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Gene: Tifa (TRAF-interacting protein with forkhead-associated domain) Rattus norvegicus

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Symbol:

Tifa

Name:

TRAF-interacting protein with forkhead-associated domain

RGD ID:

1359151

Description:

Predicted to be involved in several processes, including positive regulation of canonical NF-kappaB signal transduction; protein homooligomerization; and tumor necrosis factor-mediated signaling pathway. Predicted to be active in cytoplasm. Orthologous to human TIFA (TRAF interacting protein with forkhead associated domain); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-diaminodiphenylmethane; bisphenol A.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

Ab2-389; LOC310877; T2bp; TRAF-interacting protein with FHA domain-containing protein A; Traf2 binding protein; TRAF2-binding protein

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	218,927,724 - 218,942,111 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	2	218,909,915 - 218,956,224 (+)	Ensembl				GRCr8
mRatBN7.2	2	216,257,926 - 216,267,635 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	216,234,774 - 216,267,841 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	2	223,922,080 - 223,931,305 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	221,821,777 - 221,831,000 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	216,675,867 - 216,685,087 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	232,104,394 - 232,137,425 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	232,104,809 - 232,137,422 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	2	251,423,679 - 251,482,346 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	2	225,067,695 - 225,076,898 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	2	208,569,719 - 208,578,933 (+)	NCBI		Celera
RGSC_v3.1	2	225,054,374 - 225,063,575 (+)	NCBI
Cytogenetic Map	2	q42	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

4,4'-diaminodiphenylmethane (EXP)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

arsane (ISO)

arsenic atom (ISO)

Benoxacor (ISO)

benzo[a]pyrene diol epoxide I (ISO)

benzo[b]fluoranthene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

cadmium dichloride (EXP,ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

cisplatin (ISO)

clothianidin (ISO)

cobalt dichloride (EXP)

Cuprizon (EXP)

cyclosporin A (ISO)

Dibutyl phosphate (ISO)

dibutyl phthalate (EXP)

diclofenac (ISO)

dicrotophos (ISO)

dimethylarsinic acid (ISO)

dorsomorphin (ISO)

endosulfan (EXP)

entinostat (ISO)

epoxiconazole (ISO)

ethanol (ISO)

fipronil (EXP)

folic acid (ISO)

formaldehyde (ISO)

FR900359 (ISO)

furan (EXP)

gardiquimod (ISO)

genistein (EXP)

gentamycin (EXP)

hypochlorous acid (ISO)

ketamine (EXP)

lipopolysaccharide (ISO)

methylarsonic acid (ISO)

orphenadrine (EXP)

perfluorooctane-1-sulfonic acid (ISO)

phenobarbital (ISO)

phenylmercury acetate (ISO)

pirinixic acid (ISO)

potassium chromate (ISO)

protein kinase inhibitor (ISO)

quercetin (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

SB 431542 (ISO)

silicon dioxide (ISO)

silver atom (ISO)

silver(0) (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

sodium dichromate (EXP)

Soman (EXP)

succimer (ISO)

sunitinib (ISO)

tamoxifen (ISO)

tetraphene (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

trichloroethene (EXP)

trichostatin A (ISO)

urethane (ISO)

valproic acid (ISO)

vanadyl sulfate (ISO)

vinclozolin (EXP)

vorinostat (ISO)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cytoplasmic pattern recognition receptor signaling pathway (IBA,ISO,ISS)

immune system process (IEA)

innate immune response (IBA,IEA,ISO,ISS)

positive regulation of canonical NF-kappaB signal transduction (IBA,IEA,ISO,ISS)

protein homooligomerization (ISO,ISS)

regulation of canonical NF-kappaB signal transduction (ISO)

tumor necrosis factor-mediated signaling pathway (ISO)

Cellular Component

cytoplasm (IBA,IEA,ISO,ISS)

Molecular Function

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
3.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:11798190	PMID:22566686	PMID:26068852	PMID:28222186	PMID:28877472	PMID:30111836

Genomics

Comparative Map Data

Tifa
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	218,927,724 - 218,942,111 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	2	218,909,915 - 218,956,224 (+)	Ensembl				GRCr8
mRatBN7.2	2	216,257,926 - 216,267,635 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	216,234,774 - 216,267,841 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	2	223,922,080 - 223,931,305 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	221,821,777 - 221,831,000 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	216,675,867 - 216,685,087 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	232,104,394 - 232,137,425 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	232,104,809 - 232,137,422 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	2	251,423,679 - 251,482,346 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	2	225,067,695 - 225,076,898 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	2	208,569,719 - 208,578,933 (+)	NCBI		Celera
RGSC_v3.1	2	225,054,374 - 225,063,575 (+)	NCBI
Cytogenetic Map	2	q42	NCBI

TIFA
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	4	112,274,537 - 112,285,904 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	4	112,272,968 - 112,285,955 (-)	Ensembl			hg38	GRCh38
GRCh37	4	113,195,693 - 113,207,060 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	4	113,416,231 - 113,426,508 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Celera	4	110,490,861 - 110,501,136 (-)	NCBI		Celera
Cytogenetic Map	4	q25	NCBI
HuRef	4	108,928,327 - 108,938,602 (-)	NCBI		HuRef
CHM1_1	4	113,173,595 - 113,183,871 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	4	115,582,899 - 115,594,247 (-)	NCBI		T2T-CHM13v2.0

Tifa
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	3	127,582,524 - 127,592,043 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	3	127,583,454 - 127,625,813 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	3	127,788,875 - 127,798,394 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	3	127,789,805 - 127,832,164 (+)	Ensembl			mm10	GRCm38
MGSCv37	3	127,492,831 - 127,501,307 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	3	127,781,941 - 127,800,104 (+)	NCBI		MGSCv36	mm8
MGSCv36	3	128,273,227 - 128,291,450 (+)	NCBI		MGSCv36	mm8
Celera	3	134,292,137 - 134,300,604 (+)	NCBI		Celera
Cytogenetic Map	3	G2	NCBI
cM Map	3	56.54	NCBI

Tifa
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955457	14,444,814 - 14,450,767 (+)	Ensembl
ChiLan1.0	NW_004955457	14,444,811 - 14,460,168 (+)	NCBI	ChiLan1.0	ChiLan1.0

TIFA
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	3	110,350,189 - 110,362,391 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	4	110,637,766 - 110,655,760 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	4	104,765,007 - 104,776,217 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	4	115,328,436 - 115,338,732 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2

TIFA
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	32	32,125,870 - 32,135,159 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	32	32,126,634 - 32,127,191 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	32	9,896,747 - 9,907,233 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	32	32,349,595 - 32,360,055 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	32	32,349,597 - 32,359,545 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	32	32,332,694 - 32,343,179 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	32	32,093,596 - 32,104,107 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	32	7,757,210 - 7,767,777 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Tifa
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405301	8,750,214 - 8,757,559 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936563	3,152,049 - 3,158,999 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936563	3,151,515 - 3,159,071 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TIFA
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	8	110,377,892 - 110,389,604 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	8	110,377,817 - 110,394,190 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	8	118,358,074 - 118,366,203 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TIFA
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	7	60,074,764 - 60,085,029 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	7	60,076,999 - 60,077,556 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666037	38,834,354 - 38,846,161 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Tifa
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624838	6,160,712 - 6,167,408 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Tifa
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	3	31,544,766 - 31,554,116 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Tifa
172 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	409
Count of miRNA genes:	228
Interacting mature miRNAs:	266
Transcripts:	ENSRNOT00000014533
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1358356	Srcrt1	Stress Responsive Cort QTL1	3.66		blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	2	163997722	225110681	Rat
1331734	Bp204	Blood pressure QTL 204	3.61192		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	170656145	239614549	Rat
631563	Hcuc3	Hepatic copper content QTL 3	3.87		liver copper amount (VT:0003065)	liver copper weight to liver dry weight ratio (CMO:0001512)	2	212145502	231732847	Rat
631566	Bp90	Blood pressure QTL 90		0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	149957381	221199885	Rat
1298075	Scl17	Serum cholesterol level QTL 17	3.4		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	2	214404877	251712708	Rat
1354648	Bp239	Blood pressure QTL 239		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	67845370	229470703	Rat
1354649	Kidm17	Kidney mass QTL 17	2.9		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	2	83465462	229820014	Rat
1300126	Bp175	Blood pressure QTL 175	3.46		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	204795005	249795005	Rat
10755499	Bp389	Blood pressure QTL 389	2.61		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	20695736	231474293	Rat
1581576	Pur7	Proteinuria QTL 7		0.0001	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	2	80396178	220931218	Rat
1581578	Cm49	Cardiac mass QTL 49	4.9	0.01	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	2	145807215	220931416	Rat
1302789	Stl26	Serum triglyceride level QTL 26	3.1	0.0035	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	2	206613059	226891081	Rat
1581569	Uae32	Urinary albumin excretion QTL 32		0.0001	urine protein amount (VT:0005160)	urine albumin excretion rate (CMO:0000757)	2	80396178	220931218	Rat
2317752	Glom23	Glomerulus QTL 23	3.6		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	2	196140964	251540988	Rat
61467	Bp14	Blood pressure QTL 14	2.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	205135267	250135267	Rat
1549836	Bss2	Bone structure and strength QTL 2	7.5		femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	2	214404877	251712708	Rat
70175	BpQTLCluster3	Blood pressure QTL cluster 3	4.128		arterial blood pressure trait (VT:2000000)	absolute change in systolic blood pressure (CMO:0000607)	2	205135267	250135267	Rat
1358900	Bw48	Body weight QTL 48	4.88		body mass (VT:0001259)	body weight (CMO:0000012)	2	159440891	220931218	Rat
1359031	Bp275	Blood pressure QTL 275			arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	188565047	233565047	Rat
1581499	Esta2	Estrogen-induced thymic atrophy QTL 2			thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	2	192287802	229609668	Rat
9589044	Scfw1	Subcutaneous fat weight QTL 1	5.8	0.001	subcutaneous adipose mass (VT:1000472)	abdominal subcutaneous fat pad weight (CMO:0002069)	2	184856304	229856304	Rat
8694435	Bw166	Body weight QTL 166	14.08	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	2	184856304	229856304	Rat
631203	Gluco14	Glucose level QTL 14		0.0001	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	2	209350500	221678003	Rat
7207490	Bss111	Bone structure and strength QTL 111	6.4		femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	2	214404877	251712708	Rat
8662832	Vetf7	Vascular elastic tissue fragility QTL 7	3.5		aorta elastin amount (VT:0003905)	aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)	2	83400752	223709938	Rat
1331745	Bp203	Blood pressure QTL 203	4.377		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	192287802	221089121	Rat
8694194	Abfw1	Abdominal fat weight QTL 1	11.7	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	2	184856304	229856304	Rat
61366	Iddm3	Insulin dependent diabetes mellitus QTL 3	4.7		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	2	192287802	237287802	Rat
1578671	Bmd10	Bone mineral density QTL 10	5.4		femur mineral mass (VT:0010011)	compact volumetric bone mineral density (CMO:0001730)	2	175931416	220931416	Rat
1641891	Alcrsp17	Alcohol response QTL 17			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	2	151869660	251712708	Rat
724534	Uae6	Urinary albumin excretion QTL 6	10		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	2	80396034	220931416	Rat
2300189	Bmd48	Bone mineral density QTL 48	5.8	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	2	182024327	227024327	Rat
8662843	Vetf9	Vascular elastic tissue fragility QTL 9	2.05		thoracic aorta molecular composition trait (VT:0010568)	aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)	2	159440760	228950743	Rat
2301408	Kidm36	Kidney mass QTL 36		0.002	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	184482291	229482291	Rat
631501	Bp101	Blood pressure QTL 101	2.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	205135267	250135267	Rat
1598813	Memor9	Memory QTL 9	2.7		exploratory behavior trait (VT:0010471)	average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)	2	202029709	236904960	Rat
2307174	Activ3	Activity QTL 3	4.83	0.000058	locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	2	210956252	251712708	Rat
1331794	Bp202	Blood pressure QTL 202	3.66819		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	143344967	251712708	Rat
1331805	Cm29	Cardiac mass QTL 29	3.50746		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	2	143344967	251712708	Rat
2298479	Eau5	Experimental allergic uveoretinitis QTL 5		0.0021	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	2	205135267	225627153	Rat
7207484	Bss108	Bone structure and strength QTL 108	5.3		femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	2	214404877	251712708	Rat
2313073	Bmd75	Bone mineral density QTL 75	4.1	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	2	218051934	251712708	Rat
738013	Alc15	Alcohol consumption QTL 15	4.1	0.00022	consumption behavior trait (VT:0002069)	ethanol drink intake rate to body weight ratio (CMO:0001616)	2	186850607	231850607	Rat
61398	Bp50	Blood pressure QTL 50	4.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	192287802	237287802	Rat
7207482	Bss107	Bone structure and strength QTL 107	7		femur strength trait (VT:0010010)	femur ultimate force (CMO:0001675)	2	214404877	251712708	Rat
1641925	Alcrsp2	Alcohol response QTL 2			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	2	151869660	223841096	Rat
61417	Cia10	Collagen induced arthritis QTL 10	3.4		joint integrity trait (VT:0010548)	experimental arthritis severity measurement (CMO:0001459)	2	182635347	227635347	Rat
1354622	Kidm16	Kidney mass QTL 16	3		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	2	83465462	225110681	Rat
631522	Bp74	Blood pressure QTL 74		0.05	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	175008837	220008837	Rat
8694383	Bw158	Body weight QTL 158	7.69	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	2	184856304	229856304	Rat
1598835	Anxrr18	Anxiety related response QTL 18	2.98		body movement coordination trait (VT:0005424)	number of rearing movements in an experimental apparatus (CMO:0001752)	2	203664411	248664411	Rat
2306901	Bp337	Blood pressure QTL 337		0.01	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	166372086	229820014	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	165	91	90	59	92	59	6	356	192	11	144	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001014044	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017590938	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039102463	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039102464	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039102465	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005500306	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010063617	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010063618	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AY325204	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC083765	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473952	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000002	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000014533 ⟹ ENSRNOP00000061870

