068 - 122,360,237 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03130,945,435 - 130,959,618 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03128,602,173 - 128,616,342 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03123,776,147 - 123,790,572 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3123,776,181 - 123,790,567 (+)Ensemblrn6Rnor6.0
Rnor_5.03130,273,531 - 130,287,792 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43118,938,433 - 118,953,081 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3117,259,863 - 117,274,017 (+)NCBICelera
RGSC_v3.13118,844,005 - 118,858,653 (+)NCBI
Cytogenetic Map3q36NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
beauvericin  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
Brodifacoum  (EXP)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
coumarin  (ISO)
dextran sulfate  (ISO)
dicrotophos  (ISO)
dimethyl sulfoxide  (ISO)
dioxygen  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (ISO)
erianin  (ISO)
folic acid  (ISO)
FR900359  (ISO)
glyphosate  (ISO)
GSK-J4  (ISO)
hydrogen peroxide  (ISO)
hydroxychloroquine  (ISO)
ivermectin  (ISO)
ketamine  (EXP)
lipopolysaccharide  (ISO)
methamphetamine  (ISO)
methimazole  (EXP)
methyl methanesulfonate  (ISO)
morphine  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
nitrates  (ISO)
ochratoxin A  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
rotenone  (EXP,ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
sulfadimethoxine  (EXP)
temozolomide  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
triptonide  (ISO)
trovafloxacin  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of innate immune response  (ISO,ISS)
antiviral innate immune response  (ISO)
cellular response to exogenous dsRNA  (ISO,ISS)
cellular response to interferon-beta  (ISO)
cytoplasmic pattern recognition receptor signaling pathway  (IEA,ISO)
defense response to bacterium  (ISO,ISS)
defense response to virus  (IEA)
immune system process  (IEA)
innate immune response  (IEA,ISO,ISS)
intracellular signal transduction  (ISO)
negative regulation of viral genome replication  (IEA,ISO)
positive regulation of canonical NF-kappaB signal transduction  (ISO)
positive regulation of chemokine (C-C motif) ligand 5 production  (ISO)
positive regulation of defense response to virus by host  (IEA,ISO,ISS)
positive regulation of interferon-alpha production  (IEA,ISO,ISS)
positive regulation of interferon-beta production  (IEA,ISO,ISS)
positive regulation of interleukin-6 production  (IEA,ISO,ISS)
positive regulation of interleukin-8 production  (ISO)
positive regulation of IP-10 production  (ISO)
positive regulation of myeloid dendritic cell cytokine production  (ISO,ISS)
positive regulation of NLRP3 inflammasome complex assembly  (IEA,ISO)
positive regulation of protein import into nucleus  (ISO)
positive regulation of response to cytokine stimulus  (ISO,ISS)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of tumor necrosis factor production  (ISO,ISS)
positive regulation of type I interferon production  (ISO)
positive regulation of type I interferon-mediated signaling pathway  (ISO)
protein localization to mitochondrion  (IEA,ISO)
protein tetramerization  (ISO)
regulation of peroxisome organization  (IEA,ISO)
RIG-I signaling pathway  (ISO)
signal transduction  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Extrinsic MAVS signaling is critical for Treg maintenance of Foxp3 expression following acute flavivirus infection. Da Costa A, etal., Sci Rep. 2017 Jan 17;7:40720. doi: 10.1038/srep40720.
2. Mitochondrial antiviral-signalling protein plays an essential role in host immunity against human metapneumovirus. Deng J, etal., J Gen Virol. 2015 Aug;96(8):2104-2113. doi: 10.1099/vir.0.000178. Epub 2015 May 7.
3. Rotavirus VP3 targets MAVS for degradation to inhibit type III interferon expression in intestinal epithelial cells. Ding S, etal., Elife. 2018 Nov 21;7. pii: 39494. doi: 10.7554/eLife.39494.
