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Gene: Wipi2 (WD repeat domain, phosphoinositide interacting 2) Rattus norvegicus

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Symbol:

Wipi2

Name:

WD repeat domain, phosphoinositide interacting 2

RGD ID:

1359154

Description:

Predicted to enable phosphatidylinositol phosphate binding activity and protein-macromolecule adaptor activity. Predicted to be involved in autophagy of mitochondrion; cellular response to starvation; and macroautophagy. Predicted to act upstream of or within xenophagy. Predicted to be located in autophagosome; membrane; and phagophore assembly site. Predicted to be part of protein-containing complex. Predicted to be active in cytosol and phagophore assembly site membrane. Orthologous to human WIPI2 (WD repeat domain, phosphoinositide interacting 2); INTERACTS WITH (+)-schisandrin B; 2,2',5,5'-tetrachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

MGC94226; similar to RIKEN cDNA 1110018O08; WD repeat domain phosphoinositide-interacting protein 2; WIPI-2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	WIPI2 (WD repeat domain, phosphoinositide interacting 2)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Wipi2 (WD repeat domain, phosphoinositide interacting 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Wipi2 (WD repeat domain, phosphoinositide interacting 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	WIPI2 (WD repeat domain, phosphoinositide interacting 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	WIPI2 (WD repeat domain, phosphoinositide interacting 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Wipi2 (WD repeat domain, phosphoinositide interacting 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	WIPI2 (WD repeat domain, phosphoinositide interacting 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	WIPI2 (WD repeat domain, phosphoinositide interacting 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Wipi2 (WD repeat domain, phosphoinositide interacting 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Wipi2 (WD repeat domain, phosphoinositide interacting 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	WIPI1 (WD repeat domain, phosphoinositide interacting 1)	HGNC	OrthoDB
Alliance orthologs ³
Mus musculus (house mouse):	Wipi2 (WD repeat domain, phosphoinositide interacting 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	WIPI2 (WD repeat domain, phosphoinositide interacting 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	wipi2 (WD repeat domain, phosphoinositide interacting 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Atg18a	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	ATG18	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	ATG18	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|PANTHER\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	ATG21	Alliance	DIOPT (OrthoFinder\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	atg-18	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Atg18b	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	wipi2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	12	17,024,876 - 17,053,306 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	12	17,024,878 - 17,071,406 (-)	Ensembl				GRCr8
mRatBN7.2	12	11,911,369 - 11,939,799 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	11,911,337 - 11,939,794 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	12	12,714,291 - 12,742,732 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	12	13,337,552 - 13,365,985 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	12	12,368,675 - 12,397,110 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	12	13,969,704 - 13,998,134 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	13,969,586 - 13,998,172 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	12	15,997,274 - 16,025,704 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	12	12,306,563 - 12,334,993 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	12	13,695,386 - 13,723,757 (-)	NCBI		Celera
RGSC_v3.1	12	12,336,492 - 12,364,921 (-)	NCBI
Cytogenetic Map	12	p11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

INTELLECTUAL DEVELOPMENTAL DISORDER WITH SHORT STATURE AND VARIABLE SKELETAL ANOMALIES (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

2,2',5,5'-tetrachlorobiphenyl (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dinitrotoluene (EXP)

2,6-dinitrotoluene (EXP)

2-hydroxypropanoic acid (ISO)

3-chloropropane-1,2-diol (EXP)

4,4'-diaminodiphenylmethane (EXP)

4,4'-sulfonyldiphenol (ISO)

aflatoxin B1 (ISO)

apilimod (ISO)

arsane (ISO)

arsenic atom (ISO)

atrazine (EXP)

benzo[a]pyrene (ISO)

bisphenol A (EXP)

bisphenol F (ISO)

Butylbenzyl phthalate (ISO)

cadmium dichloride (EXP,ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

choline (ISO)

cisplatin (ISO)

cobalt dichloride (ISO)

coumestrol (ISO)

diazinon (ISO)

diuron (EXP)

fipronil (EXP)

flutamide (EXP)

folic acid (ISO)