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	2	218,932,133 - 218,956,224 (+)	Ensembl
mRatBN7.2 Ensembl	2	216,258,189 - 216,267,841 (+)	Ensembl
Rnor_6.0 Ensembl	2	232,128,235 - 232,137,422 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000083193 ⟹ ENSRNOP00000072333

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	2	218,909,915 - 218,941,297 (+)	Ensembl
mRatBN7.2 Ensembl	2	216,235,440 - 216,266,816 (+)	Ensembl
Rnor_6.0 Ensembl	2	232,104,809 - 232,135,991 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000097096 ⟹ ENSRNOP00000088802

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	2	218,923,731 - 218,942,218 (+)	Ensembl
mRatBN7.2 Ensembl	2	216,234,774 - 216,266,827 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000102851 ⟹ ENSRNOP00000087830

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	2	218,932,728 - 218,942,922 (+)	Ensembl
mRatBN7.2 Ensembl	2	216,258,217 - 216,267,841 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000112612 ⟹ ENSRNOP00000077082

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	2	218,934,445 - 218,942,108 (+)	Ensembl
mRatBN7.2 Ensembl	2	216,259,279 - 216,267,841 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000151461 ⟹ ENSRNOP00000101228

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	2	218,923,731 - 218,942,218 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000151568 ⟹ ENSRNOP00000105247

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	2	218,932,734 - 218,943,543 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000159449 ⟹ ENSRNOP00000111754

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	2	218,924,735 - 218,942,218 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000173023 ⟹ ENSRNOP00000107732

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	2	218,921,850 - 218,942,218 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000173754 ⟹ ENSRNOP00000111274

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	2	218,925,861 - 218,942,218 (+)	Ensembl

RefSeq Acc Id:

NM_001014044 ⟹ NP_001014066

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	218,932,886 - 218,942,111 (+)	NCBI
mRatBN7.2	2	216,258,407 - 216,267,630 (+)	NCBI
Rnor_6.0	2	232,128,235 - 232,137,425 (+)	NCBI
Rnor_5.0	2	251,423,679 - 251,482,346 (+)	NCBI
RGSC_v3.4	2	225,067,695 - 225,076,898 (+)	RGD
Celera	2	208,569,719 - 208,578,933 (+)	RGD

Sequence:

show sequence

CGCGAGGGCTTTGCTGAGGTCACTCGCGCGAGGCCGCTCTTGGCGCGCCCGTGGGAGGCTCGGT
GGCACGGGAGGACTGGCGACCTGCGGGTTCGGCGAGCTCGTACGGCGCTGGTCGCGACGACGGT
CCCCCACCGAGGCCGCGCCCCGCCGCTTCCACCGAAGGCTCCGCAAGGCTCACGGACCACCCAG
CCCTCCCAGCCCCAGGAGAAGAGACAAGGCCCAAGAGTCCTGATCTAGCTGTGGCCACTGGAAG
ACTCTCAGGCCGGGGAGCGTCATGTCCACCTTTGAAGACGCTGATACAGAAGAGACGGTCACTT
GTCTCCAGATGACCATTTACCATCCTGGCCAGCTGCAAAGTGGAATATTTAAATCGATAAGGTT
TTGCAGCAAGGAGAAATTCCCTTCCATTGAAGTGGTGAAATTTGGACGGAATTCCAATATGTGC
CAGTACACGTTTCAGGACAAACAGGTTTCCCGAGTTCAGTTTGCTTTACAGCCGTTTAAACAAT
TCAACAGCTCGGTTCTGTCGTTTGAAATAAAAAACATGAGCAAGAAGACGAGTCTGATGGTGGA
CAACCAGGAGCTCGGCTACCTCAATAAAATGGACCTGCCTTACAAGTGCATGCTCCGGTTCGGA
GAGTATCAGTTCCTGCTGCAGAAGGAAGATGGAGAGTCAGTAGAATCTTTTGAGACTCAATTTA
TCTTGTCTCCAAGACCTCTCTTGCAAGAAAACAACTGGCCAACGCAGAGCCCCATACCCGAGGA
TGGGGTGTATTCTTCCTACTTCACCCATAGAAGTTCTCCTGCAGAAATGGATGAAAACGAGCTG
TGAAGAGGGTCCACCCGGAGACACGTGAAGGATGAGGACGCATGGGTAGACACTCCTGCTTCCC
TGGAGTTCGTGAGTGTAGCATAACACAGACGTCCGCGTGCTGACTTCAGTTTTGGCAGTGGCAT
TTGGAAGTCTGTACACTGGGTTAGTCATCAACTTAGTCAACTGTTTGAGTTTCGGCTCTAGCAA
GAATTAAGTGTGCGGAGGTGGCGCGTAAGACACGCCTTCCGCGTAATGACGTCACTCTCGTTGC
TTCTCTGCTTGACGCCACCCCCACGCTATGTCTTGGTAGCAGCCATCTTGTCCTGGTCACGTCA
TTTCGCGGCAGCCTTTGTTTTTCAAGTTTAGAGCCTGGGCAGATTGTTCGCTGCTGGTGTCTTC
GGCATGCTAGTGCTTGTAGAGCCAGAGTCCTGGGCTAAGCTCTAGAGTGCTGAGTCCCTGAGTC
ACTGTGGCTCCATTATGGAAAGACTTGAGAAATAGCTCCTTGGTTTTCTTTCTATGGAACTGTC
ATGTCCATCCCTAAGACGGCAGCTTTGCTTTCTTATGTGTAGGCCCTTCAGCTAACATGTAAAG
AACCAAAATGGTTTTCTCCTGAAGTCGAAAGTGAATTTTTTTGTATCTTAACAGATTTAGAAAT
GGCAGAAATCAAAACGGTTTAGCAGCCTCTTCGCATATGATGAAGTCGGAGCTCAGTTCCTCAG
CTGCTTCTTTGAAACTTCTTAAAGGGAAACATCTGTTCTTAGGCCGCTCTACAGAAGTCAGTAT
ATGTGAATATTTATAATAAATGCTTAACTATTTCTAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_039102463 ⟹ XP_038958391

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	218,933,767 - 218,942,111 (+)	NCBI
mRatBN7.2	2	216,259,339 - 216,267,635 (+)	NCBI

RefSeq Acc Id:

XM_039102464 ⟹ XP_038958392

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	218,932,149 - 218,942,111 (+)	NCBI
mRatBN7.2	2	216,257,926 - 216,267,635 (+)	NCBI

RefSeq Acc Id:

XM_039102465 ⟹ XP_038958393

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	218,934,271 - 218,942,111 (+)	NCBI
mRatBN7.2	2	216,259,772 - 216,267,635 (+)	NCBI

RefSeq Acc Id:

XR_005500306

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	218,932,667 - 218,942,111 (+)	NCBI
mRatBN7.2	2	216,258,472 - 216,267,635 (+)	NCBI

RefSeq Acc Id:

XR_010063617

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	218,927,724 - 218,934,611 (+)	NCBI

RefSeq Acc Id:

XR_010063618

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	218,927,724 - 218,934,611 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001014066	(Get FASTA)	NCBI Sequence Viewer
	XP_038958391	(Get FASTA)	NCBI Sequence Viewer
	XP_038958392	(Get FASTA)	NCBI Sequence Viewer
	XP_038958393	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH83765	(Get FASTA)	NCBI Sequence Viewer
	AAP92605	(Get FASTA)	NCBI Sequence Viewer
	EDL82156	(Get FASTA)	NCBI Sequence Viewer
	EDL82157	(Get FASTA)	NCBI Sequence Viewer
	EDL82158	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000061870
	ENSRNOP00000061870.1
	ENSRNOP00000077082
	ENSRNOP00000077082.1
	ENSRNOP00000087830.1
	ENSRNOP00000105247
GenBank Protein	Q5XIB9	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_001014066 ⟸ NM_001014044
- UniProtKB:	Q5XIB9 (UniProtKB/Swiss-Prot), A6HVM2 (UniProtKB/TrEMBL)
- Sequence:	show sequence MSTFEDADTEETVTCLQMTIYHPGQLQSGIFKSIRFCSKEKFPSIEVVKFGRNSNMCQYTFQDK QVSRVQFALQPFKQFNSSVLSFEIKNMSKKTSLMVDNQELGYLNKMDLPYKCMLRFGEYQFLLQ KEDGESVESFETQFILSPRPLLQENNWPTQSPIPEDGVYSSYFTHRSSPAEMDENEL hide sequence