4. Transcriptomic response to Yersinia pestis: RIG-I like receptor signaling response is detrimental to the host against plague. Du Z, etal., J Genet Genomics. 2014 Jul 20;41(7):379-96. doi: 10.1016/j.jgg.2014.05.006. Epub 2014 Jun 3.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Constitutively Active MAVS Inhibits HIV-1 Replication via Type I Interferon Secretion and Induction of HIV-1 Restriction Factors. Gupta S, etal., PLoS One. 2016 Feb 5;11(2):e0148929. doi: 10.1371/journal.pone.0148929. eCollection 2016.
7. RIG-I Signaling Is Critical for Efficient Polyfunctional T Cell Responses during Influenza Virus Infection. Kandasamy M, etal., PLoS Pathog. 2016 Jul 20;12(7):e1005754. doi: 10.1371/journal.ppat.1005754. eCollection 2016 Jul.
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. GOA pipeline RGD automated data pipeline
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. MAVS O-GlcNAcylation Is Essential for Host Antiviral Immunity against Lethal RNA Viruses. Song N, etal., Cell Rep. 2019 Aug 27;28(9):2386-2396.e5. doi: 10.1016/j.celrep.2019.07.085.
12. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
13. VISA is an adapter protein required for virus-triggered IFN-beta signaling. Xu LG, etal., Mol Cell 2005 Sep 16;19(6):727-40.
Additional References at PubMed
PMID:12761501   PMID:15489334   PMID:16127453   PMID:16641100   PMID:18586328   PMID:18614015   PMID:18780793   PMID:18818105   PMID:19609254   PMID:19631370   PMID:20451243   PMID:21703541  
PMID:21957149   PMID:22745163  


Genomics

Comparative Map Data
Mavs
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83138,904,673 - 138,919,129 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3138,904,771 - 138,919,126 (+)EnsemblGRCr8
mRatBN7.23118,451,650 - 118,466,094 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3118,451,743 - 118,466,094 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3122,346,068 - 122,360,237 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03130,945,435 - 130,959,618 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03128,602,173 - 128,616,342 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03123,776,147 - 123,790,572 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3123,776,181 - 123,790,567 (+)Ensemblrn6Rnor6.0
Rnor_5.03130,273,531 - 130,287,792 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43118,938,433 - 118,953,081 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3117,259,863 - 117,274,017 (+)NCBICelera
RGSC_v3.13118,844,005 - 118,858,653 (+)NCBI
Cytogenetic Map3q36NCBI
MAVS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38203,846,834 - 3,876,118 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl203,842,694 - 3,876,123 (+)Ensemblhg38GRCh38
GRCh37203,827,481 - 3,856,765 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36203,775,484 - 3,795,973 (+)NCBIBuild 36Build 36hg18NCBI36
Celera203,889,325 - 3,918,630 (+)NCBICelera
Cytogenetic Map20p13NCBI
HuRef203,776,247 - 3,805,626 (+)NCBIHuRef
CHM1_1203,827,384 - 3,856,773 (+)NCBICHM1_1
T2T-CHM13v2.0203,877,778 - 3,907,055 (+)NCBIT2T-CHM13v2.0
Mavs
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392131,075,445 - 131,089,945 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2131,075,983 - 131,089,945 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm382131,234,063 - 131,248,025 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2131,234,063 - 131,248,025 (+)Ensemblmm10GRCm38
MGSCv372131,059,874 - 131,073,761 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv362130,925,579 - 130,939,466 (+)NCBIMGSCv36mm8
Celera2132,460,494 - 132,474,382 (+)NCBICelera
Cytogenetic Map2F1NCBI
cM Map263.3NCBI
Mavs
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541514,695,438 - 14,703,672 (+)Ensembl
ChiLan1.0NW_00495541514,691,918 - 14,704,782 (+)NCBIChiLan1.0ChiLan1.0
MAVS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2214,809,731 - 4,837,991 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1204,806,483 - 4,834,798 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0203,885,044 - 3,903,554 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1203,659,558 - 3,702,397 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl203,659,559 - 3,701,089 (+)EnsemblpanPan2panpan1.1