FR900359 (ISO)

fulvestrant (ISO)

GSK-J4 (ISO)

hydrogen peroxide (ISO)

L-methionine (ISO)

lead(0) (ISO)

methidathion (ISO)

paracetamol (ISO)

PCB138 (EXP)

perfluorohexanesulfonic acid (ISO)

pirinixic acid (ISO)

propiconazole (ISO)

rac-lactic acid (ISO)

sodium arsenite (ISO)

tetrachloromethane (EXP,ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

triphenyl phosphate (ISO)

triptonide (ISO)

urethane (ISO)

valproic acid (ISO)

vinclozolin (EXP)

vitamin E (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

autophagosome assembly (IEA,ISO,ISS)

autophagosome maturation (ISO)

autophagy (IEA)

autophagy of mitochondrion (IBA)

biological_process (ND)

cellular response to starvation (IEA,ISO,ISS)

glycophagy (IBA)

nucleophagy (IBA)

pexophagy (IBA)

protein lipidation involved in autophagosome assembly (ISO)

protein localization to phagophore assembly site (IBA,IEA,ISO,ISS)

response to stress (IEA)

xenophagy (ISO)

Cellular Component

autophagosome (ISO)

autophagosome membrane (ISO)

cytosol (IBA,IEA,ISO,ISS)

membrane (IEA,ISO)

phagophore assembly site (IEA,ISO)

phagophore assembly site membrane (IBA,IEA,ISO,ISS)

protein-containing complex (IEA,ISO)

Molecular Function

lipid binding (IEA)

phosphatidylinositol-3,5-bisphosphate binding (IBA,IEA,ISO,ISS)

phosphatidylinositol-3-phosphate binding (IBA,IEA,ISO,ISS)

phosphatidylinositol-5-phosphate binding (ISO)

protein binding (ISO)

protein-macromolecule adaptor activity (IBA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	WIPI-1alpha (WIPI49), a member of the novel 7-bladed WIPI protein family, is aberrantly expressed in human cancer and is linked to starvation-induced autophagy.	Proikas-Cezanne T, etal., Oncogene 2004 Dec 16;23(58):9314-25.
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
4.	Comprehensive gene review and curation	RGD comprehensive gene curation
5.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:15489334	PMID:20505359	PMID:22456507	PMID:24954904	PMID:25578879	PMID:28561066

Genomics

Comparative Map Data

Wipi2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	12	17,024,876 - 17,053,306 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	12	17,024,878 - 17,071,406 (-)	Ensembl				GRCr8
mRatBN7.2	12	11,911,369 - 11,939,799 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	11,911,337 - 11,939,794 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	12	12,714,291 - 12,742,732 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	12	13,337,552 - 13,365,985 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	12	12,368,675 - 12,397,110 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	12	13,969,704 - 13,998,134 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	13,969,586 - 13,998,172 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	12	15,997,274 - 16,025,704 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	12	12,306,563 - 12,334,993 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	12	13,695,386 - 13,723,757 (-)	NCBI		Celera
RGSC_v3.1	12	12,336,492 - 12,364,921 (-)	NCBI
Cytogenetic Map	12	p11	NCBI

WIPI2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	7	5,190,233 - 5,233,855 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	7	5,190,182 - 5,233,840 (+)	Ensembl			hg38	GRCh38
GRCh37	7	5,229,864 - 5,273,486 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	7	5,196,361 - 5,240,012 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Celera	7	5,188,959 - 5,232,605 (+)	NCBI		Celera
Cytogenetic Map	7	p22.1	NCBI
HuRef	7	5,144,841 - 5,188,513 (+)	NCBI		HuRef
CHM1_1	7	5,229,458 - 5,273,114 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	7	5,307,988 - 5,351,615 (+)	NCBI		T2T-CHM13v2.0
CRA_TCAGchr7v2	7	5,276,190 - 5,319,841 (+)	NCBI

Wipi2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	142,615,269 - 142,655,427 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	142,613,453 - 142,656,343 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	5	142,629,533 - 142,669,672 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	142,627,698 - 142,670,588 (+)	Ensembl			mm10	GRCm38
MGSCv37	5	143,105,538 - 143,145,326 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	5	142,882,057 - 142,921,846 (+)	NCBI		MGSCv36	mm8
Celera	5	139,684,840 - 139,724,789 (+)	NCBI		Celera
Cytogenetic Map	5	G2	NCBI
cM Map	5	81.53	NCBI

Wipi2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955460	10,090,349 - 10,130,384 (+)	Ensembl
ChiLan1.0	NW_004955460	10,090,343 - 10,132,724 (+)	NCBI	ChiLan1.0	ChiLan1.0

WIPI2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	6	10,155,837 - 10,197,419 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	7	58,480,548 - 58,522,122 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	7	5,446,621 - 5,488,170 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	7	5,467,334 - 5,510,538 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	7	5,467,334 - 5,510,538 (+)	Ensembl			panPan2	panpan1.1

WIPI2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	6	12,656,469 - 12,698,623 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	6	12,658,239 - 12,698,734 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	6	14,127,107 - 14,169,430 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	6	12,792,644 - 12,834,821 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	6	12,792,652 - 12,834,919 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	6	12,603,540 - 12,645,764 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	6	12,536,719 - 12,578,660 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	6	12,813,373 - 12,855,416 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Wipi2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	140,918,058 - 140,955,730 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936765	907,877 - 946,822 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936765	909,118 - 946,788 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

WIPI2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	3,800,186 - 3,834,413 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	3	3,800,170 - 3,830,973 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	4,487,181 - 4,517,990 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

