Or6s1 (olfactory receptor family 6 subfamily S member 1) - Rat Genome Database

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Gene: Or6s1 (olfactory receptor family 6 subfamily S member 1) Rattus norvegicus
Analyze
Symbol: Or6s1
Name: olfactory receptor family 6 subfamily S member 1
RGD ID: 1333368
Description: Predicted to enable olfactory receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway and detection of chemical stimulus involved in sensory perception of smell. Predicted to be located in plasma membrane. Orthologous to human OR6S1 (olfactory receptor family 6 subfamily S member 1); INTERACTS WITH acetamide; bisphenol A; 3-methylcholanthrene (ortholog).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: olfactory receptor 1637; olfactory receptor gene Olr1637; olfactory receptor Olr1637; Olr1637
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81526,765,062 - 26,766,057 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1526,761,131 - 26,769,719 (-)EnsemblGRCr8
mRatBN7.21524,291,540 - 24,292,535 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1524,291,243 - 24,295,559 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1527,062,704 - 27,063,699 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01528,022,158 - 28,023,153 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01526,271,259 - 26,272,254 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01527,996,520 - 27,999,286 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1527,996,815 - 27,997,810 (-)Ensemblrn6Rnor6.0
Rnor_5.01531,814,450 - 31,832,055 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41527,051,246 - 27,052,241 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1524,611,413 - 24,612,408 (-)NCBICelera
RGSC_v3.11527,066,945 - 27,067,941 (-)NCBI
Cytogenetic Map15p14NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
membrane  (IEA)
plasma membrane  (IBA,IEA)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Gibbs RA, etal., Nature 2004 Apr 1;428(6982):493-521.
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Or6s1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81526,765,062 - 26,766,057 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1526,761,131 - 26,769,719 (-)EnsemblGRCr8
mRatBN7.21524,291,540 - 24,292,535 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1524,291,243 - 24,295,559 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1527,062,704 - 27,063,699 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01528,022,158 - 28,023,153 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01526,271,259 - 26,272,254 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01527,996,520 - 27,999,286 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1527,996,815 - 27,997,810 (-)Ensemblrn6Rnor6.0
Rnor_5.01531,814,450 - 31,832,055 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41527,051,246 - 27,052,241 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1524,611,413 - 24,612,408 (-)NCBICelera
RGSC_v3.11527,066,945 - 27,067,941 (-)NCBI
Cytogenetic Map15p14NCBI
OR6S1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381420,640,696 - 20,641,691 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1420,640,696 - 20,641,691 (-)Ensemblhg38GRCh38
GRCh371421,108,855 - 21,109,850 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361420,178,695 - 20,179,690 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341420,178,694 - 20,179,690NCBI
Celera14969,732 - 970,727 (-)NCBICelera
Cytogenetic Map14q11.2NCBI
HuRef141,229,809 - 1,230,804 (-)NCBIHuRef
CHM1_11421,110,894 - 21,111,889 (-)NCBICHM1_1
T2T-CHM13v2.01414,837,806 - 14,838,801 (-)NCBIT2T-CHM13v2.0
Or6s1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391451,307,768 - 51,308,899 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1451,303,758 - 51,311,892 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381451,070,311 - 51,071,442 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1451,066,301 - 51,074,435 (-)Ensemblmm10GRCm38
MGSCv371451,689,986 - 51,691,117 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361449,992,347 - 49,993,342 (-)NCBIMGSCv36mm8
Celera1447,348,028 - 47,349,159 (-)NCBICelera
Cytogenetic Map14C1NCBI
cM Map1426.37NCBI
LOC102026574
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555501,434,291 - 1,438,383 (-)Ensembl
ChiLan1.0NW_0049555501,434,291 - 1,438,383 (-)NCBIChiLan1.0ChiLan1.0
LOC100992836
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21522,140,201 - 22,141,614 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11421,356,688 - 21,358,101 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0141,505,560 - 1,506,695 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11419,562,882 - 19,563,877 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1419,562,882 - 19,563,877 (-)EnsemblpanPan2panpan1.1
OR6S1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11517,933,904 - 17,935,530 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1517,934,181 - 17,935,176 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1518,418,535 - 18,419,868 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01518,193,056 - 18,194,389 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
UMICH_Zoey_3.11517,874,767 - 17,876,100 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01517,930,666 - 17,931,999 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01518,059,179 - 18,060,512 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
LOC101965133
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864077,887,051 - 77,888,222 (-)NCBIHiC_Itri_2
SpeTri2.0NW_00493719071,137 - 72,125 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOC100154303
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl778,307,070 - 78,308,065 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1778,307,070 - 78,308,065 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2783,334,079 - 83,335,074 (+)NCBISscrofa10.2Sscrofa10.2susScr3
OR6S1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12921,166,555 - 21,168,727 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605925,263,669 - 25,264,709 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
LOC101713076
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248254,548,165 - 4,549,172 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
LOC116913988
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11272,242,337 - 72,243,539 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Or6s1
68 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:38
Count of miRNA genes:35
Interacting mature miRNAs:38
Transcripts:ENSRNOT00000034647
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1641913Colcr2Colorectal carcinoma resistance QTL 26.570.0197intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)15231575947315759Rat
5684946Bss98Bone structure and strength QTL 983.90.0026tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)15139411584Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15144836456Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15231575953331089Rat
10755503Bp391Blood pressure QTL 3912.37arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)152272835342072050Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1525285835104695021Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)152233635152597086Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)1525285835104695021Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151915576287086765Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)15278592347785923Rat
1354657Despr13Despair related QTL 130.0022locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)15132342855Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151492659471614418Rat
631550Bw7Body weight QTL 73.6body mass (VT:0001259)body weight (CMO:0000012)152233635167336351Rat
5685002Bss103Bone structure and strength QTL 1032.8tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)151691152132439851Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)1525285835104695021Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
11 3 23 71 80 85 57 81 57 4 228 118 2 57 39 63 28 10 10