MAVS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12417,510,209 - 17,529,286 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2417,512,761 - 17,523,807 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2417,342,451 - 17,353,500 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02417,930,606 - 17,947,974 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2417,930,603 - 17,942,617 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12417,526,451 - 17,537,501 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02417,637,457 - 17,648,500 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02417,965,346 - 17,976,396 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Mavs
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640166,413,582 - 166,427,872 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648514,842,160 - 14,859,202 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493648514,842,778 - 14,859,163 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAVS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1731,850,900 - 31,869,188 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11731,850,646 - 31,869,273 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21736,193,888 - 36,210,273 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MAVS
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1234,534,433 - 34,555,406 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl234,541,229 - 34,552,823 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660719,898,086 - 9,918,187 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mavs
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247414,939,040 - 4,954,058 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247414,936,556 - 4,951,081 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Mavs
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v15110,959,649 - 110,973,551 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Mavs
125 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:180
Count of miRNA genes:115
Interacting mature miRNAs:125
Transcripts:ENSRNOT00000034146
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582233Insul10Insulin level QTL 105.40.0015blood insulin amount (VT:0001560)serum insulin level times blood glucose level (CMO:0002040)3133259579178259579Rat
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)396509147141509147Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)3129154923182114333Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)367641776167835660Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)358601291153936591Rat
7387306Bw124Body weight QTL 1243.20.0003body mass (VT:0001259)body weight (CMO:0000012)3104545086149545086Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3133134628178134628Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)381425008141509147Rat
8694437Bw167Body weight QTL 16722.460.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)3112250810157250810Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)379649560177741895Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)396509147141509147Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)3117537367162537367Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3125116475170116475Rat
631649Bp123Blood pressure QTL 1233.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3110225882155225882Rat
1358204Insglur1Insulin/glucose ratio QTL 13.8blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)3136091420155634702Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)390755164141509147Rat
5686842Rf59Renal function QTL 59urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)3122395989167395989Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)3131036586176036586Rat
631673Iddm13Insulin dependent diabetes mellitus QTL 131.30.663blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)3137114333182114333Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)3131036586176036586Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)398651826167012663Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)3125814931139636791Rat
1331758Bp207Blood pressure QTL 2072.848arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3110634702155634702Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)3116188400161188400Rat

Markers in Region
AI502240  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23118,465,695 - 118,465,911 (+)MAPPERmRatBN7.2
Rnor_6.03123,790,174 - 123,790,389NCBIRnor6.0
Rnor_5.03130,287,394 - 130,287,609UniSTSRnor5.0
RGSC_v3.43118,952,687 - 118,952,902UniSTSRGSC3.4
Celera3117,273,623 - 117,273,838UniSTS
RH 3.4 Map31012.9UniSTS
Cytogenetic Map3q36UniSTS