Ensembl Acc Id:

ENSRNOP00000061870 ⟸ ENSRNOT00000014533

Ensembl Acc Id:

ENSRNOP00000072333 ⟸ ENSRNOT00000083193

RefSeq Acc Id:	XP_038958392 ⟸ XM_039102464
- Peptide Label:	isoform X1
- UniProtKB:	Q5XIB9 (UniProtKB/Swiss-Prot), A6HVM2 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038958391 ⟸ XM_039102463
- Peptide Label:	isoform X1
- UniProtKB:	Q5XIB9 (UniProtKB/Swiss-Prot), A6HVM2 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038958393 ⟸ XM_039102465
- Peptide Label:	isoform X1
- UniProtKB:	Q5XIB9 (UniProtKB/Swiss-Prot), A6HVM2 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000077082 ⟸ ENSRNOT00000112612

Ensembl Acc Id:

ENSRNOP00000088802 ⟸ ENSRNOT00000097096

Ensembl Acc Id:

ENSRNOP00000087830 ⟸ ENSRNOT00000102851

Ensembl Acc Id:

ENSRNOP00000111274 ⟸ ENSRNOT00000173754

Ensembl Acc Id:

ENSRNOP00000111754 ⟸ ENSRNOT00000159449

Ensembl Acc Id:

ENSRNOP00000101228 ⟸ ENSRNOT00000151461

Ensembl Acc Id:

ENSRNOP00000105247 ⟸ ENSRNOT00000151568

Ensembl Acc Id:

ENSRNOP00000107732 ⟸ ENSRNOT00000173023

Protein Domains

FHA

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q5XIB9-F1-model_v2	AlphaFold	Q5XIB9	1-185	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13691742

Promoter ID:

EPDNEW_R2267

Type:

initiation region

Name:

Tifa_1

Description:

TRAF-interacting protein with forkhead-associated domain

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	2	232,128,256 - 232,128,316	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1359151	AgrOrtholog
BioCyc Gene	G2FUF-51266	BioCyc
Ensembl Genes	ENSRNOG00000010941	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000014533	ENTREZGENE
	ENSRNOT00000014533.7	UniProtKB/Swiss-Prot
	ENSRNOT00000102851.1	UniProtKB/Swiss-Prot
	ENSRNOT00000112612	ENTREZGENE
	ENSRNOT00000112612.1	UniProtKB/Swiss-Prot
	ENSRNOT00000151568	ENTREZGENE
IMAGE_CLONE	IMAGE:7193165	IMAGE-MGC_LOAD
InterPro	FHA_dom	UniProtKB/Swiss-Prot
	SMAD_FHA_dom_sf	UniProtKB/Swiss-Prot
	TIFA	UniProtKB/Swiss-Prot
KEGG Report	rno:310877	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:94710	IMAGE-MGC_LOAD
NCBI Gene	310877	ENTREZGENE
PANTHER	PTHR31266	UniProtKB/Swiss-Prot
	TRAF-INTERACTING PROTEIN WITH FHA DOMAIN-CONTAINING PROTEIN A	UniProtKB/Swiss-Prot
Pfam	FHA	UniProtKB/Swiss-Prot
PhenoGen	Tifa	PhenoGen
PROSITE	FHA_DOMAIN	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000010941	RatGTEx
Superfamily-SCOP	SSF49879	UniProtKB/Swiss-Prot
UniProt	A0A0G2K2Q4_RAT	UniProtKB/TrEMBL
	A0A8I6AA78_RAT	UniProtKB/TrEMBL
	A6HVM2	ENTREZGENE, UniProtKB/TrEMBL
	Q5XIB9	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-05-02	Tifa	TRAF-interacting protein with forkhead-associated domain	T2bp	Traf2 binding protein	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-03-05	T2bp	Traf2 binding protein	LOC310877	TRAF2 binding protein	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-07-29	LOC310877	TRAF2 binding protein			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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