Sequence


Ensembl Acc Id: ENSRNOT00000034647   ⟹   ENSRNOP00000031284
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1526,764,687 - 26,769,719 (-)Ensembl
mRatBN7.2 Ensembl1524,291,243 - 24,295,559 (-)Ensembl
Rnor_6.0 Ensembl1527,996,815 - 27,997,810 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000121958   ⟹   ENSRNOP00000107030
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1526,764,928 - 26,767,491 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000159206   ⟹   ENSRNOP00000112012
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1526,761,131 - 26,766,256 (-)Ensembl
RefSeq Acc Id: NM_001000503   ⟹   NP_001000503
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81526,765,062 - 26,766,057 (-)NCBI
mRatBN7.21524,291,540 - 24,292,535 (-)NCBI
Rnor_6.01527,996,815 - 27,997,810 (-)NCBI
Rnor_5.01531,814,450 - 31,832,055 (-)NCBI
RGSC_v3.41527,051,246 - 27,052,241 (-)RGD
Celera1524,611,413 - 24,612,408 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001000503 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL88435 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000031284.3
  ENSRNOP00000107030
  ENSRNOP00000107030.1
  ENSRNOP00000112012.1
RefSeq Acc Id: NP_001000503   ⟸   NM_001000503
- UniProtKB: A6KED0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000031284   ⟸   ENSRNOT00000034647
Ensembl Acc Id: ENSRNOP00000107030   ⟸   ENSRNOT00000121958
Ensembl Acc Id: ENSRNOP00000112012   ⟸   ENSRNOT00000159206
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZBB6-F1-model_v2 AlphaFold D3ZBB6 1-331 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1333368 AgrOrtholog
BioCyc Gene G2FUF-14036 BioCyc
Ensembl Genes ENSRNOG00000025640 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000034647.4 UniProtKB/TrEMBL
  ENSRNOT00000121958 ENTREZGENE
  ENSRNOT00000121958.1 UniProtKB/TrEMBL
  ENSRNOT00000159206.1 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro 7TM_GPCR_Rhodpsn UniProtKB/TrEMBL
  GPCR_Rhodpsn_supfam UniProtKB/TrEMBL
  Olfact_rcpt UniProtKB/TrEMBL
  Olfact_rcpt_6C-like UniProtKB/TrEMBL
NCBI Gene 305841 ENTREZGENE
PANTHER OLFACTORY RECEPTOR UniProtKB/TrEMBL
  OLFACTORY RECEPTOR 6S1 UniProtKB/TrEMBL
Pfam 7tm_4 UniProtKB/TrEMBL
PhenoGen Or6s1 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/TrEMBL
  OLFACTORYR UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000025640 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/TrEMBL
UniProt A0ABK0LX88_RAT UniProtKB/TrEMBL
  A0ABK0MA81_RAT UniProtKB/TrEMBL
  A6KED0 ENTREZGENE, UniProtKB/TrEMBL
  D3ZBB6_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-08-16 Or6s1  olfactory receptor family 6 subfamily S member 1  Olr1637  olfactory receptor 1637  Symbol and Name Changed 1299863 APPROVED
2008-04-30 Olr1637  olfactory receptor 1637   Olr1637_predicted  olfactory receptor 1637 (predicted)  'predicted' is removed 2292626 APPROVED
2005-02-04 Olr1637_predicted  olfactory receptor 1637 (predicted)      Symbol and Name status set to approved 70820 APPROVED