RH139303  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23118,452,224 - 118,452,348 (+)MAPPERmRatBN7.2
Rnor_6.03123,776,692 - 123,776,815NCBIRnor6.0
Rnor_5.03130,274,059 - 130,274,182UniSTSRnor5.0
RGSC_v3.43118,938,870 - 118,938,993UniSTSRGSC3.4
Celera3117,260,300 - 117,260,423UniSTS
RH 3.4 Map31016.3UniSTS
Cytogenetic Map3q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001005556 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006235034 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006235035 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006235036 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006235037 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008762179 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039105011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283774 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283775 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283776 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283778 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283779 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283780 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283781 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283782 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC105811 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC110439 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC081869 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473949 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232000 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000034146   ⟹   ENSRNOP00000033476
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3138,911,671 - 138,919,126 (+)Ensembl
mRatBN7.2 Ensembl3118,458,647 - 118,466,094 (+)Ensembl
Rnor_6.0 Ensembl3123,776,255 - 123,790,567 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000090764   ⟹   ENSRNOP00000073053
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3138,904,771 - 138,919,125 (+)Ensembl
mRatBN7.2 Ensembl3118,451,743 - 118,466,094 (+)Ensembl
Rnor_6.0 Ensembl3123,776,181 - 123,789,637 (+)Ensembl
RefSeq Acc Id: NM_001005556   ⟹   NP_001005556
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83138,904,812 - 138,919,125 (+)NCBI
mRatBN7.23118,451,788 - 118,466,090 (+)NCBI
Rnor_6.03123,776,255 - 123,790,568 (+)NCBI
Rnor_5.03130,273,531 - 130,287,792 (+)NCBI
RGSC_v3.43118,938,433 - 118,953,081 (+)RGD
Celera3117,259,863 - 117,274,017 (+)RGD
Sequence:
RefSeq Acc Id: XM_006235034   ⟹   XP_006235096
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83138,904,674 - 138,919,129 (+)NCBI
mRatBN7.23118,451,650 - 118,466,094 (+)NCBI
Rnor_6.03123,776,147 - 123,790,572 (+)NCBI
Rnor_5.03130,273,531 - 130,287,792 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006235035   ⟹   XP_006235097
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83138,904,736 - 138,919,129 (+)NCBI
mRatBN7.23118,451,733 - 118,466,094 (+)NCBI
Rnor_6.03123,776,173 - 123,790,572 (+)NCBI
Rnor_5.03130,273,531 - 130,287,792 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006235036   ⟹   XP_006235098
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83138,904,743 - 138,919,129 (+)NCBI
mRatBN7.23118,451,754 - 118,466,094 (+)NCBI
Rnor_6.03123,776,172 - 123,790,572 (+)NCBI
Rnor_5.03130,273,531 - 130,287,792 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006235037   ⟹   XP_006235099
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83138,904,812 - 138,919,129 (+)NCBI
mRatBN7.23118,451,733 - 118,466,094 (+)NCBI
Rnor_6.03123,776,174 - 123,790,572 (+)NCBI
Rnor_5.03130,273,531 - 130,287,792 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039105011   ⟹   XP_038960939
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83138,904,790 - 138,919,129 (+)NCBI
mRatBN7.23118,451,727 - 118,466,094 (+)NCBI
RefSeq Acc Id: XM_063283774   ⟹   XP_063139844
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83138,906,047 - 138,919,129 (+)NCBI
RefSeq Acc Id: XM_063283775   ⟹   XP_063139845
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83138,904,731 - 138,919,129 (+)NCBI
RefSeq Acc Id: XM_063283776   ⟹   XP_063139846
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83138,904,788 - 138,919,129 (+)NCBI
RefSeq Acc Id: XM_063283778   ⟹   XP_063139848
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83138,904,796 - 138,919,129 (+)NCBI
RefSeq Acc Id: XM_063283779   ⟹   XP_063139849
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83138,904,787 - 138,919,129 (+)NCBI
RefSeq Acc Id: XM_063283780   ⟹   XP_063139850
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83138,906,044 - 138,919,129 (+)NCBI
RefSeq Acc Id: XM_063283781   ⟹   XP_063139851
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83138,904,673 - 138,919,129 (+)NCBI
RefSeq Acc Id: XM_063283782   ⟹   XP_063139852
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83138,906,043 - 138,916,715 (+)NCBI
RefSeq Acc Id: NP_001005556   ⟸   NM_001005556
- UniProtKB: Q66HG9 (UniProtKB/Swiss-Prot),   A6HQD4 (UniProtKB/TrEMBL),   A0A8L2QH64 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006235096   ⟸   XM_006235034
- Peptide Label: isoform X1
- UniProtKB: Q66HG9 (UniProtKB/Swiss-Prot),   A6HQD4 (UniProtKB/TrEMBL),   A0A8L2QH64 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006235099   ⟸   XM_006235037
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_006235098   ⟸   XM_006235036
- Peptide Label: isoform X1
- UniProtKB: Q66HG9 (UniProtKB/Swiss-Prot),   A6HQD4 (UniProtKB/TrEMBL),   A0A8L2QH64 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006235097   ⟸   XM_006235035
- Peptide Label: isoform X1
- UniProtKB: Q66HG9 (UniProtKB/Swiss-Prot),   A6HQD4 (UniProtKB/TrEMBL),   A0A8L2QH64 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000073053   ⟸   ENSRNOT00000090764
Ensembl Acc Id: ENSRNOP00000033476   ⟸   ENSRNOT00000034146
RefSeq Acc Id: XP_038960939   ⟸   XM_039105011
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063139851   ⟸   XM_063283781
- Peptide Label: isoform X2
- UniProtKB: A0A8L2QH64 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063139845   ⟸   XM_063283775
- Peptide Label: isoform X1
- UniProtKB: Q66HG9 (UniProtKB/Swiss-Prot),   A6HQD4 (UniProtKB/TrEMBL),   A0A8L2QH64 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063139849   ⟸   XM_063283779
- Peptide Label: isoform X2
- UniProtKB: A0A8L2QH64 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063139846   ⟸   XM_063283776
- Peptide Label: isoform X1
- UniProtKB: Q66HG9 (UniProtKB/Swiss-Prot),   A6HQD4 (UniProtKB/TrEMBL),   A0A8L2QH64 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063139848   ⟸   XM_063283778
- Peptide Label: isoform X1
- UniProtKB: Q66HG9 (UniProtKB/Swiss-Prot),   A6HQD4 (UniProtKB/TrEMBL),   A0A8L2QH64 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063139852   ⟸   XM_063283782
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063139850   ⟸   XM_063283780
- Peptide Label: isoform X2
- UniProtKB: A0A8L2QH64 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063139844   ⟸   XM_063283774
- Peptide Label: isoform X1
- UniProtKB: Q66HG9 (UniProtKB/Swiss-Prot),   A6HQD4 (UniProtKB/TrEMBL),   A0A8L2QH64 (UniProtKB/TrEMBL)
Protein Domains
CARD   Caspase recruitment

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q66HG9-F1-model_v2 AlphaFold Q66HG9 1-507 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692453
Promoter ID:EPDNEW_R2973
Type:initiation region
Name:Mavs_1
Description:mitochondrial antiviral signaling protein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03123,776,210 - 123,776,270EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1359371 AgrOrtholog
BioCyc Gene G2FUF-47818 BioCyc
Ensembl Genes ENSRNOG00000025295 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000090764 ENTREZGENE
  ENSRNOT00000090764.2 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.533.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7106026 IMAGE-MGC_LOAD
InterPro CARD_dom UniProtKB/Swiss-Prot
  CARD_IPS1 UniProtKB/Swiss-Prot
  DEATH-like_dom_sf UniProtKB/Swiss-Prot
  MAVS UniProtKB/Swiss-Prot
KEGG Report rno:311430 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93707 IMAGE-MGC_LOAD
NCBI Gene 311430 ENTREZGENE
PANTHER DUF3504 DOMAIN-CONTAINING PROTEIN UniProtKB/Swiss-Prot
  PTHR21446:SF6 UniProtKB/Swiss-Prot
Pfam CARD_2 UniProtKB/Swiss-Prot
PhenoGen Mavs PhenoGen
RatGTEx ENSRNOG00000025295 RatGTEx
UniProt A0A8L2QH64 ENTREZGENE, UniProtKB/TrEMBL
  A6HQD4 ENTREZGENE, UniProtKB/TrEMBL
  MAVS_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-05-05 Mavs  mitochondrial antiviral signaling protein  Visa  virus-induced signaling adapter  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-06 Visa  virus-induced signaling adapter  MGC93707  similar to RIKEN cDNA D430028G21  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-07-29 MGC93707  similar to RIKEN cDNA D430028G21      Symbol and Name status set to provisional 70820 PROVISIONAL