WIPI2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	28	16,504,557 - 16,558,670 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	28	16,502,435 - 16,558,650 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666090	5,423,866 - 5,470,061 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Wipi2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624740	28,306,052 - 28,346,508 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624740	28,306,655 - 28,346,430 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Wipi2
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	16	10,476,269 - 10,508,928 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Wipi2
310 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	33
Count of miRNA genes:	31
Interacting mature miRNAs:	33
Transcripts:	ENSRNOT00000001476
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2312418	Kidm41	Kidney mass QTL 41	3.7	0.0001	kidney mass (VT:0002707)	single kidney wet weight to body weight ratio (CMO:0000622)	12	5921918	25247790	Rat
70213	Niddm27	Non-insulin dependent diabetes mellitus QTL 27	3.72		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	12	11200494	52308831	Rat
2306789	Ean6	Experimental allergic neuritis QTL 6	4.9		nervous system integrity trait (VT:0010566)	experimental autoimmune neuritis severity score (CMO:0001528)	12	1	29775522	Rat
8552964	Pigfal17	Plasma insulin-like growth factor 1 level QTL 17	3.5		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	11200494	52308831	Rat
7411641	Foco19	Food consumption QTL 19	27.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	11200494	52308831	Rat
5684888	Pia42	Pristane induced arthritis QTL 42			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	3489416	48489416	Rat
1331739	Hrtrt14	Heart rate QTL 14	3.56232		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	12	1	38687564	Rat
8552912	Pigfal6	Plasma insulin-like growth factor 1 level QTL 6	5		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	11200497	52308831	Rat
1549829	Scl48	Serum cholesterol level QTL 48	5		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	12	15264248	52308831	Rat
61331	Eau2	Experimental allergic uveoretinitis QTL 2		0.0005	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	12	1	33700600	Rat
10059594	Kidm46	Kidney mass QTL 46	3.79	0.025	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	12	11743528	52308831	Rat
8552918	Pigfal7	Plasma insulin-like growth factor 1 level QTL 7			blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	11200494	52308831	Rat
2293684	Bmd26	Bone mineral density QTL 26	4.4	0.0002	femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	12	1	38635130	Rat
6893681	Bw109	Body weight QTL 109	2.3	0.004	body mass (VT:0001259)	body weight (CMO:0000012)	12	1	28133365	Rat
1302792	Scl21	Serum cholesterol level QTL 21	3.8	0.0011	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	12	12233000	30490641	Rat
1300174	Bw15	Body weight QTL 15	2.93		body mass (VT:0001259)	body weight loss (CMO:0001399)	12	1	28606299	Rat
1331786	Kidm11	Kidney mass QTL 11	3.571		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	12	16187438	52308831	Rat
1331787	Rf41	Renal function QTL 41	2.998		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	12	1	33700556	Rat
2293699	Bss49	Bone structure and strength QTL 49	5.61	0.0001	lumbar vertebra size trait (VT:0010518)	lumbar vertebra trabecular cross-sectional area (CMO:0001692)	12	16135029	52308831	Rat
1331761	Bp218	Blood pressure QTL 218	2.973		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	12	16187438	51213550	Rat
1331763	Wbc2	White blood cell count QTL 2	3.162		leukocyte quantity (VT:0000217)	total white blood cell count (CMO:0000365)	12	11200494	52308831	Rat
7204484	Bp358	Blood pressure QTL 358		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	12	1	24849755	Rat
7411547	Bw129	Body weight QTL 129		0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	6	11200494	52308831	Rat
7387292	Kidm42	Kidney mass QTL 42	3.03	0.0004	kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	12	1	41361854	Rat
1298081	Cia25	Collagen induced arthritis QTL 25	4.7		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	2747694	47747694	Rat
2303568	Bw88	Body weight QTL 88	3		body mass (VT:0001259)	body weight (CMO:0000012)	12	1	28606299	Rat
2303575	Insul14	Insulin level QTL 14	4		blood insulin amount (VT:0001560)	blood insulin level (CMO:0000349)	12	3087180	48087180	Rat
7411588	Foco6	Food consumption QTL 6		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	11200494	52308831	Rat
7243862	Mcs30	Mammary carcinoma susceptibility QTL 30	8.62		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	12	5633306	50633306	Rat
2300186	Bmd59	Bone mineral density QTL 59	7.1	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	12	16135029	52308831	Rat
2293086	Iddm30	Insulin dependent diabetes mellitus QTL 30	3.82		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	12	7901625	33938215	Rat
7411597	Foco10	Food consumption QTL 10		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	11200494	52308831	Rat
1331755	Bp219	Blood pressure QTL 219	3.041		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	12	16187438	33700556	Rat

Markers in Region

AU046750

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	12	11,931,086 - 11,931,354 (+)	MAPPER	mRatBN7.2
Rnor_6.0	12	13,989,422 - 13,989,689	NCBI	Rnor6.0
Rnor_5.0	12	16,016,992 - 16,017,259	UniSTS	Rnor5.0
RGSC_v3.4	12	12,326,281 - 12,326,548	UniSTS	RGSC3.4
Celera	12	13,715,080 - 13,715,347	UniSTS
Cytogenetic Map	12	p11	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	162	91	90	59	92	59	6	356	192	11	141	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001007615	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC079184	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474012	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000012	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000001476 ⟹ ENSRNOP00000001476

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	12	17,024,878 - 17,053,306 (-)	Ensembl
mRatBN7.2 Ensembl	12	11,911,337 - 11,939,794 (-)	Ensembl
Rnor_6.0 Ensembl	12	13,969,586 - 13,998,172 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000130618 ⟹ ENSRNOP00000099245

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	12	17,024,878 - 17,071,406 (-)	Ensembl

RefSeq Acc Id:

NM_001007615 ⟹ NP_001007616

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	17,024,876 - 17,053,306 (-)	NCBI
mRatBN7.2	12	11,911,369 - 11,939,799 (-)	NCBI
Rnor_6.0	12	13,969,704 - 13,998,134 (-)	NCBI
Rnor_5.0	12	15,997,274 - 16,025,704 (-)	NCBI
RGSC_v3.4	12	12,306,563 - 12,334,993 (-)	RGD
Celera	12	13,695,386 - 13,723,757 (-)	RGD

Sequence:

show sequence

CGGCTCTGGAGCATAAACAAGAGTGGGGACGGTATGAGGCGGCAGTTGGTCCCCGCGCAGCGAG
AGGGGGCGAGCGGGGCGGCGACCCGGACCGGGTACAGATCCTGAGTGTAGCGTGCTCCCGCGGG
CCGCCCGACTTGAGCCGCGCGCGCTCCCGCCAAGGGGGTCCGAGTCCGTCGCGCGCGCGCAGCC
ATGAACCTGGCAAGCCAGAGCGGAGAGGCCGGCGCCGGCCAGCTGCTGTTCGCCAACTTCAACC
AGGATAACACGTCCCTAGCTGTTGGTAGTAAGTCCGGGTATAAGTTTTTCTCCCTATCTTCTGT
GGATAAGCTGGAACAGATCTATGAATGCACTGACACCGAAGATGTCTGCATCGTGGAGAGATTG
TTCTCAAGCAGCTTGGTGGCCATCGTCAGCCTCAAAGCTCCCAGGAAGCTGAAGGTTTGCCACT
TTAAGAAGGGGACTGAGATTTGCAACTACAGCTACTCCAACACCATCCTGGCTGTGAAGCTGAA
CAGGCAGAGGCTCATCGTGTGTCTAGAAGAGTCGCTCTATATACACAACATCCGGGACATGAAG
GTACTTCATACCATCCGAGAGACACCCCCGAACCCTGCAGGCTTGTGTGCACTGTCAATAAACA
ATGACAACTGCTACTTGGCGTACCCAGGGAGTGCGACCATTGGAGAGGTGCAGGTCTTCGACAC
CATTAACTTGAGGGCTGCAAACATGATCCCAGCTCATGACAGTCCCTTAGCAGCCCTGGCTTTT
GACGCAAGTGGGACCAAGCTTGCCACTGCTTCTGAGAAGGGGACTGTGATTCGAGTGTTCTCCA
TTCCAGAGGGACAGAAGCTGTTTGAGTTCAGGAGAGGAGTGAAAAGGTGTGTGAGCATCTGCTC
CCTGGCCTTCAGCATGGACGGCATGTTTCTCTCCGCATCCAGCAACACCGAAACAGTGCACATC
TTCAAACTTGAAGCCGTGAGGGAAAAACCTCCGGAAGAGCCCACCACCTGGACTGGCTACTTTG
GGAAGGTTCTCATGGCATCTACCAGCTACCTGCCCTCACAAGTGACAGAAATGTTCAATCAGGG
AAGGGCCTTTGCCACCGTCCGCCTGCCATTTTGTGGCCACAAAAACATCTGCTCACTCACCACA
ATTCAGAAGATCCCGCGATTGCTGGTGGGAGCGTCGGATGGTTATTTGTACATGTACAACCTGG
ACCCCCAGGAAGGCGGCGAGTGCGCCCTGATGCGTCAGCACAGGCTTGATGGCAGCATGGAGAC
GACCAGTGAAATTGTAGACTCTGCATCTCATGACTGCCCCTTAGTAACGCAGACATACGGCACA
GCAGCTGCCAAAGGTGCCTATGTGCCCTCGTCCCCAACAAGACTTGGTAAAGGACAGGACGCCA
ACTTGGAAGCCTACACCGATGACCTGGGTGCTGTGGGTGGCGCATGCCTAGAGGATGAAGCCAG
CGCTCTACGCCTGGATGAAGATAGTGAACATCCTCCCATGATTCTCCGGACTGACTGATCCTGA
CCTGTGAACTCTGGCCCAGGAGCAGACAACACTGGCCTGGCTGAGGACTTGAGCATTGCTGCTA
TGAACTTTGACCTGAATTGAGGGAGAGGATGGCAGAGACTTTAAAGCAAAGAGATTGTAGTTAT
AGCCTATCCATACTGTTGAGAAAATACAGGTTTCACTTCAGTGACTAAAAAAAAAAAAAAAAAA
AAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001007616	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH79184	(Get FASTA)	NCBI Sequence Viewer
	EDL89704	(Get FASTA)	NCBI Sequence Viewer
	EDL89705	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000001476
	ENSRNOP00000001476.3
GenBank Protein	Q6AY57	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001007616 ⟸ NM_001007615

- UniProtKB:

Q6AY57 (UniProtKB/Swiss-Prot), A6K1P6 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MNLASQSGEAGAGQLLFANFNQDNTSLAVGSKSGYKFFSLSSVDKLEQIYECTDTEDVCIVERL
FSSSLVAIVSLKAPRKLKVCHFKKGTEICNYSYSNTILAVKLNRQRLIVCLEESLYIHNIRDMK
VLHTIRETPPNPAGLCALSINNDNCYLAYPGSATIGEVQVFDTINLRAANMIPAHDSPLAALAF
DASGTKLATASEKGTVIRVFSIPEGQKLFEFRRGVKRCVSICSLAFSMDGMFLSASSNTETVHI
FKLEAVREKPPEEPTTWTGYFGKVLMASTSYLPSQVTEMFNQGRAFATVRLPFCGHKNICSLTT
IQKIPRLLVGASDGYLYMYNLDPQEGGECALMRQHRLDGSMETTSEIVDSASHDCPLVTQTYGT
AAAKGAYVPSSPTRLGKGQDANLEAYTDDLGAVGGACLEDEASALRLDEDSEHPPMILRTD

hide sequence

Ensembl Acc Id:

ENSRNOP00000001476 ⟸ ENSRNOT00000001476

Ensembl Acc Id:

ENSRNOP00000099245 ⟸ ENSRNOT00000130618

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q6AY57-F1-model_v2	AlphaFold	Q6AY57	1-445	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13698447

Promoter ID:

EPDNEW_R8972

Type:

initiation region

Name:

Wipi2_1

Description:

WD repeat domain, phosphoinositide interacting 2

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	12	13,998,145 - 13,998,205	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1359154	AgrOrtholog
BioCyc Gene	G2FUF-19972	BioCyc
Ensembl Genes	ENSRNOG00000001114	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000001476	ENTREZGENE
	ENSRNOT00000001476.6	UniProtKB/Swiss-Prot
Gene3D-CATH	2.130.10.10	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7131054	IMAGE-MGC_LOAD
InterPro	PROPPIN	UniProtKB/Swiss-Prot
	WD40/YVTN_repeat-like_dom_sf	UniProtKB/Swiss-Prot
	WD40_repeat	UniProtKB/Swiss-Prot
	WD40_repeat_dom_sf	UniProtKB/Swiss-Prot
KEGG Report	rno:288498	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:94226	IMAGE-MGC_LOAD
NCBI Gene	288498	ENTREZGENE
PANTHER	WD-REPEAT PROTEIN INTERACTING WITH PHOSPHOINOSIDES WIPI -RELATED	UniProtKB/Swiss-Prot
Pfam	PROPPIN	UniProtKB/Swiss-Prot
PhenoGen	Wipi2	PhenoGen
RatGTEx	ENSRNOG00000001114	RatGTEx
SMART	WD40	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF50978	UniProtKB/Swiss-Prot
UniProt	A0ABK0LCY1_RAT	UniProtKB/TrEMBL
	A6K1P6	ENTREZGENE, UniProtKB/TrEMBL
	A6K1P7_RAT	UniProtKB/TrEMBL
	Q6AY57	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2006-03-30	Wipi2	WD repeat domain, phosphoinositide interacting 2	MGC94226	similar to RIKEN cDNA 1110018O08	Symbol and Name updated	1299863	APPROVED
2005-07-29	MGC94226	similar to RIKEN cDNA 1110018O08			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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