Or4n4 (olfactory receptor family 4 subfamily N member 4) - Rat Genome Database

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Gene: Or4n4 (olfactory receptor family 4 subfamily N member 4) Rattus norvegicus
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Symbol: Or4n4
Name: olfactory receptor family 4 subfamily N member 4
RGD ID: 1333578
Description: Predicted to enable olfactory receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway and detection of chemical stimulus involved in sensory perception of smell. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to several human genes including OR4N4 (olfactory receptor family 4 subfamily N member 4); INTERACTS WITH bisphenol A; C60 fullerene; vinclozolin.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: olfactory receptor 1611; olfactory receptor 4N2; olfactory receptor 4N4; olfactory receptor 733; olfactory receptor gene Olr1611; olfactory receptor Olr1611; Olfr733; Olr1611; ratchr15-26035847-26036773_ORF
RGD Orthologs
Human
Mouse
Dog
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81525,968,149 - 25,969,140 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1525,968,149 - 25,969,140 (+)EnsemblGRCr8
mRatBN7.21523,494,563 - 23,495,554 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1523,492,445 - 23,498,563 (+)EnsemblmRatBN7.2
Rnor_6.01527,076,234 - 27,077,198 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1527,076,234 - 27,077,160 (-)Ensemblrn6Rnor6.0
RGSC_v3.41526,020,147 - 26,022,189 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1523,826,467 - 23,827,527 (+)NCBICelera
RGSC_v3.11526,035,846 - 26,036,755 (+)NCBI
Cytogenetic Map15p14NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
membrane  (IEA)
plasma membrane  (IBA,IEA)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Gibbs RA, etal., Nature 2004 Apr 1;428(6982):493-521.
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Or4n4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81525,968,149 - 25,969,140 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1525,968,149 - 25,969,140 (+)EnsemblGRCr8
mRatBN7.21523,494,563 - 23,495,554 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1523,492,445 - 23,498,563 (+)EnsemblmRatBN7.2
Rnor_6.01527,076,234 - 27,077,198 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1527,076,234 - 27,077,160 (-)Ensemblrn6Rnor6.0
RGSC_v3.41526,020,147 - 26,022,189 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1523,826,467 - 23,827,527 (+)NCBICelera
RGSC_v3.11526,035,846 - 26,036,755 (+)NCBI
Cytogenetic Map15p14NCBI
OR4N4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381522,094,522 - 22,095,862 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1522,094,522 - 22,095,862 (+)Ensemblhg38GRCh38
GRCh371522,382,473 - 22,383,813 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361519,883,837 - 19,884,787 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341519,883,836 - 19,884,787NCBI
Celera15246,446 - 247,396 (-)NCBICelera
Cytogenetic Map15q11.2NCBI
HuRef15783,093 - 784,435 (+)NCBIHuRef
CHM1_11522,324,624 - 22,325,965 (+)NCBICHM1_1
T2T-CHM13v2.01519,000,207 - 19,001,547 (+)NCBIT2T-CHM13v2.0
Or4n4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391450,518,685 - 50,519,728 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1450,515,930 - 50,521,663 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381450,281,228 - 50,282,271 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1450,278,473 - 50,284,206 (-)Ensemblmm10GRCm38
MGSCv371450,900,903 - 50,901,946 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361449,203,276 - 49,204,202 (-)NCBIMGSCv36mm8
Celera1446,515,083 - 46,516,126 (-)NCBICelera
Cytogenetic Map14C1NCBI
cM Map1426.03NCBI
OR4N2B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11517,248,135 - 17,249,061 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1517,248,135 - 17,249,061 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1517,711,912 - 17,712,838 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01517,505,492 - 17,506,418 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1517,505,492 - 17,506,418 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11517,191,361 - 17,192,287 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01517,246,667 - 17,247,593 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01517,371,312 - 17,372,238 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
LOC100157798
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1779,003,689 - 79,004,969 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27133,543,058 - 133,543,984 (-)NCBISscrofa10.2Sscrofa10.2susScr3

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:118
Count of miRNA genes:99
Interacting mature miRNAs:106
Transcripts:ENSRNOT00000016721
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1641913Colcr2Colorectal carcinoma resistance QTL 26.570.0197intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)15231575947315759Rat
5684946Bss98Bone structure and strength QTL 983.90.0026tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)15139411584Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15144836456Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15231575953331089Rat
10755503Bp391Blood pressure QTL 3912.37arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)152272835342072050Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1525285835104695021Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)152233635152597086Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)1525285835104695021Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151915576287086765Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)15278592347785923Rat
1354657Despr13Despair related QTL 130.0022locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)15132342855Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151492659471614418Rat
631550Bw7Body weight QTL 73.6body mass (VT:0001259)body weight (CMO:0000012)152233635167336351Rat
5685002Bss103Bone structure and strength QTL 1032.8tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)151691152132439851Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)1525285835104695021Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
endocrine system
endoderm
hemolymphoid system
mesenchyme
mesoderm
respiratory system
1 6 8 15 16 15 8

Sequence


Ensembl Acc Id: ENSRNOT00000016721   ⟹   ENSRNOP00000016721
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1523,479,417 - 23,482,838 (-)Ensembl
Rnor_6.0 Ensembl1527,076,234 - 27,077,160 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000107291   ⟹   ENSRNOP00000084436
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1523,493,320 - 23,498,563 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000111045   ⟹   ENSRNOP00000092916
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1523,492,445 - 23,498,563 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000145158   ⟹   ENSRNOP00000101582
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1525,968,149 - 25,969,140 (+)Ensembl
RefSeq Acc Id: NM_001408737   ⟹   NP_001395666
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81525,968,149 - 25,969,140 (+)NCBI
mRatBN7.21523,494,563 - 23,495,554 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001395666 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000101582
  ENSRNOP00000101582.1
Ensembl Acc Id: ENSRNOP00000016721   ⟸   ENSRNOT00000016721
Ensembl Acc Id: ENSRNOP00000084436   ⟸   ENSRNOT00000107291
Ensembl Acc Id: ENSRNOP00000092916   ⟸   ENSRNOT00000111045
RefSeq Acc Id: NP_001395666   ⟸   NM_001408737
- UniProtKB: A0A8I6GAD9 (UniProtKB/TrEMBL),   A6KE97 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000101582   ⟸   ENSRNOT00000145158
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A090-F1-model_v2 AlphaFold D4A090 1-308 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1333578 AgrOrtholog
BioCyc Gene G2FUF-14086 BioCyc
Ensembl Genes ENSRNOG00000047419 Ensembl
  ENSRNOG00000065899 Ensembl
  ENSRNOG00000077425 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000145158 ENTREZGENE
  ENSRNOT00000145158.1 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro 7TM_GPCR_Rhodpsn UniProtKB/TrEMBL
  GPCR_Rhodpsn_supfam UniProtKB/TrEMBL
  Olfact_rcpt UniProtKB/TrEMBL
  Olfactory_Receptors UniProtKB/TrEMBL
NCBI Gene 290009 ENTREZGENE
PANTHER OLFACTORY RECEPTOR UniProtKB/TrEMBL
Pfam 7tm_4 UniProtKB/TrEMBL
PhenoGen Or4n4 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/TrEMBL
  OLFACTORYR UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000047419 RatGTEx
  ENSRNOG00000065899 RatGTEx
  ENSRNOG00000077425 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/TrEMBL
UniProt A0A8I6GAD9 ENTREZGENE, UniProtKB/TrEMBL
  A6KE97 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-08-16 Or4n4  olfactory receptor family 4 subfamily N member 4  Olr1611  olfactory receptor 1611  Symbol and Name Changed 1299863 APPROVED
2022-06-02 Olr1611  olfactory receptor 1611  Olr1611  olfactory receptor 1611  Data merged from RGD:149736203 737654 PROVISIONAL
2021-08-09 Olr1611  olfactory receptor 1611      Symbol and Name status set to provisional 45752 PROVISIONAL
2008-04-30 Olr1611  olfactory receptor 1611   Olr1611_predicted  olfactory receptor 1611 (predicted)  'predicted' is removed 2292626 APPROVED
2005-02-07 Olr1611_predicted  olfactory receptor 1611 (predicted)  Olfr733_predicted  olfactory receptor 733 (predicted)  Symbol and Name status set to approved 737654 APPROVED
2005-02-04 Olr1611_predicted  olfactory receptor 1611 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-01-12 Olfr733_predicted  olfactory receptor 733 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL